目的了解铅作业工人的δ-氨基酮戊酸脱氢酶(ALAD)基因分布并分析不同基因型与工人血铅(PbB)、临床症状表现的关系。方法用聚合酶链反应-限制性长度多态分析法分析不同ALAD基因型与PbB、工人症状表现的关系,比较预防措施实施前后含ALAD2...目的了解铅作业工人的δ-氨基酮戊酸脱氢酶(ALAD)基因分布并分析不同基因型与工人血铅(PbB)、临床症状表现的关系。方法用聚合酶链反应-限制性长度多态分析法分析不同ALAD基因型与PbB、工人症状表现的关系,比较预防措施实施前后含ALAD2型等位基因工人PbB等指标的变化。结果铅作业工人176人ALAD基因分布呈现多态现象,ALAD1-1型占89.77%,ALAD1-2型占10.23%。ALAD1等位基因比例为94.88%,ALAD2等位基因比例为5.12%,等位基因分布频率符合遗传学Hardy-W e inberg平衡。含ALAD2等位基因的个体较ALAD1型等位基因的个体具有较高的PbB浓度、较明显的神经征表现,采取措施后含ALAD2等位基因的18名工人的PbB、尿δ-氨基酮戊酸(δ-ALA)、锌原卟啉(ZPP)值有明显的降低,PbB平均下降19.06%,-δALA平均下降18.64%,ZPP平均下降15.88%。结论相同职业性铅接触条件下,ALAD2等位基因个体的PbB浓度增加并出现一些临床症状表现,通过采取针对性防护对策,可降低工人PbB浓度,保护含ALAD2等位基因的个体。展开更多
Background: Photodynamic therapy (PDT) using topical δ-aminolevulinic acid (ALA) has been used for nonmelanoma skin cancers, including malignant cutaneous T-cell lymphomas. Moreover, PDT has been tried for benign inf...Background: Photodynamic therapy (PDT) using topical δ-aminolevulinic acid (ALA) has been used for nonmelanoma skin cancers, including malignant cutaneous T-cell lymphomas. Moreover, PDT has been tried for benign inflammatory or infectious skin lesions. Objective: To evaluate the effects of ALA-PDT on skin lesions of lymphadenosis benigna cutis (LABC). Patients and Methods: Two 16-year-old females with solitary and infiltrated nodules were treated 5 times with topical ALA-PDT. Results: Both patients responded well and showed dramatic clinical an d histopathological improvement without visible scars. Conclusion: The results c onfirm that topical ALA-PDT is an effective and safe modality for the treatment of LABC, and that such treatment may be cosmetically beneficial.展开更多
文摘目的了解铅作业工人的δ-氨基酮戊酸脱氢酶(ALAD)基因分布并分析不同基因型与工人血铅(PbB)、临床症状表现的关系。方法用聚合酶链反应-限制性长度多态分析法分析不同ALAD基因型与PbB、工人症状表现的关系,比较预防措施实施前后含ALAD2型等位基因工人PbB等指标的变化。结果铅作业工人176人ALAD基因分布呈现多态现象,ALAD1-1型占89.77%,ALAD1-2型占10.23%。ALAD1等位基因比例为94.88%,ALAD2等位基因比例为5.12%,等位基因分布频率符合遗传学Hardy-W e inberg平衡。含ALAD2等位基因的个体较ALAD1型等位基因的个体具有较高的PbB浓度、较明显的神经征表现,采取措施后含ALAD2等位基因的18名工人的PbB、尿δ-氨基酮戊酸(δ-ALA)、锌原卟啉(ZPP)值有明显的降低,PbB平均下降19.06%,-δALA平均下降18.64%,ZPP平均下降15.88%。结论相同职业性铅接触条件下,ALAD2等位基因个体的PbB浓度增加并出现一些临床症状表现,通过采取针对性防护对策,可降低工人PbB浓度,保护含ALAD2等位基因的个体。
文摘Background: Photodynamic therapy (PDT) using topical δ-aminolevulinic acid (ALA) has been used for nonmelanoma skin cancers, including malignant cutaneous T-cell lymphomas. Moreover, PDT has been tried for benign inflammatory or infectious skin lesions. Objective: To evaluate the effects of ALA-PDT on skin lesions of lymphadenosis benigna cutis (LABC). Patients and Methods: Two 16-year-old females with solitary and infiltrated nodules were treated 5 times with topical ALA-PDT. Results: Both patients responded well and showed dramatic clinical an d histopathological improvement without visible scars. Conclusion: The results c onfirm that topical ALA-PDT is an effective and safe modality for the treatment of LABC, and that such treatment may be cosmetically beneficial.
