目的分析基于TLR4/MyD88/NF-κB信号通路探讨梓醇对T2DM大鼠肾损伤的保护作用。方法选择SPF级雄性SD大鼠50只,造模过程中有10只大鼠造模失败,采用随机数表法将大鼠分为正常组(control,10只)和模型组、西药组、梓醇组四组,每组各10只。...目的分析基于TLR4/MyD88/NF-κB信号通路探讨梓醇对T2DM大鼠肾损伤的保护作用。方法选择SPF级雄性SD大鼠50只,造模过程中有10只大鼠造模失败,采用随机数表法将大鼠分为正常组(control,10只)和模型组、西药组、梓醇组四组,每组各10只。比较各组大鼠干预前后空腹血糖、肾功能指标以及TLR4、MyD88、NF-κB蛋白表达量。结果干预4周后,模型组和西药组、梓醇组FPG、FINS、HOMA-IR水平比较,差异均具有统计学意义(P<0.05);模型组、西药组和梓醇组FPG、FINS、HOMAIR均高于正常组,差异均具有统计学意义(P<0.05);西药组和梓醇组FPG、FINS、HOMAIR低于模型组,差异具有统计学意义(P<0.05);且梓醇组FPG、FINS、HOMAIR低于西药组,差异均具有统计学意义(P<0.05);干预4周后,模型组和西药组、梓醇组BUN、Scr及24 h mALB水平比较,差异均具有统计学意义(P<0.05);模型组、西药组和梓醇组BUN、Scr及24 h mALB均高于正常组,差异均具有统计学意义(P<0.05);西药组和梓醇组BUN、Scr及24 h mALB低于模型组,差异具有统计学意义(P<0.05);且梓醇组BUN、Scr及24 h mALB低于西药组,差异均具有统计学意义(P<0.05);模型组与正常组相比,大鼠肾组织TLR4、MyD88、NF-κB的表达明显上调;与模型组相比,西药组、梓醇组的肾组织TLR4、MyD88、NF-κB的表达明显下调。模型组、西药组、梓醇组TLR4、MyD88、NF-κB的mRNA相对表达量均明显高于正常组,且西药组、梓醇组TLR4、MyD88、NF-κB的mRNA相对表达量明显低于模型组,差异具有统计学意义(P<0.05);梓醇组TLR4、MyD88、NF-κB的mRNA相对表达量低于西药组,差异具有统计学意义(P<0.05)。结论梓醇对2型糖尿病大鼠肾损伤有一定保护作用,可能与抑制TLR4/MyD88/NF-κB信号通路异常激活有关。展开更多
目的:分析成年人甘油三酯葡萄糖乘积(TyG)指数与2型糖尿病(T2DM)伴超重/肥胖状况之间的影响因素。方法:本研究选取60例T2DM伴超重/肥胖的患者组成患病组,同时选取30名健康个体构成健康对照组。收集两组的基本信息、检验参数指标,行统计...目的:分析成年人甘油三酯葡萄糖乘积(TyG)指数与2型糖尿病(T2DM)伴超重/肥胖状况之间的影响因素。方法:本研究选取60例T2DM伴超重/肥胖的患者组成患病组,同时选取30名健康个体构成健康对照组。收集两组的基本信息、检验参数指标,行统计学分析。结果:健康组与患病组在TyG指数、甘油三酯水平(TG)、空腹血糖值(FPG)、体重指数(BMI)、糖化血红蛋白(HbA1c)、红细胞计数(RBC)及空腹C肽浓度(FCP)等指标方面有显著差异。TyG指数、BMI的升高以及HbA1c的上升伴随RBC的下降,是T2DM伴超重/肥胖的独立风险因素。ROC曲线下面积(AUC)为0.841。结论:TyG指数在T2DM伴超重/肥胖人群的诊断与预测中发挥着重要作用。Objective: To analyze the influencing factors between adult triglyceride glucose product (TyG) index and type 2 diabetes mellitus (T2DM) with overweight and obesity. Methods: In this study, 60 patients with T2DM with overweight and obesity were selected to form the disease group, and 30 healthy individuals were selected to form the healthy control group to collect basic information of the two groups. The parameters were tested and the difference was compared by binary and multi-factor Logistic regression ROC curve. Results: TyG index, triglyceride level (TG), fasting blood glucose value (FPG), body mass index (BMI), glycosylated hemoglobin (HbA1c) in the healthy group and the diseased group. There were significant differences in red blood cell count (RBC) and fasting C-peptide concentration (FCP), and the increase of TyG BMI and HbA1c were accompanied by the decrease of RBC. The area under ROC curve (AUC) of T2DM with overweight and obesity was 0.841. Conclusion: TyG index plays an important role in the diagnosis and prediction of T2DM patients with overweight and obesity.展开更多
文摘目的分析基于TLR4/MyD88/NF-κB信号通路探讨梓醇对T2DM大鼠肾损伤的保护作用。方法选择SPF级雄性SD大鼠50只,造模过程中有10只大鼠造模失败,采用随机数表法将大鼠分为正常组(control,10只)和模型组、西药组、梓醇组四组,每组各10只。比较各组大鼠干预前后空腹血糖、肾功能指标以及TLR4、MyD88、NF-κB蛋白表达量。结果干预4周后,模型组和西药组、梓醇组FPG、FINS、HOMA-IR水平比较,差异均具有统计学意义(P<0.05);模型组、西药组和梓醇组FPG、FINS、HOMAIR均高于正常组,差异均具有统计学意义(P<0.05);西药组和梓醇组FPG、FINS、HOMAIR低于模型组,差异具有统计学意义(P<0.05);且梓醇组FPG、FINS、HOMAIR低于西药组,差异均具有统计学意义(P<0.05);干预4周后,模型组和西药组、梓醇组BUN、Scr及24 h mALB水平比较,差异均具有统计学意义(P<0.05);模型组、西药组和梓醇组BUN、Scr及24 h mALB均高于正常组,差异均具有统计学意义(P<0.05);西药组和梓醇组BUN、Scr及24 h mALB低于模型组,差异具有统计学意义(P<0.05);且梓醇组BUN、Scr及24 h mALB低于西药组,差异均具有统计学意义(P<0.05);模型组与正常组相比,大鼠肾组织TLR4、MyD88、NF-κB的表达明显上调;与模型组相比,西药组、梓醇组的肾组织TLR4、MyD88、NF-κB的表达明显下调。模型组、西药组、梓醇组TLR4、MyD88、NF-κB的mRNA相对表达量均明显高于正常组,且西药组、梓醇组TLR4、MyD88、NF-κB的mRNA相对表达量明显低于模型组,差异具有统计学意义(P<0.05);梓醇组TLR4、MyD88、NF-κB的mRNA相对表达量低于西药组,差异具有统计学意义(P<0.05)。结论梓醇对2型糖尿病大鼠肾损伤有一定保护作用,可能与抑制TLR4/MyD88/NF-κB信号通路异常激活有关。
文摘目的:分析成年人甘油三酯葡萄糖乘积(TyG)指数与2型糖尿病(T2DM)伴超重/肥胖状况之间的影响因素。方法:本研究选取60例T2DM伴超重/肥胖的患者组成患病组,同时选取30名健康个体构成健康对照组。收集两组的基本信息、检验参数指标,行统计学分析。结果:健康组与患病组在TyG指数、甘油三酯水平(TG)、空腹血糖值(FPG)、体重指数(BMI)、糖化血红蛋白(HbA1c)、红细胞计数(RBC)及空腹C肽浓度(FCP)等指标方面有显著差异。TyG指数、BMI的升高以及HbA1c的上升伴随RBC的下降,是T2DM伴超重/肥胖的独立风险因素。ROC曲线下面积(AUC)为0.841。结论:TyG指数在T2DM伴超重/肥胖人群的诊断与预测中发挥着重要作用。Objective: To analyze the influencing factors between adult triglyceride glucose product (TyG) index and type 2 diabetes mellitus (T2DM) with overweight and obesity. Methods: In this study, 60 patients with T2DM with overweight and obesity were selected to form the disease group, and 30 healthy individuals were selected to form the healthy control group to collect basic information of the two groups. The parameters were tested and the difference was compared by binary and multi-factor Logistic regression ROC curve. Results: TyG index, triglyceride level (TG), fasting blood glucose value (FPG), body mass index (BMI), glycosylated hemoglobin (HbA1c) in the healthy group and the diseased group. There were significant differences in red blood cell count (RBC) and fasting C-peptide concentration (FCP), and the increase of TyG BMI and HbA1c were accompanied by the decrease of RBC. The area under ROC curve (AUC) of T2DM with overweight and obesity was 0.841. Conclusion: TyG index plays an important role in the diagnosis and prediction of T2DM patients with overweight and obesity.
