Introduction: Crohn’s Disease (CD) is a chronic inflammatory disorder with a heterogeneous presentation. While diarrhea, abdominal pain, and weight loss are hallmarks, atypical manifestations can obscure the diagnosi...Introduction: Crohn’s Disease (CD) is a chronic inflammatory disorder with a heterogeneous presentation. While diarrhea, abdominal pain, and weight loss are hallmarks, atypical manifestations can obscure the diagnosis. This report highlights an unusual presentation of CD to emphasize the need for comprehensive diagnostic strategies. Case Report: A 25-year-old male presented with peripheral edema, anorexia, and abdominal distension but lacked classic gastrointestinal (GI) symptoms. Laboratory findings included microcytic anemia and hypoalbuminemia, while imaging revealed ascites and bowel wall thickening. Elevated fecal calprotectin and positive Anti-Saccharomyces cerevisiae antibodies (ASCA) supported the diagnosis. Endoscopy confirmed ileocolic Crohn’s Disease (L3 + L4). Infliximab therapy resulted in marked clinical improvement. Discussion: This case underscores the complexity of atypical CD presentations. Early use of serological markers, imaging, and endoscopy guided the diagnosis. Recognition of CD’s diverse manifestations is critical for timely intervention. Conclusion: Atypical CD presentations require heightened clinical suspicion and a multidisciplinary approach to reduce diagnostic delays and improve patient outcomes.展开更多
Information plays a crucial role in guiding behavioral decisions during public health emergencies. Individuals communicate to acquire relevant knowledge about an epidemic, which influences their decisions to adopt pro...Information plays a crucial role in guiding behavioral decisions during public health emergencies. Individuals communicate to acquire relevant knowledge about an epidemic, which influences their decisions to adopt protective measures.However, whether to disseminate specific information is also a behavioral decision. In light of this understanding, we develop a coupled information–vaccination–epidemic model to depict these co-evolutionary dynamics in a three-layer network. Negative information dissemination and vaccination are treated as separate decision-making processes. We then examine the combined effects of herd and risk motives on information dissemination and vaccination decisions through the lens of game theory. The microscopic Markov chain approach(MMCA) is used to describe the dynamic process and to derive the epidemic threshold. Simulation results indicate that increasing the cost of negative information dissemination and providing timely clarification can effectively control the epidemic. Furthermore, a phenomenon of diminishing marginal utility is observed as the cost of dissemination increases, suggesting that authorities do not need to overinvest in suppressing negative information. Conversely, reducing the cost of vaccination and increasing vaccine efficacy emerge as more effective strategies for outbreak control. In addition, we find that the scale of the epidemic is greater when the herd motive dominates behavioral decision-making. In conclusion, this study provides a new perspective for understanding the complexity of epidemic spreading by starting with the construction of different behavioral decisions.展开更多
Accurate acquisition of the rock stress is crucial for various rock engineering applications.The hollow inclusion (HI) technique is widely used for measuring in-situ rock stress.This technique calculates the stress te...Accurate acquisition of the rock stress is crucial for various rock engineering applications.The hollow inclusion (HI) technique is widely used for measuring in-situ rock stress.This technique calculates the stress tensor by measuring strain using an HI strain cell.However,existing analytical solutions for stress calculation based on an HI strain cell in a double-layer medium are not applicable when an HI strain cell is used in a three-layer medium,leading to erroneous stress calculations.To address this issue,this paper presents a method for calculating stress tensors in a three-layer medium using numerical simulations,specifically by obtaining a constitutive matrix that relates strain measurements to stress tensors in a three-layer medium.Furthermore,using Latin hypercube sampling (LHS) and orthogonal experimental design strategies,764 groups of numerical models encompassing various stress measurement scenarios have been established and calculated using FLAC^(3D)software.Finally,a surrogate model based on artificial neural network (ANN) was developed to predict constitutive matrices,achieving a goodness of fit (R^(2)) of 0.999 and a mean squared error (MSE) of 1.254.A software program has been developed from this surrogate model for ease of use in practical engineering applications.The method’s accuracy was verified through numerical simulations,analytical solution and laboratory experiment,demonstrating its effectiveness in calculating stress in a three-layer medium.The surrogate model was applied to calculate mining-induced stress in the roadway roof rock of a coal mine,a typical case for stress measurement in a three-layer medium.Errors in stress calculations arising from the use of existing analytical solutions were corrected.The study also highlights the significant errors associated with using double-layer analytical solutions in a three-layer medium,which could lead to inappropriate engineering design.展开更多
BACKGROUND Renal cysts,especially the cortical type,are a prevalent renal pathology.Most cases are asymptomatic and detected incidentally during abdominal imaging examination for unrelated complaints.They are often be...BACKGROUND Renal cysts,especially the cortical type,are a prevalent renal pathology.Most cases are asymptomatic and detected incidentally during abdominal imaging examination for unrelated complaints.They are often benign,but they can rarely transform into cystic renal malignancies.When huge or complicated,especially with an abscess,it may become symptomatic from the renal capsular stretch or inflammation.The open surgical,endoscopic,laparoscopic,and robotic appro-aches are available for symptomatic renal cyst treatment.This paper aims to report our experience in the management of a case of a giant renal cyst abscess.CASE SUMMARY This is a 26-year-old housewife who was referred to the urology outpatient clinic with a history of left flank pain and swelling for 5 months,with the transabdo-minal ultrasound scan and computerized tomography scan findings of a huge left renal cortical cyst(Bosniak I).She had associated anorexia,weight loss,nausea,and intermittent fever,which on one occasion was severe and high-grade with chills and rigors.This warranted hospital admission,analgesic and antibiotic therapy.The physical examination was unremarkable at presentation except for a ballotable and mildly tender left lumbar cystic mass.Her vital signs were stable.There was leukocytosis with relative neutrophilia.Further review of the imaging films confirmed the diagnosis of a left giant renal cortical cyst abscess.She was counselled and had open surgical exploration,drainage of 300 mL of pus,cyst unroofing with marsupialization,and was discharged home on the 10th postoperative day.CONCLUSION Treatment of giant simple renal cortical cyst abscesses should be individualized depending on the pathology in question,the surgeon’s experience,patient preference and availability of facilities for endoscopic,laparoscopic or robotic modalities.Notwithstanding open surgical exploration,cyst unroofing and marsupialization are useful modalities in giant renal cortical cyst abscesses and are associated with patient satisfaction.展开更多
This study examines the intricate occurrences of thermal and solutal Marangoni convection in three-layered flows of viscous fluids,with a particular emphasis on their relevance to renewable energy systems.This researc...This study examines the intricate occurrences of thermal and solutal Marangoni convection in three-layered flows of viscous fluids,with a particular emphasis on their relevance to renewable energy systems.This research examines the flow of a three-layered viscous fluid,considering the combined influence of heat and solutal buoyancy driven Rayleigh-Bénard convection,as well as thermal and solutal Marangoni convection.The homotopy perturbation method is used to examine and simulate complex fluid flow and transport phenomena,providing important understanding of the fundamental physics and assisting in the optimization of various battery configurations.The inquiry examines the primary elements that influence Marangoni convection and its impact on battery performance,providing insights on possible enhancements in energy storage devices.The findings indicate that the velocity profiles shown graphically exhibit a prominent core zone characterized by the maximum speed,which progressively decreases as it approaches the walls of the channel.This study enhances our comprehension of fluid dynamics and the transmission of heat and mass in intricate systems,which has substantial ramifications for the advancement of sustainable energy solutions.展开更多
Mycobacterium tuberculosis(Mtb)employs multiple mechanisms,such as phagocytosis and autophagy,to evade innate immune clearance and establish infection.In the present study,we identified the ESX-1 secretion-associated ...Mycobacterium tuberculosis(Mtb)employs multiple mechanisms,such as phagocytosis and autophagy,to evade innate immune clearance and establish infection.In the present study,we identified the ESX-1 secretion-associated protein EspL,which promotes Mtb survival by inhibiting phagosome maturation and autophagy initiation.EspL knockout decreased Mtb intracellular survival,while EspL overexpression increased bacterial survival by interfering with phagocytosis and autophagy.EspL interacts with ULK1 and promotes its phosphorylation at Ser^(757),leading to the inhibition of autophagy initiation.Additionally,overexpression of EspL reduced antigen presentation and T-cell responses both in vitro and in vivo.Our findings revealed that EspL interferes with autophagy and antigen presenta-tion by suppressing ULK1 activation.These insights provide a novel understanding of Mtb pathogenicity.展开更多
Buried interface passivation is crucial for high-efficiency,stable perovskite solar cells(PSCs).Herein,we design a three-layer passivation structure toward the buried interface of inverted PSCs,consisting of NiO_(x),p...Buried interface passivation is crucial for high-efficiency,stable perovskite solar cells(PSCs).Herein,we design a three-layer passivation structure toward the buried interface of inverted PSCs,consisting of NiO_(x),poly(V-p-TPD)and PFN-Br(V-p-TPD,N,N'-di-p-tolyl-N,-N'-bis(4-vinylphenyl)-[1,1'-biphenyl]-4,4'-diamine;PFN-Br,poly[(9,9-bis(3'-((N,N-dimethyl)-N-ethylammonium)-propyl)-2,7-fluorene)-alt-2,7-(9,9-dioctylfluorene)]dibromide).Typically,in situ poly(V-p-TPD)layer on the NiO_(x) surface was obtained by a simple thermal crosslinking process.This poly(V-p-TPD)/NiO_(x) bilayer structure is beneficial for hole extraction and high-quality perovskite films with larger grain sizes and less lattice distortion.On this basis,the PFN-Br is further introduced as a surface modification layer,which can not only optimize the energy level alignment with the perovskite but also passivate defects and suppress carrier recombination at the perovskite bottom interface.Finally,inverted PSCs based on(FA_(0.95)Cs_(0.05))PbI_(3) present 25.5%efficiency with a low V_(OC)deficit.Besides,the devices could maintain 91.15%of the initial efficiency after being stored at 85℃for 1080 h,indicating excellent thermal stability.This work highlights the potential of a three-layered passivation structure based on crosslinking polymer HTLs for highly efficient and stable PSCs.展开更多
Face Presentation Attack Detection(fPAD)plays a vital role in securing face recognition systems against various presentation attacks.While supervised learning-based methods demonstrate effectiveness,they are prone to ...Face Presentation Attack Detection(fPAD)plays a vital role in securing face recognition systems against various presentation attacks.While supervised learning-based methods demonstrate effectiveness,they are prone to overfitting to known attack types and struggle to generalize to novel attack scenarios.Recent studies have explored formulating fPAD as an anomaly detection problem or one-class classification task,enabling the training of generalized models for unknown attack detection.However,conventional anomaly detection approaches encounter difficulties in precisely delineating the boundary between bonafide samples and unknown attacks.To address this challenge,we propose a novel framework focusing on unknown attack detection using exclusively bonafide facial data during training.The core innovation lies in our pseudo-negative sample synthesis(PNSS)strategy,which facilitates learning of compact decision boundaries between bonafide faces and potential attack variations.Specifically,PNSS generates synthetic negative samples within low-likelihood regions of the bonafide feature space to represent diverse unknown attack patterns.To overcome the inherent imbalance between positive and synthetic negative samples during iterative training,we implement a dual-loss mechanism combining focal loss for classification optimization with pairwise confusion loss as a regularizer.This architecture effectively mitigates model bias towards bonafide samples while maintaining discriminative power.Comprehensive evaluations across three benchmark datasets validate the framework’s superior performance.Notably,our PNSS achieves 8%–18% average classification error rate(ACER)reduction compared with state-of-the-art one-class fPAD methods in cross-dataset evaluations on Idiap Replay-Attack and MSU-MFSD datasets.展开更多
The Third International Conference on Rail Transportation(ICRT),which was initiated by Southwest Jiaotong University and hosted by Tongji University,took place successfully in Shanghai,China,from August 7 to 9,2024.As...The Third International Conference on Rail Transportation(ICRT),which was initiated by Southwest Jiaotong University and hosted by Tongji University,took place successfully in Shanghai,China,from August 7 to 9,2024.As the chairman of the ICRT conference,I am delighted to witness its remarkable achievement.Based on the success of previous editions held in Chengdu in 2017 and 2021,this conference aims to provide a premier platform for extensive interaction and collaboration among universities,research institutions,and enterprises worldwide.展开更多
Monkeypox(Mpox),a zoonotic infection caused by the Mpox virus,has reemerged as a global public health concern,with unique implications for neonatal health.Although rare in newborns,cases of neonatal Mpox pose signific...Monkeypox(Mpox),a zoonotic infection caused by the Mpox virus,has reemerged as a global public health concern,with unique implications for neonatal health.Although rare in newborns,cases of neonatal Mpox pose significant diagnostic and therapeutic challenges due to limited clinical data and the vulnerability of this population.This narrative review explores the pathophysiology,clinical presentation,diagnostic barriers,and therapeutic strategies associated with Mpox in neonates.Vertical and perinatal transmission have been identified,with some cases presenting with vesicular rashes,fever,lymphadenopathy,and systemic involvement such as respiratory or neurological complications.Diagnosis often relies on polymerase chain reaction testing,yet resource limitations and symptom overlap with other neonatal infections can hinder accurate identification.Antiviral treatments like tecovirimat and cidofovir are considered in severe cases,but dosing in neonates remains uncertain due to a lack of robust safety data.Supportive care,including hydration,fever management,and prevention of secondary infections,is critical.Breastfeeding decisions require individualized assessment due to the unknown risk of viral transmission through breast milk.Preventive strategies emphasize early isolation,surveillance,and infection control measures in neonatal care settings.The review highlights significant research gaps in understanding neonatal Mpox,especially concerning long-term outcomes and optimal treatment protocols.A coordinated global effort is essential to improve diagnostics,develop safe therapeutic options,and establish evidence-based guidelines tailored to neonates.展开更多
Three-layer composite ingot of 4045/3004/4045 aluminum alloys was prepared by direct-chill semi-continuous casting process,the temperature field distribution near the composite interface,macro-morphology,microstructur...Three-layer composite ingot of 4045/3004/4045 aluminum alloys was prepared by direct-chill semi-continuous casting process,the temperature field distribution near the composite interface,macro-morphology,microstructure and composition distribution of the composite interface were investigated.The results show that semi-solid layer with a certain thickness forms near the interface due to the effect of cooling plate,which ensures successful implementation of casting the composite ingot.Two different aluminum alloys are well bonded metallurgically.The mechanical properties of composite interface were measured,the tensile and shearing strengths of composite interface are 105 and 88 MPa,respectively,which proves that the composite interface is a kind of metallurgical bonding.展开更多
As an improvement on the conventional two-layer electrode （active material layerlcurrent collector）, a novel sandwich-like three-layer electrode （conductive layerlactive material layertcurrent collector） for catho...As an improvement on the conventional two-layer electrode （active material layerlcurrent collector）, a novel sandwich-like three-layer electrode （conductive layerlactive material layertcurrent collector） for cathode material LiFePO4/C was introduced in order to improve its electrochemical performance. LiFePO4/C in the three-layer electrode exhibited superior rate capability in comparison with that in the two-layer electrode in accordance with charge-discharge examination. Cyclic voltammetry and electrochemical impedance spectroscopy indicated that Fe3＋/Fe2＋ redox couple for LiFePO4 in the three-layer electrode displayed faster kinetics, better reversibility and much lower charge transfer resistance than that in the two-layer electrode in electrochemical process. For three-layer electrode, the holes in the surface of active material layer were filled by smaller acetylene black grains, which formed electrical connections and provided more pathways to electron transport to/from LiFePO4/C particles exposed to the bulk electrolyte.展开更多
文摘Introduction: Crohn’s Disease (CD) is a chronic inflammatory disorder with a heterogeneous presentation. While diarrhea, abdominal pain, and weight loss are hallmarks, atypical manifestations can obscure the diagnosis. This report highlights an unusual presentation of CD to emphasize the need for comprehensive diagnostic strategies. Case Report: A 25-year-old male presented with peripheral edema, anorexia, and abdominal distension but lacked classic gastrointestinal (GI) symptoms. Laboratory findings included microcytic anemia and hypoalbuminemia, while imaging revealed ascites and bowel wall thickening. Elevated fecal calprotectin and positive Anti-Saccharomyces cerevisiae antibodies (ASCA) supported the diagnosis. Endoscopy confirmed ileocolic Crohn’s Disease (L3 + L4). Infliximab therapy resulted in marked clinical improvement. Discussion: This case underscores the complexity of atypical CD presentations. Early use of serological markers, imaging, and endoscopy guided the diagnosis. Recognition of CD’s diverse manifestations is critical for timely intervention. Conclusion: Atypical CD presentations require heightened clinical suspicion and a multidisciplinary approach to reduce diagnostic delays and improve patient outcomes.
基金Project supported by the National Natural Science Foundation of China (Grant No. 72174121)the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, and the Soft Science Research Project of Shanghai (Grant No. 22692112600)。
文摘Information plays a crucial role in guiding behavioral decisions during public health emergencies. Individuals communicate to acquire relevant knowledge about an epidemic, which influences their decisions to adopt protective measures.However, whether to disseminate specific information is also a behavioral decision. In light of this understanding, we develop a coupled information–vaccination–epidemic model to depict these co-evolutionary dynamics in a three-layer network. Negative information dissemination and vaccination are treated as separate decision-making processes. We then examine the combined effects of herd and risk motives on information dissemination and vaccination decisions through the lens of game theory. The microscopic Markov chain approach(MMCA) is used to describe the dynamic process and to derive the epidemic threshold. Simulation results indicate that increasing the cost of negative information dissemination and providing timely clarification can effectively control the epidemic. Furthermore, a phenomenon of diminishing marginal utility is observed as the cost of dissemination increases, suggesting that authorities do not need to overinvest in suppressing negative information. Conversely, reducing the cost of vaccination and increasing vaccine efficacy emerge as more effective strategies for outbreak control. In addition, we find that the scale of the epidemic is greater when the herd motive dominates behavioral decision-making. In conclusion, this study provides a new perspective for understanding the complexity of epidemic spreading by starting with the construction of different behavioral decisions.
基金funding support from the National Natural Science Foundation of China (Nos. 42477208 and 52079134)the Natural Science Foundation of Hubei Province, China (No. 2024AFA072)+2 种基金the Youth Innovation Promotion Association CAS (No. 2022332)the National Key R&D Program of China (No. 2024YFF0508203)the Open Research Fund of State Key Laboratory of Geomechanics and Geotechnical Engineering Safety (Nos. SKLGME-JBGS2402 and SKLGME022022)。
文摘Accurate acquisition of the rock stress is crucial for various rock engineering applications.The hollow inclusion (HI) technique is widely used for measuring in-situ rock stress.This technique calculates the stress tensor by measuring strain using an HI strain cell.However,existing analytical solutions for stress calculation based on an HI strain cell in a double-layer medium are not applicable when an HI strain cell is used in a three-layer medium,leading to erroneous stress calculations.To address this issue,this paper presents a method for calculating stress tensors in a three-layer medium using numerical simulations,specifically by obtaining a constitutive matrix that relates strain measurements to stress tensors in a three-layer medium.Furthermore,using Latin hypercube sampling (LHS) and orthogonal experimental design strategies,764 groups of numerical models encompassing various stress measurement scenarios have been established and calculated using FLAC^(3D)software.Finally,a surrogate model based on artificial neural network (ANN) was developed to predict constitutive matrices,achieving a goodness of fit (R^(2)) of 0.999 and a mean squared error (MSE) of 1.254.A software program has been developed from this surrogate model for ease of use in practical engineering applications.The method’s accuracy was verified through numerical simulations,analytical solution and laboratory experiment,demonstrating its effectiveness in calculating stress in a three-layer medium.The surrogate model was applied to calculate mining-induced stress in the roadway roof rock of a coal mine,a typical case for stress measurement in a three-layer medium.Errors in stress calculations arising from the use of existing analytical solutions were corrected.The study also highlights the significant errors associated with using double-layer analytical solutions in a three-layer medium,which could lead to inappropriate engineering design.
文摘BACKGROUND Renal cysts,especially the cortical type,are a prevalent renal pathology.Most cases are asymptomatic and detected incidentally during abdominal imaging examination for unrelated complaints.They are often benign,but they can rarely transform into cystic renal malignancies.When huge or complicated,especially with an abscess,it may become symptomatic from the renal capsular stretch or inflammation.The open surgical,endoscopic,laparoscopic,and robotic appro-aches are available for symptomatic renal cyst treatment.This paper aims to report our experience in the management of a case of a giant renal cyst abscess.CASE SUMMARY This is a 26-year-old housewife who was referred to the urology outpatient clinic with a history of left flank pain and swelling for 5 months,with the transabdo-minal ultrasound scan and computerized tomography scan findings of a huge left renal cortical cyst(Bosniak I).She had associated anorexia,weight loss,nausea,and intermittent fever,which on one occasion was severe and high-grade with chills and rigors.This warranted hospital admission,analgesic and antibiotic therapy.The physical examination was unremarkable at presentation except for a ballotable and mildly tender left lumbar cystic mass.Her vital signs were stable.There was leukocytosis with relative neutrophilia.Further review of the imaging films confirmed the diagnosis of a left giant renal cortical cyst abscess.She was counselled and had open surgical exploration,drainage of 300 mL of pus,cyst unroofing with marsupialization,and was discharged home on the 10th postoperative day.CONCLUSION Treatment of giant simple renal cortical cyst abscesses should be individualized depending on the pathology in question,the surgeon’s experience,patient preference and availability of facilities for endoscopic,laparoscopic or robotic modalities.Notwithstanding open surgical exploration,cyst unroofing and marsupialization are useful modalities in giant renal cortical cyst abscesses and are associated with patient satisfaction.
基金Project(52276068)supported by the National Natural Science Foundation of China。
文摘This study examines the intricate occurrences of thermal and solutal Marangoni convection in three-layered flows of viscous fluids,with a particular emphasis on their relevance to renewable energy systems.This research examines the flow of a three-layered viscous fluid,considering the combined influence of heat and solutal buoyancy driven Rayleigh-Bénard convection,as well as thermal and solutal Marangoni convection.The homotopy perturbation method is used to examine and simulate complex fluid flow and transport phenomena,providing important understanding of the fundamental physics and assisting in the optimization of various battery configurations.The inquiry examines the primary elements that influence Marangoni convection and its impact on battery performance,providing insights on possible enhancements in energy storage devices.The findings indicate that the velocity profiles shown graphically exhibit a prominent core zone characterized by the maximum speed,which progressively decreases as it approaches the walls of the channel.This study enhances our comprehension of fluid dynamics and the transmission of heat and mass in intricate systems,which has substantial ramifications for the advancement of sustainable energy solutions.
基金supported by the National Natural Science Foundation of China under grant number U21A20259the National Key Research and Development Program of China under grant number 2021YFD1800401.
文摘Mycobacterium tuberculosis(Mtb)employs multiple mechanisms,such as phagocytosis and autophagy,to evade innate immune clearance and establish infection.In the present study,we identified the ESX-1 secretion-associated protein EspL,which promotes Mtb survival by inhibiting phagosome maturation and autophagy initiation.EspL knockout decreased Mtb intracellular survival,while EspL overexpression increased bacterial survival by interfering with phagocytosis and autophagy.EspL interacts with ULK1 and promotes its phosphorylation at Ser^(757),leading to the inhibition of autophagy initiation.Additionally,overexpression of EspL reduced antigen presentation and T-cell responses both in vitro and in vivo.Our findings revealed that EspL interferes with autophagy and antigen presenta-tion by suppressing ULK1 activation.These insights provide a novel understanding of Mtb pathogenicity.
基金financial support from the Ministry of Science and Technology of China(2021YFB3800103)Natural Science Foundation of China(U24A6003,52361145847,52172260,52227803,52222212)Chinese Academy of Sciences-Commonwealth Scientific and Industrial Research Organization(CAS-CSIRO)Joint Project(112111KYSB20210017)。
文摘Buried interface passivation is crucial for high-efficiency,stable perovskite solar cells(PSCs).Herein,we design a three-layer passivation structure toward the buried interface of inverted PSCs,consisting of NiO_(x),poly(V-p-TPD)and PFN-Br(V-p-TPD,N,N'-di-p-tolyl-N,-N'-bis(4-vinylphenyl)-[1,1'-biphenyl]-4,4'-diamine;PFN-Br,poly[(9,9-bis(3'-((N,N-dimethyl)-N-ethylammonium)-propyl)-2,7-fluorene)-alt-2,7-(9,9-dioctylfluorene)]dibromide).Typically,in situ poly(V-p-TPD)layer on the NiO_(x) surface was obtained by a simple thermal crosslinking process.This poly(V-p-TPD)/NiO_(x) bilayer structure is beneficial for hole extraction and high-quality perovskite films with larger grain sizes and less lattice distortion.On this basis,the PFN-Br is further introduced as a surface modification layer,which can not only optimize the energy level alignment with the perovskite but also passivate defects and suppress carrier recombination at the perovskite bottom interface.Finally,inverted PSCs based on(FA_(0.95)Cs_(0.05))PbI_(3) present 25.5%efficiency with a low V_(OC)deficit.Besides,the devices could maintain 91.15%of the initial efficiency after being stored at 85℃for 1080 h,indicating excellent thermal stability.This work highlights the potential of a three-layered passivation structure based on crosslinking polymer HTLs for highly efficient and stable PSCs.
基金supported in part by the National Natural Science Foundation of China under Grants 61972267,and 61772070in part by the Natural Science Foundation of Hebei Province under Grant F2024210005.
文摘Face Presentation Attack Detection(fPAD)plays a vital role in securing face recognition systems against various presentation attacks.While supervised learning-based methods demonstrate effectiveness,they are prone to overfitting to known attack types and struggle to generalize to novel attack scenarios.Recent studies have explored formulating fPAD as an anomaly detection problem or one-class classification task,enabling the training of generalized models for unknown attack detection.However,conventional anomaly detection approaches encounter difficulties in precisely delineating the boundary between bonafide samples and unknown attacks.To address this challenge,we propose a novel framework focusing on unknown attack detection using exclusively bonafide facial data during training.The core innovation lies in our pseudo-negative sample synthesis(PNSS)strategy,which facilitates learning of compact decision boundaries between bonafide faces and potential attack variations.Specifically,PNSS generates synthetic negative samples within low-likelihood regions of the bonafide feature space to represent diverse unknown attack patterns.To overcome the inherent imbalance between positive and synthetic negative samples during iterative training,we implement a dual-loss mechanism combining focal loss for classification optimization with pairwise confusion loss as a regularizer.This architecture effectively mitigates model bias towards bonafide samples while maintaining discriminative power.Comprehensive evaluations across three benchmark datasets validate the framework’s superior performance.Notably,our PNSS achieves 8%–18% average classification error rate(ACER)reduction compared with state-of-the-art one-class fPAD methods in cross-dataset evaluations on Idiap Replay-Attack and MSU-MFSD datasets.
文摘The Third International Conference on Rail Transportation(ICRT),which was initiated by Southwest Jiaotong University and hosted by Tongji University,took place successfully in Shanghai,China,from August 7 to 9,2024.As the chairman of the ICRT conference,I am delighted to witness its remarkable achievement.Based on the success of previous editions held in Chengdu in 2017 and 2021,this conference aims to provide a premier platform for extensive interaction and collaboration among universities,research institutions,and enterprises worldwide.
文摘Monkeypox(Mpox),a zoonotic infection caused by the Mpox virus,has reemerged as a global public health concern,with unique implications for neonatal health.Although rare in newborns,cases of neonatal Mpox pose significant diagnostic and therapeutic challenges due to limited clinical data and the vulnerability of this population.This narrative review explores the pathophysiology,clinical presentation,diagnostic barriers,and therapeutic strategies associated with Mpox in neonates.Vertical and perinatal transmission have been identified,with some cases presenting with vesicular rashes,fever,lymphadenopathy,and systemic involvement such as respiratory or neurological complications.Diagnosis often relies on polymerase chain reaction testing,yet resource limitations and symptom overlap with other neonatal infections can hinder accurate identification.Antiviral treatments like tecovirimat and cidofovir are considered in severe cases,but dosing in neonates remains uncertain due to a lack of robust safety data.Supportive care,including hydration,fever management,and prevention of secondary infections,is critical.Breastfeeding decisions require individualized assessment due to the unknown risk of viral transmission through breast milk.Preventive strategies emphasize early isolation,surveillance,and infection control measures in neonatal care settings.The review highlights significant research gaps in understanding neonatal Mpox,especially concerning long-term outcomes and optimal treatment protocols.A coordinated global effort is essential to improve diagnostics,develop safe therapeutic options,and establish evidence-based guidelines tailored to neonates.
基金Project (2005CB623707) supported by the National Basic Research Program of China
文摘Three-layer composite ingot of 4045/3004/4045 aluminum alloys was prepared by direct-chill semi-continuous casting process,the temperature field distribution near the composite interface,macro-morphology,microstructure and composition distribution of the composite interface were investigated.The results show that semi-solid layer with a certain thickness forms near the interface due to the effect of cooling plate,which ensures successful implementation of casting the composite ingot.Two different aluminum alloys are well bonded metallurgically.The mechanical properties of composite interface were measured,the tensile and shearing strengths of composite interface are 105 and 88 MPa,respectively,which proves that the composite interface is a kind of metallurgical bonding.
基金Project(2010ZCO51)supported by Natural Science Foundation of Yunnan ProvinceProject supported by Analysis and Testing Foundation(2009-041)Starting Research Fund(14118245)from Kunming University of Science and Technology
文摘As an improvement on the conventional two-layer electrode （active material layerlcurrent collector）, a novel sandwich-like three-layer electrode （conductive layerlactive material layertcurrent collector） for cathode material LiFePO4/C was introduced in order to improve its electrochemical performance. LiFePO4/C in the three-layer electrode exhibited superior rate capability in comparison with that in the two-layer electrode in accordance with charge-discharge examination. Cyclic voltammetry and electrochemical impedance spectroscopy indicated that Fe3＋/Fe2＋ redox couple for LiFePO4 in the three-layer electrode displayed faster kinetics, better reversibility and much lower charge transfer resistance than that in the two-layer electrode in electrochemical process. For three-layer electrode, the holes in the surface of active material layer were filled by smaller acetylene black grains, which formed electrical connections and provided more pathways to electron transport to/from LiFePO4/C particles exposed to the bulk electrolyte.
