摘要
背景:线粒体在脊髓损伤后轴突再生和细胞凋亡中起着重要作用,因此,线粒体成为治疗脊髓损伤研究领域中不可忽视的重要环节。目的:归纳线粒体与脊髓损伤治疗相关文献,利用文献计量学,了解有关线粒体与脊髓损伤治疗领域研究现状、全球发展趋势及学术认知全貌。方法:以Web of Science核心合集数据库为数据源,检索1990-2024年间线粒体与脊髓损伤治疗领域相关文献,运用CiteSpace 5.8和VOS Viewer 1.6.18软件进行可视化分析,绘制知识图谱,检测发文数量、中心性、H指数等指标,通过关键词分析、共被引期刊分析、共被引文献分析、高共被引文献分析、文献爆发分析等对相关文献进行分析,归纳该领域的研究热点和研究方向。结果与结论:共纳入558篇文献进行文献计量学分析,涉及48个国家、3036名作者、713家机构与252种期刊,为线粒体与脊髓损伤治疗领域做出贡献。分析结果显示,线粒体与脊髓损伤治疗领域发文量呈现逐年递增趋势,美国和中国在该领域的表现突出,论文发表数量、引用频次、核心作者及研究机构等方面均位居全球前列。当前,该领域研究热点聚焦于细胞凋亡、氧化应激等方向,未来研究方向可重点围绕分子作用机制、炎症反应及神经修复等关键问题展开探索。线粒体与脊髓损伤治疗领域极具发展前景,近年来该领域的整体研究水平稳步提高,但仍面临诸多挑战,如高质量文献数量有限、不同地区研究进展差异显著,这些问题有待于科研人员进一步完善。
BACKGROUND:Mitochondria are vital for axonal regeneration and apoptosis following spinal cord injury,making them an essential area of therapeutic research for this condition.OBJECTIVE:To summarize literature on mitochondria and spinal cord injury treatment,using bibliometric methods to elucidate the current research landscape,global trends,and comprehensive academic understanding in this field.METHODS:We retrieved relevant literature published between 1990 and 2024 from the Web of Science Core Collection database on topics related to mitochondria and the treatment of spinal cord injury.Visual analysis was conducted using CiteSpace 5.8 and VOS Viewer 1.6.18 software to draw knowledge maps and examine metrics such as publications,centrality,and H-index.Keyword analysis,co-cited journal analysis,co-cited document analysis,highly co-cited document analysis,and publication burst analysis were conducted to identify research hotspots and directions within the field.RESULTS AND CONCLUSION:A total of 558 publications were included in this bibliometric analysis,involving 48 countries,3036 authors,713 institutions,and 252 journals contributing to the field of mitochondrial and spinal cord injury treatment.This analysis demonstrated a consistent annual rise in publications within this field,with the United States and China showing strong global performance in terms of publication output,citation frequency,key authors,and research institutions.Although apoptosis and oxidative stress remain current research hotspots,future work should delve into crucial aspects such as molecular mechanisms,inflammatory responses,and neural repair,recognizing the vital function of mitochondria in axonal regeneration and apoptosis following spinal injury.Mitochondria hold tremendous potential in the field of spinal cord injury treatment.While overall research standards in this area have steadily improved in recent years,significant challenges remain.These include a limited number of high-quality publications and substantial disparities in research progress across different regions.Researchers are therefore required to further refine their work to address these concerns.
作者
王磊
胡宝阳
房芳
Wang Lei;Hu Baoyang;Fang Fang(Tongliao Clinical Medical College,Inner Mongolia Medical University,Tongliao 028000,Inner Mongolia Autonomous Region,China;Department of Spinal Surgery,Tongliao People’s Hospital,Tongliao 028000,Inner Mongolia Autonomous Region,China)
出处
《中国组织工程研究》
北大核心
2026年第29期7764-7772,共9页
Chinese Journal of Tissue Engineering Research
关键词
脊髓损伤
线粒体
文献计量学
可视化分析
研究热点
趋势
spinal cord injury
mitochondria
bibliometrics
visualization analysis
research hotspots
trends
