The purpose of this article is to analyze the advantages and application paths of BIM5D technology in the cost control of completed houses.In the research phase,based on the reading of literature and the combination o...The purpose of this article is to analyze the advantages and application paths of BIM5D technology in the cost control of completed houses.In the research phase,based on the reading of literature and the combination of project materials,the advantages of BIM5D in the cost control project of completed houses are analyzed after introducing the cost control of completed houses and the connotation of BIM5D technology.Finally,this article starts from multiple perspectives,including BIM5D modeling,cost deviation analysis under dynamic cost control,etc.,and finally forms a relatively systematic and complete BIM cost control technology system.It is hoped that this article can provide technical reference value for China’s completed housing projects,promote the improvement of the project team’s cost control level,obtain considerable economic benefits based on completing project construction with quality and quantity,and enhance the competitiveness of enterprises.展开更多
近十年来,在建筑行业中建筑信息模型(building information modeling,BIM)5D的应用和研究越来越多,在传统建筑工程项目管理上得到了极大的发展。然而,基于BIM5D的传统建筑设计、施工管理、成本控制等领域的研究较多,但在装配式建筑领域B...近十年来,在建筑行业中建筑信息模型(building information modeling,BIM)5D的应用和研究越来越多,在传统建筑工程项目管理上得到了极大的发展。然而,基于BIM5D的传统建筑设计、施工管理、成本控制等领域的研究较多,但在装配式建筑领域BIM5D的应用研究有限。因此,回顾分析了相关的文献综述,归纳总结了BIM5D在装配式建筑工程管理中政策方面、技术方面、人才方面、使用成本方面等影响因素,填补了文献空白,进而推进BIM5D技术在装配式建筑工程管理中的应用,促进装配式建筑在建筑行业的发展。展开更多
Background:Hepatocellular carcinoma(HCC)is a prevalent liver malignancy.This study examined the roles of transforming growth factor beta(TGF-β)and cytochrome b5 domain containing 2(CYB5D2)in HCC etiology and their pr...Background:Hepatocellular carcinoma(HCC)is a prevalent liver malignancy.This study examined the roles of transforming growth factor beta(TGF-β)and cytochrome b5 domain containing 2(CYB5D2)in HCC etiology and their prognostic biomarker potential.Methods:Key modules and prognostic genes were identified by analyzing the GSE101685 dataset by weighted gene co-expression network analysis(WGCNA)and Least absolute shrinkage and selection operator(LASSO)Cox regression.The expression levels of CYB5D2 and TGF-βin HCC cell lines were quantified using Quantitative reverse transcription polymerase chain reaction(qRT-PCR)and Western blotting(WB)assays.Effects of CYB5D2 overexpression on cell proliferation,migration,invasion,and epithelial-mesenchymal transition(EMT)marker regulation were assessed in vitro,while in vivo tumorigenicity was evaluated using a xenograft model of HCC in nude mice.Results:In this study,WGCNA identified the turquoise module as significantly associated with HCC,containing 452 DEGs.LASSO Cox regression analysis revealed 9 key prognostic genes,with CYB5D2 being underexpressed in HCC cells and tissues.TGF-βwas negatively correlated with CYB5D2 expression,resulting in poor patient prognosis.Functional assays demonstrated that CYB5D2 overexpression inhibited proliferation,migration,and invasion of HCC cell lines,and altered EMT marker expression.Furthermore,the addition of TGF-βpartially reversed the suppressive effects caused by CYB5D2 overexpression.In vivo,CYB5D2 overexpression significantly reduced tumor growth,indicating its potential as a therapeutic target for HCC.Conclusion:The tumor suppressor function of CYB5D2 in HCC and its interaction with TGF-βoffered fresh information on the molecular pathophysiology of HCC and possible treatment avenues.展开更多
文摘The purpose of this article is to analyze the advantages and application paths of BIM5D technology in the cost control of completed houses.In the research phase,based on the reading of literature and the combination of project materials,the advantages of BIM5D in the cost control project of completed houses are analyzed after introducing the cost control of completed houses and the connotation of BIM5D technology.Finally,this article starts from multiple perspectives,including BIM5D modeling,cost deviation analysis under dynamic cost control,etc.,and finally forms a relatively systematic and complete BIM cost control technology system.It is hoped that this article can provide technical reference value for China’s completed housing projects,promote the improvement of the project team’s cost control level,obtain considerable economic benefits based on completing project construction with quality and quantity,and enhance the competitiveness of enterprises.
文摘近十年来,在建筑行业中建筑信息模型(building information modeling,BIM)5D的应用和研究越来越多,在传统建筑工程项目管理上得到了极大的发展。然而,基于BIM5D的传统建筑设计、施工管理、成本控制等领域的研究较多,但在装配式建筑领域BIM5D的应用研究有限。因此,回顾分析了相关的文献综述,归纳总结了BIM5D在装配式建筑工程管理中政策方面、技术方面、人才方面、使用成本方面等影响因素,填补了文献空白,进而推进BIM5D技术在装配式建筑工程管理中的应用,促进装配式建筑在建筑行业的发展。
基金National Natural Science Foundation of China Youth Training Project(2021GZR003)Medical-Engineering Interdisciplinary Research Youth Training Project(2022YGJC001).
文摘Background:Hepatocellular carcinoma(HCC)is a prevalent liver malignancy.This study examined the roles of transforming growth factor beta(TGF-β)and cytochrome b5 domain containing 2(CYB5D2)in HCC etiology and their prognostic biomarker potential.Methods:Key modules and prognostic genes were identified by analyzing the GSE101685 dataset by weighted gene co-expression network analysis(WGCNA)and Least absolute shrinkage and selection operator(LASSO)Cox regression.The expression levels of CYB5D2 and TGF-βin HCC cell lines were quantified using Quantitative reverse transcription polymerase chain reaction(qRT-PCR)and Western blotting(WB)assays.Effects of CYB5D2 overexpression on cell proliferation,migration,invasion,and epithelial-mesenchymal transition(EMT)marker regulation were assessed in vitro,while in vivo tumorigenicity was evaluated using a xenograft model of HCC in nude mice.Results:In this study,WGCNA identified the turquoise module as significantly associated with HCC,containing 452 DEGs.LASSO Cox regression analysis revealed 9 key prognostic genes,with CYB5D2 being underexpressed in HCC cells and tissues.TGF-βwas negatively correlated with CYB5D2 expression,resulting in poor patient prognosis.Functional assays demonstrated that CYB5D2 overexpression inhibited proliferation,migration,and invasion of HCC cell lines,and altered EMT marker expression.Furthermore,the addition of TGF-βpartially reversed the suppressive effects caused by CYB5D2 overexpression.In vivo,CYB5D2 overexpression significantly reduced tumor growth,indicating its potential as a therapeutic target for HCC.Conclusion:The tumor suppressor function of CYB5D2 in HCC and its interaction with TGF-βoffered fresh information on the molecular pathophysiology of HCC and possible treatment avenues.
