Enantiomer identification is of paramount industrial value and physiological significance.Construction of sensitive chiral sensors with high enantiomeric discrimination ability is highly desirable.In this work,a chira...Enantiomer identification is of paramount industrial value and physiological significance.Construction of sensitive chiral sensors with high enantiomeric discrimination ability is highly desirable.In this work,a chiral covalent organic framework/anodic aluminum oxide(c-COF/AAO)membrane was prepared for electrochemical enantioselective recognition and sensing.Benefiting from the remarkable asymmetry,the asprepared nanofluidic c-COF/AAO presents a distinct ion current rectification(ICR)characteristic,enabling sensitive bioanalysis.In addition,owing to the large surface area,high chemical stability and perfect ion selectivity of chiral COF,the prepared c-COF/AAO membrane presents exceptionally selective mass transport and thereby enables excellent chiral discrimination for S-/R-Naproxen(S-/R-Npx)enantiomers.It is especially noteworthy that the detection limit is achieved as low as 3.88 pmol/L.These results raise the possibility for a facile,stable and low-cost method to carry out sensitive enantioselective recognition and detection.展开更多
We study the colour-locked twin-noisy-field correlation effects in the fifth-order nonlinear susceptibility of ultrafast polarization beats in a cascade four-level system. More importantly, the fifth-order phase-sensi...We study the colour-locked twin-noisy-field correlation effects in the fifth-order nonlinear susceptibility of ultrafast polarization beats in a cascade four-level system. More importantly, the fifth-order phase-sensitive heterodyne detection of ultrafast polarization beats has been exploited. The fifth-order nonlinear optical response can be controlled and modified through the colour-locked correlation of twin noisy fields. Thus, this method with the phase dispersion information is a good way to measure the real and imaginary parts of the fifth-order nonlinear susceptibility.展开更多
Afour-month period of national special rectification for product quality and food safety officially started on August 25, and was focused on eight fields, including those of agricultural products and processed foo... Afour-month period of national special rectification for product quality and food safety officially started on August 25, and was focused on eight fields, including those of agricultural products and processed foods.……展开更多
Mixed integer linear programming （MILP） approach for simultaneous gross error detection and data reconciliation has been proved as an efficient way to adjust process data with material, energy, and other balance con...Mixed integer linear programming （MILP） approach for simultaneous gross error detection and data reconciliation has been proved as an efficient way to adjust process data with material, energy, and other balance constrains. But the efficiency will decrease significantly when this method is applled in a large-scale problem because there are too many binary variables involved. In this article, an improved method is proposed in order to gen- erate gross error candidates with reliability factors before data rectification. Candidates are used in the MILP objec- tive function to improve the efficiency and accuracy by reducing the number of binary variables and giving accurate weights for suspected gross errors candidates. Performance of this improved method is compared and discussed by applying the algorithm in a widely used industrial example.展开更多
Outer-surface functionalized solid-state nanochannels have emerged as a new powerful tool for labelfree and sensitive detection of biotargets,owing to the unique advantages,such as the target's size is not limited...Outer-surface functionalized solid-state nanochannels have emerged as a new powerful tool for labelfree and sensitive detection of biotargets,owing to the unique advantages,such as the target's size is not limited by the nanochannel size,probes on the outer surface are easier to modify and characterize.Despite the advancements,the current outer-surface functionalized nanochannels can only achieve single target detection,which is insufficient for understanding disease pathogenesis and clinical diagnosis.Herein,we develop an ordered mesoporous carbon-silicon/anodic aluminum oxide hybrid membrane(MCS/AAO)with outer surface probes for in situ detecting living cells released secretions with a wide size range(from nano-scale to micron-scale).Due to asymmetric nanochannel structure and charge distribution,the hybrid membrane exhibits cation selectivity and a high ionic current rectification value of 29.21.By taking advantage of this mechanism,different cell secretions can be selectively and sensitively detected through replacing the modified aptamers on the outer surface of hybrid membrane.ATP(adenosine triphosphate),VEGF(vascular endothelial growth factor),and HepG2-MVs(micro vesicles)are chosen as model secretions representing different sizes.The detection limits are 0.64 fmol/L for ATP,3.31fg/m L for VEGF,and 5.37×10^(4) particles/m L for HepG2-MVs,which was over 10-fold higher than that of commercial assay kits.In addition,the prepared hybrid membrane has exceptional mechanical stability,the detection interface could be regenerated at least 5 times.This work provides a promising platform for in situ detection of cell secretions with different types and sizes by one sensing device and facilitates the clinical diagnosis of secretion-related diseases.展开更多
基金supported by grants from the National Natural Science Foundation of China(Nos.22274076,22304084)the Primary Research&Development Plan of Jiangsu Province(No.BE2022793)+1 种基金the Natural Science Foundation of Jiangsu Province of China(No.BK20230377)Jiangsu Provincial Department of Education(No.211090B52303)。
文摘Enantiomer identification is of paramount industrial value and physiological significance.Construction of sensitive chiral sensors with high enantiomeric discrimination ability is highly desirable.In this work,a chiral covalent organic framework/anodic aluminum oxide(c-COF/AAO)membrane was prepared for electrochemical enantioselective recognition and sensing.Benefiting from the remarkable asymmetry,the asprepared nanofluidic c-COF/AAO presents a distinct ion current rectification(ICR)characteristic,enabling sensitive bioanalysis.In addition,owing to the large surface area,high chemical stability and perfect ion selectivity of chiral COF,the prepared c-COF/AAO membrane presents exceptionally selective mass transport and thereby enables excellent chiral discrimination for S-/R-Naproxen(S-/R-Npx)enantiomers.It is especially noteworthy that the detection limit is achieved as low as 3.88 pmol/L.These results raise the possibility for a facile,stable and low-cost method to carry out sensitive enantioselective recognition and detection.
基金Project supported by the National Natural Science Foundation of China(Grant Nos60308002and60678005)the Foundation for the Author of National Excellent Doctoral Dissertation of China(Grant No200339)+2 种基金the Foundation for Key Program of Ministry of Education,China(Grant No105156)the Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China(Grant No101061)the Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No20050698017)
文摘We study the colour-locked twin-noisy-field correlation effects in the fifth-order nonlinear susceptibility of ultrafast polarization beats in a cascade four-level system. More importantly, the fifth-order phase-sensitive heterodyne detection of ultrafast polarization beats has been exploited. The fifth-order nonlinear optical response can be controlled and modified through the colour-locked correlation of twin noisy fields. Thus, this method with the phase dispersion information is a good way to measure the real and imaginary parts of the fifth-order nonlinear susceptibility.
文摘 Afour-month period of national special rectification for product quality and food safety officially started on August 25, and was focused on eight fields, including those of agricultural products and processed foods.……
基金Supported by the National High Technology Research and Development Program of China (2007AA40702 and 2007AA04Z191)
文摘Mixed integer linear programming （MILP） approach for simultaneous gross error detection and data reconciliation has been proved as an efficient way to adjust process data with material, energy, and other balance constrains. But the efficiency will decrease significantly when this method is applled in a large-scale problem because there are too many binary variables involved. In this article, an improved method is proposed in order to gen- erate gross error candidates with reliability factors before data rectification. Candidates are used in the MILP objec- tive function to improve the efficiency and accuracy by reducing the number of binary variables and giving accurate weights for suspected gross errors candidates. Performance of this improved method is compared and discussed by applying the algorithm in a widely used industrial example.
基金supported by National Natural Science Foundation of China(Nos.22374019,22174016)Start-up Research Fund of Southeast University(No.RF1028624037)。
文摘Outer-surface functionalized solid-state nanochannels have emerged as a new powerful tool for labelfree and sensitive detection of biotargets,owing to the unique advantages,such as the target's size is not limited by the nanochannel size,probes on the outer surface are easier to modify and characterize.Despite the advancements,the current outer-surface functionalized nanochannels can only achieve single target detection,which is insufficient for understanding disease pathogenesis and clinical diagnosis.Herein,we develop an ordered mesoporous carbon-silicon/anodic aluminum oxide hybrid membrane(MCS/AAO)with outer surface probes for in situ detecting living cells released secretions with a wide size range(from nano-scale to micron-scale).Due to asymmetric nanochannel structure and charge distribution,the hybrid membrane exhibits cation selectivity and a high ionic current rectification value of 29.21.By taking advantage of this mechanism,different cell secretions can be selectively and sensitively detected through replacing the modified aptamers on the outer surface of hybrid membrane.ATP(adenosine triphosphate),VEGF(vascular endothelial growth factor),and HepG2-MVs(micro vesicles)are chosen as model secretions representing different sizes.The detection limits are 0.64 fmol/L for ATP,3.31fg/m L for VEGF,and 5.37×10^(4) particles/m L for HepG2-MVs,which was over 10-fold higher than that of commercial assay kits.In addition,the prepared hybrid membrane has exceptional mechanical stability,the detection interface could be regenerated at least 5 times.This work provides a promising platform for in situ detection of cell secretions with different types and sizes by one sensing device and facilitates the clinical diagnosis of secretion-related diseases.
