In this study,precise control over the thickness and termination of Ti3C2TX MXene flakes is achieved to enhance their electrical properties,environmental stability,and gas-sensing performance.Utilizing a hybrid method...In this study,precise control over the thickness and termination of Ti3C2TX MXene flakes is achieved to enhance their electrical properties,environmental stability,and gas-sensing performance.Utilizing a hybrid method involving high-pressure processing,stirring,and immiscible solutions,sub-100 nm MXene flake thickness is achieved within the MXene film on the Si-wafer.Functionalization control is achieved by defunctionalizing MXene at 650℃ under vacuum and H2 gas in a CVD furnace,followed by refunctionalization with iodine and bromine vaporization from a bubbler attached to the CVD.Notably,the introduction of iodine,which has a larger atomic size,lower electronegativity,reduce shielding effect,and lower hydrophilicity(contact angle:99°),profoundly affecting MXene.It improves the surface area(36.2 cm^(2) g^(-1)),oxidation stability in aqueous/ambient environments(21 days/80 days),and film conductivity(749 S m^(-1)).Additionally,it significantly enhances the gas-sensing performance,including the sensitivity(0.1119Ωppm^(-1)),response(0.2% and 23%to 50 ppb and 200 ppm NO_(2)),and response/recovery times(90/100 s).The reduced shielding effect of the–I-terminals and the metallic characteristics of MXene enhance the selectivity of I-MXene toward NO2.This approach paves the way for the development of stable and high-performance gas-sensing two-dimensional materials with promising prospects for future studies.展开更多
目的研究社区老年2型糖尿病(type 2 diabetes mellitus,T2DM)对骨密度(bone mineral density,BMD)、下肢肌功能、跌倒及骨折的影响。方法选取上海市5家社区卫生服务中心的60岁以上老年人9 584例,其中T2DM组1 201例,对照组8 383例;T2DM...目的研究社区老年2型糖尿病(type 2 diabetes mellitus,T2DM)对骨密度(bone mineral density,BMD)、下肢肌功能、跌倒及骨折的影响。方法选取上海市5家社区卫生服务中心的60岁以上老年人9 584例,其中T2DM组1 201例,对照组8 383例;T2DM患者分为骨折组184例,非骨折组1 017例。分别记录受试者的年龄、性别、身高及体质量,计算出体质量指数(body mass index,BMI),起立行走计时测试(the timed up and go,TUG)评估下肢肌力情况,询问受试者骨折史,吸烟、饮酒情况,1年内跌倒及骨折情况,父母发生髋部骨折史,并询问T2DM患者的病程,药物治疗情况。利用跟骨超声骨密度仪(quantitative ultrasound system-bone mineral density,QUS-BMD)测量骨密度值。比较T2DM与对照组的一般基础资料及发生跌倒和骨折情况,比较T2DM患者骨折组与非骨折组各临床指标。结果 T2DM组吸烟率20.4%明显高于对照组17.8%(P=0.030),完成TUG所需中位数时间10.75 s明显高于对照组10.12 s(P=0.000),BMD(0.920±0.040)g/cm^2高于对照组(0.790±0.030)g/cm^2(P=0.000),1年内跌倒发生率10.1%高于对照组7.1%(P=0.000),1年内骨折发生率15.3%高于对照组12.1%(P=0.080);T2DM患者中,与非骨折组相比,骨折组女性的比例高(89.1%vs.52.1%,P=0.000)、糖尿病病程长[(11.6±0.6)年vs.(9.6±0.2)年,P=0.000]、吸烟比率高(95.1%vs.67.9%,P=0.000)、饮酒比率高(93.5%vs.80.7%,P=0.000)、使用胰岛素比率高(23.9%vs.14.9%,P=0.002)、父母髋部骨折史高(9.2%vs.3.7%,P=0.001)、1年内发生跌倒率高(20.7%vs.8.3%,P=0.000)、跌倒风险评分高[(2.98±0.01)分vs.(1.8±0.01)分,P=0.000]、TUG高(10.92 s vs.10.34 s,P=0.000)、骨密度低[(0.635±0.026)g/cm^2vs.(0.780±0.030)g/cm^2,P=0.000]。结论与对照组相比,患T2DM的老年人虽然BMD高,但是下肢肌功能降低、跌倒及骨折的发生率明显增高,揭示T2DM降低了老年人肌肉功能,增加了跌倒和骨折的发生,且该作用独立于BMD以外。展开更多
目的探讨利拉鲁肽与格列美脲对胰岛素控制血糖欠佳的2型糖尿病患者血糖指标、胰岛功能及下肢血管功能的影响。方法选取我院2019年1月至2021年1月收治的60例胰岛素控制血糖欠佳的2型糖尿病患者作为研究对象,以随机数字表法将其分为对照组...目的探讨利拉鲁肽与格列美脲对胰岛素控制血糖欠佳的2型糖尿病患者血糖指标、胰岛功能及下肢血管功能的影响。方法选取我院2019年1月至2021年1月收治的60例胰岛素控制血糖欠佳的2型糖尿病患者作为研究对象,以随机数字表法将其分为对照组(30例,格列美脲)和观察组(30例,利拉鲁肽)。比较两组治疗前、后的血糖指标、血糖波动指标、胰岛功能指标、下肢血管功能指标、HSP60、Nesfatin-1水平。结果治疗后,观察组的FPG、2 h PG、HbA1c水平均低于对照组(P<0.05)。治疗后,观察组的MBG、SDBG、LAGE水平均低于对照组(P<0.05)。治疗后,观察组的FINS水平低于对照组,HOMA-IR小于对照组,HOMA-β大于对照组(P<0.05)。治疗后,观察组下肢血管IMT、PSV、直径狭窄率均小于对照组(P<0.05)。治疗后,观察组的HSP60、Nesfatin-1水平均低于对照组(P<0.05)。结论治疗胰岛素控制血糖欠佳的2型糖尿病患者采用利拉鲁肽较格列美脲更有优势,利拉鲁肽有助于提高患者的血糖控制效果,促进胰岛功能及下肢血管功能的进一步改善,下调HSP60、Nesfatin-1水平,值得推广。展开更多
基金supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT)(No. 2021R1I1A1A0105621313, No. 2022R1F1A1074441, No. 2022K1A3A1A20014496, and No. 2022R1F1A1074083)supported by the Ministry of Education Funding (No. RIS 2021-004)supported by the Brain Pool program funded by the Ministry of Science and ICT through the National Research Foundation of Korea (RS-2023-00284318).
文摘In this study,precise control over the thickness and termination of Ti3C2TX MXene flakes is achieved to enhance their electrical properties,environmental stability,and gas-sensing performance.Utilizing a hybrid method involving high-pressure processing,stirring,and immiscible solutions,sub-100 nm MXene flake thickness is achieved within the MXene film on the Si-wafer.Functionalization control is achieved by defunctionalizing MXene at 650℃ under vacuum and H2 gas in a CVD furnace,followed by refunctionalization with iodine and bromine vaporization from a bubbler attached to the CVD.Notably,the introduction of iodine,which has a larger atomic size,lower electronegativity,reduce shielding effect,and lower hydrophilicity(contact angle:99°),profoundly affecting MXene.It improves the surface area(36.2 cm^(2) g^(-1)),oxidation stability in aqueous/ambient environments(21 days/80 days),and film conductivity(749 S m^(-1)).Additionally,it significantly enhances the gas-sensing performance,including the sensitivity(0.1119Ωppm^(-1)),response(0.2% and 23%to 50 ppb and 200 ppm NO_(2)),and response/recovery times(90/100 s).The reduced shielding effect of the–I-terminals and the metallic characteristics of MXene enhance the selectivity of I-MXene toward NO2.This approach paves the way for the development of stable and high-performance gas-sensing two-dimensional materials with promising prospects for future studies.
文摘目的研究社区老年2型糖尿病(type 2 diabetes mellitus,T2DM)对骨密度(bone mineral density,BMD)、下肢肌功能、跌倒及骨折的影响。方法选取上海市5家社区卫生服务中心的60岁以上老年人9 584例,其中T2DM组1 201例,对照组8 383例;T2DM患者分为骨折组184例,非骨折组1 017例。分别记录受试者的年龄、性别、身高及体质量,计算出体质量指数(body mass index,BMI),起立行走计时测试(the timed up and go,TUG)评估下肢肌力情况,询问受试者骨折史,吸烟、饮酒情况,1年内跌倒及骨折情况,父母发生髋部骨折史,并询问T2DM患者的病程,药物治疗情况。利用跟骨超声骨密度仪(quantitative ultrasound system-bone mineral density,QUS-BMD)测量骨密度值。比较T2DM与对照组的一般基础资料及发生跌倒和骨折情况,比较T2DM患者骨折组与非骨折组各临床指标。结果 T2DM组吸烟率20.4%明显高于对照组17.8%(P=0.030),完成TUG所需中位数时间10.75 s明显高于对照组10.12 s(P=0.000),BMD(0.920±0.040)g/cm^2高于对照组(0.790±0.030)g/cm^2(P=0.000),1年内跌倒发生率10.1%高于对照组7.1%(P=0.000),1年内骨折发生率15.3%高于对照组12.1%(P=0.080);T2DM患者中,与非骨折组相比,骨折组女性的比例高(89.1%vs.52.1%,P=0.000)、糖尿病病程长[(11.6±0.6)年vs.(9.6±0.2)年,P=0.000]、吸烟比率高(95.1%vs.67.9%,P=0.000)、饮酒比率高(93.5%vs.80.7%,P=0.000)、使用胰岛素比率高(23.9%vs.14.9%,P=0.002)、父母髋部骨折史高(9.2%vs.3.7%,P=0.001)、1年内发生跌倒率高(20.7%vs.8.3%,P=0.000)、跌倒风险评分高[(2.98±0.01)分vs.(1.8±0.01)分,P=0.000]、TUG高(10.92 s vs.10.34 s,P=0.000)、骨密度低[(0.635±0.026)g/cm^2vs.(0.780±0.030)g/cm^2,P=0.000]。结论与对照组相比,患T2DM的老年人虽然BMD高,但是下肢肌功能降低、跌倒及骨折的发生率明显增高,揭示T2DM降低了老年人肌肉功能,增加了跌倒和骨折的发生,且该作用独立于BMD以外。
文摘目的探讨利拉鲁肽与格列美脲对胰岛素控制血糖欠佳的2型糖尿病患者血糖指标、胰岛功能及下肢血管功能的影响。方法选取我院2019年1月至2021年1月收治的60例胰岛素控制血糖欠佳的2型糖尿病患者作为研究对象,以随机数字表法将其分为对照组(30例,格列美脲)和观察组(30例,利拉鲁肽)。比较两组治疗前、后的血糖指标、血糖波动指标、胰岛功能指标、下肢血管功能指标、HSP60、Nesfatin-1水平。结果治疗后,观察组的FPG、2 h PG、HbA1c水平均低于对照组(P<0.05)。治疗后,观察组的MBG、SDBG、LAGE水平均低于对照组(P<0.05)。治疗后,观察组的FINS水平低于对照组,HOMA-IR小于对照组,HOMA-β大于对照组(P<0.05)。治疗后,观察组下肢血管IMT、PSV、直径狭窄率均小于对照组(P<0.05)。治疗后,观察组的HSP60、Nesfatin-1水平均低于对照组(P<0.05)。结论治疗胰岛素控制血糖欠佳的2型糖尿病患者采用利拉鲁肽较格列美脲更有优势,利拉鲁肽有助于提高患者的血糖控制效果,促进胰岛功能及下肢血管功能的进一步改善,下调HSP60、Nesfatin-1水平,值得推广。
