在建筑行业数字化转型进程中,建筑信息模型(Building Information Modeling,BIM)技术已成为关键研究方向。智慧工地理念通过整合数字技术,正在改变传统的施工管理模式。建立了基于BIM的智慧工地管理理论体系,重点分析该体系的核心内涵,...在建筑行业数字化转型进程中,建筑信息模型(Building Information Modeling,BIM)技术已成为关键研究方向。智慧工地理念通过整合数字技术,正在改变传统的施工管理模式。建立了基于BIM的智慧工地管理理论体系,重点分析该体系的核心内涵,详细解析了系统组成架构及其关键要素,构建了层次化的管理框架模型。基于研究结果,提出管理机制优化、硬件设施建设、标准规范制定3个方面的实施策略,为智慧工地发展提供理论支撑和实践指导。以国道G104线工程为例,验证了该理论体系的可行性,阐述了BIM技术在智慧工地建设中的应用路径。展开更多
Lactiplantibacillus plantarum 104,which was previously screened in the laboratory,has been confirmed to have the effect of lowering lipids and regulating intestinal microbial homeostasis.However,the mechanism of actio...Lactiplantibacillus plantarum 104,which was previously screened in the laboratory,has been confirmed to have the effect of lowering lipids and regulating intestinal microbial homeostasis.However,the mechanism of action of its fermentation supernatant in alleviating metabolic disorders is unclear.L.plantarum 104 cell-free supernatant(LP104s)was fed to high-fat diet C57BL/6N mice for 8 weeks.The intervention of LP104s increased the concentration of conjugated bile acids in the ileum,especially taur-α/β-muricholic acid sodium salt(T-α-MCA or T-β-MCA),inhibited intestinal farnesoid X receptor(FXR)-related signaling pathways.LP104s reduced cholesterol levels by increasing the synthesis of hepatic cholic acid(CA),chenodeoxycholic acid(CDCA),and the excretion of bile acids in feces.Moreover,Western blotting results showed that TLR2/NF-κB signaling pathway expression was inhibited.In addition,16S r RNA sequencing results showed that LP104s regulated the relative abundance of bacteria associated with inflammatory response and obesity(Prevotella,Ruminococcus,and Clostridium).Therefore,this paper further elaborates the role of gut microbiology and bile acids in improving metabolism from the perspective of secondary bile acids and intestinal chronic inflammation and also lays a theoretical foundation for the next step in the development of fermentation products of this strain.展开更多
文摘在建筑行业数字化转型进程中,建筑信息模型(Building Information Modeling,BIM)技术已成为关键研究方向。智慧工地理念通过整合数字技术,正在改变传统的施工管理模式。建立了基于BIM的智慧工地管理理论体系,重点分析该体系的核心内涵,详细解析了系统组成架构及其关键要素,构建了层次化的管理框架模型。基于研究结果,提出管理机制优化、硬件设施建设、标准规范制定3个方面的实施策略,为智慧工地发展提供理论支撑和实践指导。以国道G104线工程为例,验证了该理论体系的可行性,阐述了BIM技术在智慧工地建设中的应用路径。
基金supported by the Jilin Province Science and Technology Plan Project(20230402032GH)。
文摘Lactiplantibacillus plantarum 104,which was previously screened in the laboratory,has been confirmed to have the effect of lowering lipids and regulating intestinal microbial homeostasis.However,the mechanism of action of its fermentation supernatant in alleviating metabolic disorders is unclear.L.plantarum 104 cell-free supernatant(LP104s)was fed to high-fat diet C57BL/6N mice for 8 weeks.The intervention of LP104s increased the concentration of conjugated bile acids in the ileum,especially taur-α/β-muricholic acid sodium salt(T-α-MCA or T-β-MCA),inhibited intestinal farnesoid X receptor(FXR)-related signaling pathways.LP104s reduced cholesterol levels by increasing the synthesis of hepatic cholic acid(CA),chenodeoxycholic acid(CDCA),and the excretion of bile acids in feces.Moreover,Western blotting results showed that TLR2/NF-κB signaling pathway expression was inhibited.In addition,16S r RNA sequencing results showed that LP104s regulated the relative abundance of bacteria associated with inflammatory response and obesity(Prevotella,Ruminococcus,and Clostridium).Therefore,this paper further elaborates the role of gut microbiology and bile acids in improving metabolism from the perspective of secondary bile acids and intestinal chronic inflammation and also lays a theoretical foundation for the next step in the development of fermentation products of this strain.
