当我们临床医师似乎已经学会了应用各种最新权威指南一致推荐的有理有据的食品药品监督管理局（Food and Drug Administration,FDA）批准的阿尔茨海默病（Alzheimer’s disease,AD）一线治疗药物乙酰胆碱酯酶抑制剂（acetylcholinestera...当我们临床医师似乎已经学会了应用各种最新权威指南一致推荐的有理有据的食品药品监督管理局（Food and Drug Administration,FDA）批准的阿尔茨海默病（Alzheimer’s disease,AD）一线治疗药物乙酰胆碱酯酶抑制剂（acetylcholinesterase inhibitors,ACh EI）及谷氨酸NMDA受体（N-methyl-D-aspartic acid receptor）拮抗剂治疗痴呆时,展开更多
This paper focuses on anti-jamming and anti-eavesdropping problem in air-to-ground(A2G)communication networks considering the impact of body jitter of unmanned aerial vehicle(UAV).A full-duplex(FD)active ground eavesd...This paper focuses on anti-jamming and anti-eavesdropping problem in air-to-ground(A2G)communication networks considering the impact of body jitter of unmanned aerial vehicle(UAV).A full-duplex(FD)active ground eavesdropper launches jamming attack while eavesdropping to stimulate the legitimate transmitter(i.e.,UAV)to increase its transmission power.The legitimate transmitter’s objective is to against the simultaneous wiretapping and jamming with a robust and power-efficient transmission scheme.The active eavesdropper aims to minimize the system secrecy rate.To study the interaction between the legitimate transmitter and the active eavesdropper,a non-cooperative game framework is formulated.Detailed,considering the impact of UAV jitter on antenna array response and secrecy performance,we first investigate the UAV’s transmission power minimization problem for the worst scenario with minimum legitimate data rate and maximum eavesdropping data rate under UAV jitter.Then,the active eavesdropper’s secrecy rate minimization problem with the worst scenario is investigated by optimizing its jamming strategy.Nash equilibrium is proved to be existed and obtained with the proposed iterative algorithm.Finally,extensive numerical results are provided to evaluate the system secrecy performance and to show the secrecy performance gains of the proposed method.展开更多
In the face of increasingly serious environmental pollution,the health of human lung tissues is also facing serious threats.Mogroside IIE(M2E)is the main metabolite of sweetening agents mogrosides from the anti-tussiv...In the face of increasingly serious environmental pollution,the health of human lung tissues is also facing serious threats.Mogroside IIE(M2E)is the main metabolite of sweetening agents mogrosides from the anti-tussive Chinese herbal Siraitia grosvenori.The study elucidated the anti-inflammatory action and molecular mechanism of M2E against acute lung injury(ALI).A lipopolysaccharide(LPS)-induced ALI model was established in mice and MH-S cells were employed to explore the protective mechanism of M2E through the western blotting,co-immunoprecipitation,and quantitative real time-PCR analysis.The results indicated that M2E alleviated LPS-induced lung injury through restraining the activation of secreted phospholipase A2 type IIA(Pla2g2a)-epidermal growth factor receptor(EGFR).The interaction of Pla2g2a and EGFR was identified by co-immunoprecipitation.In addition,M2E protected ALI induced with LPS against inflammatory and damage which were significantly dependent upon the downregulation of AKT and m TOR via the inhibition of Pla2g2a-EGFR.Pla2g2a may represent a potential target for M2E in the improvement of LPS-induced lung injury,which may represent a promising strategy to treat ALI.展开更多
As important infrastructure for airborne communication platforms,unmanned aerial vehicles(UAVs)are expected to become a key part of 6G wireless networks.Thus,modeling low-and medium-altitude propagation channels has a...As important infrastructure for airborne communication platforms,unmanned aerial vehicles(UAVs)are expected to become a key part of 6G wireless networks.Thus,modeling low-and medium-altitude propagation channels has attracted much attention.Air-to-ground(A2G)propagation channel models vary in different scenarios,requiring accurate models for designing and evaluating UAV communication links.Unlike terrestrial models,A2G channel models lack detailed investigation.Therefore,this paper provides an overview of existing A2G channel measurement campaigns,different types of A2G channel models for various environments,and future research directions for UAV airland channel modeling.This study focuses on the potential of millimeter-wave technology for UAV A2G channel modeling and highlights nonsuburban scenarios requiring consideration in future modeling efforts.展开更多
文摘当我们临床医师似乎已经学会了应用各种最新权威指南一致推荐的有理有据的食品药品监督管理局（Food and Drug Administration,FDA）批准的阿尔茨海默病（Alzheimer’s disease,AD）一线治疗药物乙酰胆碱酯酶抑制剂（acetylcholinesterase inhibitors,ACh EI）及谷氨酸NMDA受体（N-methyl-D-aspartic acid receptor）拮抗剂治疗痴呆时,
基金supported in part by the Beijing Municipal Natural Science Foundation under Grant 4212005in part by the National Natural Science Foundation of China under 62271076+1 种基金in part by Young Elite Scientists Sponsorship Program by CAST(YESS20200283)in part by the Fundamental Research Funds for the Central Universities under Grant 2242022k60006.
文摘This paper focuses on anti-jamming and anti-eavesdropping problem in air-to-ground(A2G)communication networks considering the impact of body jitter of unmanned aerial vehicle(UAV).A full-duplex(FD)active ground eavesdropper launches jamming attack while eavesdropping to stimulate the legitimate transmitter(i.e.,UAV)to increase its transmission power.The legitimate transmitter’s objective is to against the simultaneous wiretapping and jamming with a robust and power-efficient transmission scheme.The active eavesdropper aims to minimize the system secrecy rate.To study the interaction between the legitimate transmitter and the active eavesdropper,a non-cooperative game framework is formulated.Detailed,considering the impact of UAV jitter on antenna array response and secrecy performance,we first investigate the UAV’s transmission power minimization problem for the worst scenario with minimum legitimate data rate and maximum eavesdropping data rate under UAV jitter.Then,the active eavesdropper’s secrecy rate minimization problem with the worst scenario is investigated by optimizing its jamming strategy.Nash equilibrium is proved to be existed and obtained with the proposed iterative algorithm.Finally,extensive numerical results are provided to evaluate the system secrecy performance and to show the secrecy performance gains of the proposed method.
基金the National Natural Science Foundation(81773982,82003937)Youth Academic leaders of the Qinglan Project in Jiangsu province for financial support。
文摘In the face of increasingly serious environmental pollution,the health of human lung tissues is also facing serious threats.Mogroside IIE(M2E)is the main metabolite of sweetening agents mogrosides from the anti-tussive Chinese herbal Siraitia grosvenori.The study elucidated the anti-inflammatory action and molecular mechanism of M2E against acute lung injury(ALI).A lipopolysaccharide(LPS)-induced ALI model was established in mice and MH-S cells were employed to explore the protective mechanism of M2E through the western blotting,co-immunoprecipitation,and quantitative real time-PCR analysis.The results indicated that M2E alleviated LPS-induced lung injury through restraining the activation of secreted phospholipase A2 type IIA(Pla2g2a)-epidermal growth factor receptor(EGFR).The interaction of Pla2g2a and EGFR was identified by co-immunoprecipitation.In addition,M2E protected ALI induced with LPS against inflammatory and damage which were significantly dependent upon the downregulation of AKT and m TOR via the inhibition of Pla2g2a-EGFR.Pla2g2a may represent a potential target for M2E in the improvement of LPS-induced lung injury,which may represent a promising strategy to treat ALI.
基金supported by the National Natural Science Foundation of China under Grant No.42176190Fundamental Research Funds for the Central Universities,CHD under Grant Nos.300102243401 and 300102244203Research Funds for the Interdisciplinary Projects,CHU under Grant Nos.300104240912 and 300104240922。
文摘As important infrastructure for airborne communication platforms,unmanned aerial vehicles(UAVs)are expected to become a key part of 6G wireless networks.Thus,modeling low-and medium-altitude propagation channels has attracted much attention.Air-to-ground(A2G)propagation channel models vary in different scenarios,requiring accurate models for designing and evaluating UAV communication links.Unlike terrestrial models,A2G channel models lack detailed investigation.Therefore,this paper provides an overview of existing A2G channel measurement campaigns,different types of A2G channel models for various environments,and future research directions for UAV airland channel modeling.This study focuses on the potential of millimeter-wave technology for UAV A2G channel modeling and highlights nonsuburban scenarios requiring consideration in future modeling efforts.
