Due to the limited transmission resources for data relay in the tracking and data relay satellite system （TDRSS）, there are many job requirements in busy days which will be discarded in the conventional job scheduli...Due to the limited transmission resources for data relay in the tracking and data relay satellite system （TDRSS）, there are many job requirements in busy days which will be discarded in the conventional job scheduling model. Therefore, the improvement of scheduling efficiency in the TDRSS can not only help to increase the resource utilities, but also to reduce the scheduling failure ratio. A model of nonhomogeneous parallel machines scheduling problems with time window （NPM-TW） is firstly built up for the TDRSS, considering the distinct features of the variable preparation time and the nonhomogeneous transmission rates for different types of antennas on each tracking and data relay satellite （TDRS）. Then, an adaptive subsequence adjustment （ASA） framework with evolutionary asymmetric path-relinking （EvAPR） is proposed to solve this problem, in which an asymmetric progressive crossover operation is involved to overcome the local optima by the conventional job inserting methods. The numerical results show that, compared with the classical greedy randomized adaptive search procedure （GRASP） algorithm, the scheduling failure ratio of jobs can be reduced over 11% on average by the proposed ASA with EvAPR.展开更多
In this paper, with the aid of large deviation formulas established in strong topology of functional space generated by HSlder norm, we discuss the functional sample path properties of subsequence＇s C-R increments fo...In this paper, with the aid of large deviation formulas established in strong topology of functional space generated by HSlder norm, we discuss the functional sample path properties of subsequence＇s C-R increments for a Wiener process in HSlder norm. The obtained results, generalize the corresponding results of Chen and the classic Strassen＇s law of iterated logarithm for a Wiener process.展开更多
The recent advancements in sensor technology have made it possible to collect enormous amounts of data in real time.How to find out unusual pattern from time series data plays a very important role in data mining.In t...The recent advancements in sensor technology have made it possible to collect enormous amounts of data in real time.How to find out unusual pattern from time series data plays a very important role in data mining.In this paper,we focus on the abnormal subsequence detection.The original definition of discord subsequences is defective for some kind of time series,in this paper we give a more robust definition which is based on the k nearest neighbors.We also donate a novel method for time series representation,it has better performance than traditional methods(like PAA/SAX)to represent the characteristic of some special time series.To speed up the process of abnormal subsequence detection,we used the clustering method to optimize the outer loop ordering and early abandon subsequence which is impossible to be abnormal.The experiment results validate that the algorithm is correct and has a high efficiency.展开更多
Parkinson's disease(PD) has a complex and multifactorial pathophysiology. Various studies, conducted both in pre-clinical models and PD patients, have reported a link between the disruption of calcium(Ca^(2+)) hom...Parkinson's disease(PD) has a complex and multifactorial pathophysiology. Various studies, conducted both in pre-clinical models and PD patients, have reported a link between the disruption of calcium(Ca^(2+)) homeostasis and the subsequent development of PD. Ca^(2+) regulation is crucial for neuronal survival, differentiation,exocytosis at synapses,gene transcription,and proliferation.展开更多
Let X1,X2,…,Xn,…be a sequence of i.i.d.random variables uniformly distributed on[0;1],and denote by Ln the length of the longest increasing subsequences of X1,X2,…,Xn.Consider the poissonized version Hn based on Ha...Let X1,X2,…,Xn,…be a sequence of i.i.d.random variables uniformly distributed on[0;1],and denote by Ln the length of the longest increasing subsequences of X1,X2,…,Xn.Consider the poissonized version Hn based on Hammersley’s representation in the 2-dimensional space.A law of the iterated logarithm for Hn is established using the well-known subsequence method and Borel-Cantelli lemma.The key technical ingredients in the argument include superadditivity,increment independence and precise tail estimates for the Hn’s.The work was motivated by recent works due to Ledoux(J.Theoret.Probab.31,(2018)).It remains open to establish an analog for the Ln itself.展开更多
Let G be a finite abelian group and S be a sequence with elements of G.We say that S is a regular sequence over G if|SH|≤|H|-1 holds for every proper subgroup H of G,where SH denotes the subsequence of S consisting o...Let G be a finite abelian group and S be a sequence with elements of G.We say that S is a regular sequence over G if|SH|≤|H|-1 holds for every proper subgroup H of G,where SH denotes the subsequence of S consisting of all terms of S contained in H.We say that S is a zero-sum free sequence over G if 0■Σ(S),where Σ(S)■G denotes the set of group elements which can be expressed as a sum of a nonempty subsequence of S.In this paper,we study the inverse problems associated with Σ(S)when S is a regular sequence or a zero-sum free sequence over G=Cp■Cp,where p is a prime.展开更多
Background This study investigated the potential impacts of increasing linoleic andα-linolenic acid intake during lactation and wean-to-breeding on subsequent reproduction of sows.A total of 309 sows(PIC Camborough L...Background This study investigated the potential impacts of increasing linoleic andα-linolenic acid intake during lactation and wean-to-breeding on subsequent reproduction of sows.A total of 309 sows(PIC Camborough L42)were balanced by parity(140 and 169 sows representing parity 1 to 2[P1-2]and 3 to 9[P3+],respectively)and assigned within parity to a 2×2 factorial arrangement.Factors included essential fatty acid(EFA)supplementation(control diets containing 1.2%linoleic and 0.15%α-linolenic acid or diets with 3.0%linoleic and 0.38%α-linolenic acid)and supplementation period(lactation or wean-to-breeding).Tallow(low EFA diets)or soybean oil(high EFA diets)were included at 4%in sorghum-soybean meal-wheat middlings-based diets to attain targeted EFA levels.Results High levels of EFA fed during lactation had no effect on feed intake or litter performance,but increased subsequent farrowing rate(P=0.027;82.1%vs.70.4%),tended to reduce the proportion of sows removed(P=0.070;12.4%vs.20.8%),decreased the number of total pigs born in the following litter(P=0.072;15.3 vs.16.2),and increased total pigs born alive per 100 sows weaned(P=0.062;1,122 vs.974),regardless of sow parity.Young sows(P1-2)consuming the high EFA diet during lactation displayed a shorter wean-to-estrus interval(P=0.035;4.2 vs.4.6),but P3+sows were unaffected.Increasing EFA intake for P3+sows,but not P1-2 sows,resulted in more sows bred by d 5(P=0.028;91.1%vs.81.7%)and more mummies in the subsequent litter(P=0.040;0.32 vs.0.16).Feeding increased EFA to P1-2 sows during the wean-to-breeding period decreased subsequent farrowing rate(P=0.042;72.0%vs.87.7%),and increased removal rate(P=0.003;28.8%vs.9.4%).Total pigs born alive per 100 sows weaned was reduced(P=0.007)in P1-2 sows when supplemented with EFA during wean-breeding(939 vs.1,149)but was not impacted in P3+sows(1,131 vs.982).Conclusions Supplemental EFA in lactation diets benefited subsequent reproduction of sows,regardless of parity.Increasing dietary levels of EFA during the wean-to-breeding period to younger sows negatively impacted subsequent reproduction.展开更多
BACKGROUND The combination of anti-epidermal growth factor receptor(EGFR)therapy and chemotherapy is currently a preferred first-line treatment for patients with unre-sectable,RAS and BRAF wild-type,left-sided metasta...BACKGROUND The combination of anti-epidermal growth factor receptor(EGFR)therapy and chemotherapy is currently a preferred first-line treatment for patients with unre-sectable,RAS and BRAF wild-type,left-sided metastatic colorectal cancer(mCRC).Several studies have also demonstrated the benefit of anti-EGFR therapy in sub-sequent line settings for this patient population.However,direct evidence com-paring the effectiveness of frontline vs subsequent anti-EGFR therapy remains limited,leaving a crucial gap in guiding optimal treatment strategies.AIM To compare overall survival(OS)between frontline and subsequent anti-EGFR treatment in patients with unresectable,RAS and BRAF wild-type,left-sided mCRC.METHODS We retrospectively reviewed the medical records of mCRC patients treated at The King Chulalongkorn Memorial Hospital and Songklanagarind Hospital,Thailand,between January 2013 and April 2023.Patients were classified into two groups based on the sequence of their anti-EGFR treatment.The primary endpoint was OS.RESULTS Among 222 patients with a median follow-up of 29 months,no significant difference in OS was observed between the frontline and subsequent-line groups(HR 1.03,95%CI:0.73-1.46,P=0.878).The median OS was 35.53 months(95%CI:26.59-44.47)for the frontline group and 31.60 months(95%CI:27.83-35.37)for the subsequent-line group.In the subsequent-line group,71 patients(32.4%)who ultimately never received anti-EGFR therapy had a significantly worse median OS of 19.70 months(95%CI:12.87-26.53).CONCLUSION Frontline and subsequent-line anti-EGFR treatments provide comparable OS in unresectable,RAS/BRAF wild-type,left-sided mCRC patients,but early exposure is vital for those unlikely to receive subsequent therapy.展开更多
Dear Editor,As mass vaccination has been accomplished worldwide and a growing number of individuals have already been infected by SARS-CoV-2,understanding the incidence of subsequent re-infection is urgently required ...Dear Editor,As mass vaccination has been accomplished worldwide and a growing number of individuals have already been infected by SARS-CoV-2,understanding the incidence of subsequent re-infection is urgently required for comprehending the transmission dynamics of COVID-19(Bobrovitz et al.,2023).Additionally,current SARS-CoV-2 variants cause widespread escape from the neutralizing antibody(nAb)elicited by current vaccines.Meanwhile,durable neutralization and memory B cell responses can be predicted by rapid CD4t T cell responses,particularly strong circulating T follicular helper(cTfh)cell responses,in individuals infected with SARS-CoV-2(Gong et al.,2020;Boppana et al.,2021;Narowski et al.,2022).Although nAb titers are known as predictors of protection against SARS-CoV-2 variants(Khoury et al.,2021),identifying more potential factors that could predict the risk of re-infection following primary infection and vaccination has become quite important in shaping prevention strategies(Chemaitelly et al.,2023).展开更多
BACKGROUND With the increasing incidence of total joint arthroplasty(TJA),there is a desire to reduce peri-operative complications and resource utilization.As degenerative conditions progress in multiple joints,many p...BACKGROUND With the increasing incidence of total joint arthroplasty(TJA),there is a desire to reduce peri-operative complications and resource utilization.As degenerative conditions progress in multiple joints,many patients undergo multiple proce-dures.AIM To determine if both physicians and patients learn from the patient’s initial arth-roplasty,resulting in improved outcomes following the second procedure.METHODS The institutional database was retrospectively queried for primary total hip arth-roplasty(THA)and total knee arthroplasty(TKA).Patients with only unilateral THA or TKA,and patients undergoing same-day bilateral TJA,were excluded.Patient demographics,comorbidities,and implant sizes were collected at the time of each procedure and patients were stratified by first vs second surgery.Outcome metrics evaluated included operative time,length of stay(LOS),disposition,90-d readmissions and emergency department(ED)visits.RESULTS A total of 642 patients,including 364 undergoing staged bilateral TKA and 278 undergoing bilateral THA,were analyzed.There was no significant difference in demographics or comorbidities between the first and second procedure,which were separated by a mean of 285 d.For THA and TKA,LOS was significantly less for the second surgery,with 66%of patients having a shorter hospitalization(P<0.001).THA patients had significantly decreased operative time only when the same sized implant was utilized(P=0.025).The vast majority(93.3%)of patients were discharged to the same type of location following their second surgery.However,when a change in disposition was present from the first surgery,patients were significantly more likely to be discharged to home after the second procedure(P=0.033).There was no difference between procedures for post-operative readmissions(P=0.438)or ED visits(P=0.915).CONCLUSION After gaining valuable experience recovering from the initial surgery,a patient’s perioperative outcomes are improved for their second TJA.This may be the result of increased confidence and decreased anxiety,and it supports the theory that enhanced patient education pre-operatively may improve outcomes.For the surgical team,the second procedure of a staged THA is more efficient,although this finding did not hold for TKA.展开更多
The anomalous activation of glycolysis and subsequent accumulation of L-lactate under aerobic conditions,known as the Warburg effect,are prominent metabolic hallmarks of cancer1.Extensive research has revealed that la...The anomalous activation of glycolysis and subsequent accumulation of L-lactate under aerobic conditions,known as the Warburg effect,are prominent metabolic hallmarks of cancer1.Extensive research has revealed that lactate acts not only as an energy-supplying substrate but also as a signaling molecule in glioma2.In addition,lactate accumulation contributes to the formation of a suppressive immune microenvironment in glioma,owing to its acidifying effects.However,emerging findings regarding the lysine lactylome indicate that the roles of lactate extend beyond these functions3。展开更多
A fundamental problem in sequence stratigraphy is whether the sequences are global in extent and whether the sea level changes are eustatic in nature. Study on the Upper Devonian and Lower Carboniferous depositional s...A fundamental problem in sequence stratigraphy is whether the sequences are global in extent and whether the sea level changes are eustatic in nature. Study on the Upper Devonian and Lower Carboniferous depositional sequences in different facies belts on the southern margin of the Upper Yangtze platform shows that different orders of sequences possess distinctive distribution and correlation in space, although the sea level changes in various orders of sequences may be primarily global in nature. The present paper regards the distribution in space, especially in different facies belts, as a criterion for defining and recognizing the various orders of sequences. The orthosequence (third order sequence) is probably global in nature, which may be discerned in various depositional facies belts on the continental margin and can be correlated over long distances, sometimes maybe worldwide. Commonly, correlation of the subsequences (fourth order sequences with time interval of 0.5 Ma to 1.5 Ma) is difficult in different facies belts, although some of them are probably also worldwide in distribution. A subsequence should be distinguishable and correlatable within at least one facies belt. The higher order sequences, including parasequences (fifth order sequences) and microsequences (sixth order sequences), are regional or local in distribution. They may have reflected the longer and shorter Milankovitch cycles respectively. Orthosequences and subsequences are usually recognizable in different facies belts, while parasequences and microsequences may be distinguished only in shallow marine deposits, but not in slope and basin facies deposits.展开更多
This paper introduces a novel transform method to produce the newly generated programs through code transform model called the second generation of Generative Pre-trained Transformer(GPT-2)reasonably,improving the pro...This paper introduces a novel transform method to produce the newly generated programs through code transform model called the second generation of Generative Pre-trained Transformer(GPT-2)reasonably,improving the program execution performance significantly.Besides,a theoretical estimation in statistics has given the minimum number of generated programs as required,which guarantees to find the best one within them.The proposed approach can help the voice assistant machine resolve the problem of inefficient execution of application code.In addition to GPT-2,this study develops the variational Simhash algorithm to check the code similarity between sample program and newly generated program,and conceives the piecewise longest common subsequence algorithm to examine the execution’s conformity from the two programs mentioned above.The code similarity check deducts the redundant generated programs,and the output conformity check finds the best-performing generative program.In addition to texts,the proposed approach can also prove the other media,including images,sounds,and movies.As a result,the newly generated program outperforms the sample program significantly because the number of code lines reduces 27.21%,and the program execution time shortens 24.62%.展开更多
A study was made on temporal sequence of the earthquake swarm with M6. 7 which took place in Batang County, Sichuan Province, from April to Sept., 1989. Temporal sequence of the swarm was characterized by obvious sect...A study was made on temporal sequence of the earthquake swarm with M6. 7 which took place in Batang County, Sichuan Province, from April to Sept., 1989. Temporal sequence of the swarm was characterized by obvious sectional release process, in dex rise of creeping curve, certain order behavior among the peak values in the early sequence, transient tranquility before strong aftershocks and abnormal high values in sequential entropy. Subsequence of the swarm were represented by the forms of isolation pattern and mainshock-aftershock pattern,changed from the former pattern to the latter and characterized by fast-slow-fast attenuating pattern. According to time fractional dimension calculation results of the swarm sequence and the subsequences, it was discovered that non-scaling regions existed in the complicated temporal sequence structure, the span of non-scaling region of capacity dimension Do was different from that of the information dimension D1 of the same sequence, and the self-organizational features of the same sequence were different when various magnitude threshold values were selected for calculating. From the stochastic non-uniform spread of swarming high fractures in the seismic regions, it was primarily explained that the exponential attenuation of time sequence variation was likely to occur.Meanwhile, the level structures of various order sequences of the strong seismic swarm and the order problems were discussed.展开更多
The scheduling efficiency of the tracking and data relay satellite system（TDRSS）is strictly limited by the scheduling degrees of freedom（DoF）,including time DoF defined by jobs＇ flexible time windows and spatial ...The scheduling efficiency of the tracking and data relay satellite system（TDRSS）is strictly limited by the scheduling degrees of freedom（DoF）,including time DoF defined by jobs＇ flexible time windows and spatial DoF brought by multiple servable tracking and data relay satellites（TDRSs）.In this paper,ageneralized multiple time windows（GMTW）model is proposed to fully exploit the time and spatial DoF.Then,the improvements of service capability and job-completion probability based on the GMTW are theoretically proved.Further,an asymmetric path-relinking（APR）based heuristic job scheduling framework is presented to maximize the usage of DoF provided by the GMTW.Simulation results show that by using our proposal 11%improvement of average jobcompletion probability can be obtained.Meanwhile,the computing time of the time-to-target can be shorten to 1/9 of the GRASP.展开更多
The existing multi-source contour matching studies have focused on the matching methods with consideration of topological relations and similarity measurement based on spatial Euclidean distance,while it is lack of ta...The existing multi-source contour matching studies have focused on the matching methods with consideration of topological relations and similarity measurement based on spatial Euclidean distance,while it is lack of taking the contour geometric features into account,which may lead to mismatching in map boundaries and areas with intensive contours or extreme terrain changes.In light of this,it is put forward that a matching strategy from coarse to precious based on the contour geometric features.The proposed matching strategy can be described as follows.Firstly,the point sequence is converted to feature sequence according to a feature descriptive function based on curvature and angle of normal vector.Then the level of similarity among multi-source contours is calculated by using the longest common subsequence solution.Accordingly,the identical contours could be matched based on the above calculated results.In the experiment for the proposed method,the reliability and efficiency of the matching method are verified using simulative datasets and real datasets respectively.It has been proved that the proposed contour matching strategy has a high matching precision and good applicability.展开更多
Our previous work has introduced the newly generated program using the code transformation model GPT-2,verifying the generated programming codes through simhash(SH)and longest common subsequence(LCS)algo-rithms.Howeve...Our previous work has introduced the newly generated program using the code transformation model GPT-2,verifying the generated programming codes through simhash(SH)and longest common subsequence(LCS)algo-rithms.However,the entire code transformation process has encountered a time-consuming problem.Therefore,the objective of this study is to speed up the code transformation process signicantly.This paper has proposed deep learning approaches for modifying SH using a variational simhash(VSH)algorithm and replacing LCS with a piecewise longest common subsequence(PLCS)algorithm to faster the verication process in the test phase.Besides the code transformation model GPT-2,this study has also introduced MicrosoMASS and Facebook BART for a comparative analysis of their performance.Meanwhile,the explainable AI technique using local interpretable model-agnostic explanations(LIME)can also interpret the decision-making ofAImodels.The experimental results show that VSH can reduce the number of qualied programs by 22.11%,and PLCS can reduce the execution time of selected pocket programs by 32.39%.As a result,the proposed approaches can signicantly speed up the entire code transformation process by 1.38 times on average compared with our previous work.展开更多
This paper investigates a procedure developed and reports on experiments performed to studying the utility of applying a combined structural property of a text’s sentences and term expansion using WordNet [1] and a l...This paper investigates a procedure developed and reports on experiments performed to studying the utility of applying a combined structural property of a text’s sentences and term expansion using WordNet [1] and a local thesaurus [2] in the selection of the most appropriate extractive text summarization for a particular document. Sentences were tagged and normalized then subjected to the Longest Common Subsequence (LCS) algorithm [3] [4] for the selection of the most similar subset of sentences. Calculated similarity was based on LCS of pairs of sentences that make up the document. A normalized score was calculated and used to rank sentences. A selected top subset of the most similar sentences was then tokenized to produce a set of important keywords or terms. The produced terms were further expanded into two subsets using 1) WorldNet;and 2) a local electronic dictionary/thesaurus. The three sets obtained (the original and the expanded two) were then re-cycled to further refine and expand the list of selected sentences from the original document. The process was repeated a number of times in order to find the best representative set of sentences. A final set of the top (best) sentences was selected as candidate sentences for summarization. In order to verify the utility of the procedure, a number of experiments were conducted using an email corpus. The results were compared to those produced by human annotators as well as to results produced using some basic sentences similarity calculation method. Produced results were very encouraging and compared well to those of human annotators and Jacquard sentences similarity.展开更多
An integration processing system of three-dimensional laser scanning information visualization in goaf was developed. It is provided with multiple functions, such as laser scanning information management for goaf, clo...An integration processing system of three-dimensional laser scanning information visualization in goaf was developed. It is provided with multiple functions, such as laser scanning information management for goaf, cloud data de-noising optimization, construction, display and operation of three-dimensional model, model editing, profile generation, calculation of goaf volume and roof area, Boolean calculation among models and interaction with the third party soft ware. Concerning this system with a concise interface, plentiful data input/output interfaces, it is featured with high integration, simple and convenient operations of applications. According to practice, in addition to being well-adapted, this system is favorably reliable and stable.展开更多
基金supported by the National Natural Science Foundation of China(6113200291338101+3 种基金91338108)the National S&T Major Project(2011ZX03004-001-01)the Research Fund of Tsinghua University(2011Z05117)the Co-innovation Laboratory of Aerospace Broadband Network Technology
文摘Due to the limited transmission resources for data relay in the tracking and data relay satellite system （TDRSS）, there are many job requirements in busy days which will be discarded in the conventional job scheduling model. Therefore, the improvement of scheduling efficiency in the TDRSS can not only help to increase the resource utilities, but also to reduce the scheduling failure ratio. A model of nonhomogeneous parallel machines scheduling problems with time window （NPM-TW） is firstly built up for the TDRSS, considering the distinct features of the variable preparation time and the nonhomogeneous transmission rates for different types of antennas on each tracking and data relay satellite （TDRS）. Then, an adaptive subsequence adjustment （ASA） framework with evolutionary asymmetric path-relinking （EvAPR） is proposed to solve this problem, in which an asymmetric progressive crossover operation is involved to overcome the local optima by the conventional job inserting methods. The numerical results show that, compared with the classical greedy randomized adaptive search procedure （GRASP） algorithm, the scheduling failure ratio of jobs can be reduced over 11% on average by the proposed ASA with EvAPR.
基金Supported by the Natural Science Foundation of Hubei Province of China(2011CDB229)
文摘In this paper, with the aid of large deviation formulas established in strong topology of functional space generated by HSlder norm, we discuss the functional sample path properties of subsequence＇s C-R increments for a Wiener process in HSlder norm. The obtained results, generalize the corresponding results of Chen and the classic Strassen＇s law of iterated logarithm for a Wiener process.
文摘The recent advancements in sensor technology have made it possible to collect enormous amounts of data in real time.How to find out unusual pattern from time series data plays a very important role in data mining.In this paper,we focus on the abnormal subsequence detection.The original definition of discord subsequences is defective for some kind of time series,in this paper we give a more robust definition which is based on the k nearest neighbors.We also donate a novel method for time series representation,it has better performance than traditional methods(like PAA/SAX)to represent the characteristic of some special time series.To speed up the process of abnormal subsequence detection,we used the clustering method to optimize the outer loop ordering and early abandon subsequence which is impossible to be abnormal.The experiment results validate that the algorithm is correct and has a high efficiency.
文摘Parkinson's disease(PD) has a complex and multifactorial pathophysiology. Various studies, conducted both in pre-clinical models and PD patients, have reported a link between the disruption of calcium(Ca^(2+)) homeostasis and the subsequent development of PD. Ca^(2+) regulation is crucial for neuronal survival, differentiation,exocytosis at synapses,gene transcription,and proliferation.
基金supported by the National Natural Science Foundation of China(Nos.11871425,11731012)the Fundamental Research Funds for Central Universities.
文摘Let X1,X2,…,Xn,…be a sequence of i.i.d.random variables uniformly distributed on[0;1],and denote by Ln the length of the longest increasing subsequences of X1,X2,…,Xn.Consider the poissonized version Hn based on Hammersley’s representation in the 2-dimensional space.A law of the iterated logarithm for Hn is established using the well-known subsequence method and Borel-Cantelli lemma.The key technical ingredients in the argument include superadditivity,increment independence and precise tail estimates for the Hn’s.The work was motivated by recent works due to Ledoux(J.Theoret.Probab.31,(2018)).It remains open to establish an analog for the Ln itself.
基金supported in part by the Fundamental Research Funds for the Central Universities(No.3122019152)the National Natural Science Foundation of China(Grant Nos.11701256,11871258)+2 种基金the Youth Backbone Teacher Foundation of Henan's University(No.2019GGJS196)the China Scholarship Council(Grant No.201908410132)was also supported in part by a Discovery Grant from the Natural Sciences and Engineering Research Council of Canada(Grant No.RGPIN 2017-03903).
文摘Let G be a finite abelian group and S be a sequence with elements of G.We say that S is a regular sequence over G if|SH|≤|H|-1 holds for every proper subgroup H of G,where SH denotes the subsequence of S consisting of all terms of S contained in H.We say that S is a zero-sum free sequence over G if 0■Σ(S),where Σ(S)■G denotes the set of group elements which can be expressed as a sum of a nonempty subsequence of S.In this paper,we study the inverse problems associated with Σ(S)when S is a regular sequence or a zero-sum free sequence over G=Cp■Cp,where p is a prime.
文摘Background This study investigated the potential impacts of increasing linoleic andα-linolenic acid intake during lactation and wean-to-breeding on subsequent reproduction of sows.A total of 309 sows(PIC Camborough L42)were balanced by parity(140 and 169 sows representing parity 1 to 2[P1-2]and 3 to 9[P3+],respectively)and assigned within parity to a 2×2 factorial arrangement.Factors included essential fatty acid(EFA)supplementation(control diets containing 1.2%linoleic and 0.15%α-linolenic acid or diets with 3.0%linoleic and 0.38%α-linolenic acid)and supplementation period(lactation or wean-to-breeding).Tallow(low EFA diets)or soybean oil(high EFA diets)were included at 4%in sorghum-soybean meal-wheat middlings-based diets to attain targeted EFA levels.Results High levels of EFA fed during lactation had no effect on feed intake or litter performance,but increased subsequent farrowing rate(P=0.027;82.1%vs.70.4%),tended to reduce the proportion of sows removed(P=0.070;12.4%vs.20.8%),decreased the number of total pigs born in the following litter(P=0.072;15.3 vs.16.2),and increased total pigs born alive per 100 sows weaned(P=0.062;1,122 vs.974),regardless of sow parity.Young sows(P1-2)consuming the high EFA diet during lactation displayed a shorter wean-to-estrus interval(P=0.035;4.2 vs.4.6),but P3+sows were unaffected.Increasing EFA intake for P3+sows,but not P1-2 sows,resulted in more sows bred by d 5(P=0.028;91.1%vs.81.7%)and more mummies in the subsequent litter(P=0.040;0.32 vs.0.16).Feeding increased EFA to P1-2 sows during the wean-to-breeding period decreased subsequent farrowing rate(P=0.042;72.0%vs.87.7%),and increased removal rate(P=0.003;28.8%vs.9.4%).Total pigs born alive per 100 sows weaned was reduced(P=0.007)in P1-2 sows when supplemented with EFA during wean-breeding(939 vs.1,149)but was not impacted in P3+sows(1,131 vs.982).Conclusions Supplemental EFA in lactation diets benefited subsequent reproduction of sows,regardless of parity.Increasing dietary levels of EFA during the wean-to-breeding period to younger sows negatively impacted subsequent reproduction.
文摘BACKGROUND The combination of anti-epidermal growth factor receptor(EGFR)therapy and chemotherapy is currently a preferred first-line treatment for patients with unre-sectable,RAS and BRAF wild-type,left-sided metastatic colorectal cancer(mCRC).Several studies have also demonstrated the benefit of anti-EGFR therapy in sub-sequent line settings for this patient population.However,direct evidence com-paring the effectiveness of frontline vs subsequent anti-EGFR therapy remains limited,leaving a crucial gap in guiding optimal treatment strategies.AIM To compare overall survival(OS)between frontline and subsequent anti-EGFR treatment in patients with unresectable,RAS and BRAF wild-type,left-sided mCRC.METHODS We retrospectively reviewed the medical records of mCRC patients treated at The King Chulalongkorn Memorial Hospital and Songklanagarind Hospital,Thailand,between January 2013 and April 2023.Patients were classified into two groups based on the sequence of their anti-EGFR treatment.The primary endpoint was OS.RESULTS Among 222 patients with a median follow-up of 29 months,no significant difference in OS was observed between the frontline and subsequent-line groups(HR 1.03,95%CI:0.73-1.46,P=0.878).The median OS was 35.53 months(95%CI:26.59-44.47)for the frontline group and 31.60 months(95%CI:27.83-35.37)for the subsequent-line group.In the subsequent-line group,71 patients(32.4%)who ultimately never received anti-EGFR therapy had a significantly worse median OS of 19.70 months(95%CI:12.87-26.53).CONCLUSION Frontline and subsequent-line anti-EGFR treatments provide comparable OS in unresectable,RAS/BRAF wild-type,left-sided mCRC patients,but early exposure is vital for those unlikely to receive subsequent therapy.
基金supported by the National Key R&D Program of Department of Science and Technology of China(2022YFC0870700)the Important Key Program of Natural Science Foundation of China(NSFC)(92169201)+3 种基金the Exchange Program of NSFC(82150710553)the Emergency Key Program of Guangzhou National Laboratory(EKPG21-24)the Key R&D Program of Department of Science and Technology of Guangdong(2022B1111020004)to H.Z.Natural Science Foundation of China(92169108 and 32000613)Guangdong Natural Science Funds for Distinguished Young Scholar(2023B1515020005)to Y.Z.
文摘Dear Editor,As mass vaccination has been accomplished worldwide and a growing number of individuals have already been infected by SARS-CoV-2,understanding the incidence of subsequent re-infection is urgently required for comprehending the transmission dynamics of COVID-19(Bobrovitz et al.,2023).Additionally,current SARS-CoV-2 variants cause widespread escape from the neutralizing antibody(nAb)elicited by current vaccines.Meanwhile,durable neutralization and memory B cell responses can be predicted by rapid CD4t T cell responses,particularly strong circulating T follicular helper(cTfh)cell responses,in individuals infected with SARS-CoV-2(Gong et al.,2020;Boppana et al.,2021;Narowski et al.,2022).Although nAb titers are known as predictors of protection against SARS-CoV-2 variants(Khoury et al.,2021),identifying more potential factors that could predict the risk of re-infection following primary infection and vaccination has become quite important in shaping prevention strategies(Chemaitelly et al.,2023).
文摘BACKGROUND With the increasing incidence of total joint arthroplasty(TJA),there is a desire to reduce peri-operative complications and resource utilization.As degenerative conditions progress in multiple joints,many patients undergo multiple proce-dures.AIM To determine if both physicians and patients learn from the patient’s initial arth-roplasty,resulting in improved outcomes following the second procedure.METHODS The institutional database was retrospectively queried for primary total hip arth-roplasty(THA)and total knee arthroplasty(TKA).Patients with only unilateral THA or TKA,and patients undergoing same-day bilateral TJA,were excluded.Patient demographics,comorbidities,and implant sizes were collected at the time of each procedure and patients were stratified by first vs second surgery.Outcome metrics evaluated included operative time,length of stay(LOS),disposition,90-d readmissions and emergency department(ED)visits.RESULTS A total of 642 patients,including 364 undergoing staged bilateral TKA and 278 undergoing bilateral THA,were analyzed.There was no significant difference in demographics or comorbidities between the first and second procedure,which were separated by a mean of 285 d.For THA and TKA,LOS was significantly less for the second surgery,with 66%of patients having a shorter hospitalization(P<0.001).THA patients had significantly decreased operative time only when the same sized implant was utilized(P=0.025).The vast majority(93.3%)of patients were discharged to the same type of location following their second surgery.However,when a change in disposition was present from the first surgery,patients were significantly more likely to be discharged to home after the second procedure(P=0.033).There was no difference between procedures for post-operative readmissions(P=0.438)or ED visits(P=0.915).CONCLUSION After gaining valuable experience recovering from the initial surgery,a patient’s perioperative outcomes are improved for their second TJA.This may be the result of increased confidence and decreased anxiety,and it supports the theory that enhanced patient education pre-operatively may improve outcomes.For the surgical team,the second procedure of a staged THA is more efficient,although this finding did not hold for TKA.
基金supported by the National Natural Science Foundation of China(Grant No.82072768)Youth Beijing Scholar(Grant No.055)+1 种基金The Outstanding Young Scientist Program of Beijing Universities(Grant No.JWZQ20240101026)Beijing Municipal Health Commission Research Ward Excellence Clinical Research Program(Grant No.BRWEP2024W032040200).
文摘The anomalous activation of glycolysis and subsequent accumulation of L-lactate under aerobic conditions,known as the Warburg effect,are prominent metabolic hallmarks of cancer1.Extensive research has revealed that lactate acts not only as an energy-supplying substrate but also as a signaling molecule in glioma2.In addition,lactate accumulation contributes to the formation of a suppressive immune microenvironment in glioma,owing to its acidifying effects.However,emerging findings regarding the lysine lactylome indicate that the roles of lactate extend beyond these functions3。
文摘A fundamental problem in sequence stratigraphy is whether the sequences are global in extent and whether the sea level changes are eustatic in nature. Study on the Upper Devonian and Lower Carboniferous depositional sequences in different facies belts on the southern margin of the Upper Yangtze platform shows that different orders of sequences possess distinctive distribution and correlation in space, although the sea level changes in various orders of sequences may be primarily global in nature. The present paper regards the distribution in space, especially in different facies belts, as a criterion for defining and recognizing the various orders of sequences. The orthosequence (third order sequence) is probably global in nature, which may be discerned in various depositional facies belts on the continental margin and can be correlated over long distances, sometimes maybe worldwide. Commonly, correlation of the subsequences (fourth order sequences with time interval of 0.5 Ma to 1.5 Ma) is difficult in different facies belts, although some of them are probably also worldwide in distribution. A subsequence should be distinguishable and correlatable within at least one facies belt. The higher order sequences, including parasequences (fifth order sequences) and microsequences (sixth order sequences), are regional or local in distribution. They may have reflected the longer and shorter Milankovitch cycles respectively. Orthosequences and subsequences are usually recognizable in different facies belts, while parasequences and microsequences may be distinguished only in shallow marine deposits, but not in slope and basin facies deposits.
基金This work is fully supported by the Ministry of Science and Technology,Taiwan,Republic of China,under Grant Nos.MOST 110-2622-E-390-001 and MOST 109-2622-E-390-002-CC3.
文摘This paper introduces a novel transform method to produce the newly generated programs through code transform model called the second generation of Generative Pre-trained Transformer(GPT-2)reasonably,improving the program execution performance significantly.Besides,a theoretical estimation in statistics has given the minimum number of generated programs as required,which guarantees to find the best one within them.The proposed approach can help the voice assistant machine resolve the problem of inefficient execution of application code.In addition to GPT-2,this study develops the variational Simhash algorithm to check the code similarity between sample program and newly generated program,and conceives the piecewise longest common subsequence algorithm to examine the execution’s conformity from the two programs mentioned above.The code similarity check deducts the redundant generated programs,and the output conformity check finds the best-performing generative program.In addition to texts,the proposed approach can also prove the other media,including images,sounds,and movies.As a result,the newly generated program outperforms the sample program significantly because the number of code lines reduces 27.21%,and the program execution time shortens 24.62%.
文摘A study was made on temporal sequence of the earthquake swarm with M6. 7 which took place in Batang County, Sichuan Province, from April to Sept., 1989. Temporal sequence of the swarm was characterized by obvious sectional release process, in dex rise of creeping curve, certain order behavior among the peak values in the early sequence, transient tranquility before strong aftershocks and abnormal high values in sequential entropy. Subsequence of the swarm were represented by the forms of isolation pattern and mainshock-aftershock pattern,changed from the former pattern to the latter and characterized by fast-slow-fast attenuating pattern. According to time fractional dimension calculation results of the swarm sequence and the subsequences, it was discovered that non-scaling regions existed in the complicated temporal sequence structure, the span of non-scaling region of capacity dimension Do was different from that of the information dimension D1 of the same sequence, and the self-organizational features of the same sequence were different when various magnitude threshold values were selected for calculating. From the stochastic non-uniform spread of swarming high fractures in the seismic regions, it was primarily explained that the exponential attenuation of time sequence variation was likely to occur.Meanwhile, the level structures of various order sequences of the strong seismic swarm and the order problems were discussed.
基金Supported by the National Natural Science Foundation of China(91338101,91338108,61132002,6132106)Research Fund of Tsinghua University(2011Z05117)Co-innovation Laboratory of Aerospace Broadband Network Technology
文摘The scheduling efficiency of the tracking and data relay satellite system（TDRSS）is strictly limited by the scheduling degrees of freedom（DoF）,including time DoF defined by jobs＇ flexible time windows and spatial DoF brought by multiple servable tracking and data relay satellites（TDRSs）.In this paper,ageneralized multiple time windows（GMTW）model is proposed to fully exploit the time and spatial DoF.Then,the improvements of service capability and job-completion probability based on the GMTW are theoretically proved.Further,an asymmetric path-relinking（APR）based heuristic job scheduling framework is presented to maximize the usage of DoF provided by the GMTW.Simulation results show that by using our proposal 11%improvement of average jobcompletion probability can be obtained.Meanwhile,the computing time of the time-to-target can be shorten to 1/9 of the GRASP.
基金National Science Foundation of China(Nos.41801388,41901397)。
文摘The existing multi-source contour matching studies have focused on the matching methods with consideration of topological relations and similarity measurement based on spatial Euclidean distance,while it is lack of taking the contour geometric features into account,which may lead to mismatching in map boundaries and areas with intensive contours or extreme terrain changes.In light of this,it is put forward that a matching strategy from coarse to precious based on the contour geometric features.The proposed matching strategy can be described as follows.Firstly,the point sequence is converted to feature sequence according to a feature descriptive function based on curvature and angle of normal vector.Then the level of similarity among multi-source contours is calculated by using the longest common subsequence solution.Accordingly,the identical contours could be matched based on the above calculated results.In the experiment for the proposed method,the reliability and efficiency of the matching method are verified using simulative datasets and real datasets respectively.It has been proved that the proposed contour matching strategy has a high matching precision and good applicability.
基金supported by the Ministry of Science and Technology,Taiwan,under Grant Nos.MOST 111-2221-E-390-012 and MOST 111-2622-E-390-001.
文摘Our previous work has introduced the newly generated program using the code transformation model GPT-2,verifying the generated programming codes through simhash(SH)and longest common subsequence(LCS)algo-rithms.However,the entire code transformation process has encountered a time-consuming problem.Therefore,the objective of this study is to speed up the code transformation process signicantly.This paper has proposed deep learning approaches for modifying SH using a variational simhash(VSH)algorithm and replacing LCS with a piecewise longest common subsequence(PLCS)algorithm to faster the verication process in the test phase.Besides the code transformation model GPT-2,this study has also introduced MicrosoMASS and Facebook BART for a comparative analysis of their performance.Meanwhile,the explainable AI technique using local interpretable model-agnostic explanations(LIME)can also interpret the decision-making ofAImodels.The experimental results show that VSH can reduce the number of qualied programs by 22.11%,and PLCS can reduce the execution time of selected pocket programs by 32.39%.As a result,the proposed approaches can signicantly speed up the entire code transformation process by 1.38 times on average compared with our previous work.
文摘This paper investigates a procedure developed and reports on experiments performed to studying the utility of applying a combined structural property of a text’s sentences and term expansion using WordNet [1] and a local thesaurus [2] in the selection of the most appropriate extractive text summarization for a particular document. Sentences were tagged and normalized then subjected to the Longest Common Subsequence (LCS) algorithm [3] [4] for the selection of the most similar subset of sentences. Calculated similarity was based on LCS of pairs of sentences that make up the document. A normalized score was calculated and used to rank sentences. A selected top subset of the most similar sentences was then tokenized to produce a set of important keywords or terms. The produced terms were further expanded into two subsets using 1) WorldNet;and 2) a local electronic dictionary/thesaurus. The three sets obtained (the original and the expanded two) were then re-cycled to further refine and expand the list of selected sentences from the original document. The process was repeated a number of times in order to find the best representative set of sentences. A final set of the top (best) sentences was selected as candidate sentences for summarization. In order to verify the utility of the procedure, a number of experiments were conducted using an email corpus. The results were compared to those produced by human annotators as well as to results produced using some basic sentences similarity calculation method. Produced results were very encouraging and compared well to those of human annotators and Jacquard sentences similarity.
基金Project(51274250)supported by the National Natural Science Foundation of ChinaProject(2012BAK09B02-05)supported by the National Key Technology R&D Program during the 12th Five-year Plan of China
文摘An integration processing system of three-dimensional laser scanning information visualization in goaf was developed. It is provided with multiple functions, such as laser scanning information management for goaf, cloud data de-noising optimization, construction, display and operation of three-dimensional model, model editing, profile generation, calculation of goaf volume and roof area, Boolean calculation among models and interaction with the third party soft ware. Concerning this system with a concise interface, plentiful data input/output interfaces, it is featured with high integration, simple and convenient operations of applications. According to practice, in addition to being well-adapted, this system is favorably reliable and stable.
