Urban areas worldwide face escalating challenges in managing municipal solid waste (MSW) due to rapid urbanization, population growth, and changing consumption patterns. Inefficient waste management systems contribute...Urban areas worldwide face escalating challenges in managing municipal solid waste (MSW) due to rapid urbanization, population growth, and changing consumption patterns. Inefficient waste management systems contribute to environmental degradation, public health risks, and resource depletion, underscoring the need for innovative solutions. This review employing AI-driven sorting technologies in urban waste management as a transformative framework for sustainable MSW management, emphasizing waste reduction, resource recovery, and closed-loop systems. The paper synthesizes existing literature, case studies, and technological advancements to explore strategies for integrating CE principles into MSW management. Key areas of focus include the application of emerging technologies such as artificial intelligence, machine learning, and big data analytics;advancements in waste-to-resource technologies;the development of scalable and adaptable CE models tailored to diverse urban contexts;and fostering collaboration among governments, private sectors, and communities. Findings highlight the potential of CE frameworks to minimize waste generation, enhance resource efficiency, and create resilient urban systems. However, significant barriers remain, including technological, financial, and policy challenges. The review concludes by identifying future research directions and actionable recommendations for stakeholders, aiming to advance the global transition toward sustainable urban waste management.展开更多
An analytical solution for scattering of plane P waves by circular-arc layered alluvial valleys was derived by Fourier-Bessel series expansion technique, and the solution was utilized to analyze the effects of alluvia...An analytical solution for scattering of plane P waves by circular-arc layered alluvial valleys was derived by Fourier-Bessel series expansion technique, and the solution was utilized to analyze the effects of alluvial sequence and their relative stiffness on the scattering of incident waves.展开更多
Making use of basic equation of large deformation of circular membrane under the concentrated force and its boundary conditions and Hencky transformation, the problems of nonlinear boundary condition were solved. The ...Making use of basic equation of large deformation of circular membrane under the concentrated force and its boundary conditions and Hencky transformation, the problems of nonlinear boundary condition were solved. The Hencky transformation was extended and a exact solution of large deformation of circular membrane under the concentrated force has been obtained.展开更多
A narrow strip is used to control mean and fluctuating forces on a circular cylinder at Reynolds numbers from 2.0 ×10^4 to 1.0 ×^ 10^5. The axes of the strip and cylinder are parallel. The control parameters...A narrow strip is used to control mean and fluctuating forces on a circular cylinder at Reynolds numbers from 2.0 ×10^4 to 1.0 ×^ 10^5. The axes of the strip and cylinder are parallel. The control parameters are strip width ratio and strip position characterized by angle of attack and distance from the cylinder. Wind tunnel tests show that the vortex shedding from both sides of the cylinder can be suppressed, and mean drag and fluctuating lift on the cylinder can be reduced if the strip is installed in an effective zone downstream of the cylinder. A phenomenon of mono-side vortex shedding is found. The strip-induced local changes of velocity profiles in the near wake of the cylinder are measured, and the relation between base suction and peak value in the power spectrum of fluctuating lift is studied. The control mechanism is then discussed from different points of view.展开更多
Concepts and connotations of circular economy and eco-agricultural tourism were introduced,and feasibility of applying circular economy in eco-agricultural tourism was further studied.It was stressed that development ...Concepts and connotations of circular economy and eco-agricultural tourism were introduced,and feasibility of applying circular economy in eco-agricultural tourism was further studied.It was stressed that development of eco-agricultural tourism complies with the theme of resource recycling,moreover,both eco-agricultural tourist products and circular economy value environment protection,and target at the win-win of ecological and economic benefits.From the perspective of circular economy,the construction of eco-agricultural tourist product mode was studied,construction of eco-agricultural tourist areas,catering and accommodation areas and traffic construction of eco-agricultural scenic areas were discussed.The study stressed that connotations of circular economy can be used to restrain eco-agricultural tourism,and realize recycling and sustainable development of resources.展开更多
BACKGROUND Increasing evidence demonstrates that by acting as microRNA sponges modulating gene expression at the transcriptional or post-transcriptional level,circular RNAs(circRNAs)participate in the pathogenesis of ...BACKGROUND Increasing evidence demonstrates that by acting as microRNA sponges modulating gene expression at the transcriptional or post-transcriptional level,circular RNAs(circRNAs)participate in the pathogenesis of a variety of diseases and are considered ideal biomarkers of human disease.AIM To examine the expression of circRNA_103516 in inflammatory bowel disease(IBD)and its associations with clinical phenotypes and inflammatory cytokines.METHODS Peripheral blood mononuclear cells(PBMCs)were obtained from patients with IBD,healthy controls(HCs),and patient controls(PCs).Expression of circRNA_103516 and hsa-miR-19b-1-5p was assessed by quantitative reverse transcription-polymerase chain reaction.Crohn's disease activity index(CDAI),Mayo score,C-reactive protein(CRP)level,and erythrocyte sedimentation rate(ESR)were measured.To assess the inflammatory cytokines tumour necrosis factorα(TNF-α),interferon-γ(IFN-γ),and interleukin-10(IL-10),blood samples were analysed by flow cytometry.RESULTS Ninety Crohn’s disease(CD)and 90 ulcerative colitis(UC)patients,80 HCs,and 35 PCs were included in the study.CircRNA_103516 was upregulated in CD and UC patients compared with HCs and PCs(P<0.05).The area under the curve of circRNA_103516 for diagnosing CD and UC was 0.790 and 0.687,respectively.In addition,circRNA_103516 levels were increased in active CD and UC compared with remittent groups(P=0.027,P=0.045).Furthermore,in CD,circRNA_103516 correlated positively with CDAI(P<0.001),CRP(P<0.001),ESR(P<0.001),TNFα(P<0.001),and IFN-γ(P<0.001)and negatively correlated with IL-10(P=0.006).In UC patients,circRNA_103516 correlated with Mayo score(P<0.001),CRP(P<0.001),ESR(P<0.001),TNFα(P<0.001),IFN-γ(P=0.011),and IL-10(P=0.002).Additionally,circRNA_103516 correlated positively with stricturing(P=0.018)and penetrating(P=0.031)behaviour.Moreover,hsamiR-19b-1-5p correlated negatively with circRNA_103516 in CD.CONCLUSION CircRNA_103516 levels in PBMCs can be considered an ideal candidate biomarker for diagnosing IBD.Dysregulation of circRNA_103516 may participate in the molecular mechanism of IBD through hsa-miR-19b-1-5p sponging.展开更多
AIM To analyze the diagnostic value of a circular RNA(circR NA), circ-LDLRAD3, in pancreatic cancer.METHODS Expression levels of circ-LDLRAD3 were tested in both cells and clinical samples; the latter included 30 pair...AIM To analyze the diagnostic value of a circular RNA(circR NA), circ-LDLRAD3, in pancreatic cancer.METHODS Expression levels of circ-LDLRAD3 were tested in both cells and clinical samples; the latter included 30 paired pancreatic cancer tissues and adjacent non-tumorous tissues, 31 plasma samples from patients with pancreatic cancer, and 31 plasma samples from healthy volunteers. Real-time quantitative reverse transcriptionpolymerase chain reaction(q RT-PCR) was performed to measure expression levels of circ-LDLRAD3 in cells and clinical samples; then, the relationship between clinicopathological factors of patient samples and expression of circ-LDLRAD3 in pancreatic cancer was analyzed. The diagnostic value of circ-LDLRAD3 was verified by receiver operating characteristic(ROC) curve analysis.RESULTS Circ-LDLRAD3 was up-regulated in pancreatic cancer cell lines(P < 0.01), pancreatic cancer tissues(P < 0.01), and plasma samples from patients with pancreatic cancer(P < 0.01). High expression of circLDLRAD3 was significantly associated with venous invasion, lymphatic invasion, and metastasis. The area under the ROC curve of circ-LDLRAD3 alone or combination with CA19-9 was 0.67 and 0.87, respectively, with a sensitivity and specificity of 0.5738(alone) and 0.7049(alone), and 0.8033(combination) and 0.9355(combination), respectively.CONCLUSION These data suggest that circ-LDLRAD3 may be a biomarker in the diagnosis of pancreatic cancer.展开更多
Synaptic dysfunction and abnormal processing of amyloid precursor protein(APP) are early pathological features in Alzheimer’s disease(AD). Recently, noncoding RNAs such as micro RNAs(mi RNAs) and circular RNAs(circ R...Synaptic dysfunction and abnormal processing of amyloid precursor protein(APP) are early pathological features in Alzheimer’s disease(AD). Recently, noncoding RNAs such as micro RNAs(mi RNAs) and circular RNAs(circ RNAs) have been reported to contribute to the pathogenesis of AD. We found an age-dependent elevation of mi R-138 in APP/PS1(presenilin-1) mice. Mi R-138 inhibited the expression of ADAM10 [a disintegrin and metalloproteinase domain-containing protein 10], promoted amyloid beta(Ab) production, and induced synaptic and learning/memory deficits in APP/PS1 mice, while its suppression alleviated the AD-like phenotype in these mice. Overexpression of sirtuin 1(Sirt1), a target of mi R-138, ameliorated the mi R-138-induced inhibition of ADAM10 and elevation of Ab in vitro. The circ RNA HDAC9(circ HDAC9) was predicted to contain a mi R-138 binding site in several databases. Its expression was inversely correlated with mi R-138 in both Ab-oligomertreated N2 a cells and APP/PS1 mice, and it co-localized with mi R-138 in the cytoplasm of N2 a cells. Circ HDAC9 acted as a mi R-138 sponge, decreasing mi R-138 expression, and reversing the Sirt1 suppression and excessive Ab production induced by mi R-138 in vitro. Moreover,circ HDAC9 was decreased in the serum of both AD patients and individuals with mild cognitive impairment.These results suggest that the circ HDAC9/mi R-138/Sirt1 pathway mediates synaptic function and APP processing in AD, providing a potential therapeutic target for its treatment.展开更多
As a newly discovered type of RNA, circular RNAs(circRNAs) are widespread throughout the eukaryotic genome. The expression of circRNAs is regulated by both cis-elements and trans-factors, and the expression pattern of...As a newly discovered type of RNA, circular RNAs(circRNAs) are widespread throughout the eukaryotic genome. The expression of circRNAs is regulated by both cis-elements and trans-factors, and the expression pattern of circRNAs is cell type-and diseasespecific. Similar to other types of non-coding RNAs, functions of circRNAs are also versatile. CircRNAs have been reported previously to function as microRNA(miRNA) sponges, protein sponges, coding RNAs or scaffolds for protein complexes.Recently, several circRNAs have been reported to play important roles in human malignancies, including glioma. Here, we reviewed several reports related to circRNAs and glioma, as well as the potential diagnostic and therapeutic applications of circRNAs in brain cancer. In general, some circRNAs, such as circSMARCA5 and circCFH, are found to be expressed in a gliomaspecific pattern, these circRNAs may be used as tumor biomarkers. In addition, some circRNAs have been found to play oncogenic roles in glioma(e.g., circNFIX and circNT5E), whereas others have been reported to function as tumor suppressors(e.g.,circFBXW7 and circSHPRH). Furthermore, circRNA is a good tool for protein expression because of its higher stability compared to linear RNAs. Thus, circRNAs may also be an ideal choice for gene/protein delivery in future brain cancer therapies. There are some challenges in circRNA research in glioma and other diseases. Research related to circRNAs in glioma is comparatively new and many mysteries remain to be solved.展开更多
Quarter circular breakwater （QCB） is a new-type breakwater developed from senti-circular breakwater （SCB）. The superstructure of QCB is composed of a quarter circular front wall, a horizontal base slab and a verti...Quarter circular breakwater （QCB） is a new-type breakwater developed from senti-circular breakwater （SCB）. The superstructure of QCB is composed of a quarter circular front wall, a horizontal base slab and a vertical rear wall. The width of QCB＇ s base slab is about half that of SCB, which makes QCB suitable to be used on relatively finn soil foundation. The numerical wave flume based on the Reynolds averaged Navier-Stokes equations for impressible viscosity fluid is adopted in this paper to simulate the hydraulic performances of QCB. Since the geometry of both breakwaters is similar and SCB has been studied in depth, the hydraulic performances of QCB are given in comparison with those of SCB.展开更多
Background:Circular RNAs(circRNAs)are a special group of long-chain and non-coding RNAs characterized by a closed-loop structure without 3’and 5’polarity.In recent years,studies have demonstrated that circRNAs act a...Background:Circular RNAs(circRNAs)are a special group of long-chain and non-coding RNAs characterized by a closed-loop structure without 3’and 5’polarity.In recent years,studies have demonstrated that circRNAs act as microRNA(miRNA)sponges to regulate the function of miRNAs.Increasing evidence indicates that circRNAs and targeted miRNAs are involved in the development,progression and metastasis of various cancers and drug resistance.A number of miRNAs are known to be associated with the pathogenesis,development and treatment of pancreatic cancer by regulating the autophagic activity.Data sources:A comprehensive literature search was executed in PubMed and EMBASE using the medical subject headings(MeSH)terms“Pancreatic Neoplasms”,“autophagy”,“RNA,circular”and“microRNA”.We also used text terms such as“diagnosis”,“prognosis”and“biomarker”to supplement the results.Results:Autophagy-related miRNAs is closely related to pancreatic cancer.On basis of the retrieval results,we summarized the synthesis,features and functions of circRNAs and analyzed the association between autophagy-related miRNAs and pancreatic cancer.Conclusions:circRNAs act as the miRNA sponges and there is an association between miRNAs and autophagy,which provides a new concept to broaden the knowledge about the mechanisms underlying the development,progression and metastasis of pancreatic cancer.Additionally,clinical value of circRNAs and autophagy-related miRNAs in the diagnosis and treatment of pancreatic cancer would be further verified with in-depth researches.展开更多
The results of design and experiment of a submerged semi-circular breakwater at the Yangtze estuary show that the submerged structure will be unsafe when the general empirical wave force formula for semi-circular brea...The results of design and experiment of a submerged semi-circular breakwater at the Yangtze estuary show that the submerged structure will be unsafe when the general empirical wave force formula for semi-circular breakwater is used in design. Therefore, a new calculation method for the wave forces acting on a submerged semi-circular structure is given in this paper, in which the wave force acting on the inside circumference of semi-circular arch is included, and the phase modification coefficient in the general empirical formula is adjusted as well. The new wave force calculation method has been Verified by the results of seven related physical model tests and adopted in the design of the south esturary jetty of the first stage project of Deep Channel Improvement Project of the Yangtze River Estuary, the total jetty length being 17.5 km.展开更多
文摘Urban areas worldwide face escalating challenges in managing municipal solid waste (MSW) due to rapid urbanization, population growth, and changing consumption patterns. Inefficient waste management systems contribute to environmental degradation, public health risks, and resource depletion, underscoring the need for innovative solutions. This review employing AI-driven sorting technologies in urban waste management as a transformative framework for sustainable MSW management, emphasizing waste reduction, resource recovery, and closed-loop systems. The paper synthesizes existing literature, case studies, and technological advancements to explore strategies for integrating CE principles into MSW management. Key areas of focus include the application of emerging technologies such as artificial intelligence, machine learning, and big data analytics;advancements in waste-to-resource technologies;the development of scalable and adaptable CE models tailored to diverse urban contexts;and fostering collaboration among governments, private sectors, and communities. Findings highlight the potential of CE frameworks to minimize waste generation, enhance resource efficiency, and create resilient urban systems. However, significant barriers remain, including technological, financial, and policy challenges. The review concludes by identifying future research directions and actionable recommendations for stakeholders, aiming to advance the global transition toward sustainable urban waste management.
基金State Natural Science Foundation of China (No.59878032).
文摘An analytical solution for scattering of plane P waves by circular-arc layered alluvial valleys was derived by Fourier-Bessel series expansion technique, and the solution was utilized to analyze the effects of alluvial sequence and their relative stiffness on the scattering of incident waves.
文摘Making use of basic equation of large deformation of circular membrane under the concentrated force and its boundary conditions and Hencky transformation, the problems of nonlinear boundary condition were solved. The Hencky transformation was extended and a exact solution of large deformation of circular membrane under the concentrated force has been obtained.
基金the National Natural Science Foundation of China(10172087 and 10472124).
文摘A narrow strip is used to control mean and fluctuating forces on a circular cylinder at Reynolds numbers from 2.0 ×10^4 to 1.0 ×^ 10^5. The axes of the strip and cylinder are parallel. The control parameters are strip width ratio and strip position characterized by angle of attack and distance from the cylinder. Wind tunnel tests show that the vortex shedding from both sides of the cylinder can be suppressed, and mean drag and fluctuating lift on the cylinder can be reduced if the strip is installed in an effective zone downstream of the cylinder. A phenomenon of mono-side vortex shedding is found. The strip-induced local changes of velocity profiles in the near wake of the cylinder are measured, and the relation between base suction and peak value in the power spectrum of fluctuating lift is studied. The control mechanism is then discussed from different points of view.
基金Supported by Scientific Research Foundation of Shandong Jiaotong University(R200907)~~
文摘Concepts and connotations of circular economy and eco-agricultural tourism were introduced,and feasibility of applying circular economy in eco-agricultural tourism was further studied.It was stressed that development of eco-agricultural tourism complies with the theme of resource recycling,moreover,both eco-agricultural tourist products and circular economy value environment protection,and target at the win-win of ecological and economic benefits.From the perspective of circular economy,the construction of eco-agricultural tourist product mode was studied,construction of eco-agricultural tourist areas,catering and accommodation areas and traffic construction of eco-agricultural scenic areas were discussed.The study stressed that connotations of circular economy can be used to restrain eco-agricultural tourism,and realize recycling and sustainable development of resources.
基金Supported by the Natural Science Foundation of Jiangsu Province,No.BK20161232the Suzhou Special Project of Diagnosis and Treatment for Key Clinical Disease,No.LCZX201715
文摘BACKGROUND Increasing evidence demonstrates that by acting as microRNA sponges modulating gene expression at the transcriptional or post-transcriptional level,circular RNAs(circRNAs)participate in the pathogenesis of a variety of diseases and are considered ideal biomarkers of human disease.AIM To examine the expression of circRNA_103516 in inflammatory bowel disease(IBD)and its associations with clinical phenotypes and inflammatory cytokines.METHODS Peripheral blood mononuclear cells(PBMCs)were obtained from patients with IBD,healthy controls(HCs),and patient controls(PCs).Expression of circRNA_103516 and hsa-miR-19b-1-5p was assessed by quantitative reverse transcription-polymerase chain reaction.Crohn's disease activity index(CDAI),Mayo score,C-reactive protein(CRP)level,and erythrocyte sedimentation rate(ESR)were measured.To assess the inflammatory cytokines tumour necrosis factorα(TNF-α),interferon-γ(IFN-γ),and interleukin-10(IL-10),blood samples were analysed by flow cytometry.RESULTS Ninety Crohn’s disease(CD)and 90 ulcerative colitis(UC)patients,80 HCs,and 35 PCs were included in the study.CircRNA_103516 was upregulated in CD and UC patients compared with HCs and PCs(P<0.05).The area under the curve of circRNA_103516 for diagnosing CD and UC was 0.790 and 0.687,respectively.In addition,circRNA_103516 levels were increased in active CD and UC compared with remittent groups(P=0.027,P=0.045).Furthermore,in CD,circRNA_103516 correlated positively with CDAI(P<0.001),CRP(P<0.001),ESR(P<0.001),TNFα(P<0.001),and IFN-γ(P<0.001)and negatively correlated with IL-10(P=0.006).In UC patients,circRNA_103516 correlated with Mayo score(P<0.001),CRP(P<0.001),ESR(P<0.001),TNFα(P<0.001),IFN-γ(P=0.011),and IL-10(P=0.002).Additionally,circRNA_103516 correlated positively with stricturing(P=0.018)and penetrating(P=0.031)behaviour.Moreover,hsamiR-19b-1-5p correlated negatively with circRNA_103516 in CD.CONCLUSION CircRNA_103516 levels in PBMCs can be considered an ideal candidate biomarker for diagnosing IBD.Dysregulation of circRNA_103516 may participate in the molecular mechanism of IBD through hsa-miR-19b-1-5p sponging.
基金Supported by Natural Science Foundation of Liaoning Province,No.20170541024the Shengjing Free Researcher Project Foundation,No.200812
文摘AIM To analyze the diagnostic value of a circular RNA(circR NA), circ-LDLRAD3, in pancreatic cancer.METHODS Expression levels of circ-LDLRAD3 were tested in both cells and clinical samples; the latter included 30 paired pancreatic cancer tissues and adjacent non-tumorous tissues, 31 plasma samples from patients with pancreatic cancer, and 31 plasma samples from healthy volunteers. Real-time quantitative reverse transcriptionpolymerase chain reaction(q RT-PCR) was performed to measure expression levels of circ-LDLRAD3 in cells and clinical samples; then, the relationship between clinicopathological factors of patient samples and expression of circ-LDLRAD3 in pancreatic cancer was analyzed. The diagnostic value of circ-LDLRAD3 was verified by receiver operating characteristic(ROC) curve analysis.RESULTS Circ-LDLRAD3 was up-regulated in pancreatic cancer cell lines(P < 0.01), pancreatic cancer tissues(P < 0.01), and plasma samples from patients with pancreatic cancer(P < 0.01). High expression of circLDLRAD3 was significantly associated with venous invasion, lymphatic invasion, and metastasis. The area under the ROC curve of circ-LDLRAD3 alone or combination with CA19-9 was 0.67 and 0.87, respectively, with a sensitivity and specificity of 0.5738(alone) and 0.7049(alone), and 0.8033(combination) and 0.9355(combination), respectively.CONCLUSION These data suggest that circ-LDLRAD3 may be a biomarker in the diagnosis of pancreatic cancer.
基金supported by the National Natural Science Foundation of China (81500925)
文摘Synaptic dysfunction and abnormal processing of amyloid precursor protein(APP) are early pathological features in Alzheimer’s disease(AD). Recently, noncoding RNAs such as micro RNAs(mi RNAs) and circular RNAs(circ RNAs) have been reported to contribute to the pathogenesis of AD. We found an age-dependent elevation of mi R-138 in APP/PS1(presenilin-1) mice. Mi R-138 inhibited the expression of ADAM10 [a disintegrin and metalloproteinase domain-containing protein 10], promoted amyloid beta(Ab) production, and induced synaptic and learning/memory deficits in APP/PS1 mice, while its suppression alleviated the AD-like phenotype in these mice. Overexpression of sirtuin 1(Sirt1), a target of mi R-138, ameliorated the mi R-138-induced inhibition of ADAM10 and elevation of Ab in vitro. The circ RNA HDAC9(circ HDAC9) was predicted to contain a mi R-138 binding site in several databases. Its expression was inversely correlated with mi R-138 in both Ab-oligomertreated N2 a cells and APP/PS1 mice, and it co-localized with mi R-138 in the cytoplasm of N2 a cells. Circ HDAC9 acted as a mi R-138 sponge, decreasing mi R-138 expression, and reversing the Sirt1 suppression and excessive Ab production induced by mi R-138 in vitro. Moreover,circ HDAC9 was decreased in the serum of both AD patients and individuals with mild cognitive impairment.These results suggest that the circ HDAC9/mi R-138/Sirt1 pathway mediates synaptic function and APP processing in AD, providing a potential therapeutic target for its treatment.
文摘As a newly discovered type of RNA, circular RNAs(circRNAs) are widespread throughout the eukaryotic genome. The expression of circRNAs is regulated by both cis-elements and trans-factors, and the expression pattern of circRNAs is cell type-and diseasespecific. Similar to other types of non-coding RNAs, functions of circRNAs are also versatile. CircRNAs have been reported previously to function as microRNA(miRNA) sponges, protein sponges, coding RNAs or scaffolds for protein complexes.Recently, several circRNAs have been reported to play important roles in human malignancies, including glioma. Here, we reviewed several reports related to circRNAs and glioma, as well as the potential diagnostic and therapeutic applications of circRNAs in brain cancer. In general, some circRNAs, such as circSMARCA5 and circCFH, are found to be expressed in a gliomaspecific pattern, these circRNAs may be used as tumor biomarkers. In addition, some circRNAs have been found to play oncogenic roles in glioma(e.g., circNFIX and circNT5E), whereas others have been reported to function as tumor suppressors(e.g.,circFBXW7 and circSHPRH). Furthermore, circRNA is a good tool for protein expression because of its higher stability compared to linear RNAs. Thus, circRNAs may also be an ideal choice for gene/protein delivery in future brain cancer therapies. There are some challenges in circRNA research in glioma and other diseases. Research related to circRNAs in glioma is comparatively new and many mysteries remain to be solved.
基金supported by the National Natural Science Foundation of China(Grant No.50779045)
文摘Quarter circular breakwater （QCB） is a new-type breakwater developed from senti-circular breakwater （SCB）. The superstructure of QCB is composed of a quarter circular front wall, a horizontal base slab and a vertical rear wall. The width of QCB＇ s base slab is about half that of SCB, which makes QCB suitable to be used on relatively finn soil foundation. The numerical wave flume based on the Reynolds averaged Navier-Stokes equations for impressible viscosity fluid is adopted in this paper to simulate the hydraulic performances of QCB. Since the geometry of both breakwaters is similar and SCB has been studied in depth, the hydraulic performances of QCB are given in comparison with those of SCB.
基金supported by a grant from Shanghai Municipal Science and Technology Commission(16411972100)
文摘Background:Circular RNAs(circRNAs)are a special group of long-chain and non-coding RNAs characterized by a closed-loop structure without 3’and 5’polarity.In recent years,studies have demonstrated that circRNAs act as microRNA(miRNA)sponges to regulate the function of miRNAs.Increasing evidence indicates that circRNAs and targeted miRNAs are involved in the development,progression and metastasis of various cancers and drug resistance.A number of miRNAs are known to be associated with the pathogenesis,development and treatment of pancreatic cancer by regulating the autophagic activity.Data sources:A comprehensive literature search was executed in PubMed and EMBASE using the medical subject headings(MeSH)terms“Pancreatic Neoplasms”,“autophagy”,“RNA,circular”and“microRNA”.We also used text terms such as“diagnosis”,“prognosis”and“biomarker”to supplement the results.Results:Autophagy-related miRNAs is closely related to pancreatic cancer.On basis of the retrieval results,we summarized the synthesis,features and functions of circRNAs and analyzed the association between autophagy-related miRNAs and pancreatic cancer.Conclusions:circRNAs act as the miRNA sponges and there is an association between miRNAs and autophagy,which provides a new concept to broaden the knowledge about the mechanisms underlying the development,progression and metastasis of pancreatic cancer.Additionally,clinical value of circRNAs and autophagy-related miRNAs in the diagnosis and treatment of pancreatic cancer would be further verified with in-depth researches.
文摘The results of design and experiment of a submerged semi-circular breakwater at the Yangtze estuary show that the submerged structure will be unsafe when the general empirical wave force formula for semi-circular breakwater is used in design. Therefore, a new calculation method for the wave forces acting on a submerged semi-circular structure is given in this paper, in which the wave force acting on the inside circumference of semi-circular arch is included, and the phase modification coefficient in the general empirical formula is adjusted as well. The new wave force calculation method has been Verified by the results of seven related physical model tests and adopted in the design of the south esturary jetty of the first stage project of Deep Channel Improvement Project of the Yangtze River Estuary, the total jetty length being 17.5 km.
