The fertile soil of the countryside is also rich in artistic inspiration.“If farmers pick up a brush,they can become artists.If one devotes oneself wholeheartedly to something,a stroke of genius will follow,”said Mi...The fertile soil of the countryside is also rich in artistic inspiration.“If farmers pick up a brush,they can become artists.If one devotes oneself wholeheartedly to something,a stroke of genius will follow,”said Miao Huixin,a cultural envoy to Shengfeng Village in Youchegang Town,Xiuzhou District,Jiaxing City,Zhejiang Province.展开更多
Despite demonstrating significant anti-tumor potential as an artemisinin derivative,artesunate faces delivery efficiency challenges due to low water solubility and insufficient targeting specificity.To improve the del...Despite demonstrating significant anti-tumor potential as an artemisinin derivative,artesunate faces delivery efficiency challenges due to low water solubility and insufficient targeting specificity.To improve the delivery efficiency,we engineered three artesunate(ART) derivatives,AC_(15)-L(linear),AC_(15)-B(branched),and AC_(15)-C(cyclic) with distinct aliphatic chain architectures.Unexpectedly,we observed that AC_(15)-C exhibited superior cytotoxicity against 4T1 breast cancer cells,and had the highest binding affinity for Lon protease 1(LONP1)(-72.6 kcal/mol).Subsequently,disulfide bond-containing lipid-PEG(DSPESS-PEG2K) modified chain architecture-engineered ART derivatives nanoassemblies(NAs) were developed to mitigate solubility-related limitations while enhancing targeting precision.Molecular docking and experimental validation demonstrated that ART derivatives inhibited LONP1 through hydrophobic interactions while preserved Fe^(2+)-mediated Fenton-like reaction activity.In vitro and in vivo evaluations demonstrated that AC_(15)-C NAs outperformed free ART and other NAs,suppressing 4T1 tumor growth via dual action:LONP1-directed mitochondrial proteostasis collapse and reactive oxygen species(ROS) amplification through Fe^(2+)-ART interactions.This study elucidated a novel anti-tumor mechanism of ART through the rational design of derivatives with spatially configured aliphatic chains,and developed reductionresponsive NAs to provide an advanced delivery strategy.展开更多
Before joining the Beijing Dragon Shadow Puppetry Art Theatre,this group of young people rarely had the chance to meet people like themselves,lacked friends,faced obstacles at work,and felt alienated from society.Now,...Before joining the Beijing Dragon Shadow Puppetry Art Theatre,this group of young people rarely had the chance to meet people like themselves,lacked friends,faced obstacles at work,and felt alienated from society.Now,they have gained appreciation,recognition,confidence,friendships,and love.展开更多
Lin Shuran and her husband Fang Chuxiang are exceptional artists who are often mentioned together when talking about contemporary Lingnan art.Compared to her husband’s fame in the field of flower-andbird painting,Lin...Lin Shuran and her husband Fang Chuxiang are exceptional artists who are often mentioned together when talking about contemporary Lingnan art.Compared to her husband’s fame in the field of flower-andbird painting,Lin shows unique artistic sensitivity as a female inheritor of the Lingnan School and quietly preserves the cultural lineage of Lingnan painting.展开更多
本文探讨Art to Wear即“可以穿的艺术”,其中大部分作品为服装,少量作品是帽子和首饰。通过分析Art to Wear代表艺术家,解读Art to Wear艺术作品,从而探讨美国20世纪60年代到80年代女性艺术家群体如何以艺术为媒介对自身经历进行叙述...本文探讨Art to Wear即“可以穿的艺术”,其中大部分作品为服装,少量作品是帽子和首饰。通过分析Art to Wear代表艺术家,解读Art to Wear艺术作品,从而探讨美国20世纪60年代到80年代女性艺术家群体如何以艺术为媒介对自身经历进行叙述性表现。60年代末70年代初处于美国女性主义的第二次浪潮,众多美国名校的年轻白人女大学生,不断为女性的参政、就业、医疗、最低工资等争取更多的权利,而到了80年代遭到美国保守主义的强烈打击,追求自由平等的女性主义运动跌入低谷。第二次女性主义运动的跌宕正是Art to Wear艺术运动的发展时期,艺术学院在读青年女生们发起Art to Wear艺术运动,她们在保守主义与激进主义的影响下寻求精神、生活的平衡,极力反叛女性束身塑形来博得男性视觉愉悦、通过同性的嫉妒来肯定自身价值。她们对家庭、事业、社会地位开始深思,通过作品叙述对社会性别与身份认定的迷茫,表达保守与激进思想的内心纠结。展开更多
With the progress of urbanization,urban landscape design has garnered increasing attention.Urban landscape design can not only reflect the construction level of a city but also has the functions of beautifying the urb...With the progress of urbanization,urban landscape design has garnered increasing attention.Urban landscape design can not only reflect the construction level of a city but also has the functions of beautifying the urban environment and enhancing the city image.Modern art enriches the expression forms of urban landscape design,and its integration with urban landscape design can greatly improve the urban landscape.This article elaborated on the connotations of modern art and urban landscape design and analyzed the application of modern art in urban landscape design.The application of modern art can help to achieve the goal of urban landscape design to the maximum extent.展开更多
HIV双阳家庭是指夫妻双方均为HIV感染者。对于这类家庭中的孕妇来说,抗逆转录病毒治疗(antiretroviral therapy,ART)和母婴阻断技术是预防母婴传播(prevention of mother-to-child transmission,PMTCT)的关键。早期ART干预可有效降低母...HIV双阳家庭是指夫妻双方均为HIV感染者。对于这类家庭中的孕妇来说,抗逆转录病毒治疗(antiretroviral therapy,ART)和母婴阻断技术是预防母婴传播(prevention of mother-to-child transmission,PMTCT)的关键。早期ART干预可有效降低母婴传播的风险,但依从性管理、伴侣间交叉感染及社会心理压力仍是挑战。本文综述了程序化ART的实施标准、临床效果及母婴阻断技术的进展,并探讨了其联合应用的协同效应及经济价值。尽管干预措施的落地使得母婴传播率有了明显的下降,但资源不均、耐药性监测不足等因素仍然限制了干预效果。未来,HIV母婴传播的防控应采取更加综合的策略,包括优化个性化ART方案、强化家庭健康教育、减少社会歧视,并结合长效抗病毒药物与新兴技术等,以期进一步降低HIV母婴传播的风险。展开更多
The Metropolitan Museum of Art is located on Fifth Avenue in New York City,USA,adjacent to Central Park.The museum was incorporated in 1870 and opened two years later.With a collection of over 2 million items,it is th...The Metropolitan Museum of Art is located on Fifth Avenue in New York City,USA,adjacent to Central Park.The museum was incorporated in 1870 and opened two years later.With a collection of over 2 million items,it is the largest art museum in New York City and one of the foremost in the world.Its permanent collections are divided into 19 collection areas,with a total of 3 floors in the exhibition hall,comprising numerous thematic galleries.展开更多
The first thing to know about the Museum of Underwater Art(MOUA)is that it is not a traditional museum housed in a building—it's a series of installations(现代雕塑装置)and sculptures within the Great Barrier Reef...The first thing to know about the Museum of Underwater Art(MOUA)is that it is not a traditional museum housed in a building—it's a series of installations(现代雕塑装置)and sculptures within the Great Barrier Reef Marine Park.展开更多
The World Wide Web provides a wealth of information about everything, including contemporary audio and visual art events, which are discussed on media outlets, blogs, and specialized websites alike. This information m...The World Wide Web provides a wealth of information about everything, including contemporary audio and visual art events, which are discussed on media outlets, blogs, and specialized websites alike. This information may become a robust source of real-world data, which may form the basis of an objective data-driven analysis. In this study, a methodology for collecting information about audio and visual art events in an automated manner from a large array of websites is presented in detail. This process uses cutting edge Semantic Web, Web Search and Generative AI technologies to convert website documents into a collection of structured data. The value of the methodology is demonstrated by creating a large dataset concerning audiovisual events in Greece. The collected information includes event characteristics, estimated metrics based on their text descriptions, outreach metrics based on the media that reported them, and a multi-layered classification of these events based on their type, subjects and methods used. This dataset is openly provided to the general and academic public through a Web application. Moreover, each event’s outreach is evaluated using these quantitative metrics, the results are analyzed with an emphasis on classification popularity and useful conclusions are drawn concerning the importance of artistic subjects, methods, and media.展开更多
The Mexican mural movement,also known as Mexican muralism,is recognized as one of the most significant art movements of the 20th century.It developed in the aftermath of the Mexican Revolution,which took place between...The Mexican mural movement,also known as Mexican muralism,is recognized as one of the most significant art movements of the 20th century.It developed in the aftermath of the Mexican Revolution,which took place between 1910 and 1920.The country was striving to rebuild and unify after years of conflict,and muralism became a powerful tool for this transformation.展开更多
文摘The fertile soil of the countryside is also rich in artistic inspiration.“If farmers pick up a brush,they can become artists.If one devotes oneself wholeheartedly to something,a stroke of genius will follow,”said Miao Huixin,a cultural envoy to Shengfeng Village in Youchegang Town,Xiuzhou District,Jiaxing City,Zhejiang Province.
基金financially supported by the Liaoning Revitalization Talents Program (No.XLYC2403107)the Excellent Youth Science Foundation of Liaoning Province (No.2024JH3/10200046)the Basic Scientific Research Project of Liaoning Provincial Department of Education (No.LJ212410163015)。
文摘Despite demonstrating significant anti-tumor potential as an artemisinin derivative,artesunate faces delivery efficiency challenges due to low water solubility and insufficient targeting specificity.To improve the delivery efficiency,we engineered three artesunate(ART) derivatives,AC_(15)-L(linear),AC_(15)-B(branched),and AC_(15)-C(cyclic) with distinct aliphatic chain architectures.Unexpectedly,we observed that AC_(15)-C exhibited superior cytotoxicity against 4T1 breast cancer cells,and had the highest binding affinity for Lon protease 1(LONP1)(-72.6 kcal/mol).Subsequently,disulfide bond-containing lipid-PEG(DSPESS-PEG2K) modified chain architecture-engineered ART derivatives nanoassemblies(NAs) were developed to mitigate solubility-related limitations while enhancing targeting precision.Molecular docking and experimental validation demonstrated that ART derivatives inhibited LONP1 through hydrophobic interactions while preserved Fe^(2+)-mediated Fenton-like reaction activity.In vitro and in vivo evaluations demonstrated that AC_(15)-C NAs outperformed free ART and other NAs,suppressing 4T1 tumor growth via dual action:LONP1-directed mitochondrial proteostasis collapse and reactive oxygen species(ROS) amplification through Fe^(2+)-ART interactions.This study elucidated a novel anti-tumor mechanism of ART through the rational design of derivatives with spatially configured aliphatic chains,and developed reductionresponsive NAs to provide an advanced delivery strategy.
文摘Before joining the Beijing Dragon Shadow Puppetry Art Theatre,this group of young people rarely had the chance to meet people like themselves,lacked friends,faced obstacles at work,and felt alienated from society.Now,they have gained appreciation,recognition,confidence,friendships,and love.
文摘Lin Shuran and her husband Fang Chuxiang are exceptional artists who are often mentioned together when talking about contemporary Lingnan art.Compared to her husband’s fame in the field of flower-andbird painting,Lin shows unique artistic sensitivity as a female inheritor of the Lingnan School and quietly preserves the cultural lineage of Lingnan painting.
文摘本文探讨Art to Wear即“可以穿的艺术”,其中大部分作品为服装,少量作品是帽子和首饰。通过分析Art to Wear代表艺术家,解读Art to Wear艺术作品,从而探讨美国20世纪60年代到80年代女性艺术家群体如何以艺术为媒介对自身经历进行叙述性表现。60年代末70年代初处于美国女性主义的第二次浪潮,众多美国名校的年轻白人女大学生,不断为女性的参政、就业、医疗、最低工资等争取更多的权利,而到了80年代遭到美国保守主义的强烈打击,追求自由平等的女性主义运动跌入低谷。第二次女性主义运动的跌宕正是Art to Wear艺术运动的发展时期,艺术学院在读青年女生们发起Art to Wear艺术运动,她们在保守主义与激进主义的影响下寻求精神、生活的平衡,极力反叛女性束身塑形来博得男性视觉愉悦、通过同性的嫉妒来肯定自身价值。她们对家庭、事业、社会地位开始深思,通过作品叙述对社会性别与身份认定的迷茫,表达保守与激进思想的内心纠结。
文摘With the progress of urbanization,urban landscape design has garnered increasing attention.Urban landscape design can not only reflect the construction level of a city but also has the functions of beautifying the urban environment and enhancing the city image.Modern art enriches the expression forms of urban landscape design,and its integration with urban landscape design can greatly improve the urban landscape.This article elaborated on the connotations of modern art and urban landscape design and analyzed the application of modern art in urban landscape design.The application of modern art can help to achieve the goal of urban landscape design to the maximum extent.
文摘HIV双阳家庭是指夫妻双方均为HIV感染者。对于这类家庭中的孕妇来说,抗逆转录病毒治疗(antiretroviral therapy,ART)和母婴阻断技术是预防母婴传播(prevention of mother-to-child transmission,PMTCT)的关键。早期ART干预可有效降低母婴传播的风险,但依从性管理、伴侣间交叉感染及社会心理压力仍是挑战。本文综述了程序化ART的实施标准、临床效果及母婴阻断技术的进展,并探讨了其联合应用的协同效应及经济价值。尽管干预措施的落地使得母婴传播率有了明显的下降,但资源不均、耐药性监测不足等因素仍然限制了干预效果。未来,HIV母婴传播的防控应采取更加综合的策略,包括优化个性化ART方案、强化家庭健康教育、减少社会歧视,并结合长效抗病毒药物与新兴技术等,以期进一步降低HIV母婴传播的风险。
文摘The Metropolitan Museum of Art is located on Fifth Avenue in New York City,USA,adjacent to Central Park.The museum was incorporated in 1870 and opened two years later.With a collection of over 2 million items,it is the largest art museum in New York City and one of the foremost in the world.Its permanent collections are divided into 19 collection areas,with a total of 3 floors in the exhibition hall,comprising numerous thematic galleries.
文摘The first thing to know about the Museum of Underwater Art(MOUA)is that it is not a traditional museum housed in a building—it's a series of installations(现代雕塑装置)and sculptures within the Great Barrier Reef Marine Park.
文摘The World Wide Web provides a wealth of information about everything, including contemporary audio and visual art events, which are discussed on media outlets, blogs, and specialized websites alike. This information may become a robust source of real-world data, which may form the basis of an objective data-driven analysis. In this study, a methodology for collecting information about audio and visual art events in an automated manner from a large array of websites is presented in detail. This process uses cutting edge Semantic Web, Web Search and Generative AI technologies to convert website documents into a collection of structured data. The value of the methodology is demonstrated by creating a large dataset concerning audiovisual events in Greece. The collected information includes event characteristics, estimated metrics based on their text descriptions, outreach metrics based on the media that reported them, and a multi-layered classification of these events based on their type, subjects and methods used. This dataset is openly provided to the general and academic public through a Web application. Moreover, each event’s outreach is evaluated using these quantitative metrics, the results are analyzed with an emphasis on classification popularity and useful conclusions are drawn concerning the importance of artistic subjects, methods, and media.
文摘The Mexican mural movement,also known as Mexican muralism,is recognized as one of the most significant art movements of the 20th century.It developed in the aftermath of the Mexican Revolution,which took place between 1910 and 1920.The country was striving to rebuild and unify after years of conflict,and muralism became a powerful tool for this transformation.
