The Main Himalayan Thrust(MHT),where the 2015 MW7.8 Gorkha earthquake occurred,features the most seismicity of any structure in Nepal.The structural complexity of the MHT makes it difficult to obtain a definitive inte...The Main Himalayan Thrust(MHT),where the 2015 MW7.8 Gorkha earthquake occurred,features the most seismicity of any structure in Nepal.The structural complexity of the MHT makes it difficult to obtain a definitive interpretation of deep seismogenic structures.The application of new methods and data in this region is necessary to enhance local seismic hazard analyses.In this study,we used a well-designed machine learning-based earthquake location workflow(LOC-FLOW),which incorporates machine learning phase picking,phase association,absolute location,and double-difference relative location,to process seismic data collected by the Hi-CLIMB and NAMASTE seismic networks.We built a high-precision earthquake catalog of both the quiet-period and aftershock seismicity in this region.The seismicity distribution suggests that the quietperiod seismicity(388 events)was controlled by a mid-crustal ramp and the aftershock seismicity(12,669 events)was controlled by several geological structures of the MHT.The higher-level detail of the catalogs derived from this machine learning method reveal clearer structural characteristics,showing how the flat-ramp geometry and a possible duplex structure affect the depth distribution of the seismic events,and how a tear fault changes this distribution along strike.展开更多
目的分析儿童急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)经中国儿童肿瘤协作组急性淋巴细胞白血病2015方案(Chinese Children's Cancer Group ALL-2015 protocol,CCCG-ALL-2015)治疗后的累积复发率(cumulative incidenc...目的分析儿童急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)经中国儿童肿瘤协作组急性淋巴细胞白血病2015方案(Chinese Children's Cancer Group ALL-2015 protocol,CCCG-ALL-2015)治疗后的累积复发率(cumulative incidence of relapse,CIR),并探讨影响复发的危险因素。方法回顾性分析2015年1月—2019年12月接受CCCG-ALL-2015方案治疗的852例患儿的临床资料,计算CIR并分析影响儿童急性B淋巴细胞白血病(B-ALL)复发的危险因素。结果852例ALL患儿中,146例(17.1%)发生复发,8年CIR为(19.8±1.6)%。B-ALL与急性T淋巴细胞白血病患儿的8年CIR比较差异无统计学意义(P>0.05)。146例复发患儿中,复发时间主要集中于极早期(62例,42.5%)和早期(46例,31.5%),极早期单纯骨髓复发42例(28.8%),早期单纯骨髓复发27例(18.5%)。Cox比例风险回归模型分析显示,融合基因MLLr阳性(HR=4.177,95%CI:2.086~8.364,P<0.001)和第46天微小残留病≥0.01%(HR=2.013,95%CI:1.163~3.483,P=0.012)是B-ALL患儿经CCCG-ALL-2015方案治疗后复发的危险因素。结论儿童ALL经CCCG-ALL-2015方案治疗后仍有较高的复发率,以极早期和早期单纯骨髓复发常见;第46天微小残留病≥0.01%、融合基因MLLr阳性与B-ALL复发密切相关。展开更多
基金funded by the National Key R&D Program of China(2022YFF0800601)National Natural Science Foundation of China(42174069,U1939204).
文摘The Main Himalayan Thrust(MHT),where the 2015 MW7.8 Gorkha earthquake occurred,features the most seismicity of any structure in Nepal.The structural complexity of the MHT makes it difficult to obtain a definitive interpretation of deep seismogenic structures.The application of new methods and data in this region is necessary to enhance local seismic hazard analyses.In this study,we used a well-designed machine learning-based earthquake location workflow(LOC-FLOW),which incorporates machine learning phase picking,phase association,absolute location,and double-difference relative location,to process seismic data collected by the Hi-CLIMB and NAMASTE seismic networks.We built a high-precision earthquake catalog of both the quiet-period and aftershock seismicity in this region.The seismicity distribution suggests that the quietperiod seismicity(388 events)was controlled by a mid-crustal ramp and the aftershock seismicity(12,669 events)was controlled by several geological structures of the MHT.The higher-level detail of the catalogs derived from this machine learning method reveal clearer structural characteristics,showing how the flat-ramp geometry and a possible duplex structure affect the depth distribution of the seismic events,and how a tear fault changes this distribution along strike.
文摘目的分析儿童急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)经中国儿童肿瘤协作组急性淋巴细胞白血病2015方案(Chinese Children's Cancer Group ALL-2015 protocol,CCCG-ALL-2015)治疗后的累积复发率(cumulative incidence of relapse,CIR),并探讨影响复发的危险因素。方法回顾性分析2015年1月—2019年12月接受CCCG-ALL-2015方案治疗的852例患儿的临床资料,计算CIR并分析影响儿童急性B淋巴细胞白血病(B-ALL)复发的危险因素。结果852例ALL患儿中,146例(17.1%)发生复发,8年CIR为(19.8±1.6)%。B-ALL与急性T淋巴细胞白血病患儿的8年CIR比较差异无统计学意义(P>0.05)。146例复发患儿中,复发时间主要集中于极早期(62例,42.5%)和早期(46例,31.5%),极早期单纯骨髓复发42例(28.8%),早期单纯骨髓复发27例(18.5%)。Cox比例风险回归模型分析显示,融合基因MLLr阳性(HR=4.177,95%CI:2.086~8.364,P<0.001)和第46天微小残留病≥0.01%(HR=2.013,95%CI:1.163~3.483,P=0.012)是B-ALL患儿经CCCG-ALL-2015方案治疗后复发的危险因素。结论儿童ALL经CCCG-ALL-2015方案治疗后仍有较高的复发率,以极早期和早期单纯骨髓复发常见;第46天微小残留病≥0.01%、融合基因MLLr阳性与B-ALL复发密切相关。
