The primary goal of this study is to provide an efficient numerical tool to analyze the seismic performance of nailed walls.Modeling such excavation supports involves complexities due partly to the interaction of supp...The primary goal of this study is to provide an efficient numerical tool to analyze the seismic performance of nailed walls.Modeling such excavation supports involves complexities due partly to the interaction of support with soil and partly because of the amplification of seismic waves through an excavation wall.Consequently,innovative modeling is suggested herein,incorporating the calibration of the soil constitutive model in a targeted range of stress and strain,and the detection of a natural period of complex systems,including soil and structure,while benefiting from Rayleigh damping to filter unwanted noises.The numerical model was achieved by simulating a previous centrifuge test of the excavation wall,manifested at the pre-failure state.Notably,the calibration of the soil constitutive model through empirical relations,which replaces the numerical reproduction of an element test,more accurately simulated the soil-nail-wall interaction.Two factors were crucial to a successful result.First,probing the natural period of the complicated geometry of the model by applying white noises.Second,considering Rayleigh damping to withdraw unwanted noises and thus assess their permanent effects on the model.Rayleigh damping was applied instead of filtering the obtained results.展开更多
Autism spectrum disorder is a developmental disorder impacting a child’s social interactions,behaviors,and communication skills.One of the crucial aspects of autism care,which is often overlooked,is the parent’s men...Autism spectrum disorder is a developmental disorder impacting a child’s social interactions,behaviors,and communication skills.One of the crucial aspects of autism care,which is often overlooked,is the parent’s mental health status while trying to improve and overcome challenges faced by their child.A study by Lu et al examined the effectiveness of remote family psychological support courses on the mental health status of parents having children with autism spectrum disorder.It was found that the integration of these remote psychological courses with conventional care had a positive impact on the parents by reducing their stress levels,leading to an increase in their competence,and hence they could engage effectively in child therapy.However,a long-term study is necessary to assess whether these interventions have a sustained effect.The study emphasizes the need for developing such culturally sensitive intervention models on a global scale,making them accessible to all and improving autism care support.展开更多
The spontaneous bursts of electrical activity in the developing auditory system are derived from the periodic release of adenosine triphosphate(ATP)by supporting cells in the Kölliker’s organ.However,the mechani...The spontaneous bursts of electrical activity in the developing auditory system are derived from the periodic release of adenosine triphosphate(ATP)by supporting cells in the Kölliker’s organ.However,the mechanisms responsible for initiating spontaneous ATP release have not been determined.Our previous study revealed that telomerase reverse transcriptase(TERT)is expressed in the basilar membrane during the first postnatal week.Its role in cochlear development remains unclear.In this study,we investigated the expression and role of TERT in postnatal cochlea supporting cells.Our results revealed that in postnatal cochlear Kölliker’s organ supporting cells,TERT shifts from the nucleus into the cytoplasm over time.We found that the TERT translocation tendency in postnatal cochlear supporting cells in vitro coincided with that observed in vivo.Further analysis showed that TERT in the cytoplasm was mainly located in mitochondria in the absence of oxidative stress or apoptosis,suggesting that TERT in mitochondria plays roles other than antioxidant or anti-apoptotic functions.We observed increased ATP synthesis,release and activation of purine signaling systems in supporting cells during the first 10 postnatal days.The phenomenon that TERT translocation coincided with changes in ATP synthesis,release and activation of the purine signaling system in postnatal cochlear supporting cells suggested that TERT may be involved in regulating ATP release and activation of the purine signaling system.Our study provides a new research direction for exploring the spontaneous electrical activity of the cochlea during the early postnatal period.展开更多
Lightweight thin-walled structures with lattice infill are widely desired in satellite for their high stiffness-to-weight ratio and superior buckling strength resulting fromthe sandwich effect.Such structures can be f...Lightweight thin-walled structures with lattice infill are widely desired in satellite for their high stiffness-to-weight ratio and superior buckling strength resulting fromthe sandwich effect.Such structures can be fabricated bymetallic additive manufacturing technique,such as selective laser melting(SLM).However,the maximum dimensions of actual structures are usually in a sub-meter scale,which results in restrictions on their appliance in aerospace and other fields.In this work,a meter-scale thin-walled structure with lattice infill is designed for the fuel tank supporting component of the satellite by integrating a self-supporting lattice into the thickness optimization of the thin-wall.The designed structure is fabricated by SLM of AlSi10Mg and cold metal transfer welding technique.Quasi-static mechanical tests and vibration tests are both conducted to verify the mechanical strength of the designed large-scale lattice thin-walled structure.The experimental results indicate that themeter-scale thin-walled structure with lattice infill could meet the dimension and lightweight requirements of most spacecrafts.展开更多
The inner ear sensory epithelium consists of two major types of cells:hair cells(HCs)and supporting cells(SCs).Critical functions of HCs in the perception of mechanical stimulation and mechanosensory transduction have...The inner ear sensory epithelium consists of two major types of cells:hair cells(HCs)and supporting cells(SCs).Critical functions of HCs in the perception of mechanical stimulation and mechanosensory transduction have long been elucidated.SCs are indispensable components of the sensory epithelia,and they maintain the structural integrity and ionic environment of the inner ear.Once delicate inner ear epithelia sustain injuries(for example,due to ototoxic drugs or noise exposure),SCs respond immediately to serve as repairers of the epithelium and as adapters to become HC progenitors,aiming at morphological and functional recovery of the inner ear.This regenerative process is extensive in non-mammals,but is limited in the mammalian inner ear,especially in the mature cochlea.This review aimed to discuss the important roles of SCs in the repair of the mammalian inner ear.展开更多
Aiming to mitigate the aerodynamic lift force imbalance between pantograph strips,which exacerbates wear and affects the current collection performance of the pantograph-catenary system,a study has been conducted to s...Aiming to mitigate the aerodynamic lift force imbalance between pantograph strips,which exacerbates wear and affects the current collection performance of the pantograph-catenary system,a study has been conducted to support the beam deflector optimization using a combination of experimental measurements and computational fluid dynamics(CFD)simulations.The results demonstrate that the size,position,and installation orientation of the wind deflectors significantly influence the amount of force compensation.They also indicate that the front strip deflectors should be installed downwards and the rear strip deflectors upwards,thereby forming a“π”shape.Moreover,the lift force compensation provided by the wind deflectors increases with the size of the deflector.Alternative wind compensation strategies,such as control circuits,are also discussed,putting emphasis on the pros and cons of various pantograph types and wind compensation approaches.展开更多
This paper discusses the important role of science and technology commissioners in the high-quality development of hundreds of counties,thousands of towns,and myriads of villages in the context of rural revitalization...This paper discusses the important role of science and technology commissioners in the high-quality development of hundreds of counties,thousands of towns,and myriads of villages in the context of rural revitalization,including building bridges,accelerating the transformation of achievements,promoting the value-added of the whole agricultural industry chain,and promoting the rapid development of rural industrial economy.It also discusses the working achievements of science and technology commissioners,in order to promote further development of rural revitalization in Guangdong Province.展开更多
The purpose of this study is to determine the teacher’s perceptions of the challenges and strategies in supporting students with reading difficulties.This study used qualitative method of research and descriptive app...The purpose of this study is to determine the teacher’s perceptions of the challenges and strategies in supporting students with reading difficulties.This study used qualitative method of research and descriptive approach as its research design,in addition to a set of structured interview questions administered through Google Forms to gather data from elementary teachers of Taal Central School,located at Taal Batangas.These structured interview questions were carefully designed to cover various dimensions of the study,including the types of challenges perceived by teachers,strategies employed,and possible solutions for addressing the problems encountered in the process of supporting students with reading difficulties.The results revealed that teachers faced several challenges when teaching students with reading difficulties such as emotional and motivational issues/factors,lack of resources or teaching aids,deficits in knowledge and skills,and problems with student engagement and participation.This study also showed common approaches utilized by the teachers in supporting students with reading difficulties,which were fostering a positive and supportive environment,adopting individualized and multifaceted approaches,and utilizing effective teaching tools and strategies.Lastly,teachers also concluded varied solutions in addressing the challenges perceived in teaching students with reading difficulties towards fostering reading proficiency.These include developing peer support,use of positive reinforcement,and parental involvement.Moreover,specialized resources,professional development for teachers,and specific teaching strategies are also highlighted as crucial components.By integrating these approaches,teachers concluded that it can create a supportive and effective learning environment tailored to the needs of students with reading difficulties.展开更多
Objective: The purpose of this study was to clarify the collaborative activities and mutual recognition between community comprehensive care unit nurses (Ns) and care managers (CM) in supporting the discharge of the e...Objective: The purpose of this study was to clarify the collaborative activities and mutual recognition between community comprehensive care unit nurses (Ns) and care managers (CM) in supporting the discharge of the elderly from the hospital. Methods: A total of 300 nurses working in community comprehensive care wards and 360 care managers working in B City in A Prefecture were surveyed using an anonymous self-administered questionnaire. Results: The highest percentage of responses regarding necessary collaborative activities with multiple professions in supporting hospital discharge were the same for Ns and CMs. The items regarding practice with the highest percentages were “relationship as a team” for Ns, and “user-centered awareness” for CM. While these professionals were willing to share information about their patients’ lives after discharge, the percentage of those explaining their expertise was low. It is thought that collaborative activities focusing on these aspects would lead to more appropriate discharge support.展开更多
The roadway support in many places of Jiulongkou Colliery, Fengfeng Mining Bureau, such as in the Permanent transportation roadway, was failed or locally caved, which seriously affected the colliery’s coal production...The roadway support in many places of Jiulongkou Colliery, Fengfeng Mining Bureau, such as in the Permanent transportation roadway, was failed or locally caved, which seriously affected the colliery’s coal production performance and safety. Based on analysis of supporting objects for roadway repairing, this paper proposes the supporting parameters and condruction technics. The industrial ted of 70m long roadway repairing shows that the proposed parameters and technics of bolt shotcrete and mesh support for roadway repairing are reasouable, bring good technical and economic results for the colliery, and the repairing is successful.展开更多
Soft rock surrounding deep roadway has poor stability and long-term rheological effect. More and larger deformation problems of surrounding rock occur due to adverse supporting measures for such roadways, which not on...Soft rock surrounding deep roadway has poor stability and long-term rheological effect. More and larger deformation problems of surrounding rock occur due to adverse supporting measures for such roadways, which not only affects the engineering safety critically but also improves the maintenance costs. This paper takes the main rail roadway with severely deformation in China＇s Zaoquan coal mine as an example to study the long-term deformation tendency and damage zone by means of in-situ deformation monitoring and acoustic wave testing technique. A three-dimensional finite element model reflecting the engineering geological condition and initial design scheme is established by ABAQUS. Then, on the basis of field monitoring deformation data, the surrounding rock geotechnical and theological parameters of the roadway are obtained by back analysis. A combined supporting technology with U-shaped steel support and anchor-grouting is proposed for the surrounding soft rock. The numerical simulation of the combined supporting technology and in-situ deformation monitoring results show that the soft rock surrounding the roadway has been held effectively.展开更多
Linear failure criterion is widely used in calculation of earth pressure acting on shallow tunnels. However, experimental evidence shows that nonlinear failure criterion is able to represent fairly well the failure of...Linear failure criterion is widely used in calculation of earth pressure acting on shallow tunnels. However, experimental evidence shows that nonlinear failure criterion is able to represent fairly well the failure of almost all types of rocks, A nonlinear Hock-Brown failure criterion is employed to estimate the supporting pressures of shallow tunnels in limit analysis framework. Two failure mechanisms are proposed for calculating the work rate of extemal force and the internal energy dissipation. A tangential line to the nonlinear failure criterion is used to formulate the supporting pressure problem as a nonlinear programming problem. The objective function formulated in this way is minimized with respect to the failure mechanism and the location of tangency point. In order to assess the validity, the supporting pressures for the proposed failure mechanisms are calculated and compared with each other, and the present results are compared with previously published solutions when the nonlinear criterion is reduced to linear criterion. The agreement supports the validity of the proposed failure mechanisms. An experiment is conducted to investigate the influences of the nonlinear criterion on collapse shape and supporting pressures of shallow tunnels.展开更多
In deep underground engineering,rock burst and other dynamic disasters are prone to occur due to stress concentration and energy accumulation in surrounding rock.The control of dynamic disasters requires bolts and cab...In deep underground engineering,rock burst and other dynamic disasters are prone to occur due to stress concentration and energy accumulation in surrounding rock.The control of dynamic disasters requires bolts and cables with high strength,high elongation,and high energy-absorbing capacity.Therefore,a constant resistance energy-absorbing(CREA)material is developed.In this study,the dynamic characteristics of the new material are obtained via the drop hammer tests and the Split Hopkinson Pressure Bar(SHPB)tests of the new material and two common bolt(CB)materials widely used in the field.The test results of drop hammer test and SHPB test show that the percentage elongation of CREA material is more than 2.64 and 3.22 times those of the CB material,and the total impact energy acting on CREA material is more than 18.50 and 21.84 times,respectively,indicating that the new material has high elongation and high energy-absorbing capacity.Subsequently,the CREA bolts and cables using the new material are developed,which are applied in roadways with high stress and strong dynamic disturbance.The field monitoring results show that CREA bolts and cables can effectively control the surrounding rock deformation and ensure engineering safety.展开更多
To analyze the stability of a shallow square tunnel, a new curved failure mechanism, representing the mechanical characteristics and collapsing form of this type of tunnel, is constructed. Based on the upper bound the...To analyze the stability of a shallow square tunnel, a new curved failure mechanism, representing the mechanical characteristics and collapsing form of this type of tunnel, is constructed. Based on the upper bound theorem of limit analysis and the Hoek-Brown nonlinear failure criterion, the supporting pressure derived from the virtual work rate equation is regarded as an objective function to achieve optimal calculation. By employing variational calculation to optimize the objective function, an upper bound solution for the supporting pressure and the collapsing block shape of a shallow square tunnel are obtained. To evaluate the validity of the failure mechanism proposed in this paper, the solutions computed by the curved failure mechanism are compared with the results calculated by the linear multiple blocks failure mechanism when the Hoek-Brown nonlinear failure criterion is converted into the Mohr-Coulomb linear criterion. The influences of rock mass parameters on the supporting pressure and collapsing block shape are discussed.展开更多
There have been substantial conflicts in the human-water relationship in the Huaihe River Basin （HRB）. To achieve sustainable economic development without degrading the water environment in the HRB, we develop a thr...There have been substantial conflicts in the human-water relationship in the Huaihe River Basin （HRB）. To achieve sustainable economic development without degrading the water environment in the HRB, we develop a three-dimensional water environmental sup- porting capacity （WESC） model based on water environmental carrying capacity （WECC）, water environmental pressure （WEP）, and water pollution prevention and control capacity （WPPC）. Geographic information systems spatial analysis with the analytical hierarchy process method and dynamic weighted summation is applied. Several proposals for suitable locations for industry and environmental protection strategies for water were presented. The following results were obtained. （1） The spatial differences in WECC are substantial; areas with high-value WECC zones are mainly located along the main stream of the Huaihe River on the south side. WEP is generally high, with an overall low level of pollution prevention and control in the whole HRB. WPPC and WEP show high spatial overlapping due to the fact that areas with higher environmental pollution usually have high level of economic development, and thus have a strong capacity for pollution control. （2） Overall, WESC is moderate in the HRB. In particular, areas with a high WESC value only account for 56.24% of the HRB in 2010 Distinct differences in WESC also exist between areas located in the south compared with in the north of the basin, and areas alongside the downstream region compared with alongside the upstream and midstream regions. （3） Consequently, according to the guidance for indus- try zoning in the HRB, the areas in the south and alongside the downstream and sub-streams with a low WEP value and high WECC and WPPC, traditional industries should be developed based on strict environmental access and pollution emission standards. While for the areas along the midstream of the HRB and along the whole Yishusi River Basin, which have a high WEP value, industrial restructuring and technological upgrading are suggested. Action should be taken to limit development and protect the environment in the upstream region of the basin which is a key source of drinking water, in the eastern route along the line of the South-toNorth Water Diversion Project, and in the ecologically fragile region alongside the basin. This will ensure good environmental functionality including subsistent provision of clean water, while at the same time satisfying the urgent need to adjust, transform, and upgrade the industrial structure.展开更多
More accurate forecasting of rock burst might be possible from observations of electromagnetic radiation emitted in the mine.We analyzed experimental observations and field data from the Muchengjian coal mine to study...More accurate forecasting of rock burst might be possible from observations of electromagnetic radiation emitted in the mine.We analyzed experimental observations and field data from the Muchengjian coal mine to study the relationship between electromagnetic radiation signal intensity and stress during the fracturing of coal, or rock, and samples under load.The results show that the signal intensity is positively correlated with stress.In addition, we investigated the change in the electromagnetic radiation intensity, the supporting resistance in a real coal mine environment, and the coal or rock stress in the mining area.The data analysis indicates that:1) electromagnetic radiation intensity can accurately reflect the distribution of stress in the mining area;and, 2) there is a correlation between electromagnetic radiation intensity and supporting resistance.The research has some practical guiding significance for rock burst forecasting and for the prevention of accidents in coal mines.展开更多
Based on the active failure mechanism generated by a spatial discretization technique, the stability of tunnel face was studied. With the help of the spatial discretization technique, not only the anisotropy and inhom...Based on the active failure mechanism generated by a spatial discretization technique, the stability of tunnel face was studied. With the help of the spatial discretization technique, not only the anisotropy and inhomogeneity of the cohesion but also the inhomogeneity of the internal friction angle was taken into account in the analysis of the supporting forces. From the perspective of upper bound theorem, the upper bound solutions of supporting pressure were derived. The influence of the anisotropy and heterogeneity on the supporting forces as well as the failure mechanisms was discussed. The results show that the spatial discretization characteristics of cohesion and internal frictional angle impose a significant effect on the supporting pressure, which indicates that above factors should be considered in the actual engineering.展开更多
The methods combined by test, field monitoring and theoretical analysis were adopted to do the systemic research on the rock mass from micro-structure to macro-deformation, and rheological model of Jinchuan rock mass ...The methods combined by test, field monitoring and theoretical analysis were adopted to do the systemic research on the rock mass from micro-structure to macro-deformation, and rheological model of Jinchuan rock mass was established to discuss the reasonable supporting time. Resuhs show that supporting after suitable stress and displacement release can benefit for the long-term stability of surrounding rock.展开更多
A new type of pit supporting structure, which was tested and verified using the sensor monitoring technology, was presented. The new supporting structure is assembled by prefabricated steel structural units. The adjac...A new type of pit supporting structure, which was tested and verified using the sensor monitoring technology, was presented. The new supporting structure is assembled by prefabricated steel structural units. The adjacent steel structural units are jointed with fasteners, and each steel structural unit has a certain radian and is welded by two steel tubes and one piece of steel disc. In order to test and verify the reliability of the new supporting structure, the field tests are designed. The main monitoring programs include the hoop stress of supporting structure, lateral earth pressure, and soil deformation. The monitoring data of the field tests show that the new supporting structure is convenient, reliable and safe.展开更多
In order to solve the large deformation controlling problem for surrounding rock of gob-side entry driving under common cable anchor support in deep mine, site survey, physical modeling experiment, numerical simulatio...In order to solve the large deformation controlling problem for surrounding rock of gob-side entry driving under common cable anchor support in deep mine, site survey, physical modeling experiment, numerical simulation and field measurement were synthetically used to analyze the deformation and failure characteristics of surrounding rock. Besides, applicability analysis, prestress field distribution characteristics of surrounding rock and the control effect on large deformation of surrounding rock were also further studied for the gob-side entry driving in deep mine using the cable-truss supporting system. The results show that, first, compared with no support and traditional bolt anchor support, roof cable-truss system can effectively restrain the initiation and propagation of tensile cracks in the roof surrounding rock and arc shear cracks in the two sides, moreover, the broken development of surrounding rock, roof separation and extrusion deformation between the two sides of the roadway are all controlled; second, a prestressed belt of trapezoidal shape is generated in the surrounding rock by the cable-truss supporting system, and the prestress field range is wide. Especially, the prestress concentration belt in the shallow surrounding rock can greatly improve the anchoring strength and deformation resisting capability of the rock stratum;third, an optimized support system of ‘‘roof and side anchor net beam, roof cable-truss supporting system and anchor cable of the narrow coal pillar" was put forward, and the support optimization design and field industrial test were conducted for the gob-side entry driving of the working face 5302 in Tangkou Mine, from which a good supporting effect was obtained.展开更多
基金supported by the International Institute of Earthquake Engineering and Seismology(IIEES) as technical project No.760
文摘The primary goal of this study is to provide an efficient numerical tool to analyze the seismic performance of nailed walls.Modeling such excavation supports involves complexities due partly to the interaction of support with soil and partly because of the amplification of seismic waves through an excavation wall.Consequently,innovative modeling is suggested herein,incorporating the calibration of the soil constitutive model in a targeted range of stress and strain,and the detection of a natural period of complex systems,including soil and structure,while benefiting from Rayleigh damping to filter unwanted noises.The numerical model was achieved by simulating a previous centrifuge test of the excavation wall,manifested at the pre-failure state.Notably,the calibration of the soil constitutive model through empirical relations,which replaces the numerical reproduction of an element test,more accurately simulated the soil-nail-wall interaction.Two factors were crucial to a successful result.First,probing the natural period of the complicated geometry of the model by applying white noises.Second,considering Rayleigh damping to withdraw unwanted noises and thus assess their permanent effects on the model.Rayleigh damping was applied instead of filtering the obtained results.
文摘Autism spectrum disorder is a developmental disorder impacting a child’s social interactions,behaviors,and communication skills.One of the crucial aspects of autism care,which is often overlooked,is the parent’s mental health status while trying to improve and overcome challenges faced by their child.A study by Lu et al examined the effectiveness of remote family psychological support courses on the mental health status of parents having children with autism spectrum disorder.It was found that the integration of these remote psychological courses with conventional care had a positive impact on the parents by reducing their stress levels,leading to an increase in their competence,and hence they could engage effectively in child therapy.However,a long-term study is necessary to assess whether these interventions have a sustained effect.The study emphasizes the need for developing such culturally sensitive intervention models on a global scale,making them accessible to all and improving autism care support.
基金supported by the National Natural Science Foundation of China,Nos.81870732(to DZ),82171161(to DZ),81900933(to YS),and 82000978(to ZL).
文摘The spontaneous bursts of electrical activity in the developing auditory system are derived from the periodic release of adenosine triphosphate(ATP)by supporting cells in the Kölliker’s organ.However,the mechanisms responsible for initiating spontaneous ATP release have not been determined.Our previous study revealed that telomerase reverse transcriptase(TERT)is expressed in the basilar membrane during the first postnatal week.Its role in cochlear development remains unclear.In this study,we investigated the expression and role of TERT in postnatal cochlea supporting cells.Our results revealed that in postnatal cochlear Kölliker’s organ supporting cells,TERT shifts from the nucleus into the cytoplasm over time.We found that the TERT translocation tendency in postnatal cochlear supporting cells in vitro coincided with that observed in vivo.Further analysis showed that TERT in the cytoplasm was mainly located in mitochondria in the absence of oxidative stress or apoptosis,suggesting that TERT in mitochondria plays roles other than antioxidant or anti-apoptotic functions.We observed increased ATP synthesis,release and activation of purine signaling systems in supporting cells during the first 10 postnatal days.The phenomenon that TERT translocation coincided with changes in ATP synthesis,release and activation of the purine signaling system in postnatal cochlear supporting cells suggested that TERT may be involved in regulating ATP release and activation of the purine signaling system.Our study provides a new research direction for exploring the spontaneous electrical activity of the cochlea during the early postnatal period.
基金The authors are grateful for the support by National Key Research and Development Program of China(2021YFF0500300,2020YFB1708300)the National Natural Science Foundation of China(52205280,12172041).
文摘Lightweight thin-walled structures with lattice infill are widely desired in satellite for their high stiffness-to-weight ratio and superior buckling strength resulting fromthe sandwich effect.Such structures can be fabricated bymetallic additive manufacturing technique,such as selective laser melting(SLM).However,the maximum dimensions of actual structures are usually in a sub-meter scale,which results in restrictions on their appliance in aerospace and other fields.In this work,a meter-scale thin-walled structure with lattice infill is designed for the fuel tank supporting component of the satellite by integrating a self-supporting lattice into the thickness optimization of the thin-wall.The designed structure is fabricated by SLM of AlSi10Mg and cold metal transfer welding technique.Quasi-static mechanical tests and vibration tests are both conducted to verify the mechanical strength of the designed large-scale lattice thin-walled structure.The experimental results indicate that themeter-scale thin-walled structure with lattice infill could meet the dimension and lightweight requirements of most spacecrafts.
基金supported by the National Natural Science Foundation of China(grant number 82371139,82371138,82101210 and 82171131)Beijing Hospital Authority Youth Program(grant number QML20230121).
文摘The inner ear sensory epithelium consists of two major types of cells:hair cells(HCs)and supporting cells(SCs).Critical functions of HCs in the perception of mechanical stimulation and mechanosensory transduction have long been elucidated.SCs are indispensable components of the sensory epithelia,and they maintain the structural integrity and ionic environment of the inner ear.Once delicate inner ear epithelia sustain injuries(for example,due to ototoxic drugs or noise exposure),SCs respond immediately to serve as repairers of the epithelium and as adapters to become HC progenitors,aiming at morphological and functional recovery of the inner ear.This regenerative process is extensive in non-mammals,but is limited in the mammalian inner ear,especially in the mature cochlea.This review aimed to discuss the important roles of SCs in the repair of the mammalian inner ear.
文摘Aiming to mitigate the aerodynamic lift force imbalance between pantograph strips,which exacerbates wear and affects the current collection performance of the pantograph-catenary system,a study has been conducted to support the beam deflector optimization using a combination of experimental measurements and computational fluid dynamics(CFD)simulations.The results demonstrate that the size,position,and installation orientation of the wind deflectors significantly influence the amount of force compensation.They also indicate that the front strip deflectors should be installed downwards and the rear strip deflectors upwards,thereby forming a“π”shape.Moreover,the lift force compensation provided by the wind deflectors increases with the size of the deflector.Alternative wind compensation strategies,such as control circuits,are also discussed,putting emphasis on the pros and cons of various pantograph types and wind compensation approaches.
文摘This paper discusses the important role of science and technology commissioners in the high-quality development of hundreds of counties,thousands of towns,and myriads of villages in the context of rural revitalization,including building bridges,accelerating the transformation of achievements,promoting the value-added of the whole agricultural industry chain,and promoting the rapid development of rural industrial economy.It also discusses the working achievements of science and technology commissioners,in order to promote further development of rural revitalization in Guangdong Province.
文摘The purpose of this study is to determine the teacher’s perceptions of the challenges and strategies in supporting students with reading difficulties.This study used qualitative method of research and descriptive approach as its research design,in addition to a set of structured interview questions administered through Google Forms to gather data from elementary teachers of Taal Central School,located at Taal Batangas.These structured interview questions were carefully designed to cover various dimensions of the study,including the types of challenges perceived by teachers,strategies employed,and possible solutions for addressing the problems encountered in the process of supporting students with reading difficulties.The results revealed that teachers faced several challenges when teaching students with reading difficulties such as emotional and motivational issues/factors,lack of resources or teaching aids,deficits in knowledge and skills,and problems with student engagement and participation.This study also showed common approaches utilized by the teachers in supporting students with reading difficulties,which were fostering a positive and supportive environment,adopting individualized and multifaceted approaches,and utilizing effective teaching tools and strategies.Lastly,teachers also concluded varied solutions in addressing the challenges perceived in teaching students with reading difficulties towards fostering reading proficiency.These include developing peer support,use of positive reinforcement,and parental involvement.Moreover,specialized resources,professional development for teachers,and specific teaching strategies are also highlighted as crucial components.By integrating these approaches,teachers concluded that it can create a supportive and effective learning environment tailored to the needs of students with reading difficulties.
文摘Objective: The purpose of this study was to clarify the collaborative activities and mutual recognition between community comprehensive care unit nurses (Ns) and care managers (CM) in supporting the discharge of the elderly from the hospital. Methods: A total of 300 nurses working in community comprehensive care wards and 360 care managers working in B City in A Prefecture were surveyed using an anonymous self-administered questionnaire. Results: The highest percentage of responses regarding necessary collaborative activities with multiple professions in supporting hospital discharge were the same for Ns and CMs. The items regarding practice with the highest percentages were “relationship as a team” for Ns, and “user-centered awareness” for CM. While these professionals were willing to share information about their patients’ lives after discharge, the percentage of those explaining their expertise was low. It is thought that collaborative activities focusing on these aspects would lead to more appropriate discharge support.
文摘The roadway support in many places of Jiulongkou Colliery, Fengfeng Mining Bureau, such as in the Permanent transportation roadway, was failed or locally caved, which seriously affected the colliery’s coal production performance and safety. Based on analysis of supporting objects for roadway repairing, this paper proposes the supporting parameters and condruction technics. The industrial ted of 70m long roadway repairing shows that the proposed parameters and technics of bolt shotcrete and mesh support for roadway repairing are reasouable, bring good technical and economic results for the colliery, and the repairing is successful.
基金Projects(51409154,41772299)supported by the National Natural Science Foundation of ChinaProject(J16LG03)supported by the Shandong Province Higher Educational Science and Technology Program,China+1 种基金Projects(2015JQJH106,2014TDJH103)supported by the SDUST Research Fund,ChinaProject(201630576)supported by the Tai’an Scientific and Technologic Development Project,China
文摘Soft rock surrounding deep roadway has poor stability and long-term rheological effect. More and larger deformation problems of surrounding rock occur due to adverse supporting measures for such roadways, which not only affects the engineering safety critically but also improves the maintenance costs. This paper takes the main rail roadway with severely deformation in China＇s Zaoquan coal mine as an example to study the long-term deformation tendency and damage zone by means of in-situ deformation monitoring and acoustic wave testing technique. A three-dimensional finite element model reflecting the engineering geological condition and initial design scheme is established by ABAQUS. Then, on the basis of field monitoring deformation data, the surrounding rock geotechnical and theological parameters of the roadway are obtained by back analysis. A combined supporting technology with U-shaped steel support and anchor-grouting is proposed for the surrounding soft rock. The numerical simulation of the combined supporting technology and in-situ deformation monitoring results show that the soft rock surrounding the roadway has been held effectively.
基金Foundation item： Project（2013CB036004） supported by the National Basic Research Program of China Project（51178468） supported by the National Natural Science Foundation of China
文摘Linear failure criterion is widely used in calculation of earth pressure acting on shallow tunnels. However, experimental evidence shows that nonlinear failure criterion is able to represent fairly well the failure of almost all types of rocks, A nonlinear Hock-Brown failure criterion is employed to estimate the supporting pressures of shallow tunnels in limit analysis framework. Two failure mechanisms are proposed for calculating the work rate of extemal force and the internal energy dissipation. A tangential line to the nonlinear failure criterion is used to formulate the supporting pressure problem as a nonlinear programming problem. The objective function formulated in this way is minimized with respect to the failure mechanism and the location of tangency point. In order to assess the validity, the supporting pressures for the proposed failure mechanisms are calculated and compared with each other, and the present results are compared with previously published solutions when the nonlinear criterion is reduced to linear criterion. The agreement supports the validity of the proposed failure mechanisms. An experiment is conducted to investigate the influences of the nonlinear criterion on collapse shape and supporting pressures of shallow tunnels.
基金This work was supported by the National Natural Science Foundation of China(Nos.41941018,52074164,and 42077267);the Natural Science Foundation of Shandong Province,China(Nos.2019SDZY04 and ZR2020JQ23)the Project of Shandong Province Higher Educational Youth Innovation Science and Technology Program,China(No.2019KJG013).
文摘In deep underground engineering,rock burst and other dynamic disasters are prone to occur due to stress concentration and energy accumulation in surrounding rock.The control of dynamic disasters requires bolts and cables with high strength,high elongation,and high energy-absorbing capacity.Therefore,a constant resistance energy-absorbing(CREA)material is developed.In this study,the dynamic characteristics of the new material are obtained via the drop hammer tests and the Split Hopkinson Pressure Bar(SHPB)tests of the new material and two common bolt(CB)materials widely used in the field.The test results of drop hammer test and SHPB test show that the percentage elongation of CREA material is more than 2.64 and 3.22 times those of the CB material,and the total impact energy acting on CREA material is more than 18.50 and 21.84 times,respectively,indicating that the new material has high elongation and high energy-absorbing capacity.Subsequently,the CREA bolts and cables using the new material are developed,which are applied in roadways with high stress and strong dynamic disturbance.The field monitoring results show that CREA bolts and cables can effectively control the surrounding rock deformation and ensure engineering safety.
基金supported by the National Natural Science Foundation of China (No. 51178468)the National Basic Research Program (973) of China (No. 2011CB013800)
文摘To analyze the stability of a shallow square tunnel, a new curved failure mechanism, representing the mechanical characteristics and collapsing form of this type of tunnel, is constructed. Based on the upper bound theorem of limit analysis and the Hoek-Brown nonlinear failure criterion, the supporting pressure derived from the virtual work rate equation is regarded as an objective function to achieve optimal calculation. By employing variational calculation to optimize the objective function, an upper bound solution for the supporting pressure and the collapsing block shape of a shallow square tunnel are obtained. To evaluate the validity of the failure mechanism proposed in this paper, the solutions computed by the curved failure mechanism are compared with the results calculated by the linear multiple blocks failure mechanism when the Hoek-Brown nonlinear failure criterion is converted into the Mohr-Coulomb linear criterion. The influences of rock mass parameters on the supporting pressure and collapsing block shape are discussed.
基金National Science and Technology Major Project,No.2009ZX07210-010Supported by Program B for Outstanding Ph D Candidate of Nanjing University
文摘There have been substantial conflicts in the human-water relationship in the Huaihe River Basin （HRB）. To achieve sustainable economic development without degrading the water environment in the HRB, we develop a three-dimensional water environmental sup- porting capacity （WESC） model based on water environmental carrying capacity （WECC）, water environmental pressure （WEP）, and water pollution prevention and control capacity （WPPC）. Geographic information systems spatial analysis with the analytical hierarchy process method and dynamic weighted summation is applied. Several proposals for suitable locations for industry and environmental protection strategies for water were presented. The following results were obtained. （1） The spatial differences in WECC are substantial; areas with high-value WECC zones are mainly located along the main stream of the Huaihe River on the south side. WEP is generally high, with an overall low level of pollution prevention and control in the whole HRB. WPPC and WEP show high spatial overlapping due to the fact that areas with higher environmental pollution usually have high level of economic development, and thus have a strong capacity for pollution control. （2） Overall, WESC is moderate in the HRB. In particular, areas with a high WESC value only account for 56.24% of the HRB in 2010 Distinct differences in WESC also exist between areas located in the south compared with in the north of the basin, and areas alongside the downstream region compared with alongside the upstream and midstream regions. （3） Consequently, according to the guidance for indus- try zoning in the HRB, the areas in the south and alongside the downstream and sub-streams with a low WEP value and high WECC and WPPC, traditional industries should be developed based on strict environmental access and pollution emission standards. While for the areas along the midstream of the HRB and along the whole Yishusi River Basin, which have a high WEP value, industrial restructuring and technological upgrading are suggested. Action should be taken to limit development and protect the environment in the upstream region of the basin which is a key source of drinking water, in the eastern route along the line of the South-toNorth Water Diversion Project, and in the ecologically fragile region alongside the basin. This will ensure good environmental functionality including subsistent provision of clean water, while at the same time satisfying the urgent need to adjust, transform, and upgrade the industrial structure.
基金Projects 50427401 supported by the National Natural Science Foundation of China2006AA06Z119 by the Hi-tech Research and Development Program of China+2 种基金NCET-06-0477 by the New Century Excellent Talent Plan of Ministry of Education2007A002 by the Science & Research Foundation for Youth of China University of Mining and Technologythe Na-tional Basic Research Program of China (2005cb221505)
文摘More accurate forecasting of rock burst might be possible from observations of electromagnetic radiation emitted in the mine.We analyzed experimental observations and field data from the Muchengjian coal mine to study the relationship between electromagnetic radiation signal intensity and stress during the fracturing of coal, or rock, and samples under load.The results show that the signal intensity is positively correlated with stress.In addition, we investigated the change in the electromagnetic radiation intensity, the supporting resistance in a real coal mine environment, and the coal or rock stress in the mining area.The data analysis indicates that:1) electromagnetic radiation intensity can accurately reflect the distribution of stress in the mining area;and, 2) there is a correlation between electromagnetic radiation intensity and supporting resistance.The research has some practical guiding significance for rock burst forecasting and for the prevention of accidents in coal mines.
基金Project(2013CB036004) supported by the National Basic Research Program of ChinaProjects(51178468,51378510) supported by the National Natural Science Foundation of China
文摘Based on the active failure mechanism generated by a spatial discretization technique, the stability of tunnel face was studied. With the help of the spatial discretization technique, not only the anisotropy and inhomogeneity of the cohesion but also the inhomogeneity of the internal friction angle was taken into account in the analysis of the supporting forces. From the perspective of upper bound theorem, the upper bound solutions of supporting pressure were derived. The influence of the anisotropy and heterogeneity on the supporting forces as well as the failure mechanisms was discussed. The results show that the spatial discretization characteristics of cohesion and internal frictional angle impose a significant effect on the supporting pressure, which indicates that above factors should be considered in the actual engineering.
文摘The methods combined by test, field monitoring and theoretical analysis were adopted to do the systemic research on the rock mass from micro-structure to macro-deformation, and rheological model of Jinchuan rock mass was established to discuss the reasonable supporting time. Resuhs show that supporting after suitable stress and displacement release can benefit for the long-term stability of surrounding rock.
基金Project(41202220) supported by the National Natural Science Foundation of ChinaProject(20120022120003) supported by the Research Fund for the Doctoral Program of Higher Education, China+1 种基金Project(2-9-2012-65) supported by the Fundamental Research Funds for the Central Universities, ChinaProject(2013006) supported by the Research Fund for Key Laboratory on Deep GeoDrilling Technology, Ministry of Land and Resources, China
文摘A new type of pit supporting structure, which was tested and verified using the sensor monitoring technology, was presented. The new supporting structure is assembled by prefabricated steel structural units. The adjacent steel structural units are jointed with fasteners, and each steel structural unit has a certain radian and is welded by two steel tubes and one piece of steel disc. In order to test and verify the reliability of the new supporting structure, the field tests are designed. The main monitoring programs include the hoop stress of supporting structure, lateral earth pressure, and soil deformation. The monitoring data of the field tests show that the new supporting structure is convenient, reliable and safe.
基金provided by the National Basic Research 973 Program of China (No. 2013CB036003)the National Natural Science Foundation of China (No. 51374198)the Annual College Graduate Research and Innovation Projects of Jiangsu Province of China (No. KYLX15_1402)
文摘In order to solve the large deformation controlling problem for surrounding rock of gob-side entry driving under common cable anchor support in deep mine, site survey, physical modeling experiment, numerical simulation and field measurement were synthetically used to analyze the deformation and failure characteristics of surrounding rock. Besides, applicability analysis, prestress field distribution characteristics of surrounding rock and the control effect on large deformation of surrounding rock were also further studied for the gob-side entry driving in deep mine using the cable-truss supporting system. The results show that, first, compared with no support and traditional bolt anchor support, roof cable-truss system can effectively restrain the initiation and propagation of tensile cracks in the roof surrounding rock and arc shear cracks in the two sides, moreover, the broken development of surrounding rock, roof separation and extrusion deformation between the two sides of the roadway are all controlled; second, a prestressed belt of trapezoidal shape is generated in the surrounding rock by the cable-truss supporting system, and the prestress field range is wide. Especially, the prestress concentration belt in the shallow surrounding rock can greatly improve the anchoring strength and deformation resisting capability of the rock stratum;third, an optimized support system of ‘‘roof and side anchor net beam, roof cable-truss supporting system and anchor cable of the narrow coal pillar" was put forward, and the support optimization design and field industrial test were conducted for the gob-side entry driving of the working face 5302 in Tangkou Mine, from which a good supporting effect was obtained.
