复方黄柏液涂剂是一首经典名方,出自《医宗金鉴》,其立方严谨,疗效可靠,由连翘、黄柏、金银花、蒲公英及蜈蚣组成,具有清热解毒、散痈消肿祛腐的功效。现代医学研究发现,该方具有抑菌、消炎、镇痛、促愈的作用,近年来被广泛应用于肛肠...复方黄柏液涂剂是一首经典名方,出自《医宗金鉴》,其立方严谨,疗效可靠,由连翘、黄柏、金银花、蒲公英及蜈蚣组成,具有清热解毒、散痈消肿祛腐的功效。现代医学研究发现,该方具有抑菌、消炎、镇痛、促愈的作用,近年来被广泛应用于肛肠类疾病的治疗中。本文从近年来复方黄柏液涂剂对治疗肛肠疾病的相关文献进行综述,为进一步促进该药的临床合理应用提供参考。因其临床中良好的治疗效果,因此基于对复方黄柏液涂剂的作用机制及药理作用值得进一步研究。Compound Huangbai Liquid Coating is a classic prescription originating from the Jingzongjinzhen, which has a rigorous formulation and reliable efficacy. It is composed of Forsythia, Huangbai, Jinshuihua, Pu Gongying, and Zhiyu, and has the functions of clearing heat, detoxifying, dispersing swelling, and removing decay. Modern medical research has found that the formula has the effects of inhibiting bacteria, anti-inflammation, analgesia, and promoting healing. In recent years, it has been widely used in the treatment of anal and rectal diseases. This paper reviews the relevant literature on the treatment of anal and rectal diseases with Compound Huangbai Liquid Coating in recent years, providing reference for further promoting its clinical rational use. Because of its good therapeutic effects in clinical practice, further research on the mechanism of action and pharmacological effects of Compound Huangbai Liquid Coating is worthwhile.展开更多
目的:系统评价复方黄柏液涂剂联合其他方式治疗带状疱疹的疗效和安全性,为临床治疗带状疱疹提供循证医学证据。方法:通过计算机检索PubMed、Embase、Cochrane图书馆、中国知网、万方数据库,收集复方黄柏液涂剂联合抗病毒药物或激光或火...目的:系统评价复方黄柏液涂剂联合其他方式治疗带状疱疹的疗效和安全性,为临床治疗带状疱疹提供循证医学证据。方法:通过计算机检索PubMed、Embase、Cochrane图书馆、中国知网、万方数据库,收集复方黄柏液涂剂联合抗病毒药物或激光或火针治疗(试验组)对比单独使用抗病毒药物、激光、火针(对照组)治疗带状疱疹的随机对照试验(randomized controlled trials,RCT),采用Rev Man 5.3统计软件进行Meta分析。结果:共纳入8项RCT,合计568例患者。Meta分析结果显示,试验组患者总有效率高于对照组,差异有统计学意义[RR=1.46,95%CI(1.23,1.74),P<0.00001];2项研究描述了实验组和对照组的止痛时间、结痂时间,两组比较具有显著性差异(P<0.05);2篇文章描述了实验组和对照组的视觉模拟评分法(VAS)评分,两组比较具有显著性差异(P<0.05);1项研究描述了实验组和对照组的带状疱疹皮疹评分。治疗后,两组患者的带状疱疹皮疹评分(水疱数量、水疱簇数、水疱变化、红斑面积)低于对照组(P<0.05);1项研究描述了实验组和对照组白细胞介素(interleukin,IL)-2,IL-6,IL-8及前列腺素E2(PGE_(2))的水平比较。经治疗后,实验组IL-2,IL-6,IL-8及PGE_(2)水平低于对照组(P<0.05);1项研究描述了两组患者的治疗满意度。结果显示实验组的满意度(88.6%)高于对照组(60.0%),两组满意度比较具有显著性差异(P<0.05);1项研究描述了实验组和对照组不良反应的发生情况。结论:复方黄柏液联合其他方式治疗带状疱疹安全有效,但仍需开展更多高质量的RCT进一步验证。展开更多
文摘复方黄柏液涂剂是一首经典名方,出自《医宗金鉴》,其立方严谨,疗效可靠,由连翘、黄柏、金银花、蒲公英及蜈蚣组成,具有清热解毒、散痈消肿祛腐的功效。现代医学研究发现,该方具有抑菌、消炎、镇痛、促愈的作用,近年来被广泛应用于肛肠类疾病的治疗中。本文从近年来复方黄柏液涂剂对治疗肛肠疾病的相关文献进行综述,为进一步促进该药的临床合理应用提供参考。因其临床中良好的治疗效果,因此基于对复方黄柏液涂剂的作用机制及药理作用值得进一步研究。Compound Huangbai Liquid Coating is a classic prescription originating from the Jingzongjinzhen, which has a rigorous formulation and reliable efficacy. It is composed of Forsythia, Huangbai, Jinshuihua, Pu Gongying, and Zhiyu, and has the functions of clearing heat, detoxifying, dispersing swelling, and removing decay. Modern medical research has found that the formula has the effects of inhibiting bacteria, anti-inflammation, analgesia, and promoting healing. In recent years, it has been widely used in the treatment of anal and rectal diseases. This paper reviews the relevant literature on the treatment of anal and rectal diseases with Compound Huangbai Liquid Coating in recent years, providing reference for further promoting its clinical rational use. Because of its good therapeutic effects in clinical practice, further research on the mechanism of action and pharmacological effects of Compound Huangbai Liquid Coating is worthwhile.
文摘目的:系统评价复方黄柏液涂剂联合其他方式治疗带状疱疹的疗效和安全性,为临床治疗带状疱疹提供循证医学证据。方法:通过计算机检索PubMed、Embase、Cochrane图书馆、中国知网、万方数据库,收集复方黄柏液涂剂联合抗病毒药物或激光或火针治疗(试验组)对比单独使用抗病毒药物、激光、火针(对照组)治疗带状疱疹的随机对照试验(randomized controlled trials,RCT),采用Rev Man 5.3统计软件进行Meta分析。结果:共纳入8项RCT,合计568例患者。Meta分析结果显示,试验组患者总有效率高于对照组,差异有统计学意义[RR=1.46,95%CI(1.23,1.74),P<0.00001];2项研究描述了实验组和对照组的止痛时间、结痂时间,两组比较具有显著性差异(P<0.05);2篇文章描述了实验组和对照组的视觉模拟评分法(VAS)评分,两组比较具有显著性差异(P<0.05);1项研究描述了实验组和对照组的带状疱疹皮疹评分。治疗后,两组患者的带状疱疹皮疹评分(水疱数量、水疱簇数、水疱变化、红斑面积)低于对照组(P<0.05);1项研究描述了实验组和对照组白细胞介素(interleukin,IL)-2,IL-6,IL-8及前列腺素E2(PGE_(2))的水平比较。经治疗后,实验组IL-2,IL-6,IL-8及PGE_(2)水平低于对照组(P<0.05);1项研究描述了两组患者的治疗满意度。结果显示实验组的满意度(88.6%)高于对照组(60.0%),两组满意度比较具有显著性差异(P<0.05);1项研究描述了实验组和对照组不良反应的发生情况。结论:复方黄柏液联合其他方式治疗带状疱疹安全有效,但仍需开展更多高质量的RCT进一步验证。
