摘要
目的:探讨Barrett's食管(BE)食管运动功能、环氧合酶-2(COX-2)的表达及其发病机制。方法:收集62例经内镜和病理确诊的BE患者的资料,对其中21例的食管动力学检查结果进行分析;采用免疫组化SP法检测其中37例食管黏膜组织中COX-2蛋白的表达。以20例同期健康体检者和23例反流性食管炎(RE)患者作对照。结果:BE组下食管括约肌(LES)压力低于RE组及健康对照组,BE组食管远端收缩波幅较RE组及对照组降低(P均<0.05),而食管近端收缩波幅3组间差异无统计学意义(P>0.05)。正常十二指肠上皮组织中COX-2无表达,而20/24无不典型增生BE肠化黏膜、12/13不典型增生BE肠化黏膜表达COX-2蛋白,且2者间表达差异无统计学意义(P<0.05)。结论:LES功能失调是BE主要发病机制,COX-2蛋白的表达是BE发生的早期事件。
Aim ： To investigate the expression of cyclooxygenase-2 （COX-2） and motor function of Barrett＇s esophagus （ BE）. Methods ： The clinical characteristics of sixty-two BE patients were analyzed, Motor function of esophagus was detected in 21 cases,and the expression of COX-2 in mucosa were detected in 37 cases. Twenty healthy individuals and 23 patients with reflux esophagitis （RE） were the control. Results： Lower esophageal sphincter （LES）pressure and distal esophageal contraction amplitude of BE patients were lower than those of RE and controls （ P 〈 0.05 ）. The expression of COX-2 were found in 20 out of 24 BE without dysplasia, and 12 out of 13 BE with dysplasia, but not in normal mucosa. Conclusion ： The dysfunction of the LES is the main mechanism of BE, and COX-2 expression is an early event in the development of BE.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2006年第5期942-944,共3页
Journal of Zhengzhou University(Medical Sciences)
