Product storage policy, single picking volume and picking routing are the three factors of vital importance that affect the efficiency of a crane to pick goods in automated storage and retrieval systems(AS/RS). Compar...Product storage policy, single picking volume and picking routing are the three factors of vital importance that affect the efficiency of a crane to pick goods in automated storage and retrieval systems(AS/RS). Comparative experiments on picking efficiency were conducted targeting picking operation with order of 1 to 20. Based on dedicated and random storage policies, 4 picking methods of patching-based, S-type, return-type and optimized-type routes were used and compared in the experiments. The results show that either the dedicated policy or the random policy was applied, crane worked most efficiently with optimizedtype route, followed by S-type path, patching-based path, and return-type path. When the number of orders in a single picking is larger(more than 5), the random storage policy is preferable to the dedicated policy.展开更多
We used whole-vacuolar patch-clamp recording mode to study the action mechanism of La3+ to Slow Vacuolar (SV) channels for the first time. We recorded SV channel currents of Xinlimei (Raphanus satirus L.) vacuolars. T...We used whole-vacuolar patch-clamp recording mode to study the action mechanism of La3+ to Slow Vacuolar (SV) channels for the first time. We recorded SV channel currents of Xinlimei (Raphanus satirus L.) vacuolars. The minimum activation potentials of voltage-dependent SV channels tied in 25+/-5 mV. The increase in cytoplasmic Ca2+ led to enhancement of SV-type currents. It was found that the threshold potential of activation shifted towards more depolarized values whenever cytoplasmic Ca2+ was increased. When 10(-10) mol/L free La3+ was added to the bath, SV-type current was suppressed by 60 similar to 75%. These data showed La3+ reduced ion permeabilities of Xinlimei root vacuolar membrane.展开更多
Objectives Heart failure （HF） is one of the most common outcome for all kinds of heart diseases, the effects of energetic therapy on HF remains controversial, especially to ischemic HF. The aim of this study was to ...Objectives Heart failure （HF） is one of the most common outcome for all kinds of heart diseases, the effects of energetic therapy on HF remains controversial, especially to ischemic HF. The aim of this study was to explore the effect of exogenous phosphocreatine with different concentration on L-type calcium（I Cc-L） current in ischemic ventricular myocytes of guinea pig and to investigate its underlying electrophysiological mechanism for the treatment of ischemic HF. Methods Single ventricular myocytes were isolated enzymatically from left ventricle of guinea pig. Peak I Ca-L current were recorded using patch clamp techniques in the whole-cell configuration when myocytes had been superfused with normal Tyrode solution, simple ischemic solution, ischemic solution containing phosphocreatine with different concentration for 10 minutes respectively. Results Peak I Ca-L current density of myocytes superfused with simple simulated ischemic solution was remarkably inhibited by 80.6 ± 5.2% compared with myocytes superfused with normal Tyrode solution（P〈0.05）. Ischemic solution containing phosphocreatine of 5, 10, 20, 30mmol/L inhibited Peak I Ca-L current density by （53.8±6.7）%, （41.8 ± 8.2）%, （38.1±7.4）%, （36.6±9.7）% respectively. There was no statistical significance among phosphocreation of 10, 20, 30 mmol / L. Conclusions Extrogenous phosphocreatine could reverse the inhibition of I Ca-L current under ischemic condition, which could be the ionic basis for the treatment of ischemic heart failure. 0-10 mmol/L phosphocreatine exerted significant dose-effect relationship which no longer existed as concentration more than 10 mmol/L. It is supposed that phosphocreatine increased I Ca-L current by many pathways rather than simple substrate for ATP synthesis.展开更多
Ultrasonic power and data transfer is a promising technology for implantable medical devices because of its non-invasiveness,deep penetration depth,and potential for a high-power transmission rate with a low specific ...Ultrasonic power and data transfer is a promising technology for implantable medical devices because of its non-invasiveness,deep penetration depth,and potential for a high-power transmission rate with a low specific absorption rate.However,ultrasound-powered implantable devices still suffer from low power transfer efficiency due to beam misalignment and are limited to short-term use due to the bulkiness of the transmitting transducers.Here,we report the first proof of concept for adaptive positioning and targeting of ultrasound-based implantable devices through ultrasound image guidance.A lightweight patch-type ultrasonic transducer array is fabricated to enable ultrasound imaging and beam-forming during long-term operation.The uniform performance of the array is established through the silicon micromachining process.We demonstrate the complete scheme of imaging,positioning,and targeted power transfer in an ex vivo environment,achieving precise targeting of moving implanted devices through real-time ultrasound imaging.Enhanced power transfer efficiency through the use of patch-type ultrasonic transducers can enhance patient comfort and minimize invasive procedures,opening new applications for ultrasonic-powered implantable devices.展开更多
基金Funded by National Social Science Foundation of China(16CGL018)the Soft Science Research Funds for Chengdu Science and Technology Project(2015-RK00-00206-ZF)the National United Engineering Laboratory of Integrated and Intelligent Transportation,Southwest Jiaotong University,China
文摘Product storage policy, single picking volume and picking routing are the three factors of vital importance that affect the efficiency of a crane to pick goods in automated storage and retrieval systems(AS/RS). Comparative experiments on picking efficiency were conducted targeting picking operation with order of 1 to 20. Based on dedicated and random storage policies, 4 picking methods of patching-based, S-type, return-type and optimized-type routes were used and compared in the experiments. The results show that either the dedicated policy or the random policy was applied, crane worked most efficiently with optimizedtype route, followed by S-type path, patching-based path, and return-type path. When the number of orders in a single picking is larger(more than 5), the random storage policy is preferable to the dedicated policy.
基金The authors acknowledge the support of the National Natural Science Foundation of ChinaProvincial Natural Science Foundation of Shanxi.
文摘We used whole-vacuolar patch-clamp recording mode to study the action mechanism of La3+ to Slow Vacuolar (SV) channels for the first time. We recorded SV channel currents of Xinlimei (Raphanus satirus L.) vacuolars. The minimum activation potentials of voltage-dependent SV channels tied in 25+/-5 mV. The increase in cytoplasmic Ca2+ led to enhancement of SV-type currents. It was found that the threshold potential of activation shifted towards more depolarized values whenever cytoplasmic Ca2+ was increased. When 10(-10) mol/L free La3+ was added to the bath, SV-type current was suppressed by 60 similar to 75%. These data showed La3+ reduced ion permeabilities of Xinlimei root vacuolar membrane.
文摘Objectives Heart failure （HF） is one of the most common outcome for all kinds of heart diseases, the effects of energetic therapy on HF remains controversial, especially to ischemic HF. The aim of this study was to explore the effect of exogenous phosphocreatine with different concentration on L-type calcium（I Cc-L） current in ischemic ventricular myocytes of guinea pig and to investigate its underlying electrophysiological mechanism for the treatment of ischemic HF. Methods Single ventricular myocytes were isolated enzymatically from left ventricle of guinea pig. Peak I Ca-L current were recorded using patch clamp techniques in the whole-cell configuration when myocytes had been superfused with normal Tyrode solution, simple ischemic solution, ischemic solution containing phosphocreatine with different concentration for 10 minutes respectively. Results Peak I Ca-L current density of myocytes superfused with simple simulated ischemic solution was remarkably inhibited by 80.6 ± 5.2% compared with myocytes superfused with normal Tyrode solution（P〈0.05）. Ischemic solution containing phosphocreatine of 5, 10, 20, 30mmol/L inhibited Peak I Ca-L current density by （53.8±6.7）%, （41.8 ± 8.2）%, （38.1±7.4）%, （36.6±9.7）% respectively. There was no statistical significance among phosphocreation of 10, 20, 30 mmol / L. Conclusions Extrogenous phosphocreatine could reverse the inhibition of I Ca-L current under ischemic condition, which could be the ionic basis for the treatment of ischemic heart failure. 0-10 mmol/L phosphocreatine exerted significant dose-effect relationship which no longer existed as concentration more than 10 mmol/L. It is supposed that phosphocreatine increased I Ca-L current by many pathways rather than simple substrate for ATP synthesis.
基金supported by the Korea Medical Device Development Fund grant funded by the Korea government(the Ministry of Science and ICT,the Ministry of Trade,Industry and Energy,the Ministry of Health&Welfare,Republic of Korea,the Ministry of Food and Drug Safety)(202011B01,RS-2020-KD000007)by the K-Brain Project of the National Research Foundation(NRF)funded by the Korean government(MSIT)(RS-2023-00262568)+3 种基金by a grant of the Korea Dementia Research Project through the Korea Dementia Research Center(KDRC)funded by the Ministry of Health&Welfare and Ministry of Science and ICT,Republic of Korea(RS-2024-00355871)by Nanomedical Devices Development Project of NNFC(1711197701)by Samsung Electronics.
文摘Ultrasonic power and data transfer is a promising technology for implantable medical devices because of its non-invasiveness,deep penetration depth,and potential for a high-power transmission rate with a low specific absorption rate.However,ultrasound-powered implantable devices still suffer from low power transfer efficiency due to beam misalignment and are limited to short-term use due to the bulkiness of the transmitting transducers.Here,we report the first proof of concept for adaptive positioning and targeting of ultrasound-based implantable devices through ultrasound image guidance.A lightweight patch-type ultrasonic transducer array is fabricated to enable ultrasound imaging and beam-forming during long-term operation.The uniform performance of the array is established through the silicon micromachining process.We demonstrate the complete scheme of imaging,positioning,and targeted power transfer in an ex vivo environment,achieving precise targeting of moving implanted devices through real-time ultrasound imaging.Enhanced power transfer efficiency through the use of patch-type ultrasonic transducers can enhance patient comfort and minimize invasive procedures,opening new applications for ultrasonic-powered implantable devices.
文摘[目的]系统评价不同中医适宜技术对寒湿痹阻型膝痹病患者的干预效果,为临床实践提供循证依据。[方法]检索英文数据库PubMed、Web of Science Core Collection、CINAHL Complete、Embase、Science Direct、Cochrane Library,中文数据库中国知网、万方、维普和中国生物医学文献数据库中关于中医适宜技术对寒湿痹阻型膝痹病患者干预效果的文献,检索时限为2019年1月1日至2024年7月18日,由2名研究者独立筛选文献,并进行资料提取和文献质量评价。采用RevMan 5.4软件进行传统Meta分析,Stata 17.0软件进行网状Meta分析。[结果]最终纳入33项研究,共3154例患者,13种中医适宜技术。网状Meta分析显示,穴位贴敷联合中药熏洗改善膝关节症状的效果最好,累计排序概率图下面积(surface under the cumulative ranking,SUCRA)为92.7%;艾灸联合中药离子导入在提高临床总有效率方面效果最好,SUCRA为86.8%。[结论]现有研究表明,穴位贴敷联合中药熏洗能有效改善寒湿痹阻型膝痹病患者膝关节症状,艾灸联合中药离子导入能有效提高临床总有效率,且联合使用不同的中医适宜技术较单一使用效果较好。建议临床医护人员可在中医辨证基础之上,制定多样化的中医适宜技术干预方案,以提高寒湿痹阻型膝痹病患者的临床疗效和护理质量。
