The nano-patterned InGaN film was used in green InGaN/GaN multiple quantum wells(MQWs)structure,to relieve the unpleasantly existing mismatch between high indium content InGaN and GaN,as well as to enhance the light o...The nano-patterned InGaN film was used in green InGaN/GaN multiple quantum wells(MQWs)structure,to relieve the unpleasantly existing mismatch between high indium content InGaN and GaN,as well as to enhance the light output.The different self-assembled nano-masks were formed on InGaN by annealing thin Ni layers of different thicknesses.Whereafter,the InGaN films were etched into nano-patterned films.Compared with the green MQWs structure grown on untreated InGaN film,which on nano-patterned InGaN had better luminous performance.Among them the MQWs performed best when 3 nm thick Ni film was used as mask,because that optimally balanced the effects of nano-patterned InGaN on the crystal quality and the light output.展开更多
A 385 nm InGaN/GaN LED on the sapphire with the nano-pattem was fabricated and its electroluminescence property was investigated in a three-dimensional （3D） space. The experimental results showed that the luminescen...A 385 nm InGaN/GaN LED on the sapphire with the nano-pattem was fabricated and its electroluminescence property was investigated in a three-dimensional （3D） space. The experimental results showed that the luminescent intensity of the LED was obviously oriented based on the nano-pattem of the sapphire substrate. And the optical interference was used to explain the luminescence orientation of the LED on the nano-pattemed substrate.展开更多
High-quality gallium nitride （GaN） film was grown on nano-pattemed sapphire substrates （NPSS） and investigated using XRD and SEM. It was found that the optimum thickness of the GaN bulter layer on the NPSS is 15 n...High-quality gallium nitride （GaN） film was grown on nano-pattemed sapphire substrates （NPSS） and investigated using XRD and SEM. It was found that the optimum thickness of the GaN bulter layer on the NPSS is 15 nm, which is thinner than that on micro-patterned sapphire substrates （MPSS）. An interesting phenomenon was observed for GaN film grown on NPSS：GaN mainly grows on the trench regions and little grows on the sidewalls of the patterns at the initial growth stage, which is dramatically different from GaN grown on MPSS. In addition. the electrical and optical properties of LEDs grown on NPSS were characterized.展开更多
Objective:To investigate the effect of nano-patterning modification on the cell proliferation and adhesion in burn wound healing of regenerated silk fibroin membrane.Methods:A total of 60 healthy SD mice were randomly...Objective:To investigate the effect of nano-patterning modification on the cell proliferation and adhesion in burn wound healing of regenerated silk fibroin membrane.Methods:A total of 60 healthy SD mice were randomly divided into three groups:group A received treatment involving nano-patterning on the surface of regenerated silk fibroin membrane,group B received treatment with recombinant human epidermal growth factor gel,and group C received the same treatment with recombinant human epidermal growth factor gel,with 20 cases in each group.Wound healing,surface structure,protein adsorption,cell proliferation and adhesion were assessed at intervals of 5th,15th and 25th d after treatment.Results:The findings indicated that:(1)The duration and pace of wound healing in groups A and B surpassed those of group C,with group A exhibiting superior results compared to group B(P<0.05);(2)Histopathological analysis revealed a progressive increase in neovascularization and fibroblast count in wound tissue across the 5th,15th,and 25th days for all three groups,with group C exhibiting a higher count of neovascularization and fibroblasts in unhealed tissue compared to groups A and B.(3)The levels of basic calponin expression in group A and group B showed an increase on the 5th and 15th day,followed by stabilization on the 25th day.In group C,the expression of basic calponin was initially high on the 5th day,and then stabilized on the 15th and 25th day(P<0.05);(4)The expression of fibroblast proliferating cell nuclear antigen in the wound tissue of mice in all three groups peaked on the 15th day and subsequently declined.The expression of PCNA in group A and group B was higher than that in group C at each time point,with group A exhibiting higher levels than group B(P<0.05);(5)As wounds healed,there was a reduction in apoptotic cells within the wound tissues of mice across three groups,with group a exhibiting a lower count compared to groups B and C(P<0.05).Conclusion:Nanopatterning on the surface of regenerated silk fibroin membrane can enhance the biocompatibility of burn wound treatment and promote the proliferation and adhesion of reparative cells.展开更多
The fabrication of precisely patterned polymers at the nanoscale is of critical importance.We have previously succeeded in creating various nanopatterned polymers with nanoscale resolution through the use of in situ a...The fabrication of precisely patterned polymers at the nanoscale is of critical importance.We have previously succeeded in creating various nanopatterned polymers with nanoscale resolution through the use of in situ atom transfer radical polymerization(ATRP)techniques on deoxyribonucleic acid(DNA)origami.However,separating nanopatterned polymers from the origami template without damaging the origami presents a significant challenge,thereby increasing costs and limiting the development of applications involving nanopatterned polymers.Here,we achieved spatially and temporally controlled release of DNA origami templates through photo-regulation by incorporating azobenzene-modified DNA into the initiator.Under UV exposure,azobenzene isomerization rapidly induces the disassociation of patterned polymers from the origami template at ambient temperatures,without damaging the DNA origami.Additionally,the released origami template can be reused as a template for the cyclic production of nanopatterned polymers.This method provides a pathway for the large-scale production of patterned polymers at reduced costs and facilitates dynamic control over the polymer-DNA complex,with potential applications in both the biomedical and chemical fields.展开更多
Because of biominerals,controlled morphology and unique properties,biominerals become the idea headspring for making organic-inorganic hybrid composite with new patterns.The preferred orientation phenomena of minerals...Because of biominerals,controlled morphology and unique properties,biominerals become the idea headspring for making organic-inorganic hybrid composite with new patterns.The preferred orientation phenomena of minerals on bioorganics are frequently observed in organisms,this can make the material′s performances become better,the human bone is a good example.By now,in most of the prepared nano-composites,the nano-particles dispersed randomly in polymer matrix.In this paper,magnetic/chitosan nano-composite in the magnetic environment was prepared via in-situ precipitation.From the XRD,TEM testing results,it can be concluded that nano magnetite particles arranged orderly in the chitosan matrix,the average diameter of the particles is about 11.3 nm.This provides a new method for preparing three-dimensional magnetic biomaterial,and has broad potential application to the bone repair field.展开更多
A new method was proposed to prepare binary composite colloidal crystal hydrogels by interlocking the as-prepared polystyrene/sulfonated polystyrene core/shell colloidal crystal hydrogel with a second responsive gel.T...A new method was proposed to prepare binary composite colloidal crystal hydrogels by interlocking the as-prepared polystyrene/sulfonated polystyrene core/shell colloidal crystal hydrogel with a second responsive gel.The shell thickness thus the core size were synchronously controlled by altering the sulfonation time and temperature.The proper monomers were radically polymerized forming the second gel within the first gel network.The composition and structure were confirmed.Nanopatterned hydrogel including porous bulk hydrogels and surface patterned hydrogels were derived by properly treating the binary composite hydrogels.Specially,some typical patterns such as arrays of “nano-bowls",arrays of “nano-ribbons" and “nano-mask" were achieved by changing the treatment method such as by immersion in the solvent,after solvent evaporation from the sample surface during high rate rotation.This work provides a method to prepare nanopatterned hydrogels.展开更多
基金the National Natural Science Foundation of China(Grant No.62074120)the State Key Laboratory on Integrated Optoelectronics(Grant No.IOSKL2018KF10)the Fundamental Research Funds for the Central Universities(Grant No.JB211108).
文摘The nano-patterned InGaN film was used in green InGaN/GaN multiple quantum wells(MQWs)structure,to relieve the unpleasantly existing mismatch between high indium content InGaN and GaN,as well as to enhance the light output.The different self-assembled nano-masks were formed on InGaN by annealing thin Ni layers of different thicknesses.Whereafter,the InGaN films were etched into nano-patterned films.Compared with the green MQWs structure grown on untreated InGaN film,which on nano-patterned InGaN had better luminous performance.Among them the MQWs performed best when 3 nm thick Ni film was used as mask,because that optimally balanced the effects of nano-patterned InGaN on the crystal quality and the light output.
文摘A 385 nm InGaN/GaN LED on the sapphire with the nano-pattem was fabricated and its electroluminescence property was investigated in a three-dimensional （3D） space. The experimental results showed that the luminescent intensity of the LED was obviously oriented based on the nano-pattem of the sapphire substrate. And the optical interference was used to explain the luminescence orientation of the LED on the nano-pattemed substrate.
基金supported by the Suzhou Nanojoin Photonics Co.,Ltd and the High-Tech Achievements Transformation of Jiangsu Province,China(No.BA2012010)
文摘High-quality gallium nitride （GaN） film was grown on nano-pattemed sapphire substrates （NPSS） and investigated using XRD and SEM. It was found that the optimum thickness of the GaN bulter layer on the NPSS is 15 nm, which is thinner than that on micro-patterned sapphire substrates （MPSS）. An interesting phenomenon was observed for GaN film grown on NPSS：GaN mainly grows on the trench regions and little grows on the sidewalls of the patterns at the initial growth stage, which is dramatically different from GaN grown on MPSS. In addition. the electrical and optical properties of LEDs grown on NPSS were characterized.
文摘Objective:To investigate the effect of nano-patterning modification on the cell proliferation and adhesion in burn wound healing of regenerated silk fibroin membrane.Methods:A total of 60 healthy SD mice were randomly divided into three groups:group A received treatment involving nano-patterning on the surface of regenerated silk fibroin membrane,group B received treatment with recombinant human epidermal growth factor gel,and group C received the same treatment with recombinant human epidermal growth factor gel,with 20 cases in each group.Wound healing,surface structure,protein adsorption,cell proliferation and adhesion were assessed at intervals of 5th,15th and 25th d after treatment.Results:The findings indicated that:(1)The duration and pace of wound healing in groups A and B surpassed those of group C,with group A exhibiting superior results compared to group B(P<0.05);(2)Histopathological analysis revealed a progressive increase in neovascularization and fibroblast count in wound tissue across the 5th,15th,and 25th days for all three groups,with group C exhibiting a higher count of neovascularization and fibroblasts in unhealed tissue compared to groups A and B.(3)The levels of basic calponin expression in group A and group B showed an increase on the 5th and 15th day,followed by stabilization on the 25th day.In group C,the expression of basic calponin was initially high on the 5th day,and then stabilized on the 15th and 25th day(P<0.05);(4)The expression of fibroblast proliferating cell nuclear antigen in the wound tissue of mice in all three groups peaked on the 15th day and subsequently declined.The expression of PCNA in group A and group B was higher than that in group C at each time point,with group A exhibiting higher levels than group B(P<0.05);(5)As wounds healed,there was a reduction in apoptotic cells within the wound tissues of mice across three groups,with group a exhibiting a lower count compared to groups B and C(P<0.05).Conclusion:Nanopatterning on the surface of regenerated silk fibroin membrane can enhance the biocompatibility of burn wound treatment and promote the proliferation and adhesion of reparative cells.
基金supported by the National Key R&D Program of China(No.2021YFF200203)the Key R&D Program of Hubei Province(No.2021BAA168)+2 种基金the National Science Foundation of China(22077042)the Max Planck Partner Group.The authors are grateful to the Analytical and Testing Centre of HUST,Analytical and Testing Centre of the School of Chemistry and Chemical Engineering(HUST)Research Core Facilities for Life Science(HUST)for instrument support.
文摘The fabrication of precisely patterned polymers at the nanoscale is of critical importance.We have previously succeeded in creating various nanopatterned polymers with nanoscale resolution through the use of in situ atom transfer radical polymerization(ATRP)techniques on deoxyribonucleic acid(DNA)origami.However,separating nanopatterned polymers from the origami template without damaging the origami presents a significant challenge,thereby increasing costs and limiting the development of applications involving nanopatterned polymers.Here,we achieved spatially and temporally controlled release of DNA origami templates through photo-regulation by incorporating azobenzene-modified DNA into the initiator.Under UV exposure,azobenzene isomerization rapidly induces the disassociation of patterned polymers from the origami template at ambient temperatures,without damaging the DNA origami.Additionally,the released origami template can be reused as a template for the cyclic production of nanopatterned polymers.This method provides a pathway for the large-scale production of patterned polymers at reduced costs and facilitates dynamic control over the polymer-DNA complex,with potential applications in both the biomedical and chemical fields.
文摘Because of biominerals,controlled morphology and unique properties,biominerals become the idea headspring for making organic-inorganic hybrid composite with new patterns.The preferred orientation phenomena of minerals on bioorganics are frequently observed in organisms,this can make the material′s performances become better,the human bone is a good example.By now,in most of the prepared nano-composites,the nano-particles dispersed randomly in polymer matrix.In this paper,magnetic/chitosan nano-composite in the magnetic environment was prepared via in-situ precipitation.From the XRD,TEM testing results,it can be concluded that nano magnetite particles arranged orderly in the chitosan matrix,the average diameter of the particles is about 11.3 nm.This provides a new method for preparing three-dimensional magnetic biomaterial,and has broad potential application to the bone repair field.
文摘A new method was proposed to prepare binary composite colloidal crystal hydrogels by interlocking the as-prepared polystyrene/sulfonated polystyrene core/shell colloidal crystal hydrogel with a second responsive gel.The shell thickness thus the core size were synchronously controlled by altering the sulfonation time and temperature.The proper monomers were radically polymerized forming the second gel within the first gel network.The composition and structure were confirmed.Nanopatterned hydrogel including porous bulk hydrogels and surface patterned hydrogels were derived by properly treating the binary composite hydrogels.Specially,some typical patterns such as arrays of “nano-bowls",arrays of “nano-ribbons" and “nano-mask" were achieved by changing the treatment method such as by immersion in the solvent,after solvent evaporation from the sample surface during high rate rotation.This work provides a method to prepare nanopatterned hydrogels.
