Ambient light display presents peripheral information unobtrusively,and it can be context aware and aesthetically enhance specific environment.However,since the abstract characteristic of light,people should attentive...Ambient light display presents peripheral information unobtrusively,and it can be context aware and aesthetically enhance specific environment.However,since the abstract characteristic of light,people should attentively keep agood balance between unobtrusiveness and effectiveness,when designing an ambient light display.Especially,in the condition of high information capacity,ambient light display need a mechanism to portray information effectively.In this paper,a framework with an overlay mechanism is evaluated for high information capacity.Based on the framework,two ambient light displays are designed to support the evaluation work.The evaluation questions are related with three aspects including information understanding,transition and encoding,special output channel.From the perception level,interpretation level and experience level,the process of evaluation is implemented.The results indicate that the framework with the overlay mechanism can effectively support varied and specific communicating information.The transitions and information encoding benefit from the proper mapping of states and notification levels in the framework.展开更多
The mitochondrial proton motive force(pmf)is a critical driver of cellular energy production and influences various cellular processes.Dysregulation of pmf is implicated in a range of diseases,including neurodegenerat...The mitochondrial proton motive force(pmf)is a critical driver of cellular energy production and influences various cellular processes.Dysregulation of pmf is implicated in a range of diseases,including neurodegenerative diseases,mitochondrial diseases,cancer and aging-related pathologies.Currently,an efficient strategy to rescue ATP production and mitigate reactive oxygen species(ROS)generation under conditions of energy deprivation is lacking.Here,we engineered a light-sensitive,mitochondria-targeting proton-pumping rhodopsin(PPR),mt-EcGAPR,capable of generating an efficient pmf for ATP synthesis while simultaneously mitigating reactive oxygen species(ROS)generation during stress and decreasing DNA double-strand breaks(DSBs).Owing to its transparency to visible light,eye is the ideal candidate for the noninvasive application of mt-EcGAPR in the treatment of mitochondria-related retinal degenerative diseases.Using a silicone oil-induced ocular hypertension glaucoma mouse model,we demonstrate that ambient light activation of mt-EcGAPR significantly increased ATP production,suppressed ROS accumulation,and protected retinal ganglion cells(RGCs)from degeneration.Mechanistically,mt-EcGAPR inhibited endoplasmic reticulum(ER)stress-ATF6-gasdermin D(GSDMD)-mediated pyroptosis,thereby preserving retinal structure and function.This intervention ultimately led to improved visual acuity in glaucomatous eyes of mice.Collectively,our findings establish mt-EcGAPR as a promising therapeutic strategy for glaucoma and potentially other neurodegenerative diseases associated with mitochondrial dysfunction and impaired bioenergetics.展开更多
Female cichlid fish living in African great lakes are known to have sensory systems that are adapted to ambient light environments.These sen-sory system adaptations are hypothesized to have influenced the evolution of...Female cichlid fish living in African great lakes are known to have sensory systems that are adapted to ambient light environments.These sen-sory system adaptations are hypothesized to have influenced the evolution of the diverse male nuptial coloration.In rock-dwelling Lake Malawi mbuna cichlids,however,the extent to which ambient light environments influence female sensory systems and potentially associated male nuptial coloration remains unknown.Yet,the ubiquitous blue flank coloration and UV reflection of male mbuna cichlids suggest the potential impacts of the blue-shifted ambient light environment on these cichlid's visual perception and male nuptial coloration in the shallow water depth in Lake Malawi.In the present study,we explored whether and how the sensory bias of females influences intersexual communication in the mbuna cichlid,Metriaclima zebra.A series of choice experiments in various light environments showed that M.zebra females (1)have a pref-erence for the blue-shifted light environment,(2)prefer to interact with males in blue-shifted light environments,(3)do not show a preference between dominant and subordinate males in full-spectrum,long-wavelength filtered,and short-wavelength filtered light environments,and (4)show a"reversed"preference for subordinate males in the UV-filtered light environment.These results suggest that the visual perception of M.zebra females may be biased to the ambient light spectra in their natural habitat by local adaptation and that this sensory bias may influence the evolution of blueand UV reflectivepatterns in male nuptial coloration.展开更多
Theill-posed character of haze or fogmakes it difficult to remove froma single image.While most existing methods rely on a transmission map refined through depth estimation and assume a constant scattering coefficient...Theill-posed character of haze or fogmakes it difficult to remove froma single image.While most existing methods rely on a transmission map refined through depth estimation and assume a constant scattering coefficient,this assumption limits their effectiveness.In this paper,we propose an enhanced transmission map that incorporates spatially varying scattering information inherent in hazy images.To improve linearity,the model utilizes the ratio of the difference between intensity and saturation to their sum.Our approach also addresses critical issues such as edge preservation and color fidelity.In terms of qualitative as well as quantitative analysis,experimental outcomes show that the suggested framework is more effective than the currently used haze removal techniques.展开更多
针对当前主流增强现实显示设备中的光学组合器存在的光效低,或系统复杂,或不便携带等问题,提出了直投式视网膜投影增强现实近眼显示光学系统的设计方案。光学系统自像面至物面之间依次包括视网膜投影透镜、平行光像源和补偿透镜组三个...针对当前主流增强现实显示设备中的光学组合器存在的光效低,或系统复杂,或不便携带等问题,提出了直投式视网膜投影增强现实近眼显示光学系统的设计方案。光学系统自像面至物面之间依次包括视网膜投影透镜、平行光像源和补偿透镜组三个部分。在仿真过程中,使用玻璃平板替代平行光像源,视网膜投影透镜选择双胶合透镜作为初始结构进行仿真和优化,在设计和仿真补偿透镜组时引入偶次非球面进行设计,同时仿真过程中使用人眼模型进行辅助优化,以模拟实际应用情况。最后,光学系统中的平行光像源使用激光光源及相关光学器件,并使用几何透镜搭建了该光学系统的实物样机以验证系统的显示效果。经过仿真和优化,所设计的光学系统工作在486~656 nm波段,对平行的像源光线进行成像时,点列图均方根(Root Mean Square,RMS)半径为9.59μm,在截止频率处的调制传递函数(Modulation Transfer Function,MTF)大于0.8;加入补偿透镜组后,整个系统对环境光成像时,在0°、3.75°和7.5°的三个半视场的点列图RMS半径分别为3.28μm、4.44μm和5.36μm,且全视场在截止频率处的MTF大于0.6,所设计的光学系统对显示像源和环境光的功率衰减分别在10%以下及30%以下。该系统可实现视网膜投影成像同时对环境光进行补偿,所搭建的样机可实现增强现实显示效果,系统有好的成像质量、高光效和结构简单等优点。展开更多
基金Supported by the Foundation Program of Education Department of Jiangsu Province for Young Teachers and Principals
文摘Ambient light display presents peripheral information unobtrusively,and it can be context aware and aesthetically enhance specific environment.However,since the abstract characteristic of light,people should attentively keep agood balance between unobtrusiveness and effectiveness,when designing an ambient light display.Especially,in the condition of high information capacity,ambient light display need a mechanism to portray information effectively.In this paper,a framework with an overlay mechanism is evaluated for high information capacity.Based on the framework,two ambient light displays are designed to support the evaluation work.The evaluation questions are related with three aspects including information understanding,transition and encoding,special output channel.From the perception level,interpretation level and experience level,the process of evaluation is implemented.The results indicate that the framework with the overlay mechanism can effectively support varied and specific communicating information.The transitions and information encoding benefit from the proper mapping of states and notification levels in the framework.
基金supported by the National Natural Science Foundation of China(NSF,Grants#92054103 and#32071137 to J.S.K.,#T2325008,#82588301 and#82021002 to J.Y.Z.,#32000522 to P.P.L.)JSK was also supported by the Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University(Grant#ZYCXTD2023014)+7 种基金Funding was provided by the Ministry of Science and Technology of China(MOST,Grants#2022ZD0208604,#2022ZD0208605,#2024YFC2510800,and#2024ZD0530302 to J.Y.Z.,#2022ZD0210000 to B.Y.)the National Key Research and Development Program of China(Grant#2024YFC2510800)P.P.L.was funded by the Joint Construction Program for Medical Science and Technology Development of Henan Province of China(Grant#2018020088)the Natural Science Foundation of Henan Province of China(Grant#202300410420)Additional support came from the Science and Technology Commission of Shanghai Municipality(Grants#21TQ013 to J.Y.Z.and#25TQ009 to B.Y.)from the Key Research and Development Program of Ningxia(Grant#2022BEG02046 to J.Y.Z.)This work has been supported by the New Cornerstone Science Foundation through the New Cornerstone Investigator Programthe XPLORER PRIZE to J.Y.Z.J.Y.Z.is a SANS explorer scholar.
文摘The mitochondrial proton motive force(pmf)is a critical driver of cellular energy production and influences various cellular processes.Dysregulation of pmf is implicated in a range of diseases,including neurodegenerative diseases,mitochondrial diseases,cancer and aging-related pathologies.Currently,an efficient strategy to rescue ATP production and mitigate reactive oxygen species(ROS)generation under conditions of energy deprivation is lacking.Here,we engineered a light-sensitive,mitochondria-targeting proton-pumping rhodopsin(PPR),mt-EcGAPR,capable of generating an efficient pmf for ATP synthesis while simultaneously mitigating reactive oxygen species(ROS)generation during stress and decreasing DNA double-strand breaks(DSBs).Owing to its transparency to visible light,eye is the ideal candidate for the noninvasive application of mt-EcGAPR in the treatment of mitochondria-related retinal degenerative diseases.Using a silicone oil-induced ocular hypertension glaucoma mouse model,we demonstrate that ambient light activation of mt-EcGAPR significantly increased ATP production,suppressed ROS accumulation,and protected retinal ganglion cells(RGCs)from degeneration.Mechanistically,mt-EcGAPR inhibited endoplasmic reticulum(ER)stress-ATF6-gasdermin D(GSDMD)-mediated pyroptosis,thereby preserving retinal structure and function.This intervention ultimately led to improved visual acuity in glaucomatous eyes of mice.Collectively,our findings establish mt-EcGAPR as a promising therapeutic strategy for glaucoma and potentially other neurodegenerative diseases associated with mitochondrial dysfunction and impaired bioenergetics.
文摘Female cichlid fish living in African great lakes are known to have sensory systems that are adapted to ambient light environments.These sen-sory system adaptations are hypothesized to have influenced the evolution of the diverse male nuptial coloration.In rock-dwelling Lake Malawi mbuna cichlids,however,the extent to which ambient light environments influence female sensory systems and potentially associated male nuptial coloration remains unknown.Yet,the ubiquitous blue flank coloration and UV reflection of male mbuna cichlids suggest the potential impacts of the blue-shifted ambient light environment on these cichlid's visual perception and male nuptial coloration in the shallow water depth in Lake Malawi.In the present study,we explored whether and how the sensory bias of females influences intersexual communication in the mbuna cichlid,Metriaclima zebra.A series of choice experiments in various light environments showed that M.zebra females (1)have a pref-erence for the blue-shifted light environment,(2)prefer to interact with males in blue-shifted light environments,(3)do not show a preference between dominant and subordinate males in full-spectrum,long-wavelength filtered,and short-wavelength filtered light environments,and (4)show a"reversed"preference for subordinate males in the UV-filtered light environment.These results suggest that the visual perception of M.zebra females may be biased to the ambient light spectra in their natural habitat by local adaptation and that this sensory bias may influence the evolution of blueand UV reflectivepatterns in male nuptial coloration.
基金The Deanship of Research and Graduate Studies at King Khalid University funded this work through a Large Research Project under grant number RGP2/274/46.
文摘Theill-posed character of haze or fogmakes it difficult to remove froma single image.While most existing methods rely on a transmission map refined through depth estimation and assume a constant scattering coefficient,this assumption limits their effectiveness.In this paper,we propose an enhanced transmission map that incorporates spatially varying scattering information inherent in hazy images.To improve linearity,the model utilizes the ratio of the difference between intensity and saturation to their sum.Our approach also addresses critical issues such as edge preservation and color fidelity.In terms of qualitative as well as quantitative analysis,experimental outcomes show that the suggested framework is more effective than the currently used haze removal techniques.
文摘针对当前主流增强现实显示设备中的光学组合器存在的光效低,或系统复杂,或不便携带等问题,提出了直投式视网膜投影增强现实近眼显示光学系统的设计方案。光学系统自像面至物面之间依次包括视网膜投影透镜、平行光像源和补偿透镜组三个部分。在仿真过程中,使用玻璃平板替代平行光像源,视网膜投影透镜选择双胶合透镜作为初始结构进行仿真和优化,在设计和仿真补偿透镜组时引入偶次非球面进行设计,同时仿真过程中使用人眼模型进行辅助优化,以模拟实际应用情况。最后,光学系统中的平行光像源使用激光光源及相关光学器件,并使用几何透镜搭建了该光学系统的实物样机以验证系统的显示效果。经过仿真和优化,所设计的光学系统工作在486~656 nm波段,对平行的像源光线进行成像时,点列图均方根(Root Mean Square,RMS)半径为9.59μm,在截止频率处的调制传递函数(Modulation Transfer Function,MTF)大于0.8;加入补偿透镜组后,整个系统对环境光成像时,在0°、3.75°和7.5°的三个半视场的点列图RMS半径分别为3.28μm、4.44μm和5.36μm,且全视场在截止频率处的MTF大于0.6,所设计的光学系统对显示像源和环境光的功率衰减分别在10%以下及30%以下。该系统可实现视网膜投影成像同时对环境光进行补偿,所搭建的样机可实现增强现实显示效果,系统有好的成像质量、高光效和结构简单等优点。
