脊柱韧带骨化性疾病是一类临床常见的多因素迟发性疾病,起病隐匿,常引起脊髓和神经根病变,以多种脊柱韧带骨化为特征,包括后纵韧带骨化（ossification of the posterior longitudinal ligament,OPLL）、黄韧带骨化（ossification of the...脊柱韧带骨化性疾病是一类临床常见的多因素迟发性疾病,起病隐匿,常引起脊髓和神经根病变,以多种脊柱韧带骨化为特征,包括后纵韧带骨化（ossification of the posterior longitudinal ligament,OPLL）、黄韧带骨化（ossification of the ligamentum flavum,OLF）和弥漫性特发性骨肥大症（diffuse idiopathic skeletal hyperostosis,DISH）[1]。展开更多
Although antenatal infection is thought to play an important role in the path ogenesis of preterm labor and neonatal diseases, the exact mechanisms are largel y unknown. We sought to clarify the relationship between a...Although antenatal infection is thought to play an important role in the path ogenesis of preterm labor and neonatal diseases, the exact mechanisms are largel y unknown. We sought to clarify the relationship between antenatal infection and intrauterine and neonatal inflammation. Samples were obtained from 41 preterm i nfants of < 33 wk gestation delivered to 36 mothers and analyzed for the presenc e of 16s ribosomal RNA (16s rRNA) genes using PCR and for the proinflammatory cy tokines IL- 6 and IL- 8. In 16 (44% )motherbaby pairings, at least one sample was found to be positive for the presence of 16s rRNA genes. All but one of the positive samples were from mothers presenting with preterm prelabor rupture of membranes (pPROM) or in spontaneous idiopathic preterm labor. A strong associati on was found between the presence of 16s rRNA genes and chorioamnionitis and wit h funisitis. A marked increase in IL- 6 and IL- 8 was noted in all tissues pos itive for 16s rRNA genes, including placenta, fetal membranes, cord blood serum, and, where samples were available, in bronchoalveolar lavage fluid (BAL) and in amniotic fluid. Interestingly, gastric fluid was always positive for 16s rRNA g enes if any other intrauterine or BAL sample was positive, suggesting that this sample may provide an alternative to amniotic fluid to identify antenatal infect ion. In conclusion, we have found that microbial genes are particularly prevalen t in pPROM and spontaneous preterm labor groups and that their presence is stron gly associated with a marked intrauterine inflammatory response.展开更多
文摘脊柱韧带骨化性疾病是一类临床常见的多因素迟发性疾病,起病隐匿,常引起脊髓和神经根病变,以多种脊柱韧带骨化为特征,包括后纵韧带骨化（ossification of the posterior longitudinal ligament,OPLL）、黄韧带骨化（ossification of the ligamentum flavum,OLF）和弥漫性特发性骨肥大症（diffuse idiopathic skeletal hyperostosis,DISH）[1]。
文摘Although antenatal infection is thought to play an important role in the path ogenesis of preterm labor and neonatal diseases, the exact mechanisms are largel y unknown. We sought to clarify the relationship between antenatal infection and intrauterine and neonatal inflammation. Samples were obtained from 41 preterm i nfants of < 33 wk gestation delivered to 36 mothers and analyzed for the presenc e of 16s ribosomal RNA (16s rRNA) genes using PCR and for the proinflammatory cy tokines IL- 6 and IL- 8. In 16 (44% )motherbaby pairings, at least one sample was found to be positive for the presence of 16s rRNA genes. All but one of the positive samples were from mothers presenting with preterm prelabor rupture of membranes (pPROM) or in spontaneous idiopathic preterm labor. A strong associati on was found between the presence of 16s rRNA genes and chorioamnionitis and wit h funisitis. A marked increase in IL- 6 and IL- 8 was noted in all tissues pos itive for 16s rRNA genes, including placenta, fetal membranes, cord blood serum, and, where samples were available, in bronchoalveolar lavage fluid (BAL) and in amniotic fluid. Interestingly, gastric fluid was always positive for 16s rRNA g enes if any other intrauterine or BAL sample was positive, suggesting that this sample may provide an alternative to amniotic fluid to identify antenatal infect ion. In conclusion, we have found that microbial genes are particularly prevalen t in pPROM and spontaneous preterm labor groups and that their presence is stron gly associated with a marked intrauterine inflammatory response.
