The structural imbalance of supply and demand of agricultural products is the result of agricultural products overemphasizing quantitative growth and neglecting quality improvement. The structural reform of agricultur...The structural imbalance of supply and demand of agricultural products is the result of agricultural products overemphasizing quantitative growth and neglecting quality improvement. The structural reform of agricultural supply side is to optimize the allocation of agricultural production factors,improve the quality and efficiency of supply,and meet the quality needs of consumers. The optimization of agricultural supply factors is the result of effective supply,rational allocation and comprehensive utilization of natural resources and social resources. The success of Chu Orange Manor has explained the function of the optimization of supply factors to the development of characteristic agriculture. That is,it has promoted the development of high-end agriculture,promoted the brand value of agricultural products,promoted the competitiveness of agriculture,broken the international green trade barrier of agricultural products,promoted the development of modern agriculture with characteristics,and realized the sustainable development of rural areas.展开更多
The supply-side reform is an important measure for the high-quality development of China's economy in the new era. The purpose of this paper is to explore the mechanism and influence of technological progress,huma...The supply-side reform is an important measure for the high-quality development of China's economy in the new era. The purpose of this paper is to explore the mechanism and influence of technological progress,human capital,consumption demand,resource endowment and government intervention on the adjustment and upgrading of industrial structure,and to deepen the understanding of supply-side reform.展开更多
Based on the present coupled mode theory of the photonic crystal resonator array in this paper, we propose a novel side-coupled waveguide to achieve highly efficient coupling of photonic crystal devices. It is found t...Based on the present coupled mode theory of the photonic crystal resonator array in this paper, we propose a novel side-coupled waveguide to achieve highly efficient coupling of photonic crystal devices. It is found that the coupling efficiency is sensitive to the interval, the total number and the quality factor of the resonator. Considering the coupling efficiency and the coupling region, we select five resonators with an interval of six lattice periods. By optimizing the structure parameters of the waveguide and resonator, the quality factors of the resonator can be modulated and the coupling efficiency of the side-coupled waveguide reaches 95.47% in theory. Compared with other coupling methods, the side-coupled waveguide can realize efficient coupling with a compact structure, a high level of integration and a low degree of operational difficulties.展开更多
Mounting evidence has shown that side population （SP） cells are enriched for cancer stem cells （CSCs） responsible for cancer malignancy. In this study, SP technology was used to isolate a small subpopulation of SP...Mounting evidence has shown that side population （SP） cells are enriched for cancer stem cells （CSCs） responsible for cancer malignancy. In this study, SP technology was used to isolate a small subpopulation of SP cells in human gallbladder cancer cell line GBC-SD, and SP cells which had superior potential for proliferation in vitro and tumorigenesis in vivo were identified. Importantly, the abundance of GBC-SD SP cells was increased by a transforming growth factor-β （TGF-β）-induced epithelial-mesenchymal transition （EMT）, and this effect was accompanied with a strong up-regulation of ABCG2 mRNA expression, and a decreased sensitivity to mitoxantrone. SP cells were restored upon the removal of TGF-β and the reversion of the cells to an epithelial phenotype, and smad3-specific siRNA reduced SP abundance in response to TGF-β. In conclusion, TGF-β-induced EMT by smad-dependent signaling pathway promotes cancer development and anti-cancer drug resistant phenotype by augmenting the abundance of GBC-SD SP cells, and a better understanding of mechanisms involved in TGF-β-induced EMT may provide a novel strategy for preventing cancer progression.展开更多
Background: Cerebrovascular disease is a worldwide health problem. Stroke, a type of cerebrovascular disease, caused by sudden loss of blood flow to parts of the brain, is the world’s second-leading cause of death an...Background: Cerebrovascular disease is a worldwide health problem. Stroke, a type of cerebrovascular disease, caused by sudden loss of blood flow to parts of the brain, is the world’s second-leading cause of death and third-leading cause of disability. It is critical to analyze risk factors to prevent cerebrovascular disease. Data and Methods: The risk factors for cerebrovascular disease were analyzed using data from 2,678,054 medical checkups obtained from the JMDC Claims Database. Logit models were used, and the odds ratio (OR) and confidence interval (CI) were calculated. The sample period was from January 2005 to September 2019. Results: Age and heart disease history were very important nonmodifiable factors. The OR comparing persons aged 70 to those aged 50 was 2.05 with a 95% CI of 1.92 - 2.05. A heart disease history was also an especially important factor (OR 2.29, 95% CI 2.18 - 2.41). Among the modifiable factors, triglyceride level and recent large weight change were very important factors, changing the risk of cerebrovascular disease by about 30%. Other significant modifiable factors were diastolic blood pressure, urine protein, having breakfast, walking ability and smoking;each of these changed the risk of cerebrovascular disease by about 10%. Taking medications to control hypertension, hyperglycemia and hypercholesterolemia respectively increased the risk of cerebrovascular disease. In particular, taking antihypertensive medications nearly doubled the risk (OR 1.93, 95% CI 1.86 - 2.00). Conclusion: It is very important for individuals with risk factors to improve their physical conditions to prevent cerebrovascular disease. Taking medications to control blood pressure, glucose level, and cholesterol might introduce risks for cerebrovascular disease. Since all medications have side effects, it is necessary to carefully manage the use of these medications to minimize the negative side effects. Limitations: The dataset was observatory. There were no experimental interventions. Further, the dataset contains only information of Japanese individuals, and the results might differ in other countries. As the data comprised claims from employment-based health insurance, the dataset includes no subjects aged 76 or over and relatively few aged 70 - 75. We need to analyze data of other countries and elderly people.展开更多
Utilities around the world have been considering Demand Side Management (DSM) in their strategic planning. The costs of constructing and operating a new capacity generation unit are increasing everyday as well as Tran...Utilities around the world have been considering Demand Side Management (DSM) in their strategic planning. The costs of constructing and operating a new capacity generation unit are increasing everyday as well as Transmission and distribution and land issues for new generation plants, which force the utilities to search for another alternatives without any additional constraints on customers comfort level or quality of delivered product. De can be defined as the selection, planning, and implementation of measures intended to have an influence on the demand or customer-side of the electric meter, either caused directly or stimulated indirectly by the utility. DSM programs are peak clipping, Valley filling, Load shifting, Load building, energy conservation and flexible load shape. The main Target of this paper is to show the relation between DSM and Load Forecasting. Moreover, it highlights on the effect of applying DSM on Forecasted demands and how this affects the planning strategies for utility companies. This target will be clearly illustrated through applying the developed algorithm in this paper on an existing residential compound in Cairo-Egypt.展开更多
基金Supported by Major Project of Yuxi Social Science Foundation in 2016-2017(YXSK134)
文摘The structural imbalance of supply and demand of agricultural products is the result of agricultural products overemphasizing quantitative growth and neglecting quality improvement. The structural reform of agricultural supply side is to optimize the allocation of agricultural production factors,improve the quality and efficiency of supply,and meet the quality needs of consumers. The optimization of agricultural supply factors is the result of effective supply,rational allocation and comprehensive utilization of natural resources and social resources. The success of Chu Orange Manor has explained the function of the optimization of supply factors to the development of characteristic agriculture. That is,it has promoted the development of high-end agriculture,promoted the brand value of agricultural products,promoted the competitiveness of agriculture,broken the international green trade barrier of agricultural products,promoted the development of modern agriculture with characteristics,and realized the sustainable development of rural areas.
文摘The supply-side reform is an important measure for the high-quality development of China's economy in the new era. The purpose of this paper is to explore the mechanism and influence of technological progress,human capital,consumption demand,resource endowment and government intervention on the adjustment and upgrading of industrial structure,and to deepen the understanding of supply-side reform.
基金Project supported by the National Natural Science Foundation of China (Grant No. 60877031)
文摘Based on the present coupled mode theory of the photonic crystal resonator array in this paper, we propose a novel side-coupled waveguide to achieve highly efficient coupling of photonic crystal devices. It is found that the coupling efficiency is sensitive to the interval, the total number and the quality factor of the resonator. Considering the coupling efficiency and the coupling region, we select five resonators with an interval of six lattice periods. By optimizing the structure parameters of the waveguide and resonator, the quality factors of the resonator can be modulated and the coupling efficiency of the side-coupled waveguide reaches 95.47% in theory. Compared with other coupling methods, the side-coupled waveguide can realize efficient coupling with a compact structure, a high level of integration and a low degree of operational difficulties.
基金supported by a grant from the National Natural Science Foundation of China(No.30772127)
文摘Mounting evidence has shown that side population （SP） cells are enriched for cancer stem cells （CSCs） responsible for cancer malignancy. In this study, SP technology was used to isolate a small subpopulation of SP cells in human gallbladder cancer cell line GBC-SD, and SP cells which had superior potential for proliferation in vitro and tumorigenesis in vivo were identified. Importantly, the abundance of GBC-SD SP cells was increased by a transforming growth factor-β （TGF-β）-induced epithelial-mesenchymal transition （EMT）, and this effect was accompanied with a strong up-regulation of ABCG2 mRNA expression, and a decreased sensitivity to mitoxantrone. SP cells were restored upon the removal of TGF-β and the reversion of the cells to an epithelial phenotype, and smad3-specific siRNA reduced SP abundance in response to TGF-β. In conclusion, TGF-β-induced EMT by smad-dependent signaling pathway promotes cancer development and anti-cancer drug resistant phenotype by augmenting the abundance of GBC-SD SP cells, and a better understanding of mechanisms involved in TGF-β-induced EMT may provide a novel strategy for preventing cancer progression.
文摘Background: Cerebrovascular disease is a worldwide health problem. Stroke, a type of cerebrovascular disease, caused by sudden loss of blood flow to parts of the brain, is the world’s second-leading cause of death and third-leading cause of disability. It is critical to analyze risk factors to prevent cerebrovascular disease. Data and Methods: The risk factors for cerebrovascular disease were analyzed using data from 2,678,054 medical checkups obtained from the JMDC Claims Database. Logit models were used, and the odds ratio (OR) and confidence interval (CI) were calculated. The sample period was from January 2005 to September 2019. Results: Age and heart disease history were very important nonmodifiable factors. The OR comparing persons aged 70 to those aged 50 was 2.05 with a 95% CI of 1.92 - 2.05. A heart disease history was also an especially important factor (OR 2.29, 95% CI 2.18 - 2.41). Among the modifiable factors, triglyceride level and recent large weight change were very important factors, changing the risk of cerebrovascular disease by about 30%. Other significant modifiable factors were diastolic blood pressure, urine protein, having breakfast, walking ability and smoking;each of these changed the risk of cerebrovascular disease by about 10%. Taking medications to control hypertension, hyperglycemia and hypercholesterolemia respectively increased the risk of cerebrovascular disease. In particular, taking antihypertensive medications nearly doubled the risk (OR 1.93, 95% CI 1.86 - 2.00). Conclusion: It is very important for individuals with risk factors to improve their physical conditions to prevent cerebrovascular disease. Taking medications to control blood pressure, glucose level, and cholesterol might introduce risks for cerebrovascular disease. Since all medications have side effects, it is necessary to carefully manage the use of these medications to minimize the negative side effects. Limitations: The dataset was observatory. There were no experimental interventions. Further, the dataset contains only information of Japanese individuals, and the results might differ in other countries. As the data comprised claims from employment-based health insurance, the dataset includes no subjects aged 76 or over and relatively few aged 70 - 75. We need to analyze data of other countries and elderly people.
文摘Utilities around the world have been considering Demand Side Management (DSM) in their strategic planning. The costs of constructing and operating a new capacity generation unit are increasing everyday as well as Transmission and distribution and land issues for new generation plants, which force the utilities to search for another alternatives without any additional constraints on customers comfort level or quality of delivered product. De can be defined as the selection, planning, and implementation of measures intended to have an influence on the demand or customer-side of the electric meter, either caused directly or stimulated indirectly by the utility. DSM programs are peak clipping, Valley filling, Load shifting, Load building, energy conservation and flexible load shape. The main Target of this paper is to show the relation between DSM and Load Forecasting. Moreover, it highlights on the effect of applying DSM on Forecasted demands and how this affects the planning strategies for utility companies. This target will be clearly illustrated through applying the developed algorithm in this paper on an existing residential compound in Cairo-Egypt.
