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慢性肾衰竭透析患者血清SP-D、PTX-3水平对合并细菌性肺炎的诊断效能
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作者 邵珏 李金玉 +1 位作者 汪成军 张赟辉 《热带医学杂志》 2025年第4期506-510,共5页
目的探讨慢性肾衰竭(CRF)透析患者血清表面活性蛋白-D(SP-D)、正五聚蛋白3(PTX-3)水平对合并细菌性肺炎的诊断效能,为临床早期诊断和有效治疗提供新的思路和方法。方法选取2019年10月-2023年10月黄山市人民医院收治的102例慢性肾衰竭透... 目的探讨慢性肾衰竭(CRF)透析患者血清表面活性蛋白-D(SP-D)、正五聚蛋白3(PTX-3)水平对合并细菌性肺炎的诊断效能,为临床早期诊断和有效治疗提供新的思路和方法。方法选取2019年10月-2023年10月黄山市人民医院收治的102例慢性肾衰竭透析患者作为研究对象,根据是否合并细菌性肺炎分为合并细菌性肺炎组(n=43)和未合并细菌性肺炎组(n=59)。采用酶联免疫吸附法检测所有研究对象血清SP-D、PTX-3水平。采用受试者工作特征(ROC)曲线评估血清SP-D、PTX-3水平对CRF患者合并细菌性肺炎的诊断价值,采用多因素logistic回归分析探讨CRF患者合并细菌性肺炎的影响因素。结果合并细菌性肺炎组患者血清SP-D、PTX-3水平显著高于未合并细菌性肺炎组,差异均有统计学意义(t=23.473、22.563,P均<0.05)。血清SP-D、PTX-3诊断慢性肾衰竭透析患者合并细菌性肺炎的曲线下面积(AUC)分别为0.832(95%CI:0.787~0.879)、0.746(95%CI:0.701~0.796),两者联合(串联实验)诊断的AUC为0.902(95%CI:0.858~0.951)。合并细菌性肺炎组患者年龄≥60岁比例、住院时间、合并疾病(糖尿病)、透析时间≥1年比例均高于未合并细菌性肺炎组,差异均有统计学意义(P均<0.05)。二分类logistic逐步回归分析显示,年龄≥60岁(OR=1.791,95%CI:1.225~2.620)、合并糖尿病(OR=2.762,95%CI:1.324~5.760)、血清SP-D≥188.27 g/L(OR=4.651,95%CI:1.822~11.868)、血清PTX-3≥17.83 ng/mL(OR=3.554,95%CI:1.741~7.253)是慢性肾衰竭透析患者合并细菌性肺炎的危险因素(P均<0.05)。结论血清SP-D、PTX-3水平在慢性肾衰竭透析合并细菌性肺炎患者中呈高表达,可作为诊断慢性肾衰竭透析患者合并细菌性肺炎潜在的生物学指标,两者联合诊断的效能更高。 展开更多
关键词 慢性肾衰竭 透析 细菌性肺炎 表面活性蛋白-d 正五聚蛋白3
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甘露糖蛋白、半乳甘露聚糖和1-3-β-D葡聚糖联合检测对艾滋病合并马尔尼菲篮状菌病的诊断价值
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作者 李小凤 张海燕 +1 位作者 何静 罗明 《中国热带医学》 北大核心 2025年第5期547-551,593,共6页
目的探讨甘露糖蛋白(mannoprotein,Mp1p)、半乳甘露聚糖(galactomannan,GM)和1-3-β-D葡聚糖(1-3-β-D glucan,BDG)单独和联合检测对艾滋病合并马尔尼菲篮状菌病(Talaromycosis marneffei,TSM)的诊断价值。方法收集291例艾滋病合并马尔... 目的探讨甘露糖蛋白(mannoprotein,Mp1p)、半乳甘露聚糖(galactomannan,GM)和1-3-β-D葡聚糖(1-3-β-D glucan,BDG)单独和联合检测对艾滋病合并马尔尼菲篮状菌病(Talaromycosis marneffei,TSM)的诊断价值。方法收集291例艾滋病合并马尔尼菲篮状菌住院患者和300例健康体检者外周血标本,检测Mp1p、GM和BDG并分析单独和联合检测诊断TSM的价值,采用ROC曲线分析Mp1p、GM、BDG和联合检测的诊断效能。结果在单独检测中,Mp1p、GM和BDG检测灵敏度和特异度之间差异有统计学意义(P<0.05),相较于GM和BDG,Mp1p的诊断效能最好,灵敏度和特异度最优。在两两联合检测中,Mp1p与GM组合灵敏度优于GM与BDG组合,差异有统计学意义(P<0.05);Mp1p与GM组合、Mp1p与BDG组合特异度优于GM与BDG组合,差异有统计学意义(P<0.05),Mp1p与GM组合的诊断效能最好。三者联合检测灵敏度优于两两联合检测,差异有统计学意义(P<0.05),Mp1p与GM组合、Mp1p与BDG组合特异度优于三者联合检测,差异有统计学意义(P<0.05)。Mp1p、GM、BDG检测阳性率分别在CD4^(+)T细胞计数≤100个/μL和>100个/μL患者中差异无统计学意义(P>0.05)。结论Mp1p、GM、BDG检测是艾滋病合并TSM早期辅助性诊断指标,其中Mp1p诊断效能优于GM和BDG,联合检测可提高诊断效能。 展开更多
关键词 甘露糖蛋白 半乳甘露聚糖 1-3-d葡聚糖 马尔尼菲篮状菌病 艾滋病
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3-D Lightning Location Solution and Precision Analysis of Cloud Flash 被引量:5
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作者 ZHANG Ping1,2, ZHAO Wenguang2,3?, HU Zhixiang2,3, WEN Yinping2,3 1. School of Architecture and Urban Planning, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China 2. School of Civil Engineering and Mechanics, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China 3. Hubei Key Laboratory of Control Structure, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China 《Wuhan University Journal of Natural Sciences》 CAS 2009年第3期241-244,共4页
Using the spatial coordinates of detection stations and the time of arrival of lightning wave, the observation equations can be expressed. For the large lightning detection network, the least square method is used to ... Using the spatial coordinates of detection stations and the time of arrival of lightning wave, the observation equations can be expressed. For the large lightning detection network, the least square method is used to process the adjustment of observation data to find the most probable value of lightning position, and the result is assessed by the mean error and dilution of precision. Lightning location precision is affected by figure factor. The conclusion can be used in the design of location network, data processing, and data analysis. 展开更多
关键词 3-d lightning location cloud flash detection solution model dilution of precision figure factor
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Fluid-based moderate collision avoidance for UAV formation in 3-D low-altitude environments 被引量:1
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作者 Menghua ZHANG Honglun WANG +5 位作者 Zhiyu LI Yanxiang WANG Xianglun ZHANG Qiang TANG Shichao MA Jianfa WU 《Chinese Journal of Aeronautics》 2025年第6期533-551,共19页
Aiming to address the Unmanned Aerial Vehicle(UAV) formation collision avoidance problem in Three-Dimensional(3-D) low-altitude environments where dense various obstacles exist, a fluid-based path planning framework n... Aiming to address the Unmanned Aerial Vehicle(UAV) formation collision avoidance problem in Three-Dimensional(3-D) low-altitude environments where dense various obstacles exist, a fluid-based path planning framework named the Formation Interfered Fluid Dynamical System(FIFDS) with Moderate Evasive Maneuver Strategy(MEMS) is proposed in this study.First, the UAV formation collision avoidance problem including quantifiable performance indexes is formulated. Second, inspired by the phenomenon of fluids continuously flowing while bypassing objects, the FIFDS for multiple UAVs is presented, which contains a Parallel Streamline Tracking(PST) method for formation keeping and the traditional IFDS for collision avoidance. Third, to rationally balance flight safety and collision avoidance cost, MEMS is proposed to generate moderate evasive maneuvers that match up with collision risks. Comprehensively containing the time and distance safety information, the 3-D dynamic collision regions are modeled for collision prediction. Then, the moderate evasive maneuver principle is refined, which provides criterions of the maneuver amplitude and direction. On this basis, an analytical parameter mapping mechanism is designed to online optimize IFDS parameters. Finally, the performance of the proposed method is validated by comparative simulation results and real flight experiments using fixed-wing UAVs. 展开更多
关键词 Unmanned aerial vehicle Formation collision avoidance:3-d low-altitude environments Interfered fluid dynamical system 3-d dynamic collision region
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Precise orbit determination for TH02-02 satellites based on BDS3 and GPS observations 被引量:3
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作者 Houzhe ZHANG Bing JU +4 位作者 Defeng GU Ying LIU Kai SHAO Xiaojun DUAN Zhiyong HUANG 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2023年第5期475-485,共11页
The Tianhui-202(TH02-02)satellite formation,as a supplement to the microwave mapping satellite system Tianhui-201(TH02-01),is the first Interferometric Synthetic Aperture Radar(InSAR)satellite formation-flying system ... The Tianhui-202(TH02-02)satellite formation,as a supplement to the microwave mapping satellite system Tianhui-201(TH02-01),is the first Interferometric Synthetic Aperture Radar(InSAR)satellite formation-flying system that supports the tracking of BeiDou global navigation Satellite system(BDS3)new B1C and B2a signals.Meanwhile,the twin TH02-02 satellites also support the tracking of Global Positioning System(GPS)L1&L2 and BDS B1I&B3I signals.As the spaceborne receiver employs two independent boards to track the Global Navigation Satellite System(GNSS)satellites,we design an orbit determination strategy by estimating independent receiver clock offsets epoch by epoch for each GNSS to realize the multi-GNSS data fusion from different boards.The performance of the spaceborne receiver is evaluated and the contribution of BDS3 to the kinematic and reduced-dynamic Precise Orbit Determination(POD)of TH02-02 satellites is investigated.The tracking data onboard shows that the average number of available BDS3 and GPS satellites are 8.7 and 9.1,respectively.The carrier-to-noise ratio and carrier phase noise of BDS3 B1C and B2a signals are comparable to those of GPS.However,strong azimuth-related systematic biases are recognized in the pseudorange multipath errors of B1C and B3I.The pseudorange noise of BDS3 signals is better than that of GPS after eliminating the multipath errors from specific signals.Taking the GPS-based reduced-dynamic orbit with single-receiver ambiguity fixing technique as a reference,the results of BDS3-only and BDS3+GPS combined POD are assessed.The Root Mean Square(RMS)of orbit comparison of BDS3-based kinematic and reduced-dynamic POD with reference orbit are better than 7 cm and 3 cm in three-Dimensional direction(3D).The POD performance based on B1C&B2a data is comparable to that based on B1I&B3I.The precision of BDS3+GPS combined kinematic orbit can reach up to 3 cm(3D RMS),which has a more than 25%improvement relative to the GPS-only solution.In addition,the consistency between the BDS3+GPS combined reduced-dynamic orbit and the GPS-based ambiguity-fixed orbit is better than 1.5 cm(3D RMS). 展开更多
关键词 BDS3 Multi-GNSS precise orbit determination Spaceborne GNSS receiver TH02-02
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Precise Orbit Determination for the FY-3C Satellite Using Onboard BDS and GPS Observations from 2013, 2015, and 2017 被引量:5
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作者 Xingxing Li Keke Zhang +4 位作者 Xiangguang Meng Wei Zhang Qian Zhang Xiaohong Zhang Xin Li 《Engineering》 SCIE EI 2020年第8期904-912,共9页
Using the FengYun-3C(FY-3C)onboard BeiDou Navigation Satellite System(BDS)and Global Positioning System(GPS)data from 2013 to 2017,this study investigates the performance and contribution of BDS to precise orbit deter... Using the FengYun-3C(FY-3C)onboard BeiDou Navigation Satellite System(BDS)and Global Positioning System(GPS)data from 2013 to 2017,this study investigates the performance and contribution of BDS to precise orbit determination(POD)for a low-Earth orbit(LEO).The overlap comparison result indicates that code bias correction of BDS can improve the POD accuracy by 12.4%.The multi-year averaged one-dimensional(1D)root mean square(RMS)of the overlapping orbit differences(OODs)for the GPS-only solution is 2.0,1.7,and 1.5 cm,respectively,during the 2013,2015,and 2017 periods.The 1D RMS for the BDS-only solution is 150.9,115.0,and 47.4 cm,respectively,during the 2013,2015,and 2017 periods,which is much worse than the GPS-only solution due to the regional system of BDS and the few BDS channels of the FY-3C receiver.For the BDS and GPS combined solution(also known as the GC combined solution),the averaged 1D RMS is 2.5,2.3,and 1.6 cm,respectively,in 2013,2015,and 2017,while the GC combined POD presents a significant accuracy improvement after the exclusion of geostationary Earth orbit(GEO)satellites.The main reason for the improvement seen after this exclusion is the unfavorable satellite tracking geometry and poor orbit accuracy of GEO satellites.The accuracy of BDS-only and GC combined solutions have gradually improved from 2013 to 2017,thanks to improvements in the accuracy of International GNSS Service(IGS)orbit and clock products in recent years,especially the availability of a high-frequency satellite clock product(30 s sampling interval)since 2015.Moreover,the GC POD(without GEO)was able to achieve slightly better accuracy than the GPS-only POD in 2017,indicating that the fusion of BDS and GPS observations can improve the accuracy of LEO POD.GC combined POD can significantly improve the reliability of LEO POD,simply due to system redundancy.An increased contribution of BDS to LEO POD can be expected with the launch of more BDS satellites and with further improvements in the accuracy of BDS satellite products in the near future. 展开更多
关键词 FengYun-3C LEO precise orbit determination(POD) Onboard BDS and GPS BDS code bias BDS/GPS combined POD
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Signal quality analysis and quality check of BDS3 Precise Point Positioning in the Arctic Ocean 被引量:2
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作者 Xiaoguo Guan Hongzhou Chai +3 位作者 Guorui Xiao Zhenqiang Du Wenlong Qi Xueping Wang 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2022年第2期166-179,共14页
This study analyzes the signal quality and the accuracy of BeiDou 3 rd generation Satellite Navigation System(BDS3) Precise Point Positioning(PPP) in the Arctic Ocean. Assessment of signal quality of BDS3 includes sig... This study analyzes the signal quality and the accuracy of BeiDou 3 rd generation Satellite Navigation System(BDS3) Precise Point Positioning(PPP) in the Arctic Ocean. Assessment of signal quality of BDS3 includes signal to noise ratio(SNR), multipath(MP), dilution of precision(DOP), and code-minus-carrier combination(CC). The results show that, 5 to 13 satellites are visible at any time in the Arctic Ocean area as of September 2018, which are sufficient for positioning. In the mid-latitude oceanic region and in the Arctic Ocean, the SNR is 25–52 dB Hz and the MP ranges from-2 m to 2 m. As the latitude increases, the DOP values show large variation, which may be related to the distribution of BDS satellites. The CC values of signals B1 I and BIC range from-5 m to 5 m in the mid-latitude sea area and the Arctic Ocean, which means the effect of pseudorange noise is small. Moreover, as to obtain the external precise reference value for GNSS positioning in the Arctic Ocean region is difficult, it is hard to evaluate the accuracy of positioning results. An improved isotropy-based protection level method based on Receiver Autonomous Integrity Monitoring is proposed in the paper, which adopts median filter to smooth the gross errors to assess the precision and reliability of PPP in the Arctic Ocean. At first, the improved algorithm is verified with the data from the International GNSS Service Station Tixi. Then the accuracy of BDS3 PPP in the Arctic Ocean is calculated based on the improved algorithm. Which shows that the kinematic accuracy of PPP can reach the decimeter level in both the horizontal and vertical directions, and it meets the precision requirements of maritime navigation. 展开更多
关键词 BDS3 Arctic Ocean signal quality analysis protection level quality check precise Point Positioning satellite navigation
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新型5,6-二氢吡啶并[2,3-d]嘧啶-4,7(3H,8H)-二酮类衍生物的设计、合成及抗结核活性研究
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作者 孙连奇 彭孝炯 +2 位作者 寇世博 易红 李卓荣 《中国药物化学杂志》 2025年第2期81-91,共11页
目的设计合成一系列新型嘧啶酮类衍生物,以期得到抗结核分枝杆菌敏感菌株H37Rv及耐药菌株14862活性都较好的新化合物。方法以氰基乙酸乙酯和硫脲为起始原料,通过三步或四步反应,得到目标化合物f1~f31。采用H37Rv对所有目标化合物进行抗... 目的设计合成一系列新型嘧啶酮类衍生物,以期得到抗结核分枝杆菌敏感菌株H37Rv及耐药菌株14862活性都较好的新化合物。方法以氰基乙酸乙酯和硫脲为起始原料,通过三步或四步反应,得到目标化合物f1~f31。采用H37Rv对所有目标化合物进行抗结核活性评价,并对其中活性较好的化合物进行抗耐药菌株14862的活性评价。采用Vero细胞进行安全性评价。结果与结论共合成了31个新化合物,其结构均经^(1)H-NMR、^(13)C-NMR和LC-MS谱确证。其中化合物f11和f28对H37Rv的MIC值分别为0.62μg·mL^(-1)和0.91μg·mL^(-1),表现出较强的抗结核活性,但对耐药菌株14862的活性弱于H37Rv。本研究进一步丰富了该系列化合物的构效关系,以期为后续新型嘧啶酮类化合物的设计提供参考。 展开更多
关键词 5 6-二氢吡啶并[2 3-d]嘧啶-4 7(3H 8H)-二酮类衍生物 抗结核分枝杆菌 结构修饰 构效关系
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Inter-satellite link augmented BeiDou-3 orbit determination for precise point positioning 被引量:1
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作者 Liqian ZHAO Xiaogong HU +4 位作者 Chengpan TANG Shanshi ZHOU Yueling CAO Qianxin WANG Ranran SU 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2022年第4期332-343,共12页
Precise Point Positioning(PPP) requires precise products, including high-accuracy satellite orbit and clock parameters. It is impossible to obtain an orbit solution that is sufficiently accurate for PPP services with ... Precise Point Positioning(PPP) requires precise products, including high-accuracy satellite orbit and clock parameters. It is impossible to obtain an orbit solution that is sufficiently accurate for PPP services with a regional tracking network;therefore, satellite orbits are usually estimated by a global tracking network with a large number of ground stations. However, it is expensive to build globally distributed stations. Fortunately, BeiDou-3 satellites carry an InterSatellite Link(ISL) payload, which can track the whole arc of the BeiDou-3 satellites and enhance the orbit determination accuracy with regional ground stations. In this contribution, a novel orbit determination strategy for BeiDou-3 PPP is proposed, in which the BeiDou-3 satellite orbits are enhanced by the ISL. First, the generation of precise satellite products is demonstrated in detail.In addition, the products are assessed by Satellite Laser Ranging(SLR) residuals and overlap comparisons. Moreover, the products are used for receivers in China's Mainland to carry out the static and kinematic modes to research the PPP performance of Bei Dou-3’s 3IGSO/24MEO constellation.The SLR validations of the satellite orbits demonstrate an accuracy better than 0.1 m in the radial component, and the orbit overlap comparisons show accuracies of 0.016 m in the radial component,0.088 m in the along-track component and 0.087 m in the cross-track component. The Standard Deviation(STD) in the differences in overlapping arcs for the estimated satellite clocks is approximately 0.10 ns. The static PPP results demonstrate that the error in both the horizontal and vertical components is smaller than 10 cm after 30 minutes of convergence. After 24 hours of convergence,the errors are 0.70 cm, 0.63 cm and 1.99 cm for the north, east and up components, respectively.The kinematic PPP experiment illustrates that the Root Mean Square(RMS) position errors in the north, east and up components are approximately 3.23 cm, 5.27 cm and 8.64 cm, respectively,after convergence. The obtainable positioning and convergence performances are comparable to those using products generated by global tracking networks. 展开更多
关键词 BeiDou-3 Clock offsets CONVERGENCE Inter-satellite link precise Point Positioning Regional ground stations Satellite orbits
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Method of Precision Control of 3-D Solid Discretization Based on the Second-Order Osculating Surface
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作者 万小利 刘淑艳 +1 位作者 杨梦辰 汪虹 《Journal of Beijing Institute of Technology》 EI CAS 2003年第2期183-185,共3页
A discretization precision control method based on the second order osculating surface is proposed. The discretization precision of 3 D solid is controlled according to the error between the discrete solid surface a... A discretization precision control method based on the second order osculating surface is proposed. The discretization precision of 3 D solid is controlled according to the error between the discrete solid surface and its second order osculating surface. The global maximal error has been gotten after analyzing all the extremums of the error function. It can be used in controlling and optimizing the discretization precision of 3 D solid in computer 3 D modeling and NC milling path generation. 展开更多
关键词 3-d solid DISCRETIZATION precision control osculating surface
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Multi-Area Vibration Precision Laying Process in Multi-Material 3D Sand Printing
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作者 Weifei Song Zhongde Shan +5 位作者 Haoqin Yang Yangyang Hu Dandan Yan Haoming Shi Jian Huang Yajun Yin 《Additive Manufacturing Frontiers》 2025年第3期134-146,共13页
Multi-material 3D sand printing has gained significant attention;however,research has mainly focused on materials and mechanisms,with limited exploration of optimizing the sand-laying process through numerical simulat... Multi-material 3D sand printing has gained significant attention;however,research has mainly focused on materials and mechanisms,with limited exploration of optimizing the sand-laying process through numerical simulations.In this study,we investigated the dynamic behavior of sand particles during a vibratory sand-laying process for multi-material additive manufacturing using discrete element simulations.The objective is to enable precise control over the amount and distribution of sand for multi-material printing.In this study,we combined experiments and simulations to calibrate the contact parameters of different sands and establish a relationship between the curing agent content and surface energy of sand particles.A model for the vibratory fall of multimaterial sand was developed to study the motion characteristics of sand particles.This allows for macro-control over the sand spreading flow and high-quality multi-material sand laying.The results show that the flow rate of falling sand increases with decreasing surface energy of the particles,wider spreader openings,and higher vibration frequencies.For silica and chromite sands,when their surface energy ranged from 0.15 to 25 J·m^(2)and0.01-0.03 J·m^(2),respectively,and the sand spreader opening was 6 mm with a vibration frequency of 500 Hz,the sand flow rates of both materials became nearly identical.However,a higher sand paving speed and height increased the scattering of sand particles outside the target area,thereby decreasing the paving quality.The results accomplished in this study enable precise and uniform sand particle deposition and offers guidelines for optimizing sand speed and height,thus expanding the application of multi-material sand 3D printing in complex and high-performance manufacturing. 展开更多
关键词 Multi-material sand 3D sand printing Discrete element Vibration precision laying
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Autonomous nighttime navigation with lunar polarized light:A 3-D attitude determination approach
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作者 Taihang CHEN Jiankai YIN +4 位作者 Pengwei HU Xiao ZHANG Xiang YU Huai-ning WU Lei GUO 《Chinese Journal of Aeronautics》 2025年第11期384-395,共12页
Nighttime navigation faces challenges from limited data and interference,especially when satellite signals are unavailable.Leveraging lunar polarized light,polarization navigation offers a promising solution for night... Nighttime navigation faces challenges from limited data and interference,especially when satellite signals are unavailable.Leveraging lunar polarized light,polarization navigation offers a promising solution for nighttime autonomous navigation.Current algorithms,however,are limited by the requirement for known horizontal attitudes,restricting applications.This study introduces an autonomous 3-D attitude determination method to overcome this limitation.Our approach utilizes the Angle of Polarization(AOP)at night to extract neutral points from the AOP pattern.This allows for the calculation of polarization meridian plane information for attitude determination.Subsequently,we present an optimized Polarization TRIAD(Pol-TRIAD)algorithm to acquire the 3-D attitude.The proposed method outperforms the existing approaches in outdoor experiments by achieving lower Root Mean Square Error(RMSE).For one baseline attitude,it improves pitch by 31.7%,roll by 21.7%,and yaw by 2.6%,while for the attitude with a larger tilt angle,the improvements are 64.4%,30.4%,and 9.1%,respectively. 展开更多
关键词 3-d attitude determination Lunar polarized light Neutral points Night navigation Polarization
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混合感染中降钙素原联合1,3-β-D葡聚糖检测的诊断价值分析
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作者 邓承晓 《实验室检测》 2025年第13期63-65,共3页
目的分析血清降钙素原(PCT)联合1,3-β-D葡聚糖检测对重症监护病房(ICU)患者混合感染的诊断价值。方法选择2023年10月—2024年10月本院ICU收治的237例疑似混合感染患者作为研究对象。根据实验室检查结果分为真菌感染组(n=66)、细菌感染... 目的分析血清降钙素原(PCT)联合1,3-β-D葡聚糖检测对重症监护病房(ICU)患者混合感染的诊断价值。方法选择2023年10月—2024年10月本院ICU收治的237例疑似混合感染患者作为研究对象。根据实验室检查结果分为真菌感染组(n=66)、细菌感染组(n=103)和混合感染组(n=68)。检测并比较三组患者血清PCT和1,3-β-D葡聚糖水平。采用Logistic回归分析评估PCT与1,3-β-D葡聚糖水平与混合感染发生的相关性;绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC),评价单项及联合检测对混合感染的诊断效能。结果混合感染组血清PCT、1,3-β-D葡聚糖水平高于真菌感染组和细菌感染组(P<0.05)。Logistic回归显示,PCT、1,3-β-D葡聚糖水平升高是ICU患者发生混合感染的影响因素(P<0.05)。PCT、1,3-β-D葡聚糖及两者联合诊断发生混合感染的AUC分别为0.629、0.714、0.752,联合的AUC更高,其敏感度和特异度分别为72.06%、74.56%(P<0.05)。结论PCT联合1,3-β-D葡聚糖诊断ICU患者混合感染的效能更高,可通过上述指标水平分析混合感染的高风险人群。 展开更多
关键词 降钙素原 1 3-d葡聚糖 混合感染 细菌感染 病毒感染
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A USEFUL AND PRECISE EXPRESSION FOR ORIENTATION FACTOR OF POLED POLYMER FILMS
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作者 Cheng YE, Jia Fu WANG Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080 《Chinese Chemical Letters》 SCIE CAS CSCD 1993年第11期1007-1010,共4页
Based on ID ROGM, d_(33) of poled films can be estimated from orientation factor <cos^3θ>. In this letter, a direct expression
关键词 A USEFUL AND precise EXPRESSION FOR ORIENTATION FACTOR OF POLED POLYMER FILMS COS~3
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一种多参数G^(3)高精度的八次Hermite插值样条
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作者 谢进 尹行 《浙江大学学报(理学版)》 北大核心 2026年第1期78-87,共10页
为解决工程计算中的连续性和精度问题,提出了一种具有高阶连续性、高精度且带多个参数的八次Hermite插值样条。首先,在多项式空间,利用高阶连续性条件,通过解方程组,给出一种带多个参数的Hermite型基函数的构造方法,并定义了相应的高阶... 为解决工程计算中的连续性和精度问题,提出了一种具有高阶连续性、高精度且带多个参数的八次Hermite插值样条。首先,在多项式空间,利用高阶连续性条件,通过解方程组,给出一种带多个参数的Hermite型基函数的构造方法,并定义了相应的高阶插值样条;其次,给出了最优插值的参数选择方法;最后,讨论了插值余项和最优插值函数的确定方法,并通过实例验证了该插值样条的有效性和高精度。与现有的带参数的分段Hermite插值样条相比,提出的八次Hermite插值样条无需增加任何条件即可自动满足G^(3)连续,且兼备形状可调性与高阶连续性,应用前景广阔。 展开更多
关键词 G^(3)连续性 高精度 八次Hermite样条 最优参数 最优插值函数
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3M Precise Mousing Surface withGel Wrist Rest
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《个人电脑》 2004年第3期271-271,共1页
关键词 鼠标 人体工程学 操作控制 3M precise Mousing SURFACE withGel WRIST REST
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多种3-D打印手术导板在骨肿瘤切除重建手术中的应用 被引量:52
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作者 付军 郭征 +6 位作者 王臻 栗向东 范宏斌 李靖 裴延军 裴国献 李丹 《中国修复重建外科杂志》 CAS CSCD 北大核心 2014年第3期304-308,共5页
目的使用多种3-D打印技术制作手术导板,探讨其在骨肿瘤切除重建手术中的应用效果,并对比不同3-D打印技术制备的手术导板优缺点。方法回顾分析2012年9月-2014年1月符合选择标准的31例骨肿瘤患者临床资料,其中男19例,女12例;年龄6~67岁,... 目的使用多种3-D打印技术制作手术导板,探讨其在骨肿瘤切除重建手术中的应用效果,并对比不同3-D打印技术制备的手术导板优缺点。方法回顾分析2012年9月-2014年1月符合选择标准的31例骨肿瘤患者临床资料,其中男19例,女12例;年龄6~67岁,中位年龄23岁。病程15 d^12个月,中位病程2个月。其中恶性肿瘤13例,良性肿瘤18例;肿瘤位于股骨9例、脊柱7例、胫骨6例、骨盆5例、肱骨3例、腓骨1例。根据术前薄层(0.625 mm)CT扫描等影像学检查所得数据行术前肿瘤切除设计,根据切除计划设计手术导板。术前加工导板使用的3-D打印技术和材料分别为:熔融沉积成型9例(ABS树脂)、光固化立体成型14例(光敏树脂)、3-D印刷工艺5例(石膏)、选择性激光烧结3例(铝合金);导板灭菌后按术前计划应用于术中。通过对比导板制作加工时间分析4种3-D打印技术效率,记录术前设计时间、手术时间、术中透视次数,与同期同类常规手术28例(对照组)进行比较。结果 4种导板制作加工时间分别为:熔融沉积成型(19.3±6.5)h、光固化立体成型(5.2±1.3)h、3-D印刷工艺(8.6±1.9)h、选择性激光烧结(51.7±12.9)h,选择性激光烧结导板制作加工时间明显长于另外3种。31例均成功进行术前设计、导板制作并应用于手术;除3例术中导板断裂变形(ABS树脂1例、石膏2例),改为常规手术治疗外;余28例定位针均成功导入,根据定位针指引准确按术前手术设计截骨。与对照组比较,28例患者术前设计时间延长、手术时间缩短、术中透视次数减少,差异均有统计学意义(P<0.05)。28例均获随访,随访时间1~12个月,平均3.7个月。术后X线片及CT检查示肿瘤均完整切除,大段同种异体骨重建稳定。结论 3-D打印手术导板很好地适应了骨肿瘤手术个体化要求,可在术中实现术前设计,不同3-D打印技术制备的手术导板各有优势,需根据具体手术方式选择。 展开更多
关键词 3-d打印技术 手术导板 骨肿瘤 修复重建
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数字化设计与3-D打印技术在个性化医疗中的应用 被引量:34
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作者 秦勉 刘亚雄 +8 位作者 贺健康 王玲 连芩 李涤尘 靳忠民 何三虎 李刚 刘彦普 王臻 《中国修复重建外科杂志》 CAS CSCD 北大核心 2014年第3期286-291,共6页
目的总结将数字化设计与3-D打印技术应用于个性化医疗中的研究进展。方法回顾分析西安交通大学及其合作单位近年来将数字化设计与3-D打印技术在个性化医疗中应用的相关研究资料和临床文献,并进行综合整理分析。结果基于3-D打印技术,根... 目的总结将数字化设计与3-D打印技术应用于个性化医疗中的研究进展。方法回顾分析西安交通大学及其合作单位近年来将数字化设计与3-D打印技术在个性化医疗中应用的相关研究资料和临床文献,并进行综合整理分析。结果基于3-D打印技术,根据患者具体病变设计并制造个性化内植物,能满足不同患者病变形状与功能的需要,解决人体组织的个性化修复问题,降低对医生经验水平的依赖,得到越来越多外科医生认可。西安交通大学在国内最早开发出商用3-D打印机,对个性化医用内植物的设计及制造进行了深入研究,已形成了完整的工艺流程,制定了产品质量标准,并成功应用于临床试验。结论 3-D打印技术制造的个性化医用内植物能实现个性化匹配,满足患者对功能和美学的要求,同时具有定位准确、连接稳定、强度高等优点。因此该技术在个性化内植物制造与应用方面有广泛应用前景。 展开更多
关键词 3-d打印技术 个性化医疗 医用内植物 临床应用
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3-D打印技术辅助经皮撬拨空心钉内固定治疗移位的跟骨关节内骨折 被引量:18
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作者 吴敏 官建中 +5 位作者 肖玉周 王照东 陈笑天 赵志 张宽宽 朱军 《中国修复重建外科杂志》 CAS CSCD 北大核心 2017年第11期1316-1321,共6页
目的探讨3-D打印技术辅助经皮撬拨复位空心钉内固定治疗移位的跟骨关节内骨折的临床疗效。方法回顾分析2015年3月—2016年5月收治的移位的跟骨关节内骨折19例(19足),其中男13例,女6例;年龄24~73岁,平均38.2岁。开放性骨折3例,闭合性骨... 目的探讨3-D打印技术辅助经皮撬拨复位空心钉内固定治疗移位的跟骨关节内骨折的临床疗效。方法回顾分析2015年3月—2016年5月收治的移位的跟骨关节内骨折19例(19足),其中男13例,女6例;年龄24~73岁,平均38.2岁。开放性骨折3例,闭合性骨折16例。根据跟骨骨折Sanders分型:Ⅱ型12例,Ⅲ型7例;根据跟骨骨折Essex-Lopresti分型:舌型13例,关节压缩型6例。受伤至手术时间1~10 d,平均4.7 d。术前行双侧跟骨薄层CT扫描,计算机辅助镜面成像技术对健侧跟骨镜像处理,按1∶1比例打印出健侧镜像及患侧跟骨模型,对比观察骨折块的移位情况,模拟撬拨复位。跟骨骨折均采用经皮斯氏针撬拨复位空心螺钉内固定治疗。在X线片上测量术后即刻及末次随访时B?hler角和Gissane角,并与术前比较;采用美国矫形足踝协会(AOFAS)踝与后足评分系统评价患足术后功能。结果手术时间25~70 min,平均45 min;术中出血量10~40 mL,平均14.5 m L。术后患者切口均Ⅰ期愈合,无皮肤坏死、钉道感染、骨髓炎等并发症发生。19例患者术后获12~25个月(平均14.6个月)随访。患者骨折均获愈合,愈合时间8~14周,平均10.3周。随访期间无螺钉退出、断裂发生;除1例SandersⅡ型骨折患者术后6周跟骨高度部分丢失外,其余患者无复位丢失及骨折再移位,无创伤性关节炎发生。术后即刻及末次随访时B?hler角和Gissane角均较术前显著改善(P<0.05),术后即刻与末次随访时比较差异无统计学意义(P>0.05)。末次随访时AOFAS踝与后足评分为76~100分,平均88.2分,其中优10足、良7足、可2足,优良率89.5%。结论 3-D打印技术辅助经皮撬拨复位空心钉内固定治疗跟骨关节内骨折,减少了手术创伤,提高了复位质量及固定强度,使手术方案更安全、精确、个体化。 展开更多
关键词 3-d打印 关节内跟骨骨折 空心钉 内固定 经皮
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深部真菌感染患者血浆1-3-β-D葡聚糖检测的临床意义 被引量:29
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作者 张建芳 徐修礼 +1 位作者 樊新 孙怡群 《中华医院感染学杂志》 CAS CSCD 北大核心 2005年第3期354-355,共2页
目的探讨深部真菌感染患者血浆1-3-β-D葡聚糖检测的临床意义。方法 应用ME-80微生物动态快速 检测系统,及GKT-5M Set动态真菌检测试剂盒定量检测血浆中1-3-β-D葡聚糖的含量。结果正常对照组血浆 1-3-β-D葡聚糖含量为(2.83士2.57)μg... 目的探讨深部真菌感染患者血浆1-3-β-D葡聚糖检测的临床意义。方法 应用ME-80微生物动态快速 检测系统,及GKT-5M Set动态真菌检测试剂盒定量检测血浆中1-3-β-D葡聚糖的含量。结果正常对照组血浆 1-3-β-D葡聚糖含量为(2.83士2.57)μg/L;深部真菌感染组为(54.06士36.13)μg/L,经t检验分析,对照组与深部 真菌感染组1-3-β-D葡聚糖平均值差异非常显著(t=7.741,P<0.001)。结论 血浆葡聚糖检测可在拟诊早期为 临床医生提供机体是否感染真菌的可靠信息,是一种实用的真菌感染早期诊断方法。 展开更多
关键词 1-3-d 葡聚糖 深部真菌 感染
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