摘要
本文探讨了δ-氨基酮戊酸—光动力疗法 (ALA -PDT)对活动期红斑狼疮 (SLE)患者外周血中激活T淋巴细胞的影响。实验采用免疫荧光单标记—流式细胞仪检测 12例活动期SLE患者外周血中CD71阳性淋巴细胞百分比 ,观察其在ALA -PDT前后的变化。发现ALA -PDT能显著降低CD71阳性淋巴细胞百分比 ,ALA -PDT前CD71阳性细胞百分比为 12 31±1 40 ,ALA -PDT后继续培养 18小时下降至 6 5 9± 0 95 ,有非常显著的差异 (P <0 0 1)。本试验证实ALA -PDT能降低活动期SLE外周血中激活T淋巴细胞百分比 。
In this paper,we investivate the influence of ALA-PDT on peripheral blood activated T lymphocytes of patients with active SLE.The immunoflourescent simple marker flow cytometry was used in this experiment to detected the percentage of CD71 positive lymphocytes of 12 cases of active SLE,and observe the changes before and after ALA PDT.We found that after ALA PDT the percentage of CD71 positive lymphocytes was 6.59±0.95,which was significantly lower than that before ALA PDT(12.31±1.40,P<0.01).The conclusion is ALA PDT could decrease the Percentage of CD71 antigen positive lymphocytes.The experiment approved that the activities of T lymphocytes could be restrained by ALA PDT.
出处
《激光杂志》
CAS
CSCD
北大核心
2001年第3期47-49,共3页
Laser Journal
