During the three decades after the adoption of the Declaration on the Right to Development, the right to development has received wider acknowledgement throughout the international community, and has become a typical ...During the three decades after the adoption of the Declaration on the Right to Development, the right to development has received wider acknowledgement throughout the international community, and has become a typical example of 'third-generation rights.' The 2030 Agenda for Sustainable Development, which puts forward 17 goals of sustainable development, was adopted at the UN Sustainable Development Summit on September 25, 2015. From the contents of the agenda, we can see that the 2030 Agenda for Sustainable Development highly conforms to the right to development. Both match, not only in purpose and content, but also in object and subject, as well as in demands for countries and the foundations needed. We may regard the 2030 Agenda for Sustainable Development as setting action targets for the realization of the right to development in the new era. Meanwhile, to realize the right to development in the new situation is to accomplish the aim of the 2030 Agenda for Sustainable Development. The two adopt different approaches that lead to the same destination.展开更多
In April 2009, after receiving ap- proval from the State Council, the Information Office of the State Council published the NationalHuman Rights Action Plan of China （2009-2010）. It is China＇s first national plan o...In April 2009, after receiving ap- proval from the State Council, the Information Office of the State Council published the NationalHuman Rights Action Plan of China （2009-2010）. It is China＇s first national plan on the theme of human rights, and serves as a policy document of the current stage for advancing China＇s human rights in a comprehensive way. It is an important move to implement the constitutional principle of respect- ing and safeguarding human rights, and to promote sustainable development and social harmony. It is also a solemn commitment to the world made by the Chinese government on human rights.展开更多
Anti-complement activity guided fractionation led to the isolation of 24 compounds from Commelina communis.Bioassay showed that six compounds inhibited the classical pathway and alternative pathway with CH 50 values o...Anti-complement activity guided fractionation led to the isolation of 24 compounds from Commelina communis.Bioassay showed that six compounds inhibited the classical pathway and alternative pathway with CH 50 values of 0.12-1.44 mM and AP 50 values of 0.28-7.05 mM,respectively.Preliminary mechanism studies demonstrated that quinovic acid acted on C1q,C2,C3,C4,C5 and C9 components of the complement system,β-sitosterol interacted with C3 and C4,（＋）-catechin-3-O-β-Dgluco（2-cinnamoyl）-pyranoside,p-cresol and 6-methoxy-3-methylbenzene-1,2,4-triol blocked C1q,C2,C3,C5 and C9.展开更多
目的应用网络药理学及分子对接技术探讨抗癌1号方中夏枯草-猫爪草-白花蛇舌草三味君药防治喉癌的作用机制。方法通过TCMSP数据库筛选三味中药活性成分及其潜在作用靶点,利用OMIM、GeneCards、MalaCards数据库筛选喉癌细胞相关效应靶点,...目的应用网络药理学及分子对接技术探讨抗癌1号方中夏枯草-猫爪草-白花蛇舌草三味君药防治喉癌的作用机制。方法通过TCMSP数据库筛选三味中药活性成分及其潜在作用靶点,利用OMIM、GeneCards、MalaCards数据库筛选喉癌细胞相关效应靶点,构建“药物-活性成分-靶点”交互作用网络。对交集靶点进行基因本体(Gene Ontology,GO)与京都基因和基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)富集分析,继而通过分子对接验证核心成分与TOP8核心靶点的结合能力。结果共筛选出24种有效活性成分(槲皮素、β-谷甾醇、山奈酚等)及304个作用靶点,核心靶点包括JUN、IL6、AKT1等。富集分析获得160条相关信号通路,包括脂质与动脉粥样硬化、PI3K-Akt、TNF、IL-17通路等。分子对接结果表明,喉癌细胞关键靶点与三药核心活性成分具有稳定结合构象。结论抗癌1号方君药夏枯草-猫爪草-白花蛇舌草可能通过多靶点、多成分、多途径对喉癌细胞发挥潜在防治作用。展开更多
Background:To explore the action mechanism of the classic ancient prescription Si-Jun-Zi decoction in slowing down cataract process by network pharmacology.Methods:In Traditional Chinese Medicines for Systems Pharmaco...Background:To explore the action mechanism of the classic ancient prescription Si-Jun-Zi decoction in slowing down cataract process by network pharmacology.Methods:In Traditional Chinese Medicines for Systems Pharmacology Database and Analysis Platform Database,screening the chemical components and functional targets of the classic ancient prescription Si-Jun-Zi decoction,and the targets of cataract disease were obtainded through GeneCards and the Online Mendelian Inheritance in Man Database.In the STRING database,the protein-protein interaction network was built.And network visualization were created in Cytoscape.The genetic ontology and Kyoto Gene and Genome Encyclopedia pathways of key proteins were enriched via the DAVID data platform.Results:Ninety-six active components and 33 key targets were obtained in this work.The protein-protein interaction network consisted of 33 proteins.There were 33 genetic ontology entries and 72 Kyoto Gene and Genome Encyclopedia pathway enrichment analysis.Conclusion:This work provided a new means to understand the pathogenesis of cataract and revealed the action mechanisms of the classic ancient prescription Si-Jun-Zi decoction.展开更多
背景:鸢尾素在机体生理调节中发挥着至关重要的作用,能够促进白色脂肪组织细胞的棕色化进程,并且在能量代谢调节、产热活动、氧化应激削减及体质量减轻等方面具有显著作用。目的:梳理鸢尾素与相关疾病的最新研究进展。方法:应用计算机检...背景:鸢尾素在机体生理调节中发挥着至关重要的作用,能够促进白色脂肪组织细胞的棕色化进程,并且在能量代谢调节、产热活动、氧化应激削减及体质量减轻等方面具有显著作用。目的:梳理鸢尾素与相关疾病的最新研究进展。方法:应用计算机检索PubMed、MedReading、Web of Science、中国知网、万方、维普数据库,文献检索时限为2011-01-01/2024-04-13,搜集相关运动产生鸢尾素对疾病影响的研究,中文检索词为“鸢尾素,运动,疾病”等,英文检索词为“irisin,physical exercise,FNDC5,disease”等。通过纳入与排除标准,最终纳入71篇文献进行综述。结果与结论:鸢尾素在抗炎、脂肪代谢、骨代谢、大脑健康、癌症、糖尿病、心血管疾病及肾脏病等方面均有重要作用。运动可以促进鸢尾素的表达,并且不同运动形式对鸢尾素水平的影响不同,急性运动、长期运动、阻力及高强度运动均可提升鸢尾素水平。鸢尾素的发现为运动疗法提供了新的潜在基础,因鸢尾素多种生物学功能成为很有前途的治疗靶点,在治疗人类代谢性疾病及其并发症、肥胖、癌症等疾病中展现出潜在治疗价值。在临床应用方面,鸢尾素作为治疗肥胖、认知功能、心血管、癌症等疾病的潜在靶点,有一定应用前景。但鸢尾素的具体作用机制尚不明确,并且可能存在不良反应,未来需深入了解其作用机制,为鸢尾素治疗肥胖、认知功能障碍、心血管疾病、癌症等提供更充分的依据。展开更多
文摘During the three decades after the adoption of the Declaration on the Right to Development, the right to development has received wider acknowledgement throughout the international community, and has become a typical example of 'third-generation rights.' The 2030 Agenda for Sustainable Development, which puts forward 17 goals of sustainable development, was adopted at the UN Sustainable Development Summit on September 25, 2015. From the contents of the agenda, we can see that the 2030 Agenda for Sustainable Development highly conforms to the right to development. Both match, not only in purpose and content, but also in object and subject, as well as in demands for countries and the foundations needed. We may regard the 2030 Agenda for Sustainable Development as setting action targets for the realization of the right to development in the new era. Meanwhile, to realize the right to development in the new situation is to accomplish the aim of the 2030 Agenda for Sustainable Development. The two adopt different approaches that lead to the same destination.
文摘In April 2009, after receiving ap- proval from the State Council, the Information Office of the State Council published the NationalHuman Rights Action Plan of China （2009-2010）. It is China＇s first national plan on the theme of human rights, and serves as a policy document of the current stage for advancing China＇s human rights in a comprehensive way. It is an important move to implement the constitutional principle of respect- ing and safeguarding human rights, and to promote sustainable development and social harmony. It is also a solemn commitment to the world made by the Chinese government on human rights.
基金National Natural Science Foundation for ExcellentYouth (Grant No.30925042)State Key Program for the InnovativeDrugs from the Ministry of Science and Technology (Grant No.2009ZX09502-013 and 2009ZX09301-011)
文摘Anti-complement activity guided fractionation led to the isolation of 24 compounds from Commelina communis.Bioassay showed that six compounds inhibited the classical pathway and alternative pathway with CH 50 values of 0.12-1.44 mM and AP 50 values of 0.28-7.05 mM,respectively.Preliminary mechanism studies demonstrated that quinovic acid acted on C1q,C2,C3,C4,C5 and C9 components of the complement system,β-sitosterol interacted with C3 and C4,（＋）-catechin-3-O-β-Dgluco（2-cinnamoyl）-pyranoside,p-cresol and 6-methoxy-3-methylbenzene-1,2,4-triol blocked C1q,C2,C3,C5 and C9.
文摘目的应用网络药理学及分子对接技术探讨抗癌1号方中夏枯草-猫爪草-白花蛇舌草三味君药防治喉癌的作用机制。方法通过TCMSP数据库筛选三味中药活性成分及其潜在作用靶点,利用OMIM、GeneCards、MalaCards数据库筛选喉癌细胞相关效应靶点,构建“药物-活性成分-靶点”交互作用网络。对交集靶点进行基因本体(Gene Ontology,GO)与京都基因和基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)富集分析,继而通过分子对接验证核心成分与TOP8核心靶点的结合能力。结果共筛选出24种有效活性成分(槲皮素、β-谷甾醇、山奈酚等)及304个作用靶点,核心靶点包括JUN、IL6、AKT1等。富集分析获得160条相关信号通路,包括脂质与动脉粥样硬化、PI3K-Akt、TNF、IL-17通路等。分子对接结果表明,喉癌细胞关键靶点与三药核心活性成分具有稳定结合构象。结论抗癌1号方君药夏枯草-猫爪草-白花蛇舌草可能通过多靶点、多成分、多途径对喉癌细胞发挥潜在防治作用。
文摘Background:To explore the action mechanism of the classic ancient prescription Si-Jun-Zi decoction in slowing down cataract process by network pharmacology.Methods:In Traditional Chinese Medicines for Systems Pharmacology Database and Analysis Platform Database,screening the chemical components and functional targets of the classic ancient prescription Si-Jun-Zi decoction,and the targets of cataract disease were obtainded through GeneCards and the Online Mendelian Inheritance in Man Database.In the STRING database,the protein-protein interaction network was built.And network visualization were created in Cytoscape.The genetic ontology and Kyoto Gene and Genome Encyclopedia pathways of key proteins were enriched via the DAVID data platform.Results:Ninety-six active components and 33 key targets were obtained in this work.The protein-protein interaction network consisted of 33 proteins.There were 33 genetic ontology entries and 72 Kyoto Gene and Genome Encyclopedia pathway enrichment analysis.Conclusion:This work provided a new means to understand the pathogenesis of cataract and revealed the action mechanisms of the classic ancient prescription Si-Jun-Zi decoction.
文摘背景:鸢尾素在机体生理调节中发挥着至关重要的作用,能够促进白色脂肪组织细胞的棕色化进程,并且在能量代谢调节、产热活动、氧化应激削减及体质量减轻等方面具有显著作用。目的:梳理鸢尾素与相关疾病的最新研究进展。方法:应用计算机检索PubMed、MedReading、Web of Science、中国知网、万方、维普数据库,文献检索时限为2011-01-01/2024-04-13,搜集相关运动产生鸢尾素对疾病影响的研究,中文检索词为“鸢尾素,运动,疾病”等,英文检索词为“irisin,physical exercise,FNDC5,disease”等。通过纳入与排除标准,最终纳入71篇文献进行综述。结果与结论:鸢尾素在抗炎、脂肪代谢、骨代谢、大脑健康、癌症、糖尿病、心血管疾病及肾脏病等方面均有重要作用。运动可以促进鸢尾素的表达,并且不同运动形式对鸢尾素水平的影响不同,急性运动、长期运动、阻力及高强度运动均可提升鸢尾素水平。鸢尾素的发现为运动疗法提供了新的潜在基础,因鸢尾素多种生物学功能成为很有前途的治疗靶点,在治疗人类代谢性疾病及其并发症、肥胖、癌症等疾病中展现出潜在治疗价值。在临床应用方面,鸢尾素作为治疗肥胖、认知功能、心血管、癌症等疾病的潜在靶点,有一定应用前景。但鸢尾素的具体作用机制尚不明确,并且可能存在不良反应,未来需深入了解其作用机制,为鸢尾素治疗肥胖、认知功能障碍、心血管疾病、癌症等提供更充分的依据。
