The loss of control over movement is one of the most devastating consequences of Parkinson’s disease(PD).The loss of control largely results from the gradual but inexorable destruction of dopamine-producing neurons i...The loss of control over movement is one of the most devastating consequences of Parkinson’s disease(PD).The loss of control largely results from the gradual but inexorable destruction of dopamine-producing neurons in the substantia nigra pars compacta.As dopamine levels fall,the ability to initiate,control,learn,and sustain actions declines.Treatment with the dopamine precursor levodopa can partly overcome motor impairments;however,years of use often leads to levodopa-induced dyskinesia(LID),a debilitating condition characterized by uncontrolled writhing and ballistic movements,making continued treatment difficult or impossible.While progress has been made towards unraveling the molecular and cellular processes driving the development of LID,far less is known about the changes in ongoing neuronal activity that contribute to LID expression.展开更多
Correction to:Nano-Micro Letters(2025)17:123 https://doi.org/10.1007/s40820-025-01654-y Following publication of the original article[1],the authors reported that Dr.Mohamed Bououdina’s affiliation needed to be corre...Correction to:Nano-Micro Letters(2025)17:123 https://doi.org/10.1007/s40820-025-01654-y Following publication of the original article[1],the authors reported that Dr.Mohamed Bououdina’s affiliation needed to be corrected from 1 to 2.The correct author affiliation has been provided in this Correction and the original article[1]has been corrected.展开更多
Rare-earth based frustrated magnets have attracted great attention as excellent candidates for magnetic refrigeration at sub-Kelvin temperatures,while the experimental identification of systems exhibiting both large v...Rare-earth based frustrated magnets have attracted great attention as excellent candidates for magnetic refrigeration at sub-Kelvin temperatures,while the experimental identification of systems exhibiting both large volumetric cooling capacity and reduced working temperatures far below 1K remains a challenge.Here,through ultra-low temperature magnetism and thermodynamic characterizations,we unveil the large magnetocaloric effect(MCE)realized at sub-Kelvin temperatures in the frustrated Kagome antiferromagnet Gd_(3)BWO_(9) with T_(N)∼1.0 K.The isothermal magnetization curves indicate the existence of field(B)induced anisotropic magnetic phase diagrams,where four distinct magnetic phases for B‖c-axis and five magnetic phases for B‖ab-plane are identified at T<T_(N).The analysis of magnetic entropy S(B,T)data and direct adiabatic demagnetization tests reveal remarkable cooling performance at sub-Kelvin temperatures featured by a large volumetric entropy density of 502.2 mJ/K/cm^(3)and a low attainable minimal temperature T_(min)∼168mK from the initial cooling condition of 2K and 6 T,surpassing most Gd-based refrigerants previously documented in temperature ranges of 0.25–4 K.The realized T_(min)∼168mK far below T_(N)∼1.0K in Gd_(3)BWO_(9) is related to the combined effects of magnetic frustration and criticality-enhanced MCE,which together leave substantial magnetic entropy at reduced temperatures by enhancing spin fluctuations.展开更多
Introduction: Family planning is one of the pillars of the Safe Motherhood Initiative which is aimed at reducing unwanted pregnancy and maternal death. Objective: To evaluate the uptake, efficacy, and safety profile o...Introduction: Family planning is one of the pillars of the Safe Motherhood Initiative which is aimed at reducing unwanted pregnancy and maternal death. Objective: To evaluate the uptake, efficacy, and safety profile of 68 mg etonogestrel subdermal implant in Alex Ekwueme Federal University Teaching Hospital Abakaliki (AEFUTHA), Ebonyi State. Materials and Methods: A 5-year retrospective descriptive analysis was carried out on 68 mg etonogestrel subdermal implant uptake among family planning attendees in AEFUTHA. The medical records of the clients that had 68 mg etonogestrel subdermal implant insertion were studied. Socio-demographic characteristics, side effects, discontinuation, and reasons for discontinuation were extracted and analyzed. Analysis was done with SPSS version 20. Data obtained were represented using frequency tables and pie chart. Results: During the study period, 2538 women accepted various methods of contraception, 14.3% (364) of the women used Implanon. The mean age of 68 mg etonogestrel subdermal implant users was 30.7 ± 13.4 years with a range of 20 - 44. Multiparous clients constituted 54.5%. The majority (55.2%) had secondary education as their highest level of education. Less than 20% of the acceptors had side effects, the commonest 24 (42.9%) being prolonged menstrual flow and followed by irregular menstrual flow 18 (32.1%). Discontinuation rate was 17.9%;desire to conceive. 40 (61.5%) was the commonest reason for discontinuation. Only one (0.3%) acceptor reported serious itching at the site of insertion. None of the women reported pregnancy during the period of use (Pearl Index = 0). Conclusion: The acceptance rate of 68 mg etonogestrel subdermal implant among the women is low, however, it is found be effective with good continuation rate in the center. Efforts should be made to increase its uptake so as to prevent unwanted pregnancy and associated sequelae.展开更多
Background: Unsafe abortion (USA) is defined as the termination of a non-desired pregnancy, performed by an unqualified person or in an environment without minimum medical standards, or both. It can impact negatively ...Background: Unsafe abortion (USA) is defined as the termination of a non-desired pregnancy, performed by an unqualified person or in an environment without minimum medical standards, or both. It can impact negatively the fertility in the future by tubo-peritoneal lesions. The current study aimed to highlight the infertility factors associated with USA. Material and Methods: From January 1st 2000 to December 31st 2021, a total of 3876 patients that sought care for infertility in the University Clinic of Kinshasa and the Edith Medical Center were enrolled. The socio-demographic, clinical and paraclinical variables were recorded and analyzed in relation to USA history. Results: The patients’ average age was 33.4 ± 5.7 years. Half of them were housewives;about sixty percent of the patients were nulliparous (59.31%). Seventy percent had a secondary infertility with 43.33% having a history of unsafe abortion. The main diagnosis was genital infections and uterus myoma. The chronic endometritis, bilateral tubal occlusion and Uterine synechiae were more associated with USA group. The spermogram anomalies and other partners’ lesions seemed of infectious origin. Conclusion: The USA remains a more frequent phenomenon in our setting. The chronic endometritis, bilateral tubal occlusion, uterine synechiae and indirectly uterus myoma were the infertility factors related to USA. The genital infection of any origin seems to be the main denominator underlying the female and the male infertility in our setting.展开更多
目的该研究聚焦于放射科住培医师亚专科报告书写岗位胜任力评估,旨在探究应用大语言模型进行自动化评价的可行性。方法以放射科乳腺亚专科住培医师报告为研究对象,模拟包含不同错误类型的100份乳腺X线摄影报告和100份乳腺MRI报告。通过...目的该研究聚焦于放射科住培医师亚专科报告书写岗位胜任力评估,旨在探究应用大语言模型进行自动化评价的可行性。方法以放射科乳腺亚专科住培医师报告为研究对象,模拟包含不同错误类型的100份乳腺X线摄影报告和100份乳腺MRI报告。通过乳腺组亚专科负责医师及教学主任协商制定岗位胜任力评价表,采用大语言模型思维链模式分步输入指令进行报告胜任力分级,并与人工分级结果对比。结果与人工相比,大语言模型(Large Language Model,LLM)判读时间仅0.13小时,效率优势显著,其分级准确性稍高于低年资带教师资,与高年资带教师资相近,且在不同级别岗位胜任力判定上表现稳定。在引入多种错误的报告中,LLM准确性达91.3%,表明能够较好进行分级优先级划分,但对MRI报告书写评价的准确率低于MM,分别为89%和93%。结论LLM用于放射科住培医师亚专科报告书写岗位胜任力评价具有准确性高、效率高、结果稳定等优势,可为住培教学评估提供有力支持,但LLM仍有处理及分析复杂文本时存在限制以及需要人工参与进行思维链提示输入等不足,未来需要进一步地探索与研究。展开更多
单点控制策略燃油经济性好,但电池经常大功率充放电,寿命衰减快;多点控制策略电池衰减慢,但燃油经济性较差。针对上述情况,提出一种基于电池荷电状态(state of charge,SOC)的分区域多点控制策略,根据APU需求功率和SOC范围调整APU工作区...单点控制策略燃油经济性好,但电池经常大功率充放电,寿命衰减快;多点控制策略电池衰减慢,但燃油经济性较差。针对上述情况,提出一种基于电池荷电状态(state of charge,SOC)的分区域多点控制策略,根据APU需求功率和SOC范围调整APU工作区域及工作点。仿真结果显示:NEDC工况下,与APU分区域多点控制策略相比,单点控制策略的综合百公里油耗提高5.11%,经济性提高5.45%,但电池容量衰减量增加4.20%;多点控制策略的百公里油耗降低11.04%,经济性降低17.41%,但电池容量衰减量减小12.33%。分区域多点控制策略在整车经济性与动力电池衰减的性能方面均表现良好。在WLTC工况下,3种控制策略的优缺点与NEDC工况下仿真结果一致。硬件在环仿真结果表明,分区域多点控制策略的性能与模型在环仿真结果基本一致。展开更多
基金supported by Arizona Biomedical Research Commission[ADHS18-198846]the National Institute of Health NINDS[R56-NS109608 and R01-NS122805]Davies,Robert and Peyton,Parkinson’s Disease Research Fund to TF.
文摘The loss of control over movement is one of the most devastating consequences of Parkinson’s disease(PD).The loss of control largely results from the gradual but inexorable destruction of dopamine-producing neurons in the substantia nigra pars compacta.As dopamine levels fall,the ability to initiate,control,learn,and sustain actions declines.Treatment with the dopamine precursor levodopa can partly overcome motor impairments;however,years of use often leads to levodopa-induced dyskinesia(LID),a debilitating condition characterized by uncontrolled writhing and ballistic movements,making continued treatment difficult or impossible.While progress has been made towards unraveling the molecular and cellular processes driving the development of LID,far less is known about the changes in ongoing neuronal activity that contribute to LID expression.
文摘Correction to:Nano-Micro Letters(2025)17:123 https://doi.org/10.1007/s40820-025-01654-y Following publication of the original article[1],the authors reported that Dr.Mohamed Bououdina’s affiliation needed to be corrected from 1 to 2.The correct author affiliation has been provided in this Correction and the original article[1]has been corrected.
基金supported by the National Key Research and Development Program(Grant Nos.2024YFA1611200 and 2023YFA1406500)the National Natural Science Foundation of China(Grant Nos.12141002 and 52088101)the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB1270000)。
文摘Rare-earth based frustrated magnets have attracted great attention as excellent candidates for magnetic refrigeration at sub-Kelvin temperatures,while the experimental identification of systems exhibiting both large volumetric cooling capacity and reduced working temperatures far below 1K remains a challenge.Here,through ultra-low temperature magnetism and thermodynamic characterizations,we unveil the large magnetocaloric effect(MCE)realized at sub-Kelvin temperatures in the frustrated Kagome antiferromagnet Gd_(3)BWO_(9) with T_(N)∼1.0 K.The isothermal magnetization curves indicate the existence of field(B)induced anisotropic magnetic phase diagrams,where four distinct magnetic phases for B‖c-axis and five magnetic phases for B‖ab-plane are identified at T<T_(N).The analysis of magnetic entropy S(B,T)data and direct adiabatic demagnetization tests reveal remarkable cooling performance at sub-Kelvin temperatures featured by a large volumetric entropy density of 502.2 mJ/K/cm^(3)and a low attainable minimal temperature T_(min)∼168mK from the initial cooling condition of 2K and 6 T,surpassing most Gd-based refrigerants previously documented in temperature ranges of 0.25–4 K.The realized T_(min)∼168mK far below T_(N)∼1.0K in Gd_(3)BWO_(9) is related to the combined effects of magnetic frustration and criticality-enhanced MCE,which together leave substantial magnetic entropy at reduced temperatures by enhancing spin fluctuations.
文摘Introduction: Family planning is one of the pillars of the Safe Motherhood Initiative which is aimed at reducing unwanted pregnancy and maternal death. Objective: To evaluate the uptake, efficacy, and safety profile of 68 mg etonogestrel subdermal implant in Alex Ekwueme Federal University Teaching Hospital Abakaliki (AEFUTHA), Ebonyi State. Materials and Methods: A 5-year retrospective descriptive analysis was carried out on 68 mg etonogestrel subdermal implant uptake among family planning attendees in AEFUTHA. The medical records of the clients that had 68 mg etonogestrel subdermal implant insertion were studied. Socio-demographic characteristics, side effects, discontinuation, and reasons for discontinuation were extracted and analyzed. Analysis was done with SPSS version 20. Data obtained were represented using frequency tables and pie chart. Results: During the study period, 2538 women accepted various methods of contraception, 14.3% (364) of the women used Implanon. The mean age of 68 mg etonogestrel subdermal implant users was 30.7 ± 13.4 years with a range of 20 - 44. Multiparous clients constituted 54.5%. The majority (55.2%) had secondary education as their highest level of education. Less than 20% of the acceptors had side effects, the commonest 24 (42.9%) being prolonged menstrual flow and followed by irregular menstrual flow 18 (32.1%). Discontinuation rate was 17.9%;desire to conceive. 40 (61.5%) was the commonest reason for discontinuation. Only one (0.3%) acceptor reported serious itching at the site of insertion. None of the women reported pregnancy during the period of use (Pearl Index = 0). Conclusion: The acceptance rate of 68 mg etonogestrel subdermal implant among the women is low, however, it is found be effective with good continuation rate in the center. Efforts should be made to increase its uptake so as to prevent unwanted pregnancy and associated sequelae.
文摘Background: Unsafe abortion (USA) is defined as the termination of a non-desired pregnancy, performed by an unqualified person or in an environment without minimum medical standards, or both. It can impact negatively the fertility in the future by tubo-peritoneal lesions. The current study aimed to highlight the infertility factors associated with USA. Material and Methods: From January 1st 2000 to December 31st 2021, a total of 3876 patients that sought care for infertility in the University Clinic of Kinshasa and the Edith Medical Center were enrolled. The socio-demographic, clinical and paraclinical variables were recorded and analyzed in relation to USA history. Results: The patients’ average age was 33.4 ± 5.7 years. Half of them were housewives;about sixty percent of the patients were nulliparous (59.31%). Seventy percent had a secondary infertility with 43.33% having a history of unsafe abortion. The main diagnosis was genital infections and uterus myoma. The chronic endometritis, bilateral tubal occlusion and Uterine synechiae were more associated with USA group. The spermogram anomalies and other partners’ lesions seemed of infectious origin. Conclusion: The USA remains a more frequent phenomenon in our setting. The chronic endometritis, bilateral tubal occlusion, uterine synechiae and indirectly uterus myoma were the infertility factors related to USA. The genital infection of any origin seems to be the main denominator underlying the female and the male infertility in our setting.
文摘目的该研究聚焦于放射科住培医师亚专科报告书写岗位胜任力评估,旨在探究应用大语言模型进行自动化评价的可行性。方法以放射科乳腺亚专科住培医师报告为研究对象,模拟包含不同错误类型的100份乳腺X线摄影报告和100份乳腺MRI报告。通过乳腺组亚专科负责医师及教学主任协商制定岗位胜任力评价表,采用大语言模型思维链模式分步输入指令进行报告胜任力分级,并与人工分级结果对比。结果与人工相比,大语言模型(Large Language Model,LLM)判读时间仅0.13小时,效率优势显著,其分级准确性稍高于低年资带教师资,与高年资带教师资相近,且在不同级别岗位胜任力判定上表现稳定。在引入多种错误的报告中,LLM准确性达91.3%,表明能够较好进行分级优先级划分,但对MRI报告书写评价的准确率低于MM,分别为89%和93%。结论LLM用于放射科住培医师亚专科报告书写岗位胜任力评价具有准确性高、效率高、结果稳定等优势,可为住培教学评估提供有力支持,但LLM仍有处理及分析复杂文本时存在限制以及需要人工参与进行思维链提示输入等不足,未来需要进一步地探索与研究。
文摘单点控制策略燃油经济性好,但电池经常大功率充放电,寿命衰减快;多点控制策略电池衰减慢,但燃油经济性较差。针对上述情况,提出一种基于电池荷电状态(state of charge,SOC)的分区域多点控制策略,根据APU需求功率和SOC范围调整APU工作区域及工作点。仿真结果显示:NEDC工况下,与APU分区域多点控制策略相比,单点控制策略的综合百公里油耗提高5.11%,经济性提高5.45%,但电池容量衰减量增加4.20%;多点控制策略的百公里油耗降低11.04%,经济性降低17.41%,但电池容量衰减量减小12.33%。分区域多点控制策略在整车经济性与动力电池衰减的性能方面均表现良好。在WLTC工况下,3种控制策略的优缺点与NEDC工况下仿真结果一致。硬件在环仿真结果表明,分区域多点控制策略的性能与模型在环仿真结果基本一致。
