BACKGROUND Large-scale functional connectivity(LSFC)patterns in the brain have unique intrinsic characteristics.Abnormal LSFC patterns have been found in patients with dementia,as well as in those with mild cognitive ...BACKGROUND Large-scale functional connectivity(LSFC)patterns in the brain have unique intrinsic characteristics.Abnormal LSFC patterns have been found in patients with dementia,as well as in those with mild cognitive impairment(MCI),and these patterns predicted their cognitive performance.It has been reported that patients with type 2 diabetes mellitus(T2DM)may develop MCI that could progress to dementia.We investigated whether we could adopt LSFC patterns as discriminative features to predict the cognitive function of patients with T2DM,using connectome-based predictive modeling(CPM)and a support vector machine.AIM To investigate the utility of LSFC for predicting cognitive impairment related to T2DM more accurately and reliably.METHODS Resting-state functional magnetic resonance images were derived from 42 patients with T2DM and 24 healthy controls.Cognitive function was assessed using the Montreal Cognitive Assessment(MoCA).Patients with T2DM were divided into two groups,according to the presence(T2DM-C;n=16)or absence(T2DM-NC;n=26)of MCI.Brain regions were marked using Harvard Oxford(HOA-112),automated anatomical labeling(AAL-116),and 264-region functional(Power-264)atlases.LSFC biomarkers for predicting MoCA scores were identified using a new CPM technique.Subsequently,we used a support vector machine based on LSFC patterns for among-group differentiation.The area under the receiver operating characteristic curve determined the appearance of the classification.RESULTS CPM could predict the MoCA scores in patients with T2DM(Pearson’s correlation coefficient between predicted and actual MoCA scores,r=0.32,P=0.0066[HOA-112 atlas];r=0.32,P=0.0078[AAL-116 atlas];r=0.42,P=0.0038[Power-264 atlas]),indicating that LSFC patterns represent cognition-level measures in these patients.Positive(anti-correlated)LSFC networks based on the Power-264 atlas showed the best predictive performance;moreover,we observed new brain regions of interest associated with T2DM-related cognition.The area under the receiver operating characteristic curve values(T2DM-NC group vs.T2DM-C group)were 0.65-0.70,with LSFC matrices based on HOA-112 and Power-264 atlases having the highest value(0.70).Most discriminative and attractive LSFCs were related to the default mode network,limbic system,and basal ganglia.CONCLUSION LSFC provides neuroimaging-based information that may be useful in detecting MCI early and accurately in patients with T2DM.展开更多
Accurate water level measurement in nuclear reactors,particularly in PWRs(pressurized water reactors)and BWRs(boiling water reactors),is essential for ensuring the safety and efficiency of reactor operations.K-type HJ...Accurate water level measurement in nuclear reactors,particularly in PWRs(pressurized water reactors)and BWRs(boiling water reactors),is essential for ensuring the safety and efficiency of reactor operations.K-type HJTCs(heated junction thermocouples)are widely used for this purpose due to their ability to withstand extreme temperatures and radiation conditions.This article explores the role of HJTCs in reactor water level measurement and compares the performance of 2-wire and 3-wire connections.While the 2-wire connection is simple and cost-effective,it can introduce measurement inaccuracies due to wire resistance.In contrast,the 3-wire connection compensates for lead resistance,offering more precise and reliable measurements,particularly in long-distance applications.This paper discusses the operational considerations of these wiring configurations in the context of nuclear reactors and highlights the importance of choosing the appropriate connection type to optimize safety and measurement accuracy in PWR and BWR reactors.展开更多
AIM:To Investigate the effects of transforming growth factorβ2(TGF-β2)and connective tissue growth factor(CTGF)on transdifferentiation of human lens epithelial cells(HLECs)cultured in vitro and synthesis of extracel...AIM:To Investigate the effects of transforming growth factorβ2(TGF-β2)and connective tissue growth factor(CTGF)on transdifferentiation of human lens epithelial cells(HLECs)cultured in vitro and synthesis of extracellular matrix(ECM).METHODS:HLECs were treated with TGF-β2(0,0.5,1.0,5,10μg/L)and CTGF(0,15,30,60,100μg/L)for different times(0,24,48,72h)in vitro and the expression ofα-smooth muscle actin(α-SMA),the main component of the extracellular matrix typeⅠcollagen(Col-1)and fibronectin(Fn)were measured by using real-time polymerase chain reaction(PCR)and western-blot.RESULTS:TGF-β2 and CTGF significantly increased expression ofα-SMA mRNA and protein(P【0.05,P【0.001),Fn mRNA and protein(P【0.001),Col-1 mRNA and protein(P【0.001).TGF-β2 could induce HLECs expression of CTGF mRNA and protein in dosedependent manner(P【0.05,P【0.001).TGF-β2 and CTGF could induce HLECs to expressα-SMA,Fn and Col-1 in time-dependent manner.Each time of TGF-β2and CTGF induced HELCs expression ofα-SMA,Fn,Col-1 mRNA and protein was significant increase compared with control(P【0.05,P【0.001).CONCLUSION:TGF-β2 and CTGF could induce HLECs epithelial mesenchymal transition and ECM synthesis.展开更多
By describing the technique of port connection and flow chart ofR/W operation between 24LC01, serial E2PROM, and EM78P447A, features of EM78P447 and its connection with I2C serial bus are introduced. In the end, the p...By describing the technique of port connection and flow chart ofR/W operation between 24LC01, serial E2PROM, and EM78P447A, features of EM78P447 and its connection with I2C serial bus are introduced. In the end, the programe of writing operation is given.展开更多
A subset S of V is called a k-connected dominating set if S is a dominating set and the induced subgraph S has at most k components.The k-connected domination number γck（G） of G is the minimum cardinality taken ove...A subset S of V is called a k-connected dominating set if S is a dominating set and the induced subgraph S has at most k components.The k-connected domination number γck（G） of G is the minimum cardinality taken over all minimal k-connected dominating sets of G.In this paper,we characterize trees and unicyclic graphs with equal connected domination and 2-connected domination numbers.展开更多
Let Y be a closed 3-manifold such that all flat SU(2)-connections on Y are non-degenerate.In this article,we prove a Uhlenbeck-type compactness theorem on Y for stable flat SL(2,C)connections satisfying an L^(2)-bound...Let Y be a closed 3-manifold such that all flat SU(2)-connections on Y are non-degenerate.In this article,we prove a Uhlenbeck-type compactness theorem on Y for stable flat SL(2,C)connections satisfying an L^(2)-bound for the real curvature.Combining the compactness theorem and a result from[7],we prove that the moduli space of the stable flat SL(2,C)connections is disconnected under certain technical assumptions.展开更多
Bollobas and Gyarfas conjectured that for n 〉 4（k - 1） every 2-edge-coloring of Kn contains a monochromatic k-connected subgraph with at least n - 2k ＋ 2 vertices. Liu, et al. proved that the conjecture holds when...Bollobas and Gyarfas conjectured that for n 〉 4（k - 1） every 2-edge-coloring of Kn contains a monochromatic k-connected subgraph with at least n - 2k ＋ 2 vertices. Liu, et al. proved that the conjecture holds when n 〉 13k - 15. In this note, we characterize all the 2-edge-colorings of Kn where each monochromatic k-connected subgraph has at most n - 2k ＋ 2 vertices for n ≥ 13k - 15.展开更多
目的探究赖氨酰氧化酶样蛋白2(lysyl oxidase-like 2,LOXL2)、甲壳质酶蛋白40(chitinase protein 40,YKL-40)在结缔组织病合并肺间质病变(CTD combined with ILD,CTD-ILD)患者血清中的表达及临床意义。方法选择2022年7月-2023年4月我院...目的探究赖氨酰氧化酶样蛋白2(lysyl oxidase-like 2,LOXL2)、甲壳质酶蛋白40(chitinase protein 40,YKL-40)在结缔组织病合并肺间质病变(CTD combined with ILD,CTD-ILD)患者血清中的表达及临床意义。方法选择2022年7月-2023年4月我院收治的CTD患者182例(CTD-ILD组85例、CTD-NILD组97例)及对照组(同期健康体检者91例)。三组受检者检测血清LOXL2、YKL-40水平。分析其与肺功能、HRCT评分的相关性,并通过Logistic回归及受试者工作特征(receiver operating characteristic,ROC)曲线评估预测价值。结果CTD-ILD组、CTD-NILD组血清LOXL2、YKL-40水平均高于对照组,且CTD-ILD组高于CTD-NILD组(P<0.05)。与CTD-NILD组相比,CTD-ILD组年龄更大(P<0.05),类风湿关节炎患者占比、血红蛋白、维生素D、血钙均更低(P<0.05),红细胞沉降率、C-反应蛋白均更高(P<0.05)。血清LOXL2、YKL-40与肺一氧化碳弥散量占预计值百分比、肺总量占预计值百分比、用力肺活量占预计值百分比均呈负相关(P<0.05),与肺部高分辨率CT评分均呈正相关(P<0.05)。二元Logistic回归分析结果显示,LOXL2、YKL-40是CTD-ILD独立危险因素(P<0.05),维生素D是CTD-ILD独立保护因素(P<0.05)。血清LOXL2、YKL-40水平预测CTD-ILD的截断值分别是391.80 pg/mL、1868.95 pg/mL,曲线下面积(area under curve,AUC)值分别是0.730(95%CI:0.646~0.834)、0.719(95%CI:0.634~0.822),二者联合预测CTD-ILD的AUC值为0.825(95%CI:0.731~0.908)。二者联合的AUC大于LOXL2(Z值=2.937,P值=0.003)和YKL-40(Z值=3.218,P值=0.001)。可见,二者联合预测CTD-ILD的价值更高。结论LOXL2、YKL-40在CTD-ILD患者中异常高表达,可作为早期预测及风险分层的潜在生物标志物。展开更多
基金Supported by the National Natural Science Foundation of China,No.81771815.
文摘BACKGROUND Large-scale functional connectivity(LSFC)patterns in the brain have unique intrinsic characteristics.Abnormal LSFC patterns have been found in patients with dementia,as well as in those with mild cognitive impairment(MCI),and these patterns predicted their cognitive performance.It has been reported that patients with type 2 diabetes mellitus(T2DM)may develop MCI that could progress to dementia.We investigated whether we could adopt LSFC patterns as discriminative features to predict the cognitive function of patients with T2DM,using connectome-based predictive modeling(CPM)and a support vector machine.AIM To investigate the utility of LSFC for predicting cognitive impairment related to T2DM more accurately and reliably.METHODS Resting-state functional magnetic resonance images were derived from 42 patients with T2DM and 24 healthy controls.Cognitive function was assessed using the Montreal Cognitive Assessment(MoCA).Patients with T2DM were divided into two groups,according to the presence(T2DM-C;n=16)or absence(T2DM-NC;n=26)of MCI.Brain regions were marked using Harvard Oxford(HOA-112),automated anatomical labeling(AAL-116),and 264-region functional(Power-264)atlases.LSFC biomarkers for predicting MoCA scores were identified using a new CPM technique.Subsequently,we used a support vector machine based on LSFC patterns for among-group differentiation.The area under the receiver operating characteristic curve determined the appearance of the classification.RESULTS CPM could predict the MoCA scores in patients with T2DM(Pearson’s correlation coefficient between predicted and actual MoCA scores,r=0.32,P=0.0066[HOA-112 atlas];r=0.32,P=0.0078[AAL-116 atlas];r=0.42,P=0.0038[Power-264 atlas]),indicating that LSFC patterns represent cognition-level measures in these patients.Positive(anti-correlated)LSFC networks based on the Power-264 atlas showed the best predictive performance;moreover,we observed new brain regions of interest associated with T2DM-related cognition.The area under the receiver operating characteristic curve values(T2DM-NC group vs.T2DM-C group)were 0.65-0.70,with LSFC matrices based on HOA-112 and Power-264 atlases having the highest value(0.70).Most discriminative and attractive LSFCs were related to the default mode network,limbic system,and basal ganglia.CONCLUSION LSFC provides neuroimaging-based information that may be useful in detecting MCI early and accurately in patients with T2DM.
文摘Accurate water level measurement in nuclear reactors,particularly in PWRs(pressurized water reactors)and BWRs(boiling water reactors),is essential for ensuring the safety and efficiency of reactor operations.K-type HJTCs(heated junction thermocouples)are widely used for this purpose due to their ability to withstand extreme temperatures and radiation conditions.This article explores the role of HJTCs in reactor water level measurement and compares the performance of 2-wire and 3-wire connections.While the 2-wire connection is simple and cost-effective,it can introduce measurement inaccuracies due to wire resistance.In contrast,the 3-wire connection compensates for lead resistance,offering more precise and reliable measurements,particularly in long-distance applications.This paper discusses the operational considerations of these wiring configurations in the context of nuclear reactors and highlights the importance of choosing the appropriate connection type to optimize safety and measurement accuracy in PWR and BWR reactors.
基金National Natural Science Foundation of China(No.81070721)Inernational Exchange Program of Shaanxi Province,China(No.2012kw-31)
文摘AIM:To Investigate the effects of transforming growth factorβ2(TGF-β2)and connective tissue growth factor(CTGF)on transdifferentiation of human lens epithelial cells(HLECs)cultured in vitro and synthesis of extracellular matrix(ECM).METHODS:HLECs were treated with TGF-β2(0,0.5,1.0,5,10μg/L)and CTGF(0,15,30,60,100μg/L)for different times(0,24,48,72h)in vitro and the expression ofα-smooth muscle actin(α-SMA),the main component of the extracellular matrix typeⅠcollagen(Col-1)and fibronectin(Fn)were measured by using real-time polymerase chain reaction(PCR)and western-blot.RESULTS:TGF-β2 and CTGF significantly increased expression ofα-SMA mRNA and protein(P【0.05,P【0.001),Fn mRNA and protein(P【0.001),Col-1 mRNA and protein(P【0.001).TGF-β2 could induce HLECs expression of CTGF mRNA and protein in dosedependent manner(P【0.05,P【0.001).TGF-β2 and CTGF could induce HLECs to expressα-SMA,Fn and Col-1 in time-dependent manner.Each time of TGF-β2and CTGF induced HELCs expression ofα-SMA,Fn,Col-1 mRNA and protein was significant increase compared with control(P【0.05,P【0.001).CONCLUSION:TGF-β2 and CTGF could induce HLECs epithelial mesenchymal transition and ECM synthesis.
基金Research on Electromagnetic Scatter Character of very Complicate Object(69571021)
文摘By describing the technique of port connection and flow chart ofR/W operation between 24LC01, serial E2PROM, and EM78P447A, features of EM78P447 and its connection with I2C serial bus are introduced. In the end, the programe of writing operation is given.
文摘A subset S of V is called a k-connected dominating set if S is a dominating set and the induced subgraph S has at most k components.The k-connected domination number γck（G） of G is the minimum cardinality taken over all minimal k-connected dominating sets of G.In this paper,we characterize trees and unicyclic graphs with equal connected domination and 2-connected domination numbers.
基金supported in part by NSF of China(11801539)the Fundamental Research Funds of the Central Universities(WK3470000019)the USTC Research Funds of the Double First-Class Initiative(YD3470002002)。
文摘Let Y be a closed 3-manifold such that all flat SU(2)-connections on Y are non-degenerate.In this article,we prove a Uhlenbeck-type compactness theorem on Y for stable flat SL(2,C)connections satisfying an L^(2)-bound for the real curvature.Combining the compactness theorem and a result from[7],we prove that the moduli space of the stable flat SL(2,C)connections is disconnected under certain technical assumptions.
基金Supported by the National Natural Science Foundation of China(10701065 and 11101378)Zhejiang Provincial Natural Science Foundation(LY14A010009)
文摘Bollobas and Gyarfas conjectured that for n 〉 4（k - 1） every 2-edge-coloring of Kn contains a monochromatic k-connected subgraph with at least n - 2k ＋ 2 vertices. Liu, et al. proved that the conjecture holds when n 〉 13k - 15. In this note, we characterize all the 2-edge-colorings of Kn where each monochromatic k-connected subgraph has at most n - 2k ＋ 2 vertices for n ≥ 13k - 15.
文摘目的探究赖氨酰氧化酶样蛋白2(lysyl oxidase-like 2,LOXL2)、甲壳质酶蛋白40(chitinase protein 40,YKL-40)在结缔组织病合并肺间质病变(CTD combined with ILD,CTD-ILD)患者血清中的表达及临床意义。方法选择2022年7月-2023年4月我院收治的CTD患者182例(CTD-ILD组85例、CTD-NILD组97例)及对照组(同期健康体检者91例)。三组受检者检测血清LOXL2、YKL-40水平。分析其与肺功能、HRCT评分的相关性,并通过Logistic回归及受试者工作特征(receiver operating characteristic,ROC)曲线评估预测价值。结果CTD-ILD组、CTD-NILD组血清LOXL2、YKL-40水平均高于对照组,且CTD-ILD组高于CTD-NILD组(P<0.05)。与CTD-NILD组相比,CTD-ILD组年龄更大(P<0.05),类风湿关节炎患者占比、血红蛋白、维生素D、血钙均更低(P<0.05),红细胞沉降率、C-反应蛋白均更高(P<0.05)。血清LOXL2、YKL-40与肺一氧化碳弥散量占预计值百分比、肺总量占预计值百分比、用力肺活量占预计值百分比均呈负相关(P<0.05),与肺部高分辨率CT评分均呈正相关(P<0.05)。二元Logistic回归分析结果显示,LOXL2、YKL-40是CTD-ILD独立危险因素(P<0.05),维生素D是CTD-ILD独立保护因素(P<0.05)。血清LOXL2、YKL-40水平预测CTD-ILD的截断值分别是391.80 pg/mL、1868.95 pg/mL,曲线下面积(area under curve,AUC)值分别是0.730(95%CI:0.646~0.834)、0.719(95%CI:0.634~0.822),二者联合预测CTD-ILD的AUC值为0.825(95%CI:0.731~0.908)。二者联合的AUC大于LOXL2(Z值=2.937,P值=0.003)和YKL-40(Z值=3.218,P值=0.001)。可见,二者联合预测CTD-ILD的价值更高。结论LOXL2、YKL-40在CTD-ILD患者中异常高表达,可作为早期预测及风险分层的潜在生物标志物。
