This study sought to elucidate the changes of nuclear factor kappa B （NF-KB） expression and locomotor function of hind limb after subdural injection of BMS-345541 was applied in rats with acute spinal cord injury. T...This study sought to elucidate the changes of nuclear factor kappa B （NF-KB） expression and locomotor function of hind limb after subdural injection of BMS-345541 was applied in rats with acute spinal cord injury. The results indicated that BMS-345541 treatment reduced the expression of NF-kB at 24 hours after injury, compared with normal saline-treated rats. This treatment also led to a significant improvement in locomotor functional recovery at 14 days after injury. Overall, the findings demonstrated that BMS-345541 significantly ameliorated spinal cord injury-induced hind limb dysfunction by inhibiting the expression of NF-kB after spinal cord injury.展开更多
With three theoretical models of nuclear effects on gluon distribution functions,the differentialcross sections and the total cross sections for associate production of J/ψ and γ with large P_T in high energyp-Fe co...With three theoretical models of nuclear effects on gluon distribution functions,the differentialcross sections and the total cross sections for associate production of J/ψ and γ with large P_T in high energyp-Fe collisions are calculated.展开更多
On February 25, the Unit 1 of Ling’ao Nuclear Power Plant phase II underwent a 41-day-long hot functional test successfully with its major systems satisfying the requirements for
Since the position of the electron in a hydrogen atom cannot be determined, the region in which it resides is said to be determined stochastically and forms an electron cloud. The probability density function of the s...Since the position of the electron in a hydrogen atom cannot be determined, the region in which it resides is said to be determined stochastically and forms an electron cloud. The probability density function of the single electron in 1s orbit is expressed as φ2, a function of distance from the nucleus. However, the probability of existence of the electron is expressed as a radial distribution function at an arbitrary distance from the nucleus, so it is estimated as the probability of the entire spherical shape of that radius. In this study, it has been found that the electron existence probability approximates the radial distribution function by assuming that the probability of existence of the electron being in the vicinity of the nucleus follows a normal distribution for arbitrary x-, y-, and z-axis directions. This implies that the probability of existence of the electron, which has been known only from the distance information, would follow a normal distribution independently in the three directions. When the electrons’ motion is extremely restricted in a certain direction by the magnetic field of both tokamak and helical fusion reactors, the probability of existence of the electron increases with proximity to the nucleus, and as a result, it is less likely to be liberated from the nucleus. Therefore, more and more energy is required to free the nucleus from the electron in order to generate plasma.展开更多
目的基于Toll样受体4(TLR4)/髓样分化因子88(MyD88)/核因子-κB(NF-κB)通路分析麝香保心丸治疗稳定型心绞痛(寒凝心脉型)的临床效果,并探讨其作用机制。方法前瞻性选取2021年2月至2024年2月郑州大学第一附属医院收治的96例稳定型心绞痛...目的基于Toll样受体4(TLR4)/髓样分化因子88(MyD88)/核因子-κB(NF-κB)通路分析麝香保心丸治疗稳定型心绞痛(寒凝心脉型)的临床效果,并探讨其作用机制。方法前瞻性选取2021年2月至2024年2月郑州大学第一附属医院收治的96例稳定型心绞痛(寒凝心脉型)患者纳入研究,按随机数表法分为联合治疗组和常规治疗组各48例。常规治疗组患者接受常规治疗,联合治疗组患者在常规治疗组基础上接受麝香保心丸治疗,两组患者均治疗1个月。比较两组患者治疗1个月后的临床疗效,以及治疗前后的TLR4/MyD88/NF-κB通路信使核糖核酸(mRNA)表达水平、血脂水平、心功能及心绞痛发作情况,同时比较两组患者治疗期间的不良反应发生情况。结果治疗后,联合治疗组患者的治疗总有效率为93.75%,明显高于常规治疗组的75.00%,差异有统计学意义(P<0.05);治疗后,两组患者的外周血单个核细胞(PBMC)中TLR4、MyD88、NF-κB m RNA表达水平均下降,且联合治疗组分别为2.71±0.78、1.48±0.47、1.45±0.48,明显低于常规治疗组的3.42±0.73、3.18±0.76、2.37±0.59,差异均有统计学意义(P<0.05)。治疗后,两组患者的血清高密度脂蛋白胆固醇(HDL-C)水平均升高,且联合治疗组患者为(2.26±0.26)mmol/L,高于常规治疗组的(1.93±0.21)mmol/L,两组患者的血清甘油三酯(TG)、胆固醇(TC)及低密度脂蛋白胆固醇(LDL-C)水平均降低,且联合治疗组患者分别为(1.90±0.41)mmol/L、(5.46±0.59)mmol/L、(2.64±0.46)mmol/L,低于常规治疗组的(2.11±0.43)mmol/L、(5.93±0.54)mmol/L、(3.16±0.44)mmol/L,差异均有统计学意义(P<0.05);治疗后,两组患者的心室射血分数(LVEF)、每搏输出量(SV)水平均升高,且联合治疗组患者分别为(58.61±4.61)%、(71.24±7.79)m L,高于常规治疗组的(53.52±4.42)%、(64.71±6.05)m L,差异均有统计学意义(P<0.05);治疗后,两组患者的心绞痛发作次数、疼痛持续时间均降低,且联合治疗组患者分别为(1.12±0.31)次/周、(1.12±0.23)min/次,低于常规治疗组的(2.15±0.47)次/周、(1.74±0.27)min/次,差异均有统计学意义(P<0.05);治疗期间,联合治疗组患者的不良反应总发生率为8.33%,略高于常规治疗组的4.17%,但差异无统计学意义(P>0.05)。结论麝香保心丸治疗稳定型心绞痛(寒凝心脉型)疗效确切,可控制心绞痛发作情况,改善心功能,且安全性良好,其作用机制与其调节TLR4/MyD88/NF-κB通路及血脂代谢有关。展开更多
文摘This study sought to elucidate the changes of nuclear factor kappa B （NF-KB） expression and locomotor function of hind limb after subdural injection of BMS-345541 was applied in rats with acute spinal cord injury. The results indicated that BMS-345541 treatment reduced the expression of NF-kB at 24 hours after injury, compared with normal saline-treated rats. This treatment also led to a significant improvement in locomotor functional recovery at 14 days after injury. Overall, the findings demonstrated that BMS-345541 significantly ameliorated spinal cord injury-induced hind limb dysfunction by inhibiting the expression of NF-kB after spinal cord injury.
基金The project supported in part by the National Natural Science Foundation of Chinathe Doctoral Program Foundation of Institution of Higher Education of Chinathe Provincial Natural Science Foundation of Hebei
文摘With three theoretical models of nuclear effects on gluon distribution functions,the differentialcross sections and the total cross sections for associate production of J/ψ and γ with large P_T in high energyp-Fe collisions are calculated.
文摘On February 25, the Unit 1 of Ling’ao Nuclear Power Plant phase II underwent a 41-day-long hot functional test successfully with its major systems satisfying the requirements for
文摘Since the position of the electron in a hydrogen atom cannot be determined, the region in which it resides is said to be determined stochastically and forms an electron cloud. The probability density function of the single electron in 1s orbit is expressed as φ2, a function of distance from the nucleus. However, the probability of existence of the electron is expressed as a radial distribution function at an arbitrary distance from the nucleus, so it is estimated as the probability of the entire spherical shape of that radius. In this study, it has been found that the electron existence probability approximates the radial distribution function by assuming that the probability of existence of the electron being in the vicinity of the nucleus follows a normal distribution for arbitrary x-, y-, and z-axis directions. This implies that the probability of existence of the electron, which has been known only from the distance information, would follow a normal distribution independently in the three directions. When the electrons’ motion is extremely restricted in a certain direction by the magnetic field of both tokamak and helical fusion reactors, the probability of existence of the electron increases with proximity to the nucleus, and as a result, it is less likely to be liberated from the nucleus. Therefore, more and more energy is required to free the nucleus from the electron in order to generate plasma.
文摘目的基于Toll样受体4(TLR4)/髓样分化因子88(MyD88)/核因子-κB(NF-κB)通路分析麝香保心丸治疗稳定型心绞痛(寒凝心脉型)的临床效果,并探讨其作用机制。方法前瞻性选取2021年2月至2024年2月郑州大学第一附属医院收治的96例稳定型心绞痛(寒凝心脉型)患者纳入研究,按随机数表法分为联合治疗组和常规治疗组各48例。常规治疗组患者接受常规治疗,联合治疗组患者在常规治疗组基础上接受麝香保心丸治疗,两组患者均治疗1个月。比较两组患者治疗1个月后的临床疗效,以及治疗前后的TLR4/MyD88/NF-κB通路信使核糖核酸(mRNA)表达水平、血脂水平、心功能及心绞痛发作情况,同时比较两组患者治疗期间的不良反应发生情况。结果治疗后,联合治疗组患者的治疗总有效率为93.75%,明显高于常规治疗组的75.00%,差异有统计学意义(P<0.05);治疗后,两组患者的外周血单个核细胞(PBMC)中TLR4、MyD88、NF-κB m RNA表达水平均下降,且联合治疗组分别为2.71±0.78、1.48±0.47、1.45±0.48,明显低于常规治疗组的3.42±0.73、3.18±0.76、2.37±0.59,差异均有统计学意义(P<0.05)。治疗后,两组患者的血清高密度脂蛋白胆固醇(HDL-C)水平均升高,且联合治疗组患者为(2.26±0.26)mmol/L,高于常规治疗组的(1.93±0.21)mmol/L,两组患者的血清甘油三酯(TG)、胆固醇(TC)及低密度脂蛋白胆固醇(LDL-C)水平均降低,且联合治疗组患者分别为(1.90±0.41)mmol/L、(5.46±0.59)mmol/L、(2.64±0.46)mmol/L,低于常规治疗组的(2.11±0.43)mmol/L、(5.93±0.54)mmol/L、(3.16±0.44)mmol/L,差异均有统计学意义(P<0.05);治疗后,两组患者的心室射血分数(LVEF)、每搏输出量(SV)水平均升高,且联合治疗组患者分别为(58.61±4.61)%、(71.24±7.79)m L,高于常规治疗组的(53.52±4.42)%、(64.71±6.05)m L,差异均有统计学意义(P<0.05);治疗后,两组患者的心绞痛发作次数、疼痛持续时间均降低,且联合治疗组患者分别为(1.12±0.31)次/周、(1.12±0.23)min/次,低于常规治疗组的(2.15±0.47)次/周、(1.74±0.27)min/次,差异均有统计学意义(P<0.05);治疗期间,联合治疗组患者的不良反应总发生率为8.33%,略高于常规治疗组的4.17%,但差异无统计学意义(P>0.05)。结论麝香保心丸治疗稳定型心绞痛(寒凝心脉型)疗效确切,可控制心绞痛发作情况,改善心功能,且安全性良好,其作用机制与其调节TLR4/MyD88/NF-κB通路及血脂代谢有关。
