摘要
目的:铁代谢紊乱会加剧罹患2型糖尿病的风险,抗菌多肽在维持体内铁稳态中起着重要作用,但抗菌多肽水平会随着炎症反应的增强而上升,目前尚不清楚罹患和未患2型糖尿人群中抗菌多肽和铁稳态的变化及其与炎症的关联程度。通过Meta分析系统评价炎症对2型糖尿病患者血清抗菌多肽及铁代谢相关参数的影响。方法:检索中国知网、PubMed、Web of Science、EBSCOhost数据库,搜集2型糖尿病患者炎症指数和抗菌多肽相关的观察性研究,检索时限为2000-09-01/2024-09-30,由3名研究人员独立筛选文献,提取数据资料并评价纳入文献的质量,采用Review Manager 5.3、Stata 17.0和GraphPad Prism 8.0.2软件进行Meta分析。结果:共纳入15篇文献(17项研究),涉及3159名参与者,其中2型糖尿病患者1357例。Meta分析结果显示:与对照组相比,2型糖尿病患者血清抗菌多肽[SMD=0.35,95%CI(0.05,0.65),P<0.05]、铁蛋白[SMD=0.49,95%CI(0.21,0.78),P<0.01]和转铁蛋白[SMD=0.19,95%CI(0.00,0.37),P<0.05]水平更高。以炎症状态作为亚组进行分析,结果显示炎症可显著提升2型糖尿病患者血清抗菌多肽[SMD=0.76,95%CI(0.17,1.34),P<0.05]、铁蛋白[SMD=0.77,95%CI(0.06,1.47),P<0.05]水平。结论:抗菌多肽水平与2型糖尿病呈正相关,炎症是2型糖尿病的危险因素之一,早期预防炎症对防止2型糖尿病患者铁代谢紊乱有一定意义。
OBJECTIVE:Disorders in iron metabolism increase the risk of type 2 diabetes mellitus.Hepcidin play an important role in maintaining iron homeostasis in the body,but its level increases with increased inflammation.Changes in hepcidin and iron homeostasis and the extent of their association with inflammation in people with and without type 2 diabetes mellitus are unknown.Meta-analysis was used to evaluate the effect of inflammation on serum hepcidin and iron metabolism related parameters in patients with type 2 diabetes mellitus.METHODS:CNKI,PubMed,Web of Science and EBSCOhost databases were searched by computer to collect observational studies related to inflammatory index and hepcidin in patients with type 2 diabetes mellitus.The search time was from September 1,2000 to September 30,2024.Three researchers independently screened the literature,extracted data and evaluated the quality of the included literature.Meta-analysis was performed by Review Manager 5.3,Stata 17.0 and GraphPad Prism 8.0.2 software.RESULTS:A total of 15 articles(17 studies)involving 3159 participants,including 1357 patients with type 2 diabetes mellitus,were included.Meta-analysis results showed that compared with the control group,patients with type 2 diabetes mellitus had higher levels of serum hepcidin[standardized mean difference(SMD)=0.35,95%confidence interval(CI)(0.05,0.65),P<0.05],serum ferritin(SMD=0.49,95%CI(0.21,0.78),P<0.01)and serum transferrin(SMD=0.19,95%CI(0.00,0.37),P<0.05).Subgroup analysis results indicated that inflammation had a significant effect on serum hepcidin(SMD=0.76,95%CI(0.17,1.34),P<0.05)and serum ferritin(SMD=0.77,95%CI(0.06,1.47),P<0.05)in patients with type 2 diabetes mellitus.CONCLUSION:Hepcidin concentration is positively correlated with type 2 diabetes mellitus.Inflammation is one of the risk factors of type 2 diabetes mellitus.Early prevention of inflammation has certain significance in preventing iron metabolism disorder in patients with type 2 diabetes mellitus.
作者
温小龙
翁锡全
冯瑶
曹文燕
刘玉倩
王海涛
Wen Xiaolong;Weng Xiquan;Feng Yao;Cao Wenyan;Liu Yuqian;Wang Haitao(Institute of Exercise and Health Promotion,Lingnan Normal University,Zhanjiang 524048,Guangdong Province,China;Key Laboratory of Exercise Biochemistry,Guangzhou Sport University,Guangzhou 510500,Guangdong Province,China;School of Physical Sciences,Lingnan Normal University,Zhanjiang 524048,Guangdong Province,China)
出处
《中国组织工程研究》
北大核心
2026年第5期1294-1301,共8页
Chinese Journal of Tissue Engineering Research
基金
教育部人文社会科学研究规划基金项目(23YJAZH088),项目负责人:刘玉倩
广东省教育科学规划课题项目(2023GXJK371),项目负责人:刘玉倩
广东省哲学社会科学规划项目(GD23XTY39),项目负责人:王海涛。
关键词
炎症
抗菌多肽
2型糖尿病
铁代谢
观察性研究
META分析
工程化组织构建
inflammation
hepcidin
type 2 diabetes mellitus
iron metabolism
observational study
meta-analysis
engineered tissue construction
