One serious lesion to the central nervous system is spinal cord injury (SCI). Due to its intricate pathophysiological mechanisms and the irreparability of nerve cells, conventional rehabilitation approaches often prov...One serious lesion to the central nervous system is spinal cord injury (SCI). Due to its intricate pathophysiological mechanisms and the irreparability of nerve cells, conventional rehabilitation approaches often prove inadequate for achieving full recovery. Consequently, most patients can only enhance their capacity for self-care in daily activities through early and proactive rehabilitation interventions. Stem cells are a class of cells that have the capacity to differentiate and are capable of safely and effectively differentiating into various types of neurons to repair or compensate for damaged cells, thereby exerting therapeutic effects. Currently, research on stem cell-based therapeutics for SCI is actively progressing and has yielded promising results. We discussed the anatomy, pathophysiological, the potential mechanisms of traditional therapy and stem cell therapy for SCI. The types of stem cells commonly used in current research and the latest progress in spinal cord therapy are described. Hope to serve as a resource for the use of stem cells in clinical settings.展开更多
文摘One serious lesion to the central nervous system is spinal cord injury (SCI). Due to its intricate pathophysiological mechanisms and the irreparability of nerve cells, conventional rehabilitation approaches often prove inadequate for achieving full recovery. Consequently, most patients can only enhance their capacity for self-care in daily activities through early and proactive rehabilitation interventions. Stem cells are a class of cells that have the capacity to differentiate and are capable of safely and effectively differentiating into various types of neurons to repair or compensate for damaged cells, thereby exerting therapeutic effects. Currently, research on stem cell-based therapeutics for SCI is actively progressing and has yielded promising results. We discussed the anatomy, pathophysiological, the potential mechanisms of traditional therapy and stem cell therapy for SCI. The types of stem cells commonly used in current research and the latest progress in spinal cord therapy are described. Hope to serve as a resource for the use of stem cells in clinical settings.
