The reaction between 2,5-Dimethylpyrrole (1) and R_FI (2)(R_F: a, Cl(CF_2)_4; b, Cl(CF_2)_6; c, Cl(CF_2)_8; d, n-C_6F_(13); e, n-C_8F_(17)) in the presence of Na_2S_2O_4-NaHCO_3 in acetonitrile resulted in the formati...The reaction between 2,5-Dimethylpyrrole (1) and R_FI (2)(R_F: a, Cl(CF_2)_4; b, Cl(CF_2)_6; c, Cl(CF_2)_8; d, n-C_6F_(13); e, n-C_8F_(17)) in the presence of Na_2S_2O_4-NaHCO_3 in acetonitrile resulted in the formation of 2-perfluoroalkyl-2,5-dimethyl-2H-pyrrole (3) as a major product in good yield.展开更多
A novel and efficient method for selective synthesis of bromo-substituted 2H-pyrroles and 3H-pyrroles has been achieved from 1,3-enynes,NBS and TMSN_(3) via H_(2)O-promoted cyclization reactions or TFA-catalyzed cycli...A novel and efficient method for selective synthesis of bromo-substituted 2H-pyrroles and 3H-pyrroles has been achieved from 1,3-enynes,NBS and TMSN_(3) via H_(2)O-promoted cyclization reactions or TFA-catalyzed cyclization/2,3-shift reactions,providing a range of structurally diverse products in moderate to good yields undermild conditions.展开更多
文摘The reaction between 2,5-Dimethylpyrrole (1) and R_FI (2)(R_F: a, Cl(CF_2)_4; b, Cl(CF_2)_6; c, Cl(CF_2)_8; d, n-C_6F_(13); e, n-C_8F_(17)) in the presence of Na_2S_2O_4-NaHCO_3 in acetonitrile resulted in the formation of 2-perfluoroalkyl-2,5-dimethyl-2H-pyrrole (3) as a major product in good yield.
基金acknowledge the National Natural Science Foundation of China(Nos.22471187,22071171 and 21602072)the Anhui Provincial Natural Science Foundation(2108085MB61)+1 种基金the Natural Science Foundation of Anhui Education Department(KJ2019ZD66 and 2022AH050368)University Natural Science Research Project of Anhui Province(gxyqzD2021112)for financial supportof thiswork.
文摘A novel and efficient method for selective synthesis of bromo-substituted 2H-pyrroles and 3H-pyrroles has been achieved from 1,3-enynes,NBS and TMSN_(3) via H_(2)O-promoted cyclization reactions or TFA-catalyzed cyclization/2,3-shift reactions,providing a range of structurally diverse products in moderate to good yields undermild conditions.
