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Autonomous nighttime navigation with lunar polarized light:A 3-D attitude determination approach
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作者 Taihang CHEN Jiankai YIN +4 位作者 Pengwei HU Xiao ZHANG Xiang YU Huai-ning WU Lei GUO 《Chinese Journal of Aeronautics》 2025年第11期384-395,共12页
Nighttime navigation faces challenges from limited data and interference,especially when satellite signals are unavailable.Leveraging lunar polarized light,polarization navigation offers a promising solution for night... Nighttime navigation faces challenges from limited data and interference,especially when satellite signals are unavailable.Leveraging lunar polarized light,polarization navigation offers a promising solution for nighttime autonomous navigation.Current algorithms,however,are limited by the requirement for known horizontal attitudes,restricting applications.This study introduces an autonomous 3-D attitude determination method to overcome this limitation.Our approach utilizes the Angle of Polarization(AOP)at night to extract neutral points from the AOP pattern.This allows for the calculation of polarization meridian plane information for attitude determination.Subsequently,we present an optimized Polarization TRIAD(Pol-TRIAD)algorithm to acquire the 3-D attitude.The proposed method outperforms the existing approaches in outdoor experiments by achieving lower Root Mean Square Error(RMSE).For one baseline attitude,it improves pitch by 31.7%,roll by 21.7%,and yaw by 2.6%,while for the attitude with a larger tilt angle,the improvements are 64.4%,30.4%,and 9.1%,respectively. 展开更多
关键词 3-d attitude determination Lunar polarized light Neutral points Night navigation Polarization
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慢性肾衰竭透析患者血清SP-D、PTX-3水平对合并细菌性肺炎的诊断效能
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作者 邵珏 李金玉 +1 位作者 汪成军 张赟辉 《热带医学杂志》 2025年第4期506-510,共5页
目的探讨慢性肾衰竭(CRF)透析患者血清表面活性蛋白-D(SP-D)、正五聚蛋白3(PTX-3)水平对合并细菌性肺炎的诊断效能,为临床早期诊断和有效治疗提供新的思路和方法。方法选取2019年10月-2023年10月黄山市人民医院收治的102例慢性肾衰竭透... 目的探讨慢性肾衰竭(CRF)透析患者血清表面活性蛋白-D(SP-D)、正五聚蛋白3(PTX-3)水平对合并细菌性肺炎的诊断效能,为临床早期诊断和有效治疗提供新的思路和方法。方法选取2019年10月-2023年10月黄山市人民医院收治的102例慢性肾衰竭透析患者作为研究对象,根据是否合并细菌性肺炎分为合并细菌性肺炎组(n=43)和未合并细菌性肺炎组(n=59)。采用酶联免疫吸附法检测所有研究对象血清SP-D、PTX-3水平。采用受试者工作特征(ROC)曲线评估血清SP-D、PTX-3水平对CRF患者合并细菌性肺炎的诊断价值,采用多因素logistic回归分析探讨CRF患者合并细菌性肺炎的影响因素。结果合并细菌性肺炎组患者血清SP-D、PTX-3水平显著高于未合并细菌性肺炎组,差异均有统计学意义(t=23.473、22.563,P均<0.05)。血清SP-D、PTX-3诊断慢性肾衰竭透析患者合并细菌性肺炎的曲线下面积(AUC)分别为0.832(95%CI:0.787~0.879)、0.746(95%CI:0.701~0.796),两者联合(串联实验)诊断的AUC为0.902(95%CI:0.858~0.951)。合并细菌性肺炎组患者年龄≥60岁比例、住院时间、合并疾病(糖尿病)、透析时间≥1年比例均高于未合并细菌性肺炎组,差异均有统计学意义(P均<0.05)。二分类logistic逐步回归分析显示,年龄≥60岁(OR=1.791,95%CI:1.225~2.620)、合并糖尿病(OR=2.762,95%CI:1.324~5.760)、血清SP-D≥188.27 g/L(OR=4.651,95%CI:1.822~11.868)、血清PTX-3≥17.83 ng/mL(OR=3.554,95%CI:1.741~7.253)是慢性肾衰竭透析患者合并细菌性肺炎的危险因素(P均<0.05)。结论血清SP-D、PTX-3水平在慢性肾衰竭透析合并细菌性肺炎患者中呈高表达,可作为诊断慢性肾衰竭透析患者合并细菌性肺炎潜在的生物学指标,两者联合诊断的效能更高。 展开更多
关键词 慢性肾衰竭 透析 细菌性肺炎 表面活性蛋白-d 正五聚蛋白3
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甘露糖蛋白、半乳甘露聚糖和1-3-β-D葡聚糖联合检测对艾滋病合并马尔尼菲篮状菌病的诊断价值 被引量:1
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作者 李小凤 张海燕 +1 位作者 何静 罗明 《中国热带医学》 北大核心 2025年第5期547-551,593,共6页
目的探讨甘露糖蛋白(mannoprotein,Mp1p)、半乳甘露聚糖(galactomannan,GM)和1-3-β-D葡聚糖(1-3-β-D glucan,BDG)单独和联合检测对艾滋病合并马尔尼菲篮状菌病(Talaromycosis marneffei,TSM)的诊断价值。方法收集291例艾滋病合并马尔... 目的探讨甘露糖蛋白(mannoprotein,Mp1p)、半乳甘露聚糖(galactomannan,GM)和1-3-β-D葡聚糖(1-3-β-D glucan,BDG)单独和联合检测对艾滋病合并马尔尼菲篮状菌病(Talaromycosis marneffei,TSM)的诊断价值。方法收集291例艾滋病合并马尔尼菲篮状菌住院患者和300例健康体检者外周血标本,检测Mp1p、GM和BDG并分析单独和联合检测诊断TSM的价值,采用ROC曲线分析Mp1p、GM、BDG和联合检测的诊断效能。结果在单独检测中,Mp1p、GM和BDG检测灵敏度和特异度之间差异有统计学意义(P<0.05),相较于GM和BDG,Mp1p的诊断效能最好,灵敏度和特异度最优。在两两联合检测中,Mp1p与GM组合灵敏度优于GM与BDG组合,差异有统计学意义(P<0.05);Mp1p与GM组合、Mp1p与BDG组合特异度优于GM与BDG组合,差异有统计学意义(P<0.05),Mp1p与GM组合的诊断效能最好。三者联合检测灵敏度优于两两联合检测,差异有统计学意义(P<0.05),Mp1p与GM组合、Mp1p与BDG组合特异度优于三者联合检测,差异有统计学意义(P<0.05)。Mp1p、GM、BDG检测阳性率分别在CD4^(+)T细胞计数≤100个/μL和>100个/μL患者中差异无统计学意义(P>0.05)。结论Mp1p、GM、BDG检测是艾滋病合并TSM早期辅助性诊断指标,其中Mp1p诊断效能优于GM和BDG,联合检测可提高诊断效能。 展开更多
关键词 甘露糖蛋白 半乳甘露聚糖 1-3-d葡聚糖 马尔尼菲篮状菌病 艾滋病
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SINGULAR PERTURBATION APPROACH TO MOVING MASS CONTROL OF BUOYANCY-DRIVEN AIRSHIP IN 3-D SPACE 被引量:1
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作者 吴小涛 Claude H Moog 胡跃明 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2011年第4期343-352,共10页
The attitude control problem and the guidance problem are solved in 3-D for a buoyancy-driven airship actuated by the combined effects of an internal air bladder which modulates the airshiprs net weight and of two mov... The attitude control problem and the guidance problem are solved in 3-D for a buoyancy-driven airship actuated by the combined effects of an internal air bladder which modulates the airshiprs net weight and of two moving masses which modulate its center of mass. A simple and clear modeling is introduced to derive the 8 degree of freedom (DOF) mathematical model. Nonlinear control loops are derived through maximal feedback linearization with internal stability for both dynamics in the longitudinal plane and in the lateral plane. Based on a singular perturbation approach, the superposition of these two control actions in the longitudinal plane and in the lateral plane is shown to achieve the control of the dynamics in 3-D space. The simulations of the airship tracking specified attitude, moving direction and speed in 3-D space are presented. 展开更多
关键词 buoyancy-driven AIRSHIP nonlinear control 3-d singular perturbation
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Fluid-based moderate collision avoidance for UAV formation in 3-D low-altitude environments 被引量:1
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作者 Menghua ZHANG Honglun WANG +5 位作者 Zhiyu LI Yanxiang WANG Xianglun ZHANG Qiang TANG Shichao MA Jianfa WU 《Chinese Journal of Aeronautics》 2025年第6期533-551,共19页
Aiming to address the Unmanned Aerial Vehicle(UAV) formation collision avoidance problem in Three-Dimensional(3-D) low-altitude environments where dense various obstacles exist, a fluid-based path planning framework n... Aiming to address the Unmanned Aerial Vehicle(UAV) formation collision avoidance problem in Three-Dimensional(3-D) low-altitude environments where dense various obstacles exist, a fluid-based path planning framework named the Formation Interfered Fluid Dynamical System(FIFDS) with Moderate Evasive Maneuver Strategy(MEMS) is proposed in this study.First, the UAV formation collision avoidance problem including quantifiable performance indexes is formulated. Second, inspired by the phenomenon of fluids continuously flowing while bypassing objects, the FIFDS for multiple UAVs is presented, which contains a Parallel Streamline Tracking(PST) method for formation keeping and the traditional IFDS for collision avoidance. Third, to rationally balance flight safety and collision avoidance cost, MEMS is proposed to generate moderate evasive maneuvers that match up with collision risks. Comprehensively containing the time and distance safety information, the 3-D dynamic collision regions are modeled for collision prediction. Then, the moderate evasive maneuver principle is refined, which provides criterions of the maneuver amplitude and direction. On this basis, an analytical parameter mapping mechanism is designed to online optimize IFDS parameters. Finally, the performance of the proposed method is validated by comparative simulation results and real flight experiments using fixed-wing UAVs. 展开更多
关键词 Unmanned aerial vehicle Formation collision avoidance:3-d low-altitude environments Interfered fluid dynamical system 3-d dynamic collision region
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A 3-D morphological approach on spatial form and cultural identity of ethnic mountain settlements:Case from Guizhou,China 被引量:3
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作者 JIA Zi-yu MENG Cheng-yu ZHOU Zheng-xu 《Journal of Mountain Science》 SCIE CSCD 2021年第5期1144-1158,共15页
Ethnic mountain settlements are living heritage of varied vernacular cultures.The preservation of both the built form and the intangible socio-cultural associations with them are global concern in process of urbanizat... Ethnic mountain settlements are living heritage of varied vernacular cultures.The preservation of both the built form and the intangible socio-cultural associations with them are global concern in process of urbanization,and in the notion of sustainable development.However,there is a lack of multi-dimensional and cross-cultural quantitative research in settlement morphology,making it difficult to guide practice effectively.Therefore,this study focuses on exploring an automatic or semi-automatic quantification and classification method for the morphological identity of ethnic mountain settlements.We introduce and combine 3-D morphological indicators with existing 2-D indicators to build and test three different sets of indication systems for semi-automatic classification for the settlements’ethnic attribute basing on spatial morphology.Taking the Miao,Dong,and Tunpu(Han)ethnic settlements in Guizhou province,southwest China as research samples,we applied factor analysis and hierarchical clustering methods to compare the classification accuracy under the three systems using data from topographic map,field investigation map,satellite imageries,and ethnography or local chronicle.The results showed that,the 3-D indication system has succeeded in semi-automatic quantification and classification of settlement morphology and ethnic identity by greatly increasing the classification accuracy to 96.30%,which is a huge improvement compared with the basic 2-D indication system(42.59%)and the advanced 2-D indication system(61.11%).The settlement samples are further divided into two sub-types with significant morphological differences in each major ethnic category under the 3-D indication system.We then discussed the potential improvement and future large-scale application of this method with the help of machine learning and other smart techniques.We hope to provide a comprehensive quantitative perspective and a more scientific reference for the future preservation and sustainable development of the massive and diverse vernacular heritages across the world. 展开更多
关键词 3-d morphology QUANTITATION Ethnic mountain settlements Cultural identity China
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Effect of microwave irradiation on thermal damage behavior of granite:Uniaxial compression test and finite-discrete approach 被引量:1
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作者 Bowen Sun Shengqi Yang +4 位作者 Shigui Du Wenling Tian Shibin Tang Heng Li Zhennan Zhu 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第2期827-844,共18页
Microwave-assisted rock-breaking technology,as a novel hybrid approach,is anticipated to facilitate the efficient excavation of complex rock formations.It is therefore crucial to understand the damage and failure mech... Microwave-assisted rock-breaking technology,as a novel hybrid approach,is anticipated to facilitate the efficient excavation of complex rock formations.It is therefore crucial to understand the damage and failure mechanisms of rocks that have been subjected to irradiation.In this study,uniaxial compression experiments were conducted on granite specimens after 1.4 kW microwave irradiation for varying durations.Furthermore,a numerical method was proposed to solve electromagnetic-thermal-mechanical coupling problems by integrating finite and discrete elements.The results demonstrated a differential temperature distribution(high temperature in the middle and low-temperature areas at the ends)in the granite specimens under microwave irradiation,which resulted in a notable reduction in their physical and mechanical properties.As the duration of irradiation increased,the rate of heating and the extent of strength reduction both diminished,while the morphology and distribution of cracks at ultimate failure became increasingly complex.The numerical method effectively addresses the simulation challenges associated with the electromagnetic selective heating of granite containing multiple polar minerals under microwave irradiation.This approach accounted for the non-uniform thermal expansion of the minerals and provided a comprehensive model of damage progression under compression. 展开更多
关键词 Microwave-assisted rock breaking GRANITE Electromagnetic-thermal-mechanical(ETM)coupling Finite-discrete approach Three-dimensional(3D)grain-based model(GBM)
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Numerical simulation of recalescence of 3-dimensional isothermal solidification for binary alloy using phase-field approach 被引量:8
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作者 朱昌盛 肖荣振 +1 位作者 王智平 冯力 《中国有色金属学会会刊:英文版》 EI CSCD 2009年第5期1286-1293,共8页
A accelerated arithmetic algorithm of the dynamic computing regions was designed,and 3-dimensional numerical simulation of isothermal solidification for a binary alloy was implemented.The dendritic growth and the reca... A accelerated arithmetic algorithm of the dynamic computing regions was designed,and 3-dimensional numerical simulation of isothermal solidification for a binary alloy was implemented.The dendritic growth and the recalescence of Ni-Cu binary alloy during the solidification at different cooling rates were investigated.The effects of cooling rate on dendritic patterns and microsegregation patterns were studied.The computed results indicate that,with the increment of the cooling rate,the dendritic growth velocity increases,both the main branch and side-branches become slender,the secondary dendrite arm spacing becomes smaller,the inadequate solute diffusion in solid aggravates,and the severity of microsegregation ahead of interface aggravates.At a higher cooling rate,the binary alloy presents recalescence;while the cooling rate is small,no recalescence occurs. 展开更多
关键词 二元合金 等温凝固 数值模拟 三维 冷却速度 二次枝晶间距 微观形态 算法设计
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Parallel computing approach for efficient 3-D X-ray-simulated image reconstruction 被引量:1
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作者 Ou-Yi Li Yang Wang +1 位作者 Qiong Zhang Yong-Hui Li 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2023年第7期122-136,共15页
Accurate 3-dimensional(3-D)reconstruction technology for nondestructive testing based on digital radiography(DR)is of great importance for alleviating the drawbacks of the existing computed tomography(CT)-based method... Accurate 3-dimensional(3-D)reconstruction technology for nondestructive testing based on digital radiography(DR)is of great importance for alleviating the drawbacks of the existing computed tomography(CT)-based method.The commonly used Monte Carlo simulation method ensures well-performing imaging results for DR.However,for 3-D reconstruction,it is limited by its high time consumption.To solve this problem,this study proposes a parallel computing method to accelerate Monte Carlo simulation for projection images with a parallel interface and a specific DR application.The images are utilized for 3-D reconstruction of the test model.We verify the accuracy of parallel computing for DR and evaluate the performance of two parallel computing modes-multithreaded applications(G4-MT)and message-passing interfaces(G4-MPI)-by assessing parallel speedup and efficiency.This study explores the scalability of the hybrid G4-MPI and G4-MT modes.The results show that the two parallel computing modes can significantly reduce the Monte Carlo simulation time because the parallel speedup increment of Monte Carlo simulations can be considered linear growth,and the parallel efficiency is maintained at a high level.The hybrid mode has strong scalability,as the overall run time of the 180 simulations using 320 threads is 15.35 h with 10 billion particles emitted,and the parallel speedup can be up to 151.36.The 3-D reconstruction of the model is achieved based on the filtered back projection(FBP)algorithm using 180 projection images obtained with the hybrid G4-MPI and G4-MT.The quality of the reconstructed sliced images is satisfactory because the images can reflect the internal structure of the test model.This method is applied to a complex model,and the quality of the reconstructed images is evaluated. 展开更多
关键词 Parallel computing Monte Carlo Digital radiography 3-d reconstruction
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新型5,6-二氢吡啶并[2,3-d]嘧啶-4,7(3H,8H)-二酮类衍生物的设计、合成及抗结核活性研究
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作者 孙连奇 彭孝炯 +2 位作者 寇世博 易红 李卓荣 《中国药物化学杂志》 2025年第2期81-91,共11页
目的设计合成一系列新型嘧啶酮类衍生物,以期得到抗结核分枝杆菌敏感菌株H37Rv及耐药菌株14862活性都较好的新化合物。方法以氰基乙酸乙酯和硫脲为起始原料,通过三步或四步反应,得到目标化合物f1~f31。采用H37Rv对所有目标化合物进行抗... 目的设计合成一系列新型嘧啶酮类衍生物,以期得到抗结核分枝杆菌敏感菌株H37Rv及耐药菌株14862活性都较好的新化合物。方法以氰基乙酸乙酯和硫脲为起始原料,通过三步或四步反应,得到目标化合物f1~f31。采用H37Rv对所有目标化合物进行抗结核活性评价,并对其中活性较好的化合物进行抗耐药菌株14862的活性评价。采用Vero细胞进行安全性评价。结果与结论共合成了31个新化合物,其结构均经^(1)H-NMR、^(13)C-NMR和LC-MS谱确证。其中化合物f11和f28对H37Rv的MIC值分别为0.62μg·mL^(-1)和0.91μg·mL^(-1),表现出较强的抗结核活性,但对耐药菌株14862的活性弱于H37Rv。本研究进一步丰富了该系列化合物的构效关系,以期为后续新型嘧啶酮类化合物的设计提供参考。 展开更多
关键词 5 6-二氢吡啶并[2 3-d]嘧啶-4 7(3H 8H)-二酮类衍生物 抗结核分枝杆菌 结构修饰 构效关系
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Conformal Invariant Asymptotic Expansion Approach for Solving (3+1)-Dimensional JM Equation 被引量:1
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作者 LI Zhi-Fang RUAN Hang-Yu 《Communications in Theoretical Physics》 SCIE CAS CSCD 2006年第6期979-984,共6页
The (3+1)-dimensional Jimbo-Miwa (JM) equation is solved approximately by using the conformal invariant asymptotic expansion approach presented by Ruan. By solving the new (3+1)-dimensional integrable models, ... The (3+1)-dimensional Jimbo-Miwa (JM) equation is solved approximately by using the conformal invariant asymptotic expansion approach presented by Ruan. By solving the new (3+1)-dimensional integrable models, which are conformal invariant and possess Painlevé property, the approximate solutions are obtained for the JM equation, containing not only one-soliton solutions but also periodic solutions and multi-soliton solutions. Some approximate solutions happen to be exact and some approximate solutions can become exact by choosing relations between the parameters properly. 展开更多
关键词 3+1)-dimensional Jimbo-Miwa (JM) equation conformal invariant asymptotic expansion approach Painlevé property approximate and exact solutions
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混合感染中降钙素原联合1,3-β-D葡聚糖检测的诊断价值分析
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作者 邓承晓 《实验室检测》 2025年第13期63-65,共3页
目的分析血清降钙素原(PCT)联合1,3-β-D葡聚糖检测对重症监护病房(ICU)患者混合感染的诊断价值。方法选择2023年10月—2024年10月本院ICU收治的237例疑似混合感染患者作为研究对象。根据实验室检查结果分为真菌感染组(n=66)、细菌感染... 目的分析血清降钙素原(PCT)联合1,3-β-D葡聚糖检测对重症监护病房(ICU)患者混合感染的诊断价值。方法选择2023年10月—2024年10月本院ICU收治的237例疑似混合感染患者作为研究对象。根据实验室检查结果分为真菌感染组(n=66)、细菌感染组(n=103)和混合感染组(n=68)。检测并比较三组患者血清PCT和1,3-β-D葡聚糖水平。采用Logistic回归分析评估PCT与1,3-β-D葡聚糖水平与混合感染发生的相关性;绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC),评价单项及联合检测对混合感染的诊断效能。结果混合感染组血清PCT、1,3-β-D葡聚糖水平高于真菌感染组和细菌感染组(P<0.05)。Logistic回归显示,PCT、1,3-β-D葡聚糖水平升高是ICU患者发生混合感染的影响因素(P<0.05)。PCT、1,3-β-D葡聚糖及两者联合诊断发生混合感染的AUC分别为0.629、0.714、0.752,联合的AUC更高,其敏感度和特异度分别为72.06%、74.56%(P<0.05)。结论PCT联合1,3-β-D葡聚糖诊断ICU患者混合感染的效能更高,可通过上述指标水平分析混合感染的高风险人群。 展开更多
关键词 降钙素原 1 3-d葡聚糖 混合感染 细菌感染 病毒感染
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Variable Separation Solutions in (1+1)-Dimensional and (3+1)-Dimensional Systems via Entangled Mapping Approach
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作者 DAI Chao-Qing YAN Cai-Jie ZHANG Jie-Fang 《Communications in Theoretical Physics》 SCIE CAS CSCD 2006年第3X期389-392,共4页
In this paper, the entangled mapping approach (EMA) is applied to obtain variable separation solutions of (1+1)-dimensional and (3+1)-dimensional systems. By analysis, we firstly find that there also exists a ... In this paper, the entangled mapping approach (EMA) is applied to obtain variable separation solutions of (1+1)-dimensional and (3+1)-dimensional systems. By analysis, we firstly find that there also exists a common formula to describe suitable physical fields or potentials for these (1+1)-dimensional models such as coupled integrable dispersionless (CID) and shallow water wave equations. Moreover, we find that the variable separation solution of the (3+1)-dimensional Burgers system satisfies the completely same form as the universal quantity U1 in (2+1)-dimensional systems. The only difference is that the function q is a solution of a constraint equation and p is an arbitrary function of three independent variables. 展开更多
关键词 entangled mapping approach (1+1)-dimensional systems 3+1)-dimensional Burgers system
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Fast identification of -emitting radionuclides based on sequential Bayesian approach
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作者 Xuan Zhang Jian-Wei Huang +5 位作者 Lin-Jian Wan Jia-Cheng Liu Xiao-Le Zhang De-Hong Li Fei Tuo Zhi-Jun Yang 《Nuclear Science and Techniques》 2026年第2期1-15,共15页
The rapid identification of γ-emitting radionuclides with low activity levels in public areas is crucial for nuclear safety.However,classical methods rely on full-energy peaks in the integral spectrum,requiring suffi... The rapid identification of γ-emitting radionuclides with low activity levels in public areas is crucial for nuclear safety.However,classical methods rely on full-energy peaks in the integral spectrum,requiring sufficient count accumulation for evaluation,thereby limiting response time.The sequential Bayesian approach,which utilizes prior information and considers both photon energies and interarrival times,can significantly enhance the performance of radionuclides identification.This study proposes a theoretical optimization method for the traditional sequential Bayesian approach.Each photon is processed sequentially,and the corresponding posterior probability is updated in real time using a noninformative prior from the Bayesian theory.By comparing the posterior probabilities of the background and radionuclides based on the energy variance and time interval,the type of γ-rays can be identified(background characteristic γ-rays,Compton plateaus γ-rays,or radionuclide-specific characteristic γ-rays).By integrating the information from these multiple characteristic γ-rays,the presence and type of radionuclides were determined based on the final decision function and a set threshold.Based on theoretical research,verification experiments were conducted using a LaBr_(3)(Ce)detector in both low-and natural background radiation environments with typical radionuclides(^(137)Cs,^(60)Co,and ^(133)Ba).The results show that this approach can identify ^(137)Cs in 7.9 s and 8.5 s(source dose rate contribution:approximately 6.5×10^(−3)μGy/h),^(60)Co in 8.1 s and 9.8 s(approximately 4.8×10^(−2)μGy/h),and ^(133)Ba in 4.05 s and 5.99 s(approximately 3.4×10^(−2)μGy/h)under low and natural background radiation,respectively,with a miss rate below 0.01%.This demonstrates the effectiveness of the proposed approach for fast radionuclides identification,even at low activity levels and highlights its potential for enhancing public safety in diverse radiation environments. 展开更多
关键词 Sequential Bayesian approach Fast radionuclides identification LaBr_(3)(Ce)detector Low background radiation laboratory
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多种3-D打印手术导板在骨肿瘤切除重建手术中的应用 被引量:52
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作者 付军 郭征 +6 位作者 王臻 栗向东 范宏斌 李靖 裴延军 裴国献 李丹 《中国修复重建外科杂志》 CAS CSCD 北大核心 2014年第3期304-308,共5页
目的使用多种3-D打印技术制作手术导板,探讨其在骨肿瘤切除重建手术中的应用效果,并对比不同3-D打印技术制备的手术导板优缺点。方法回顾分析2012年9月-2014年1月符合选择标准的31例骨肿瘤患者临床资料,其中男19例,女12例;年龄6~67岁,... 目的使用多种3-D打印技术制作手术导板,探讨其在骨肿瘤切除重建手术中的应用效果,并对比不同3-D打印技术制备的手术导板优缺点。方法回顾分析2012年9月-2014年1月符合选择标准的31例骨肿瘤患者临床资料,其中男19例,女12例;年龄6~67岁,中位年龄23岁。病程15 d^12个月,中位病程2个月。其中恶性肿瘤13例,良性肿瘤18例;肿瘤位于股骨9例、脊柱7例、胫骨6例、骨盆5例、肱骨3例、腓骨1例。根据术前薄层(0.625 mm)CT扫描等影像学检查所得数据行术前肿瘤切除设计,根据切除计划设计手术导板。术前加工导板使用的3-D打印技术和材料分别为:熔融沉积成型9例(ABS树脂)、光固化立体成型14例(光敏树脂)、3-D印刷工艺5例(石膏)、选择性激光烧结3例(铝合金);导板灭菌后按术前计划应用于术中。通过对比导板制作加工时间分析4种3-D打印技术效率,记录术前设计时间、手术时间、术中透视次数,与同期同类常规手术28例(对照组)进行比较。结果 4种导板制作加工时间分别为:熔融沉积成型(19.3±6.5)h、光固化立体成型(5.2±1.3)h、3-D印刷工艺(8.6±1.9)h、选择性激光烧结(51.7±12.9)h,选择性激光烧结导板制作加工时间明显长于另外3种。31例均成功进行术前设计、导板制作并应用于手术;除3例术中导板断裂变形(ABS树脂1例、石膏2例),改为常规手术治疗外;余28例定位针均成功导入,根据定位针指引准确按术前手术设计截骨。与对照组比较,28例患者术前设计时间延长、手术时间缩短、术中透视次数减少,差异均有统计学意义(P<0.05)。28例均获随访,随访时间1~12个月,平均3.7个月。术后X线片及CT检查示肿瘤均完整切除,大段同种异体骨重建稳定。结论 3-D打印手术导板很好地适应了骨肿瘤手术个体化要求,可在术中实现术前设计,不同3-D打印技术制备的手术导板各有优势,需根据具体手术方式选择。 展开更多
关键词 3-d打印技术 手术导板 骨肿瘤 修复重建
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数字化设计与3-D打印技术在个性化医疗中的应用 被引量:34
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作者 秦勉 刘亚雄 +8 位作者 贺健康 王玲 连芩 李涤尘 靳忠民 何三虎 李刚 刘彦普 王臻 《中国修复重建外科杂志》 CAS CSCD 北大核心 2014年第3期286-291,共6页
目的总结将数字化设计与3-D打印技术应用于个性化医疗中的研究进展。方法回顾分析西安交通大学及其合作单位近年来将数字化设计与3-D打印技术在个性化医疗中应用的相关研究资料和临床文献,并进行综合整理分析。结果基于3-D打印技术,根... 目的总结将数字化设计与3-D打印技术应用于个性化医疗中的研究进展。方法回顾分析西安交通大学及其合作单位近年来将数字化设计与3-D打印技术在个性化医疗中应用的相关研究资料和临床文献,并进行综合整理分析。结果基于3-D打印技术,根据患者具体病变设计并制造个性化内植物,能满足不同患者病变形状与功能的需要,解决人体组织的个性化修复问题,降低对医生经验水平的依赖,得到越来越多外科医生认可。西安交通大学在国内最早开发出商用3-D打印机,对个性化医用内植物的设计及制造进行了深入研究,已形成了完整的工艺流程,制定了产品质量标准,并成功应用于临床试验。结论 3-D打印技术制造的个性化医用内植物能实现个性化匹配,满足患者对功能和美学的要求,同时具有定位准确、连接稳定、强度高等优点。因此该技术在个性化内植物制造与应用方面有广泛应用前景。 展开更多
关键词 3-d打印技术 个性化医疗 医用内植物 临床应用
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3-D打印技术辅助经皮撬拨空心钉内固定治疗移位的跟骨关节内骨折 被引量:18
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作者 吴敏 官建中 +5 位作者 肖玉周 王照东 陈笑天 赵志 张宽宽 朱军 《中国修复重建外科杂志》 CAS CSCD 北大核心 2017年第11期1316-1321,共6页
目的探讨3-D打印技术辅助经皮撬拨复位空心钉内固定治疗移位的跟骨关节内骨折的临床疗效。方法回顾分析2015年3月—2016年5月收治的移位的跟骨关节内骨折19例(19足),其中男13例,女6例;年龄24~73岁,平均38.2岁。开放性骨折3例,闭合性骨... 目的探讨3-D打印技术辅助经皮撬拨复位空心钉内固定治疗移位的跟骨关节内骨折的临床疗效。方法回顾分析2015年3月—2016年5月收治的移位的跟骨关节内骨折19例(19足),其中男13例,女6例;年龄24~73岁,平均38.2岁。开放性骨折3例,闭合性骨折16例。根据跟骨骨折Sanders分型:Ⅱ型12例,Ⅲ型7例;根据跟骨骨折Essex-Lopresti分型:舌型13例,关节压缩型6例。受伤至手术时间1~10 d,平均4.7 d。术前行双侧跟骨薄层CT扫描,计算机辅助镜面成像技术对健侧跟骨镜像处理,按1∶1比例打印出健侧镜像及患侧跟骨模型,对比观察骨折块的移位情况,模拟撬拨复位。跟骨骨折均采用经皮斯氏针撬拨复位空心螺钉内固定治疗。在X线片上测量术后即刻及末次随访时B?hler角和Gissane角,并与术前比较;采用美国矫形足踝协会(AOFAS)踝与后足评分系统评价患足术后功能。结果手术时间25~70 min,平均45 min;术中出血量10~40 mL,平均14.5 m L。术后患者切口均Ⅰ期愈合,无皮肤坏死、钉道感染、骨髓炎等并发症发生。19例患者术后获12~25个月(平均14.6个月)随访。患者骨折均获愈合,愈合时间8~14周,平均10.3周。随访期间无螺钉退出、断裂发生;除1例SandersⅡ型骨折患者术后6周跟骨高度部分丢失外,其余患者无复位丢失及骨折再移位,无创伤性关节炎发生。术后即刻及末次随访时B?hler角和Gissane角均较术前显著改善(P<0.05),术后即刻与末次随访时比较差异无统计学意义(P>0.05)。末次随访时AOFAS踝与后足评分为76~100分,平均88.2分,其中优10足、良7足、可2足,优良率89.5%。结论 3-D打印技术辅助经皮撬拨复位空心钉内固定治疗跟骨关节内骨折,减少了手术创伤,提高了复位质量及固定强度,使手术方案更安全、精确、个体化。 展开更多
关键词 3-d打印 关节内跟骨骨折 空心钉 内固定 经皮
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深部真菌感染患者血浆1-3-β-D葡聚糖检测的临床意义 被引量:29
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作者 张建芳 徐修礼 +1 位作者 樊新 孙怡群 《中华医院感染学杂志》 CAS CSCD 北大核心 2005年第3期354-355,共2页
目的探讨深部真菌感染患者血浆1-3-β-D葡聚糖检测的临床意义。方法 应用ME-80微生物动态快速 检测系统,及GKT-5M Set动态真菌检测试剂盒定量检测血浆中1-3-β-D葡聚糖的含量。结果正常对照组血浆 1-3-β-D葡聚糖含量为(2.83士2.57)μg... 目的探讨深部真菌感染患者血浆1-3-β-D葡聚糖检测的临床意义。方法 应用ME-80微生物动态快速 检测系统,及GKT-5M Set动态真菌检测试剂盒定量检测血浆中1-3-β-D葡聚糖的含量。结果正常对照组血浆 1-3-β-D葡聚糖含量为(2.83士2.57)μg/L;深部真菌感染组为(54.06士36.13)μg/L,经t检验分析,对照组与深部 真菌感染组1-3-β-D葡聚糖平均值差异非常显著(t=7.741,P<0.001)。结论 血浆葡聚糖检测可在拟诊早期为 临床医生提供机体是否感染真菌的可靠信息,是一种实用的真菌感染早期诊断方法。 展开更多
关键词 1-3-d 葡聚糖 深部真菌 感染
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3-D打印技术在矫形外科的应用 被引量:30
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作者 罗强 刘德荣 +1 位作者 方欣硕 梁加利 《中国修复重建外科杂志》 CAS CSCD 北大核心 2014年第3期268-271,共4页
目的对近年来3-D打印技术在矫形外科的应用、限制及前景进行综述。方法广泛查阅近年来关于3-D打印技术在医学,尤其是在矫形外科应用的文献,并进行总结分析。结果 3-D打印技术已应用于矫形外科的术前诊断、手术方案制定及个性化假体制造... 目的对近年来3-D打印技术在矫形外科的应用、限制及前景进行综述。方法广泛查阅近年来关于3-D打印技术在医学,尤其是在矫形外科应用的文献,并进行总结分析。结果 3-D打印技术已应用于矫形外科的术前诊断、手术方案制定及个性化假体制造等方面。结论 3-D打印技术是一项有医学应用前景的技术。 展开更多
关键词 3-d打印技术 快速成型技术 矫形外科
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基于 3-D 打印技术的软骨修复及软骨下骨重建 被引量:27
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作者 张维杰 连芩 +6 位作者 李涤尘 王坤正 靳忠民 边卫国 刘亚雄 贺健康 王玲 《中国修复重建外科杂志》 CAS CSCD 北大核心 2014年第3期318-324,共7页
目的基于3-D打印技术探索骨软骨组织工程修复过程中,新生软骨下骨微结构参数变化规律及其与软骨修复间关系,为功能化组织工程软骨构建奠定基础。 方法应用3-D打印技术制备双相聚乙二醇/β-磷酸三钙骨软骨复合支架。取40只6月龄雄性新... 目的基于3-D打印技术探索骨软骨组织工程修复过程中,新生软骨下骨微结构参数变化规律及其与软骨修复间关系,为功能化组织工程软骨构建奠定基础。 方法应用3-D打印技术制备双相聚乙二醇/β-磷酸三钙骨软骨复合支架。取40只6月龄雄性新西兰白兔(体重2.5~3.5 kg),于右膝滑车部位建立直径4.8 mm、深7.5 mm骨软骨缺损模型,左侧不制备缺损为假手术组;将支架分别植入35只兔骨软骨缺损作为实验组,余5只不植入支架作为空白对照组。实验组和假手术组分别于术后1、2、4、8、16、24、52周,空白对照组于术后24周取材(n=5),行大体及组织学观察,并根据Wayne评分体系进行评分;行Micro-CT扫描及三维重建检测新生软骨下骨微结构参数:骨体积分数(bone volume fraction,BV/TV)、骨表面积分数(bone surface area fraction,BSA/BV)、骨小梁厚度(trabecular thickness,Tb.Th)、骨小梁数量(trabecular number,Tb.N)及骨小梁分离度(trabecular spacing,Tb.Sp)。采用Pearson相关分析软骨下骨微结构参数与软骨修复大体及组织学评分间的相关性。 结果实验组术后软骨明显修复,52周时以透明软骨为主,出现潮线结构;Wayne评分显示,实验组24、52周评分均显著高于16周(P 〈 0.05),24周及52周间差异无统计学意义(P 〉 0.05);但各时间点实验组评分均低于假手术组(P 〈 0.05)。实验组修复的软骨下骨逐渐从缺损周围向中央迁移,24、52周时形成软骨下骨板结构。修复术后BV/TV、BSA/BV、Tb.N均呈“双峰”样变化过程,分别在2、16周达峰值;Tb.Sp变化规律与BV/TV、BSA/BV、Tb.N相反;Tb.Th整个过程中变化不明显。相关分析显示:BV/TV、BSA/BV、Tb.Th、Tb.N、Tb.Sp与软骨修复大体及组织学评分之间均存在相关关系。 结论在兔绝对尺寸骨软骨缺损修复中,软骨下骨微结构参数与软骨修复存在相关关系;完整的软骨下骨修复需经历“增殖-重建-再增殖-再重建”的“双峰”样过程,2、16周是骨增殖的2 个关键时期。 展开更多
关键词 3-d打印技术 组织工程软骨 软骨下骨 微结构参数 软骨修复
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