OBJECTIVE: To investigate the effectiveness and safety of Zhu-yuan decoction(ZYD) in patients after functional endoscopic sinus surgery(FESS).METHODS: A total of 85 patients were randomized into two groups: 44 were tr...OBJECTIVE: To investigate the effectiveness and safety of Zhu-yuan decoction(ZYD) in patients after functional endoscopic sinus surgery(FESS).METHODS: A total of 85 patients were randomized into two groups: 44 were treated with intranasal corticosteroids(INC), and 41 were given Chinese herbal medicine(CHM). Patients with chronic rhinosinusitis(CRS) who underwent FESS were prospectively enrolled in the study. Before surgery, they were evaluated by visual analog scale(VAS), nasal endoscopy, computed tomography(CT), and routine blood test. After surgery, they were randomized to take ZYD or INC for 12 weeks and revaluated by VAS; nasal endoscopy at 4, 8, and 12 weeks;and CT at 12 weeks after surgery.RESULTS: In the both groups, VAS and endoscopyscores decreased significantly at 4, 8, and 12 weeks,and CT scores after treatment declined at 12 weeks compared with baseline scores. No significant differences were observed with regard to postoperative VAS, endoscopy, or CT scores between groups.ZYD, combined with surgery, can reduce VAS, nasal endoscopy, and CT scores and has the same efficacy and safety profile as INC in post-FESS management.No fatalities or major adverse events occurred in either group.CONCLUSION: Our findings suggest that ZYD has similar effects and safety profiles in patients after FESS compared with INC.展开更多
Objective：To investigate the influences of urapidil and nicardipine on rabbit sinus function, atrio-ventricular node function and hemodynamics. Methods：Thirty-two Angora＇ s rabbits were selected and randomly divide...Objective：To investigate the influences of urapidil and nicardipine on rabbit sinus function, atrio-ventricular node function and hemodynamics. Methods：Thirty-two Angora＇ s rabbits were selected and randomly divided into four groups. U1 group：urapidil 0.25 mg/kg; U2 group：urapidil 0.5 mg/kg; N1 group：nicardipine 10 μg/kg; N2 group： nicardipine 20 μg/kg. All these medicine were administrated within 30 seconds. Measurements were taken before and after the administration of urapidil or nicardipine for the following data： mean blood pressure（MAP）, heart rate（HR）, sino-atrial conduction time（SACT）, maximal sinoatrial recovery time（SNRTmax） corrected sinus node recovery time（CSNRT）, index of sinus node recovery time（SNRTI）, Wenckebach A-V conduction frequency （WB）, and P-R interval. Results：Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine. No significant changes could be found in the rest of the parameters. Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group（P 〈 0.01）; the MAP decreased（P 〈 0.01） and the HR increased drastically（P〈 0.01）. Conclusions：Neither urapidil（0.25 mg/kg, 0,5 mg/kg） nor nicardipine（10 μg/kg, 20 μg/kg） has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function. Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.展开更多
Objectives:Balloon sinuplasty(BSP)and functional endoscopic sinus surgery(FESS)have undergone changes in utilization over time.This study investigates national trends in BSP and FESS and postoperative outcomes over th...Objectives:Balloon sinuplasty(BSP)and functional endoscopic sinus surgery(FESS)have undergone changes in utilization over time.This study investigates national trends in BSP and FESS and postoperative outcomes over the last decade as well as the impact of Corona Virus Disease 2019(COVID-19)on these trends.Methods:The TriNetX database was queried for patients undergoing either FESS or BSP from 1/1/2011 to 5/4/2024.Data were collected on patient demographics,diagnoses,and postoperative outcomes.Results:A total of 1738 patients underwent BSP and 90,311 underwent FESS.A greater proportion of FESS patients had diabetes(p=0.001),hypertension(p<0.001),and chronic pulmonary disease,p=0.001)compared to BSP whereas a similar proportion of patients for both cohorts had a history of ischemic heart disease(p=0.73).Body mass index was higher for patients undergoing FESS(28.6±6.5)compared to BSP(28.1±6.578;p=0.02).Overall postoperative complications were similar between BSP and FESS(odds ratio[OR]=0.80,95%confidence interval[CI]=0.58-1.09)with similar rates of epistaxis(OR=0.77,95%CI=0.53-1.12)and cerebrospinal fluid(CSF)leak(OR=0.14,95%CI=0.01-2.25).Overall revision rate was higher for FESS(OR=0.34,95%CI=0.21-0.57).Thirty-day readmission(OR=0.44,95%CI=0.29-0.66)and Emergency Department visits(OR=0.51,95%CI=0.28-0.92)were less common in patients who received BSP.Surgical volume consistently increased over time for both cohorts but at a more rapid pace for BSP(425.64%)compared to FESS(274.19%)and a dramatic decrease in volume by 44.85%and 22.28%,respectively,at the onset of COVID-19.Conclusion:Overall,BSP and FESS surgical volume have steadily increased over time with a drastic reduction following the COVID-19 pandemic.BSP and FESS carry different complication profiles emphasizing the importance of patient selection and preoperative counseling.展开更多
基金Supported by the 3-year Major Support Project for Traditional Chinese Medicine Cause of Shanghai for the Treatment of Chronic Nasosinusitis(No.ZYSNXD-CC-ZDYJ026)
文摘OBJECTIVE: To investigate the effectiveness and safety of Zhu-yuan decoction(ZYD) in patients after functional endoscopic sinus surgery(FESS).METHODS: A total of 85 patients were randomized into two groups: 44 were treated with intranasal corticosteroids(INC), and 41 were given Chinese herbal medicine(CHM). Patients with chronic rhinosinusitis(CRS) who underwent FESS were prospectively enrolled in the study. Before surgery, they were evaluated by visual analog scale(VAS), nasal endoscopy, computed tomography(CT), and routine blood test. After surgery, they were randomized to take ZYD or INC for 12 weeks and revaluated by VAS; nasal endoscopy at 4, 8, and 12 weeks;and CT at 12 weeks after surgery.RESULTS: In the both groups, VAS and endoscopyscores decreased significantly at 4, 8, and 12 weeks,and CT scores after treatment declined at 12 weeks compared with baseline scores. No significant differences were observed with regard to postoperative VAS, endoscopy, or CT scores between groups.ZYD, combined with surgery, can reduce VAS, nasal endoscopy, and CT scores and has the same efficacy and safety profile as INC in post-FESS management.No fatalities or major adverse events occurred in either group.CONCLUSION: Our findings suggest that ZYD has similar effects and safety profiles in patients after FESS compared with INC.
文摘Objective：To investigate the influences of urapidil and nicardipine on rabbit sinus function, atrio-ventricular node function and hemodynamics. Methods：Thirty-two Angora＇ s rabbits were selected and randomly divided into four groups. U1 group：urapidil 0.25 mg/kg; U2 group：urapidil 0.5 mg/kg; N1 group：nicardipine 10 μg/kg; N2 group： nicardipine 20 μg/kg. All these medicine were administrated within 30 seconds. Measurements were taken before and after the administration of urapidil or nicardipine for the following data： mean blood pressure（MAP）, heart rate（HR）, sino-atrial conduction time（SACT）, maximal sinoatrial recovery time（SNRTmax） corrected sinus node recovery time（CSNRT）, index of sinus node recovery time（SNRTI）, Wenckebach A-V conduction frequency （WB）, and P-R interval. Results：Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine. No significant changes could be found in the rest of the parameters. Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group（P 〈 0.01）; the MAP decreased（P 〈 0.01） and the HR increased drastically（P〈 0.01）. Conclusions：Neither urapidil（0.25 mg/kg, 0,5 mg/kg） nor nicardipine（10 μg/kg, 20 μg/kg） has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function. Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.
文摘Objectives:Balloon sinuplasty(BSP)and functional endoscopic sinus surgery(FESS)have undergone changes in utilization over time.This study investigates national trends in BSP and FESS and postoperative outcomes over the last decade as well as the impact of Corona Virus Disease 2019(COVID-19)on these trends.Methods:The TriNetX database was queried for patients undergoing either FESS or BSP from 1/1/2011 to 5/4/2024.Data were collected on patient demographics,diagnoses,and postoperative outcomes.Results:A total of 1738 patients underwent BSP and 90,311 underwent FESS.A greater proportion of FESS patients had diabetes(p=0.001),hypertension(p<0.001),and chronic pulmonary disease,p=0.001)compared to BSP whereas a similar proportion of patients for both cohorts had a history of ischemic heart disease(p=0.73).Body mass index was higher for patients undergoing FESS(28.6±6.5)compared to BSP(28.1±6.578;p=0.02).Overall postoperative complications were similar between BSP and FESS(odds ratio[OR]=0.80,95%confidence interval[CI]=0.58-1.09)with similar rates of epistaxis(OR=0.77,95%CI=0.53-1.12)and cerebrospinal fluid(CSF)leak(OR=0.14,95%CI=0.01-2.25).Overall revision rate was higher for FESS(OR=0.34,95%CI=0.21-0.57).Thirty-day readmission(OR=0.44,95%CI=0.29-0.66)and Emergency Department visits(OR=0.51,95%CI=0.28-0.92)were less common in patients who received BSP.Surgical volume consistently increased over time for both cohorts but at a more rapid pace for BSP(425.64%)compared to FESS(274.19%)and a dramatic decrease in volume by 44.85%and 22.28%,respectively,at the onset of COVID-19.Conclusion:Overall,BSP and FESS surgical volume have steadily increased over time with a drastic reduction following the COVID-19 pandemic.BSP and FESS carry different complication profiles emphasizing the importance of patient selection and preoperative counseling.
