Subduction initiation is a critical part of the plate tectonic system,but its geodynamic process is still poorly understood due to the lack of well-preserved geological records.Based on new zircon U–Pb–Hf isotopic a...Subduction initiation is a critical part of the plate tectonic system,but its geodynamic process is still poorly understood due to the lack of well-preserved geological records.Based on new zircon U–Pb–Hf isotopic and whole-rock geochemical data,we report the first discovery of a latest Cambrian–Early Ordovician forearc-arc rock sequence in the Eastern Alps.This sequence includes granitic gneisses,amphibolites,and amphibole plagiogneisses from the ophiolitic Speik Complex and Gleinalpe Complex.These rocks exhibit geochemical affinities with typical oceanic plagiogranites,forearc basalts(FABs),and island arc basalts,respectively.The latest Cambrian plagiogranitic protoliths(491±2 Ma)are shearing-type plagiogranites that were formed in the tectonic setting of forearc spreading.The latest Cambrian FABs(496–489 Ma)have similar geochemical compositions and positiveεHf(t)values(+2.5 to+14.9)to the depleted mid-ocean ridge basalts.However,they show depletion in high field strength elements(HFSEs;e.g.,Nb,Ta,and Zr)and have relatively low Ti/V ratios.These features suggest that they were derived from a depleted mantle source modified by subducting slab-released components in a forearc environment.The Early Ordovician basaltic protoliths(476–472 Ma)of amphibole plagiogneisses show enrichment in large ion lithophile elements and depletion in HFSEs(e.g.Nb,Ta,Zr,and Hf),implying a mature island arc environment.These metaigneous rocks,along with the coeval boninite-like high-Mg amphibolites near the study area,form a typical rock sequence resembling that of the Izu–Bonin–Mariana(IBM)arc system.The Speik and Gleinalpe complexes document a complete magmatic evolution from subduction initiation to mature arc development within the West Proto-Tethys Ocean.Integrating our new data with published work,we reconstruct the late Ediacaran–early Paleozoic tectonic evolution of the northern Gondwana.During the late Ediacaran–early Cambrian,the rollback of the West Proto-Tethys oceanic plate triggered the separation of the Wechsel-Silvretta-Gleinalpe continental arc from the northern Gondwana.This process led to the formation of the Speik back-arc oceanic basin,a southwestern branch of the West Proto-Tethys Ocean.In the latest Cambrian–Early Ordovician,subduction initiation occurred in the Speik Ocean,which subsequently developed into an intra-oceanic arc system.During the Early Devonian,the Speik Ocean closed and the Wechsel-Silvretta-Gleinalpe continental arc reattached to the Gondwana,as evidenced by the metamorphic event at ca.400 Ma.展开更多
目的:多参数磁共振成像(multiparametric magnetic resonance imaging, mpMRI)联合血清碱性磷酸酶(alkaline phosphatase, ALP)、D-二聚体(D-dimer, DD2)、纤维蛋白原(fibrinogen, FIB)诊断前列腺癌骨转移的效能分析。方法:对169例前列...目的:多参数磁共振成像(multiparametric magnetic resonance imaging, mpMRI)联合血清碱性磷酸酶(alkaline phosphatase, ALP)、D-二聚体(D-dimer, DD2)、纤维蛋白原(fibrinogen, FIB)诊断前列腺癌骨转移的效能分析。方法:对169例前列腺癌患者的临床资料进行回顾性收集和分析,根据骨扫描的检查结果辅以核磁共振,将盆腔有无骨转移的病人分为前列腺癌骨转移组80例和非骨转移组89例。所有患者在手术前都接受了MRI检查,对血清PSA、ALP、D-二聚体、FIB水平进行定量检测。对不同影像指标与前列腺癌骨转移结果之间的一致性采用Kappa一致性检验;利用单因素和多因素Logistic回归分析,评估mpMRI、ALP、D-二聚体、FIB及其他临床指标在前列腺癌骨转移诊断中的价值。利用受试者工作特征(receiver operating characteristic, ROC)曲线对前列腺癌骨转移中纳入的mpMRI、ALP、D-二聚体、FIB及其联合指标的临床应用价值进行评价。结果:T1WI、T2WI压脂、DWI及mpMRI与前列腺癌骨转移结果比较的Kappa值分别为0.536、0.470、0.629、0.691 (P Objective: To analyze the efficacy of multiparametric MRI (mpMRI) combined with serum ALP, D-dimer, and FIB in the diagnosis of bone metastasis in prostate cancer. Methods: A retrospective collection and analysis of clinical data from 169 prostate cancer patients were conducted. Based on the results of bone scans supplemented by MRI, patients with or without pelvic bone metastasis were divided into the prostate cancer bone metastasis group (80 cases) and the non-bone metastasis group (89 cases). All patients underwent MRI examination prior to surgery, and serum levels of PSA, ALP, D-dimer, and FIB were quantitatively measured. Kappa consistency tests were used to analyze the agreement between different imaging indicators and the results of prostate cancer bone metastasis. Uni- and multivariable logistic regression analyses were performed to evaluate the value of mpMRI, ALP, D-dimer, FIB, and other clinical indicators in the diagnosis of prostate cancer bone metastasis. The clinical application value of mpMRI, ALP, D-dimer, FIB, and their combined indicators in diagnosing prostate cancer bone metastasis was assessed using receiver operating characteristic (ROC) curves. Results: The Kappa values comparing T1WI, T2WI fat suppression, DWI, and mpMRI with the results of prostate cancer bone metastasis were 0.536, 0.470, 0.629, and 0.691, respectively (P < 0.001). Compared to the non-bone metastasis group, the serum levels of ALP, D-dimer, and FIB in the bone metastasis group were significantly higher (P < 0.001). Multivariable logistic regression analysis indicated that mpMRI, ALP, D-dimer, and FIB are independent risk factors for prostate cancer bone metastasis (P < 0.05). The combined indicators showed the best performance, followed by the individual indicators of D-dimer, mpMRI, ALP, and FIB, all of which demonstrated good diagnostic value (P < 0.05). Conclusion: mpMRI, ALP, D-dimer, and FIB all demonstrate certain diagnostic efficacy for prostate cancer bone metastasis. The combined use of these indicators can further enhance diagnostic value, suggesting that they should be considered for broader application in clinical practice.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.42272244 and 91755212)Taishan Scholars(Grant No.ts20190918).
文摘Subduction initiation is a critical part of the plate tectonic system,but its geodynamic process is still poorly understood due to the lack of well-preserved geological records.Based on new zircon U–Pb–Hf isotopic and whole-rock geochemical data,we report the first discovery of a latest Cambrian–Early Ordovician forearc-arc rock sequence in the Eastern Alps.This sequence includes granitic gneisses,amphibolites,and amphibole plagiogneisses from the ophiolitic Speik Complex and Gleinalpe Complex.These rocks exhibit geochemical affinities with typical oceanic plagiogranites,forearc basalts(FABs),and island arc basalts,respectively.The latest Cambrian plagiogranitic protoliths(491±2 Ma)are shearing-type plagiogranites that were formed in the tectonic setting of forearc spreading.The latest Cambrian FABs(496–489 Ma)have similar geochemical compositions and positiveεHf(t)values(+2.5 to+14.9)to the depleted mid-ocean ridge basalts.However,they show depletion in high field strength elements(HFSEs;e.g.,Nb,Ta,and Zr)and have relatively low Ti/V ratios.These features suggest that they were derived from a depleted mantle source modified by subducting slab-released components in a forearc environment.The Early Ordovician basaltic protoliths(476–472 Ma)of amphibole plagiogneisses show enrichment in large ion lithophile elements and depletion in HFSEs(e.g.Nb,Ta,Zr,and Hf),implying a mature island arc environment.These metaigneous rocks,along with the coeval boninite-like high-Mg amphibolites near the study area,form a typical rock sequence resembling that of the Izu–Bonin–Mariana(IBM)arc system.The Speik and Gleinalpe complexes document a complete magmatic evolution from subduction initiation to mature arc development within the West Proto-Tethys Ocean.Integrating our new data with published work,we reconstruct the late Ediacaran–early Paleozoic tectonic evolution of the northern Gondwana.During the late Ediacaran–early Cambrian,the rollback of the West Proto-Tethys oceanic plate triggered the separation of the Wechsel-Silvretta-Gleinalpe continental arc from the northern Gondwana.This process led to the formation of the Speik back-arc oceanic basin,a southwestern branch of the West Proto-Tethys Ocean.In the latest Cambrian–Early Ordovician,subduction initiation occurred in the Speik Ocean,which subsequently developed into an intra-oceanic arc system.During the Early Devonian,the Speik Ocean closed and the Wechsel-Silvretta-Gleinalpe continental arc reattached to the Gondwana,as evidenced by the metamorphic event at ca.400 Ma.
文摘目的:多参数磁共振成像(multiparametric magnetic resonance imaging, mpMRI)联合血清碱性磷酸酶(alkaline phosphatase, ALP)、D-二聚体(D-dimer, DD2)、纤维蛋白原(fibrinogen, FIB)诊断前列腺癌骨转移的效能分析。方法:对169例前列腺癌患者的临床资料进行回顾性收集和分析,根据骨扫描的检查结果辅以核磁共振,将盆腔有无骨转移的病人分为前列腺癌骨转移组80例和非骨转移组89例。所有患者在手术前都接受了MRI检查,对血清PSA、ALP、D-二聚体、FIB水平进行定量检测。对不同影像指标与前列腺癌骨转移结果之间的一致性采用Kappa一致性检验;利用单因素和多因素Logistic回归分析,评估mpMRI、ALP、D-二聚体、FIB及其他临床指标在前列腺癌骨转移诊断中的价值。利用受试者工作特征(receiver operating characteristic, ROC)曲线对前列腺癌骨转移中纳入的mpMRI、ALP、D-二聚体、FIB及其联合指标的临床应用价值进行评价。结果:T1WI、T2WI压脂、DWI及mpMRI与前列腺癌骨转移结果比较的Kappa值分别为0.536、0.470、0.629、0.691 (P Objective: To analyze the efficacy of multiparametric MRI (mpMRI) combined with serum ALP, D-dimer, and FIB in the diagnosis of bone metastasis in prostate cancer. Methods: A retrospective collection and analysis of clinical data from 169 prostate cancer patients were conducted. Based on the results of bone scans supplemented by MRI, patients with or without pelvic bone metastasis were divided into the prostate cancer bone metastasis group (80 cases) and the non-bone metastasis group (89 cases). All patients underwent MRI examination prior to surgery, and serum levels of PSA, ALP, D-dimer, and FIB were quantitatively measured. Kappa consistency tests were used to analyze the agreement between different imaging indicators and the results of prostate cancer bone metastasis. Uni- and multivariable logistic regression analyses were performed to evaluate the value of mpMRI, ALP, D-dimer, FIB, and other clinical indicators in the diagnosis of prostate cancer bone metastasis. The clinical application value of mpMRI, ALP, D-dimer, FIB, and their combined indicators in diagnosing prostate cancer bone metastasis was assessed using receiver operating characteristic (ROC) curves. Results: The Kappa values comparing T1WI, T2WI fat suppression, DWI, and mpMRI with the results of prostate cancer bone metastasis were 0.536, 0.470, 0.629, and 0.691, respectively (P < 0.001). Compared to the non-bone metastasis group, the serum levels of ALP, D-dimer, and FIB in the bone metastasis group were significantly higher (P < 0.001). Multivariable logistic regression analysis indicated that mpMRI, ALP, D-dimer, and FIB are independent risk factors for prostate cancer bone metastasis (P < 0.05). The combined indicators showed the best performance, followed by the individual indicators of D-dimer, mpMRI, ALP, and FIB, all of which demonstrated good diagnostic value (P < 0.05). Conclusion: mpMRI, ALP, D-dimer, and FIB all demonstrate certain diagnostic efficacy for prostate cancer bone metastasis. The combined use of these indicators can further enhance diagnostic value, suggesting that they should be considered for broader application in clinical practice.
文摘类淋巴系统是近年发现的中枢神经系统内通过血管周围间隙执行代谢产物运输及代谢废物清除功能的系统,类淋巴系统功能下降与多种认知障碍疾病的发病机制相关。研究证实血管周围间隙扩散张量成像技术(diffusion tensor image analysis along the perivascular space,DTI-ALPS)所计算出的DTI-ALPS指数与阿尔茨海默病、帕金森、脑小血管病等疾病的认知功能障碍及疾病进展显著相关。本文将对DTI-ALPS技术在评估认知障碍疾病的类淋巴系统功能中的研究进展进行综述。
