Objective:To evaluate the intervention effect of childlike nursing combined with Chinese herbal patching on pediatric bronchopneumonia.Methods:1036 children with bronchopneumonia(one family member included for each ch...Objective:To evaluate the intervention effect of childlike nursing combined with Chinese herbal patching on pediatric bronchopneumonia.Methods:1036 children with bronchopneumonia(one family member included for each child)who were admitted to the hospital between January 2024 and June 2024 were selected and randomly divided into two groups using a random number table.The combined group received childlike nursing combined with Chinese herbal patching,while the control group received routine nursing.Symptom recovery time,treatment compliance,inflammatory factor levels,quality of life of the children,and family satisfaction were compared between the two groups.Results:The symptom recovery time in the combined group was shorter than that in the control group,treatment compliance was higher,inflammatory factor levels after intervention were lower,quality of life scores of the children were lower,and family satisfaction was higher(P<0.05).Conclusion:The implementation of childlike nursing combined with Chinese herbal patching for children with bronchopneumonia can shorten their symptom recovery time,significantly improve treatment compliance and quality of life,reduce inflammatory reactions,and achieve high satisfaction among family members.展开更多
Using abundant saline water for electrolysis,rather than limited freshwater,presents a promising technique for generating clean hydrogen energy.However,high concentration of corrosive chloride ions in saline water pos...Using abundant saline water for electrolysis,rather than limited freshwater,presents a promising technique for generating clean hydrogen energy.However,high concentration of corrosive chloride ions in saline water poses a great challenge in the stability of anode.In this study,we present a straightforward strategy to protect the anode from corrosion by patching the catalyst layer through a treatment of the anode with a sodium sulfide(Na2S) solution followed by electrochemical activation.The rapid sulfurization of the Ni electrode in Na2S results in the formation of a Na2S layer,which can subsequently be converted to NiOOH upon electrochemical activation,thereby shielding the inner Ni electrode from corrosion.The as-prepared electrode (P-NiFe-LDH/Ni) based on the strategy demonstrated stability over 3,500 h at an industrial current density of 0.5 A cm^(-2)in a 0.5 M NaCl and 1 M KOH solution.This study presents an effective strategy to significantly enhance the stability of anodes for saline water electrolysis by effectively patching the cracks in the catalyst layer.展开更多
A mobile transmission strategy, PMPatching (Proxy-based Mobile Patching) transmission strat-egy is proposed, it applies to the proxy-based mobile streaming media system in Wideband Code Division Multiple Access (WCDMA...A mobile transmission strategy, PMPatching (Proxy-based Mobile Patching) transmission strat-egy is proposed, it applies to the proxy-based mobile streaming media system in Wideband Code Division Multiple Access (WCDMA) network. Performance of the whole system can be improved by using patching stream to transmit anterior part of the suffix that had been played back, and by batching all the demands for the suffix arrived in prefix period and patching stream transmission threshold period. Experimental results show that this strategy can efficiently reduce average network transmission cost and number of channels consumed in central streaming media server.展开更多
AIM:To compare the efficacies of patching and penalization therapies for the treatment of amblyopia patients.METHODS:The records of 64 eyes of 50 patients 7 to16y of age who had presented to our clinics with a diagnos...AIM:To compare the efficacies of patching and penalization therapies for the treatment of amblyopia patients.METHODS:The records of 64 eyes of 50 patients 7 to16y of age who had presented to our clinics with a diagnosis of amblyopia,were evaluated retrospectively.Forty eyes of 26 patients who had received patching therapy and 24 eyes of 24 patients who had received penalization therapy included in this study.The latencies and amplitudes of visual evoked potential(VEP)records and best corrected visual acuities(BCVA)of these two groups were compared before and six months after the treatment.RESULTS:In both patching and the penalization groups,the visual acuities increased significantly following the treatments(P【0.05).The latency measurements of the P100 wave obtained at 1.0°,15 arc min.Patterns of both groups significantly decreased following the 6-months-treatment.However,the amplitude measurements increased(P【0.05).CONCLUSION:The patching and the penalization methods,which are the main methods used in the treatment of amblyopia,were also effective over the age of 7y,which has been accepted as the critical age for the treatment of amblyopia.展开更多
The physical properties and microstructure of SUF are investigated to develop a highly effective cement matrix crack-patching material for concrete cracks. The SEM and XRD determination of hardened SUF shows that the ...The physical properties and microstructure of SUF are investigated to develop a highly effective cement matrix crack-patching material for concrete cracks. The SEM and XRD determination of hardened SUF shows that the microstructure of SUF is dense and compact with a lot of C-S-H gels and ettringite. Also, the mechanism of shrinkage compensating is discussed.展开更多
New bugs and vulnerabilities are discovered and reported from time to time even after software products are released. One of the common ways to handle these bugs is to patch the software. In this paper, the authors pr...New bugs and vulnerabilities are discovered and reported from time to time even after software products are released. One of the common ways to handle these bugs is to patch the software. In this paper, the authors propose a stochastic model for optimizing the patching time for software bugs and vulnerabilities. The optimal patching time can be computed in the patching script development and operational costs in fix. The authors present two case studies using the Nimda worm vulnerability in Microsoft Internet Information Services web server and the bug report of the Debian project. These studies indicate that the patch applications are later than their optimal fix time.展开更多
Background:Patching an eye for a period of 2 hours results in a period of plasticity where inter-ocular balance shifts in favor of the patched eye.Acetylcholine has been shown to improve visual function and augment ad...Background:Patching an eye for a period of 2 hours results in a period of plasticity where inter-ocular balance shifts in favor of the patched eye.Acetylcholine has been shown to improve visual function and augment adult neural plasticity.Here we evaluate whether administering the cholinesterase inhibitor donepezil enhances the magnitude or duration of the patching induced shift in ocular balance.Methods:We used a double-blind drug treatment design to test the effect of donepezil and patching on the shift in ocular balance.We used a well-known binocular phase combination task to measure ocular balance before and after treatment.Results:Our results demonstrate that donepezil does not enhance,and may actually reduce the magnitude and duration of the patching-induced shift in ocular balance.Conclusions:Patching induced adult neural plasticity does not appear to be modulated by the cholinergic system,however,increased dose or longer drug administration periods may yield significant results.Future studies on binocular rivalry are in the pipeline.展开更多
高压电缆长期过热可能导致绝缘热击穿,进而影响电网的稳定性。然而,当前研究主要集中在传统预测模型上,忽略了温度数据的复杂性和动态特征。为了解决此问题,提出一种基于多尺度Patch与卷积交互的电缆温度预测模型(MSP-CI)。首先,采用通...高压电缆长期过热可能导致绝缘热击穿,进而影响电网的稳定性。然而,当前研究主要集中在传统预测模型上,忽略了温度数据的复杂性和动态特征。为了解决此问题,提出一种基于多尺度Patch与卷积交互的电缆温度预测模型(MSP-CI)。首先,采用通道重组采样方法降低输入维度,并构建多尺度Patch分支结构,以实现复杂时间序列的解耦;其次,结合序列分解与卷积交互策略,分别提取粗粒度Patch的宏观信息与细粒度Patch的微观信息;最后,构建注意力融合模块,以动态平衡宏观与微观信息的权重,并得到最终的预测结果。在真实高压电缆温度数据集上的实验结果表明,MSP-CI相较于TimeMixer、PatchTST(Patch Time Series Transformer)和MSGNet(Multi-Scale interseries Graph Network)等基线模型,在均方误差(MSE)上下降了7.02%~34.87%,在平均绝对误差(MAE)上下降了5.15%~32.04%。可见,MSP-CI能有效提升电缆温度预测的准确率,为电力调度运行提供依据。展开更多
Background: Acupoint herbal patching(AHP) alone or as an adjuvant therapy with conventional treatment(CT) has been widely used for prevention and treatment of chronic obstructive pulmonary disease(COPD). However, curr...Background: Acupoint herbal patching(AHP) alone or as an adjuvant therapy with conventional treatment(CT) has been widely used for prevention and treatment of chronic obstructive pulmonary disease(COPD). However, current clinical evidence from a systematic review of RCTs is lacking.Objective: To evaluate the effectiveness and safety of AHP with or without CT for people with COPD at stable stage.Methods: We searched randomized controlled trials comparing AHP(with or without CT) with no intervention, placebo, or CT from six databases. Two authors selected studies, extracted data and evaluated risk of bias of included trials. Rev Man 5.2 software was used to analysis data.Results: Twenty one RCTs(2327 participants) were included. AHP of non sanfu applied on no fixed dates with CT significantly decreased the mean frequency of acute exacerbation of COPD(times per year)(MD:-1.24; 95% CI:-2.02 to-0.46; 2 trials), and improved lung function parameters and quality of life. The AHP with CT showed no better effect in 6-minute walking distance(6 MWD) that CT alone. AHP applied at sanfu(specific dates based on lunar calendar) with CT had significant effect for 6 MWD(MD: 11.20; 95% CI: 0.83 to 21.56; I^2= 0%;3 trials). One trial reported skin irritation from AHP. Another trial reported two patients had eye discomfort, which was inferred as the adverse effects of seretide.Conclusion: AHP used as an adjunct to CT, appears to be more effective than CT alone in patients with stable COPD. However, further large,rigorously designed trials are warranted to confirm these potential effects.展开更多
Microneedles(MNs)have been extensively investigated for transdermal delivery of large-sized drugs,including proteins,nucleic acids,and even extracellular vesicles(EVs).However,for their sufficient skin penetration,con...Microneedles(MNs)have been extensively investigated for transdermal delivery of large-sized drugs,including proteins,nucleic acids,and even extracellular vesicles(EVs).However,for their sufficient skin penetration,conventional MNs employ long needles(≥600μm),leading to pain and skin irritation.Moreover,it is critical to stably apply MNs against complex skin surfaces for uniform nanoscale drug delivery.Herein,a dually amplified transdermal patch(MN@EV/SC)is developed as the stem cell-derived EV delivery platform by hierarchically integrating an octopusinspired suction cup(SC)with short MNs(≤300μm).While leveraging the suction effect to induce nanoscale deformation of the stratum corneum,MN@EV/SC minimizes skin damage and enhances the adhesion of MNs,allowing EV to penetrate deeper into the dermis.When MNs of various lengths are applied to mouse skin,the short MNs can elicit comparable corticosterone release to chemical adhesives,whereas long MNs induce a prompt stress response.MN@EV/SC can achieve a remarkable penetration depth(290μm)for EV,compared to that of MN alone(111μm).Consequently,MN@EV/SC facilitates the revitalization of fibroblasts and enhances collagen synthesis in middle-aged mice.Overall,MN@EV/SC exhibits the potential for skin regeneration by modulating the dermal microenvironment and ensuring patient comfort.展开更多
The alpine grassland vegetation on the Qinghai-Tibet Plateau is composed of plant patches in varied sizes.It remains uncertain whether vegetation recovery following grazing exclusion(GE)in degraded grasslands is drive...The alpine grassland vegetation on the Qinghai-Tibet Plateau is composed of plant patches in varied sizes.It remains uncertain whether vegetation recovery following grazing exclusion(GE)in degraded grasslands is driven by increases in patches number(NP),patch size(PS),or both.We based our predictions on two hypotheses:GE intensifies plant competition,and facilitation prevails near patches while competition prevails in interpatch spaces.We predicted that the NP would remain stable or decrease and PS would increase under GE treatment.To evaluate these predictions,we conducted a study in six lightly degraded alpine grasslands under free grazing(FG)conditions in Bangor County,Xizang Autonomous Region,China,with corresponding GE treatments using transects in 2017 and 2018.Results revealed that four sites in 2017 and five sites in 2018 had reduced NP and increased PS,with probabilities of 0.033(2017)and 0.004(2018),respectively,and a joint probability of 0.0001 under the null hypothesis that GE does not affect NP or PS.The NP reduction was solely due to the decrease in small patch sizes.An increase in PS was common across species,and a predominant tendency for NP reduction was observed among species across the sites.The overall changes in NP and PS were primarily driven by the three most abundant species(contributing more than 60%in both years),rather than by shifts in floristic composition.Our findings highlight that vegetation recovery in Bangor alpine steppes following GE relies solely on the expansion of existing patches rather than the recruitment of new ones in interpatch gaps.We recommend prioritizing growth-promoting measures,such as nutrient or water management,over seed addition when assisting with GE for restoring lightly degraded grasslands.展开更多
In this study,we developed a novel bilayered scaffold consisting of a bottom layer composed of the Decellularized Bovine Pericardium(DP)coated with Polyaniline Nanoparticles(PANINPs)and a top layer made of an electros...In this study,we developed a novel bilayered scaffold consisting of a bottom layer composed of the Decellularized Bovine Pericardium(DP)coated with Polyaniline Nanoparticles(PANINPs)and a top layer made of an electrospun Poly(lactic-co-glycolic acid)/Gelatin(PLGA/Gel)membrane incorporated with Vascular Endothelial Growth Fac-tor(VEGF)and hawthorn extract.Functionally,the DP supplies native Extracellular Matrix(ECM)components and mechanical support,while PANINPs provide conductivity.The electrospun PLGA/Gel layer mimics fibrous ECM.It incorporates bioactives,with VEGF promoting pro-angiogenic stimulation and hawthorn extract enhanc-ing anticoagulant activity,as well as increasing surface hydrophilicity.The tissue adhesive ensures the interfacial integrity between the two layers.Decellularization efficiency was confirmed histologically using 4',6-diamidino-2-phenylindole(DAPI)and Hematoxylin-Eosin(H&E)staining.The DP exhibited a DNA content of 115.9±47.8 ng/mg DNA,compared to 982.88±395.42 ng/mg in Native Pericardium(NP).The PANINPs had an average par-ticle size of 104.94±13.7 nm.The conductivity of PANINPs-coated decellularized pericardium was measured to be 9.093±8.6×10-4 S/cm using the four-point probe method.PLGA/Gel membranes containing hawthorn extract(1%,5%,10%,and 15%w/v)and VEGF(0.1μg/mL,0.5μg/mL,and 1μg/mL)were fabricated by electrospinning,result-ing in fiber diameters between 850 and 1200 nm and pore sizes between 14 and 20μm.The anticoagulant efficiency of the membranes containing hawthorn extract reached 430 s in the Activated Partial Thromboplastin Time Assay(aPTT).Mechanical testing revealed a tensile strength of 22.70±6.33 MPa,an elongation of 53.58±10.63%,and Young's modulus of 0.67±0.10 MPa.The scaffold also exhibited over 91%cell viability and excellent cardiomyo-cyte adhesion.The hemolysis ratio was determined to be 0.421±0.191%,which confirms its blood compatibility.Our results indicate that the proposed bilayered scaffold can be a promising candidate for cardiac patch applications.展开更多
The freemium pricing model has become mainstream in the software industry.A large user base can induce positive network effects while expanding security risks associated with unpatched users.This study explores a two-...The freemium pricing model has become mainstream in the software industry.A large user base can induce positive network effects while expanding security risks associated with unpatched users.This study explores a two-stage decision problem faced by software vendors that involves a freemium versioning strategy and a subsequent security-patching strategy when taking both the positive network externality and negative security externality into consideration.It is noteworthy that a joint effect of the two externalities on the vendor’s management decisions exists.First,we analytically derive three patching strategies for the vendor:PS_(1)(rebates all users),PS_(2)(rebates only freeware users),and PS_(3)(rebates no users).Our results indicate that,if the strength of the positive network externality is relatively low,the optimal security-patching strategy will be significantly affected by the negative security externality.Specifically,when the intensity of the negative security externality is low,the vendor’s optimal patching strategy will be PS_(1).However,with the increase in the negative security externality,the optimal patching strategy changes to PS_(2) and then to PS_(3),whereas the strategy spaces of PS_(1) and PS_(2) decrease in the positive network externality to zero.Nevertheless,if the strength of the positive network externality is relatively high,the vendor is better off selecting PS_(1) when the negative security externality is low.However,when the negative security externality is high,PS_(3) is optimal.Furthermore,based on optimal patching strategies,we reveal the optimal conditions required for the vendor to adopt the freemium model compared with commercial only.Of interest,we find that the vendor adopting the freemium version is also influenced by the interaction of the two externalities.Finally,through numerical experiments,we find that the vendor and social planner’s interests can be aligned under certain conditions.However,this is not always the case.展开更多
In the version of the article originally published in the volume 68,issue 12,2025 of Sci China Mater(pages 4413-4422,https://doi.org/10.1007/s40843-025-3667-7),the Chinese name of the co-first author(肖天孝)was incorr...In the version of the article originally published in the volume 68,issue 12,2025 of Sci China Mater(pages 4413-4422,https://doi.org/10.1007/s40843-025-3667-7),the Chinese name of the co-first author(肖天孝)was incorrect.The corrected Chinese name is:肖天笑.展开更多
Lipid rafts(LRs)are relatively well-ordered functional microdomains in cell membranes and play an irreplaceable role in physiological processes as a transduction platform for multiple signaling pathways.Due to their s...Lipid rafts(LRs)are relatively well-ordered functional microdomains in cell membranes and play an irreplaceable role in physiological processes as a transduction platform for multiple signaling pathways.Due to their small size and high spatiotemporal dynamics,it is difficult to perform lipid raftlocalized biomolecule imaging on the surface of living cells.Here,we report a DNA nanotechnology-based platform for reversible manipulation and localized analysis of lipid rafts,which consists of two modules:“patching and coding probe pair”and“fishing probe”.The probe pair is generated by modifying two different sets of connectable DNA structures on a lipid raft-specific protein.After recognizing lipid rafts,the two probes in close proximity are linked by a DNA ligase reaction to form a lipid raft identity(LRID)code.The LR-ID strand patches and stabilizes the lipid raft structure.Interestingly,the raft patches formed can be depatched by restriction endonucleases,providing the first reversible manipulation of the lipid raft structure in living cells.We also designed a“fishing probe”with a DNA hairpin structure using an aptamer that can specifically bind to the target.The probe can cascade the reaction to two input signals“LR-ID”and“target protein”to generate an“off-on”fluorescence switch,allowing imaging and dynamic monitoring of target proteins localized in lipid rafts.By encoding arbitrary targets(in the case of glycans)in lipid rafts,we have created a universal lipid raft-localized imaging platform.This work provides an integrated analytical and manipulative platform to reveal lipid rafts and associated signaling pathways at the molecular level.展开更多
文摘Objective:To evaluate the intervention effect of childlike nursing combined with Chinese herbal patching on pediatric bronchopneumonia.Methods:1036 children with bronchopneumonia(one family member included for each child)who were admitted to the hospital between January 2024 and June 2024 were selected and randomly divided into two groups using a random number table.The combined group received childlike nursing combined with Chinese herbal patching,while the control group received routine nursing.Symptom recovery time,treatment compliance,inflammatory factor levels,quality of life of the children,and family satisfaction were compared between the two groups.Results:The symptom recovery time in the combined group was shorter than that in the control group,treatment compliance was higher,inflammatory factor levels after intervention were lower,quality of life scores of the children were lower,and family satisfaction was higher(P<0.05).Conclusion:The implementation of childlike nursing combined with Chinese herbal patching for children with bronchopneumonia can shorten their symptom recovery time,significantly improve treatment compliance and quality of life,reduce inflammatory reactions,and achieve high satisfaction among family members.
基金financially supported by the National Key Research and Development Program(No.2023YFB4006100)the National Natural Science Foundation of China(No.52271232)+3 种基金Ningbo Youth Science and Technology Leading Talents Project(No.2023QL026)the Youth Innovation Promotion Association,CAS(No.2020300)the Natural Science Foundation of Zhejiang Province(Nos.LY21E020008 and LD21E020001)the“From 0 to 1”Innovative Program of CAS(No.ZDBS-LY-JSC021)
文摘Using abundant saline water for electrolysis,rather than limited freshwater,presents a promising technique for generating clean hydrogen energy.However,high concentration of corrosive chloride ions in saline water poses a great challenge in the stability of anode.In this study,we present a straightforward strategy to protect the anode from corrosion by patching the catalyst layer through a treatment of the anode with a sodium sulfide(Na2S) solution followed by electrochemical activation.The rapid sulfurization of the Ni electrode in Na2S results in the formation of a Na2S layer,which can subsequently be converted to NiOOH upon electrochemical activation,thereby shielding the inner Ni electrode from corrosion.The as-prepared electrode (P-NiFe-LDH/Ni) based on the strategy demonstrated stability over 3,500 h at an industrial current density of 0.5 A cm^(-2)in a 0.5 M NaCl and 1 M KOH solution.This study presents an effective strategy to significantly enhance the stability of anodes for saline water electrolysis by effectively patching the cracks in the catalyst layer.
基金Supported by: (1) Specialized Research Fund for the Doctoral Program of Higher Education (No. 20030013006) (2) National Specialized R&D Project for the Product of Mobile Communications (Develop-ment and Application of Next Generation Mobile Intel-ligent Network)+3 种基金 (3) Development Fund Key Project for Electronic and Information Industry (Core Service Plat-form for Next Generation Network) (4) Development Fund Project for Electronic and Information Industry (Value-added Service Platform and Application System for Mobile Communications) (5) Development Fund Project for Electronic and Information Industry (Con-tent-based Integrated Charging Platform for Telecom-munication Networks) (6) National Specific Project for Hi-tech Industrialization and Information Equipments (Mobile Intelligent Network Supporting Value-added Data Services).
文摘A mobile transmission strategy, PMPatching (Proxy-based Mobile Patching) transmission strat-egy is proposed, it applies to the proxy-based mobile streaming media system in Wideband Code Division Multiple Access (WCDMA) network. Performance of the whole system can be improved by using patching stream to transmit anterior part of the suffix that had been played back, and by batching all the demands for the suffix arrived in prefix period and patching stream transmission threshold period. Experimental results show that this strategy can efficiently reduce average network transmission cost and number of channels consumed in central streaming media server.
文摘AIM:To compare the efficacies of patching and penalization therapies for the treatment of amblyopia patients.METHODS:The records of 64 eyes of 50 patients 7 to16y of age who had presented to our clinics with a diagnosis of amblyopia,were evaluated retrospectively.Forty eyes of 26 patients who had received patching therapy and 24 eyes of 24 patients who had received penalization therapy included in this study.The latencies and amplitudes of visual evoked potential(VEP)records and best corrected visual acuities(BCVA)of these two groups were compared before and six months after the treatment.RESULTS:In both patching and the penalization groups,the visual acuities increased significantly following the treatments(P【0.05).The latency measurements of the P100 wave obtained at 1.0°,15 arc min.Patterns of both groups significantly decreased following the 6-months-treatment.However,the amplitude measurements increased(P【0.05).CONCLUSION:The patching and the penalization methods,which are the main methods used in the treatment of amblyopia,were also effective over the age of 7y,which has been accepted as the critical age for the treatment of amblyopia.
基金Funded by Railway Ministry Scientific Research Item
文摘The physical properties and microstructure of SUF are investigated to develop a highly effective cement matrix crack-patching material for concrete cracks. The SEM and XRD determination of hardened SUF shows that the microstructure of SUF is dense and compact with a lot of C-S-H gels and ettringite. Also, the mechanism of shrinkage compensating is discussed.
文摘New bugs and vulnerabilities are discovered and reported from time to time even after software products are released. One of the common ways to handle these bugs is to patch the software. In this paper, the authors propose a stochastic model for optimizing the patching time for software bugs and vulnerabilities. The optimal patching time can be computed in the patching script development and operational costs in fix. The authors present two case studies using the Nimda worm vulnerability in Microsoft Internet Information Services web server and the bug report of the Debian project. These studies indicate that the patch applications are later than their optimal fix time.
文摘Background:Patching an eye for a period of 2 hours results in a period of plasticity where inter-ocular balance shifts in favor of the patched eye.Acetylcholine has been shown to improve visual function and augment adult neural plasticity.Here we evaluate whether administering the cholinesterase inhibitor donepezil enhances the magnitude or duration of the patching induced shift in ocular balance.Methods:We used a double-blind drug treatment design to test the effect of donepezil and patching on the shift in ocular balance.We used a well-known binocular phase combination task to measure ocular balance before and after treatment.Results:Our results demonstrate that donepezil does not enhance,and may actually reduce the magnitude and duration of the patching-induced shift in ocular balance.Conclusions:Patching induced adult neural plasticity does not appear to be modulated by the cholinergic system,however,increased dose or longer drug administration periods may yield significant results.Future studies on binocular rivalry are in the pipeline.
文摘高压电缆长期过热可能导致绝缘热击穿,进而影响电网的稳定性。然而,当前研究主要集中在传统预测模型上,忽略了温度数据的复杂性和动态特征。为了解决此问题,提出一种基于多尺度Patch与卷积交互的电缆温度预测模型(MSP-CI)。首先,采用通道重组采样方法降低输入维度,并构建多尺度Patch分支结构,以实现复杂时间序列的解耦;其次,结合序列分解与卷积交互策略,分别提取粗粒度Patch的宏观信息与细粒度Patch的微观信息;最后,构建注意力融合模块,以动态平衡宏观与微观信息的权重,并得到最终的预测结果。在真实高压电缆温度数据集上的实验结果表明,MSP-CI相较于TimeMixer、PatchTST(Patch Time Series Transformer)和MSGNet(Multi-Scale interseries Graph Network)等基线模型,在均方误差(MSE)上下降了7.02%~34.87%,在平均绝对误差(MAE)上下降了5.15%~32.04%。可见,MSP-CI能有效提升电缆温度预测的准确率,为电力调度运行提供依据。
基金supported by the Program for Innovative Research Team(2011-CXTD-09)of Beijing University of Chinese Medicinepartially supported by the Program for the Model of Building Clinical Research Capacity for Chinese Medicine(grant number201207007)from the State Administration of Traditional Chinese Medicine of China+2 种基金the program for Young Faculty Fellow Plan of Beijing University of Chinese Medicine(2012-QNJSZX012)young elite talent plan of Beijing Municipal Commission of Education(YETP0796)supported by Ba Gui Scholarship from Guangxi Zhuang Autonomous Region
文摘Background: Acupoint herbal patching(AHP) alone or as an adjuvant therapy with conventional treatment(CT) has been widely used for prevention and treatment of chronic obstructive pulmonary disease(COPD). However, current clinical evidence from a systematic review of RCTs is lacking.Objective: To evaluate the effectiveness and safety of AHP with or without CT for people with COPD at stable stage.Methods: We searched randomized controlled trials comparing AHP(with or without CT) with no intervention, placebo, or CT from six databases. Two authors selected studies, extracted data and evaluated risk of bias of included trials. Rev Man 5.2 software was used to analysis data.Results: Twenty one RCTs(2327 participants) were included. AHP of non sanfu applied on no fixed dates with CT significantly decreased the mean frequency of acute exacerbation of COPD(times per year)(MD:-1.24; 95% CI:-2.02 to-0.46; 2 trials), and improved lung function parameters and quality of life. The AHP with CT showed no better effect in 6-minute walking distance(6 MWD) that CT alone. AHP applied at sanfu(specific dates based on lunar calendar) with CT had significant effect for 6 MWD(MD: 11.20; 95% CI: 0.83 to 21.56; I^2= 0%;3 trials). One trial reported skin irritation from AHP. Another trial reported two patients had eye discomfort, which was inferred as the adverse effects of seretide.Conclusion: AHP used as an adjunct to CT, appears to be more effective than CT alone in patients with stable COPD. However, further large,rigorously designed trials are warranted to confirm these potential effects.
基金supported by National Research Foundation of Korea(NRF)grants funded by the Korean government(MSIT)(No.RS-2023-00256265,RS-2024-00352352,RS-2024-00405818)the Korean Fund for Regenerative Medicine(KFRM)grant funded by the Korea government(the Ministry of Science and ICT,the Ministry of Health&Welfare).(No.25A0102L1)support from the Market-led K-sensor technology program(RS-2022-00154781,Development of large-area wafer-level flexible/stretchable hybrid sensor platform technology for form factor-free highly integrated convergence sensor),funded By the Ministry of Trade,Industry&Energy(MOTIE,Korea).
文摘Microneedles(MNs)have been extensively investigated for transdermal delivery of large-sized drugs,including proteins,nucleic acids,and even extracellular vesicles(EVs).However,for their sufficient skin penetration,conventional MNs employ long needles(≥600μm),leading to pain and skin irritation.Moreover,it is critical to stably apply MNs against complex skin surfaces for uniform nanoscale drug delivery.Herein,a dually amplified transdermal patch(MN@EV/SC)is developed as the stem cell-derived EV delivery platform by hierarchically integrating an octopusinspired suction cup(SC)with short MNs(≤300μm).While leveraging the suction effect to induce nanoscale deformation of the stratum corneum,MN@EV/SC minimizes skin damage and enhances the adhesion of MNs,allowing EV to penetrate deeper into the dermis.When MNs of various lengths are applied to mouse skin,the short MNs can elicit comparable corticosterone release to chemical adhesives,whereas long MNs induce a prompt stress response.MN@EV/SC can achieve a remarkable penetration depth(290μm)for EV,compared to that of MN alone(111μm).Consequently,MN@EV/SC facilitates the revitalization of fibroblasts and enhances collagen synthesis in middle-aged mice.Overall,MN@EV/SC exhibits the potential for skin regeneration by modulating the dermal microenvironment and ensuring patient comfort.
基金financially supported by the Science and Technology Bureau of Ali Prefecture,project named“Assessing the Carbon Sequestration and Carbon Sink Enhancement Potential of Natural Ecosystems in Ali Region(QYXTZX-AL2022-05)”。
文摘The alpine grassland vegetation on the Qinghai-Tibet Plateau is composed of plant patches in varied sizes.It remains uncertain whether vegetation recovery following grazing exclusion(GE)in degraded grasslands is driven by increases in patches number(NP),patch size(PS),or both.We based our predictions on two hypotheses:GE intensifies plant competition,and facilitation prevails near patches while competition prevails in interpatch spaces.We predicted that the NP would remain stable or decrease and PS would increase under GE treatment.To evaluate these predictions,we conducted a study in six lightly degraded alpine grasslands under free grazing(FG)conditions in Bangor County,Xizang Autonomous Region,China,with corresponding GE treatments using transects in 2017 and 2018.Results revealed that four sites in 2017 and five sites in 2018 had reduced NP and increased PS,with probabilities of 0.033(2017)and 0.004(2018),respectively,and a joint probability of 0.0001 under the null hypothesis that GE does not affect NP or PS.The NP reduction was solely due to the decrease in small patch sizes.An increase in PS was common across species,and a predominant tendency for NP reduction was observed among species across the sites.The overall changes in NP and PS were primarily driven by the three most abundant species(contributing more than 60%in both years),rather than by shifts in floristic composition.Our findings highlight that vegetation recovery in Bangor alpine steppes following GE relies solely on the expansion of existing patches rather than the recruitment of new ones in interpatch gaps.We recommend prioritizing growth-promoting measures,such as nutrient or water management,over seed addition when assisting with GE for restoring lightly degraded grasslands.
文摘In this study,we developed a novel bilayered scaffold consisting of a bottom layer composed of the Decellularized Bovine Pericardium(DP)coated with Polyaniline Nanoparticles(PANINPs)and a top layer made of an electrospun Poly(lactic-co-glycolic acid)/Gelatin(PLGA/Gel)membrane incorporated with Vascular Endothelial Growth Fac-tor(VEGF)and hawthorn extract.Functionally,the DP supplies native Extracellular Matrix(ECM)components and mechanical support,while PANINPs provide conductivity.The electrospun PLGA/Gel layer mimics fibrous ECM.It incorporates bioactives,with VEGF promoting pro-angiogenic stimulation and hawthorn extract enhanc-ing anticoagulant activity,as well as increasing surface hydrophilicity.The tissue adhesive ensures the interfacial integrity between the two layers.Decellularization efficiency was confirmed histologically using 4',6-diamidino-2-phenylindole(DAPI)and Hematoxylin-Eosin(H&E)staining.The DP exhibited a DNA content of 115.9±47.8 ng/mg DNA,compared to 982.88±395.42 ng/mg in Native Pericardium(NP).The PANINPs had an average par-ticle size of 104.94±13.7 nm.The conductivity of PANINPs-coated decellularized pericardium was measured to be 9.093±8.6×10-4 S/cm using the four-point probe method.PLGA/Gel membranes containing hawthorn extract(1%,5%,10%,and 15%w/v)and VEGF(0.1μg/mL,0.5μg/mL,and 1μg/mL)were fabricated by electrospinning,result-ing in fiber diameters between 850 and 1200 nm and pore sizes between 14 and 20μm.The anticoagulant efficiency of the membranes containing hawthorn extract reached 430 s in the Activated Partial Thromboplastin Time Assay(aPTT).Mechanical testing revealed a tensile strength of 22.70±6.33 MPa,an elongation of 53.58±10.63%,and Young's modulus of 0.67±0.10 MPa.The scaffold also exhibited over 91%cell viability and excellent cardiomyo-cyte adhesion.The hemolysis ratio was determined to be 0.421±0.191%,which confirms its blood compatibility.Our results indicate that the proposed bilayered scaffold can be a promising candidate for cardiac patch applications.
文摘The freemium pricing model has become mainstream in the software industry.A large user base can induce positive network effects while expanding security risks associated with unpatched users.This study explores a two-stage decision problem faced by software vendors that involves a freemium versioning strategy and a subsequent security-patching strategy when taking both the positive network externality and negative security externality into consideration.It is noteworthy that a joint effect of the two externalities on the vendor’s management decisions exists.First,we analytically derive three patching strategies for the vendor:PS_(1)(rebates all users),PS_(2)(rebates only freeware users),and PS_(3)(rebates no users).Our results indicate that,if the strength of the positive network externality is relatively low,the optimal security-patching strategy will be significantly affected by the negative security externality.Specifically,when the intensity of the negative security externality is low,the vendor’s optimal patching strategy will be PS_(1).However,with the increase in the negative security externality,the optimal patching strategy changes to PS_(2) and then to PS_(3),whereas the strategy spaces of PS_(1) and PS_(2) decrease in the positive network externality to zero.Nevertheless,if the strength of the positive network externality is relatively high,the vendor is better off selecting PS_(1) when the negative security externality is low.However,when the negative security externality is high,PS_(3) is optimal.Furthermore,based on optimal patching strategies,we reveal the optimal conditions required for the vendor to adopt the freemium model compared with commercial only.Of interest,we find that the vendor adopting the freemium version is also influenced by the interaction of the two externalities.Finally,through numerical experiments,we find that the vendor and social planner’s interests can be aligned under certain conditions.However,this is not always the case.
文摘In the version of the article originally published in the volume 68,issue 12,2025 of Sci China Mater(pages 4413-4422,https://doi.org/10.1007/s40843-025-3667-7),the Chinese name of the co-first author(肖天孝)was incorrect.The corrected Chinese name is:肖天笑.
基金support from the National Natural Science Foundation of China(21974067,22274073)the Fundamental Research Funds for the Central Universities(020514380309,021414380502,2022300324)the State Key Laboratory of Analytical Chemistry for Life Science(5431ZZXM2305,5431ZZXM2204).
文摘Lipid rafts(LRs)are relatively well-ordered functional microdomains in cell membranes and play an irreplaceable role in physiological processes as a transduction platform for multiple signaling pathways.Due to their small size and high spatiotemporal dynamics,it is difficult to perform lipid raftlocalized biomolecule imaging on the surface of living cells.Here,we report a DNA nanotechnology-based platform for reversible manipulation and localized analysis of lipid rafts,which consists of two modules:“patching and coding probe pair”and“fishing probe”.The probe pair is generated by modifying two different sets of connectable DNA structures on a lipid raft-specific protein.After recognizing lipid rafts,the two probes in close proximity are linked by a DNA ligase reaction to form a lipid raft identity(LRID)code.The LR-ID strand patches and stabilizes the lipid raft structure.Interestingly,the raft patches formed can be depatched by restriction endonucleases,providing the first reversible manipulation of the lipid raft structure in living cells.We also designed a“fishing probe”with a DNA hairpin structure using an aptamer that can specifically bind to the target.The probe can cascade the reaction to two input signals“LR-ID”and“target protein”to generate an“off-on”fluorescence switch,allowing imaging and dynamic monitoring of target proteins localized in lipid rafts.By encoding arbitrary targets(in the case of glycans)in lipid rafts,we have created a universal lipid raft-localized imaging platform.This work provides an integrated analytical and manipulative platform to reveal lipid rafts and associated signaling pathways at the molecular level.
