Parkinson’s disease （PD） is a heterogenous disease caused by multifactorial etiology. PD is characterized by the loss of dopaminergic （DA） neurons in the substantia nigra and the accumulation of Lewy bodies. In t...Parkinson’s disease （PD） is a heterogenous disease caused by multifactorial etiology. PD is characterized by the loss of dopaminergic （DA） neurons in the substantia nigra and the accumulation of Lewy bodies. In this study, two Drosophila PD models by exposing Drosophila to rotenone （sporadic PD models） are proposed, and the human α-synuclein A30P protein （family PD models） in Drosophila is expressed respectively. Both models recapitulated the main human PD symptoms including the loss of dopaminergic neurons in the brain and severe locomotor deficits. Our study finds that Rotenone induces more serious learning and memory impairment than α-synuclein A30P does.展开更多
基金supported by the Major State Basic Research and Development Program of China (Grant No.2006CB500702)the National Natural Science Foundation of China (Grant No.31070954)+1 种基金the Innovation Foundation of Shanghai Commission of Education Science and Technology (Grant No.08ZZ41)the Basic Research Foundation of Shanghai Commission of Science and Technology (Grant Nos.03JC14030,09JC1406600)
文摘Parkinson’s disease （PD） is a heterogenous disease caused by multifactorial etiology. PD is characterized by the loss of dopaminergic （DA） neurons in the substantia nigra and the accumulation of Lewy bodies. In this study, two Drosophila PD models by exposing Drosophila to rotenone （sporadic PD models） are proposed, and the human α-synuclein A30P protein （family PD models） in Drosophila is expressed respectively. Both models recapitulated the main human PD symptoms including the loss of dopaminergic neurons in the brain and severe locomotor deficits. Our study finds that Rotenone induces more serious learning and memory impairment than α-synuclein A30P does.
