Objective This study aimed to investigate the association between insulin resistance and the risk of cardiovascular disease.Methods A cross-sectional study including 2128 participants aged 40-79 years was conducted us...Objective This study aimed to investigate the association between insulin resistance and the risk of cardiovascular disease.Methods A cross-sectional study including 2128 participants aged 40-79 years was conducted using data from the National Health and Nutrition Examination Survey from 1999 to 2018.The quantitative insulin sensitivity check index(QUICKI)and homeostasis model assessment ofβ-cell function(HOMA-β)were used as independent variables.The 10-year risk of a first hard atherosclerotic cardiovascular event was used as the dependent variable,with other potential confounding factors considered.Multivariate linear regression models and smooth curve fitting were used to assess the associations between insulin resistance and 10-year risk.Results A total of 2128 patients,comprising 1191 men and 937 women,were included in our analysis.The regression analyses revealed a negative correlation between the QUICKI score and the 10-year risk of a first hard atherosclerotic car-diovascular event[β=-8.85,CI(-15.77,-1.93)]after adjusting for age,race,body mass index,systolic blood pressure,diastolic blood pressure,hypertension treatment,smoking,diabetes,and low-density lipoprotein cholesterol.Conversely,an increase in HOMA-βwas associated with 10-year risk[β=6.84,CI(0.45,13.23)].Gender-specific subgroup analysis indicated that the QUICKI had aβvalue of 0.077(0.046,0.108)for men and 0.080(0.061,0.094)for women.Conclusion This study demonstrated that increased insulin resistance is linked to an increased risk of cardiovascular disease.展开更多
Objective The study aims to predict 10-year cardiovascular disease(CVD)risk and explore its association with sleep duration among Chinese urban adults.Methods We analyzed part of the baseline data of a cohort that rec...Objective The study aims to predict 10-year cardiovascular disease(CVD)risk and explore its association with sleep duration among Chinese urban adults.Methods We analyzed part of the baseline data of a cohort that recruited adults for health screening by cluster sampling.The simplified Pittsburgh Sleep Quality Index(PSQI)and Framingham 10-year risk score(FRS)were used to measure sleep duration and CVD risk.Demographic characteristics,personal history of chronic diseases,lifestyle factors were collected using a questionnaire.Height,weight,total cholesterol(TC),and high-density lipoprotein cholesterol(HDL-C)were also measured.Multiple logistic regression models were performed to explore the association of sleep duration with the predicted CVD risk.Results We included 31,135 participants(median age 44 years,53.02%males)free of CVD,cerebral stroke,and not taking lipid-lowering agents.Overall,14.05%,and 25.55%of participants were at medium and high predicted CVD risk,respectively.Short sleep was independently associated with increased odds of medium to high risk of predicted 10-year CVD among males(OR=1.10;95%CI:1.01–1.19)and increased odds of medium to high and high risk of predicted 10-year CVD among females(OR=1.23;95%CI:1.08–1.40;OR=1.27;95%CI:1.11–1.44).In contrast,long sleep had no association with cardiovascular risk.Conclusion A substantial number of adults free of CVD were at high 10-year CVD risk.Short sleep was associated with increased odds of predicted CVD risk.展开更多
Hypertension, obesity, smoking, dyslipidemia, and type 2 diabetes (T2D) are the major risk factors for developing cardiovascular diseases (CVD). Recent studies revealed that taxi-motorbike drivers (TMDs) in Cotonou ha...Hypertension, obesity, smoking, dyslipidemia, and type 2 diabetes (T2D) are the major risk factors for developing cardiovascular diseases (CVD). Recent studies revealed that taxi-motorbike drivers (TMDs) in Cotonou had higher rates of CVD risk factors, but their impacts on cardiovascular events have rarely been studied. The Framingham risk score (FRS) is an algorithm that considers CVD risk factors and estimates the risk of developing CVD in the next 10 years. Our objectives were to assess the 10-year CVD risk predicted by the FRS, and to examine the relationships of 10-year CVD risk with plasma iron and potassium levels among TMDs. We included 134 TMDs (22 - 59 years old) who had no prior diagnosis of CVD or T2D, and not taking medications affecting iron and potassium homeostasis. Conventional cardiovascular risk factors were used to calculate the 10-year CVD risk, which was categorized as low (20%). FRS > 2%, which corresponded to the 75th percentile of FRS distribution in our study population, was used as a cut-off value to classify participants into two groups. Plasma iron and potassium levels were segregated into tertiles and their associations with 10-year CVD risk were quantified by multivariate-adjusted logistic regression to calculate the odd ratios (ORs) to being above the 75<sup>th</sup> percentile of 10-year CVD risk with the corresponding 95% confidence intervals (CIs). We found that 62.0% of participants had at least one of cardiovascular risk factors. Approximately 97.8% of TMDs had 10-year CVD risk 4.8 mmol/L led to an 83% risk reduction of having 10-year CVD risk > 2% (OR = 0.17, 95% CI: 0.04 - 0.82, P = 0.027). In conclusion, our findings showed that high plasma potassium levels associate with reduced 10-year CVD risk among TMDs. Interventions focused on monitoring of plasma potassium, particularly in those with existing cardiovascular risk factors, may help prevent CVD.展开更多
基金supported by Hostital Capability Enhancement Project of Xiyuan Hospital,CACMS.(No.XYZX0405-25).
文摘Objective This study aimed to investigate the association between insulin resistance and the risk of cardiovascular disease.Methods A cross-sectional study including 2128 participants aged 40-79 years was conducted using data from the National Health and Nutrition Examination Survey from 1999 to 2018.The quantitative insulin sensitivity check index(QUICKI)and homeostasis model assessment ofβ-cell function(HOMA-β)were used as independent variables.The 10-year risk of a first hard atherosclerotic cardiovascular event was used as the dependent variable,with other potential confounding factors considered.Multivariate linear regression models and smooth curve fitting were used to assess the associations between insulin resistance and 10-year risk.Results A total of 2128 patients,comprising 1191 men and 937 women,were included in our analysis.The regression analyses revealed a negative correlation between the QUICKI score and the 10-year risk of a first hard atherosclerotic car-diovascular event[β=-8.85,CI(-15.77,-1.93)]after adjusting for age,race,body mass index,systolic blood pressure,diastolic blood pressure,hypertension treatment,smoking,diabetes,and low-density lipoprotein cholesterol.Conversely,an increase in HOMA-βwas associated with 10-year risk[β=6.84,CI(0.45,13.23)].Gender-specific subgroup analysis indicated that the QUICKI had aβvalue of 0.077(0.046,0.108)for men and 0.080(0.061,0.094)for women.Conclusion This study demonstrated that increased insulin resistance is linked to an increased risk of cardiovascular disease.
基金the National Key R&D Program in the Thirteenth Five-year Plan from the Chinese Ministry of Science and Technology[No.2016YFC0900600,2016YFC0900604]。
文摘Objective The study aims to predict 10-year cardiovascular disease(CVD)risk and explore its association with sleep duration among Chinese urban adults.Methods We analyzed part of the baseline data of a cohort that recruited adults for health screening by cluster sampling.The simplified Pittsburgh Sleep Quality Index(PSQI)and Framingham 10-year risk score(FRS)were used to measure sleep duration and CVD risk.Demographic characteristics,personal history of chronic diseases,lifestyle factors were collected using a questionnaire.Height,weight,total cholesterol(TC),and high-density lipoprotein cholesterol(HDL-C)were also measured.Multiple logistic regression models were performed to explore the association of sleep duration with the predicted CVD risk.Results We included 31,135 participants(median age 44 years,53.02%males)free of CVD,cerebral stroke,and not taking lipid-lowering agents.Overall,14.05%,and 25.55%of participants were at medium and high predicted CVD risk,respectively.Short sleep was independently associated with increased odds of medium to high risk of predicted 10-year CVD among males(OR=1.10;95%CI:1.01–1.19)and increased odds of medium to high and high risk of predicted 10-year CVD among females(OR=1.23;95%CI:1.08–1.40;OR=1.27;95%CI:1.11–1.44).In contrast,long sleep had no association with cardiovascular risk.Conclusion A substantial number of adults free of CVD were at high 10-year CVD risk.Short sleep was associated with increased odds of predicted CVD risk.
文摘Hypertension, obesity, smoking, dyslipidemia, and type 2 diabetes (T2D) are the major risk factors for developing cardiovascular diseases (CVD). Recent studies revealed that taxi-motorbike drivers (TMDs) in Cotonou had higher rates of CVD risk factors, but their impacts on cardiovascular events have rarely been studied. The Framingham risk score (FRS) is an algorithm that considers CVD risk factors and estimates the risk of developing CVD in the next 10 years. Our objectives were to assess the 10-year CVD risk predicted by the FRS, and to examine the relationships of 10-year CVD risk with plasma iron and potassium levels among TMDs. We included 134 TMDs (22 - 59 years old) who had no prior diagnosis of CVD or T2D, and not taking medications affecting iron and potassium homeostasis. Conventional cardiovascular risk factors were used to calculate the 10-year CVD risk, which was categorized as low (20%). FRS > 2%, which corresponded to the 75th percentile of FRS distribution in our study population, was used as a cut-off value to classify participants into two groups. Plasma iron and potassium levels were segregated into tertiles and their associations with 10-year CVD risk were quantified by multivariate-adjusted logistic regression to calculate the odd ratios (ORs) to being above the 75<sup>th</sup> percentile of 10-year CVD risk with the corresponding 95% confidence intervals (CIs). We found that 62.0% of participants had at least one of cardiovascular risk factors. Approximately 97.8% of TMDs had 10-year CVD risk 4.8 mmol/L led to an 83% risk reduction of having 10-year CVD risk > 2% (OR = 0.17, 95% CI: 0.04 - 0.82, P = 0.027). In conclusion, our findings showed that high plasma potassium levels associate with reduced 10-year CVD risk among TMDs. Interventions focused on monitoring of plasma potassium, particularly in those with existing cardiovascular risk factors, may help prevent CVD.
