Dear Editor,This letter presents a novel latent factorization model for high dimensional and incomplete (HDI) tensor, namely the neural Tucker factorization (Neu Tuc F), which is a generic neural network-based latent-...Dear Editor,This letter presents a novel latent factorization model for high dimensional and incomplete (HDI) tensor, namely the neural Tucker factorization (Neu Tuc F), which is a generic neural network-based latent-factorization-of-tensors model under the Tucker decomposition framework.展开更多
Altermagnetism,a recently identified class of collinear magnetism,combines key features of antiferromagnets and ferromagnets.Despite having zero net magnetization,altermagnetic materials exhibit anomalous transport ef...Altermagnetism,a recently identified class of collinear magnetism,combines key features of antiferromagnets and ferromagnets.Despite having zero net magnetization,altermagnetic materials exhibit anomalous transport effects,including the anomalous Hall,Nernst,and thermal Hall effects,as well as magneto-optical Kerr and Faraday effects.These phenomena,previously thought unique to ferromagnets,are dictated by symmetry,as confirmed by density functional theory(DFT)calculations.However,an effective model-based approach to verify these symmetry constraints remains unavailable.In this Letter,we construct a k·ρ model for d-wave altermagnets CuX_(2)(X=F,Cl)using spin space group representations and apply it to calculate the anomalous Hall effect.The symmetry-imposed transport properties predicted by the model are in agreement with the DFT results,providing a foundation for further investigation into symmetry-restricted transport phenomena in altermagnetic materials.展开更多
Microfinance institutions in Kenya play a unique role in promoting financial inclusion,loans,and savings provision,especially to low-income individuals and small-scale entrepreneurs.However,despite their benefits,most...Microfinance institutions in Kenya play a unique role in promoting financial inclusion,loans,and savings provision,especially to low-income individuals and small-scale entrepreneurs.However,despite their benefits,most of their products and programs in Machakos County have been reducing due to re-payment challenges,threatening their financial ability to extend further credit.This could be attributed to ineffective credit scoring models which are not able to establish the nuanced non-linear repayment behavior and patterns of the loan applicants.The research objective was to enhance credit risk scoring for microfinance institutions in Machakos County using supervised machine learning algorithms.The study adopted a mixed research design under supervised machine learning approach.It randomly sampled 6771 loan application ac-count records and repayment history.Rstudio and Python programming lan-guages were deployed for data pre-processing and analysis.Logistic regression algorithm,XG Boosting and the random forest ensemble method were used.Metric evaluations used included the performance accuracy,Area under the Curve and F1-Score.Based on the study findings:XG Boosting was the best performer with 83.3%accuracy and 0.202 Brier score.Development of legal framework to govern ethical and open use of machine learning assessment was recommended.A similar research but using different machine learning al-gorithms,locations,and institutions,to ascertain the validity,reliability and the generalizability of the study findings was recommended for further re-search.展开更多
Vascular wilt caused by Fusarium oxysporum f.sp.batatas(Fob)is a devastating disease threatening global sweet potato production.To elucidate Fob’s pathogenicitymechanisms and informeffective control strategies,we gen...Vascular wilt caused by Fusarium oxysporum f.sp.batatas(Fob)is a devastating disease threatening global sweet potato production.To elucidate Fob’s pathogenicitymechanisms and informeffective control strategies,we generated a green fluorescent protein(GFP)-tagged Fob strain to track infection dynamics in sweet potato susceptible cultivar Xinzhonghua and resistant cultivar Xiangshu75-55,respectively.Through cytological observation,we found in the susceptible Xinzhonghua,Fob predominantly colonized stem villi,injured root growth points,and directly invaded vascular bundles through stemwounds.Spore germination peaked at 2-3 h post-inoculation(hpi),followed by cyclical mycelial expansion and sporulation within vascular tissues with sustaining infection.In contrast,the resistant Xiangshu75-55 exhibited strong suppression of Fob:spores rarely germinated in vascular bundles or on trichomes by 3 hpi,and mature hyphae were absent in stems at 24 hpi.Quantitative reverse transcription PCR(qRT-PCR)confirmed significantly higher Fob biomass in Xinzhonghua than in Xiangshu75-55 by 16 hpi.Additionally,transcriptional profiling revealed distinct pathogen-host interactions during the compatible and incompatible reactions.In Xinzhonghua,Fob virulence genes FobPGX1,FobICL1,FobCTF2,FobFUB5 and FobFUB6 were upregulated within 16 hpi.Conversely,host defense genes IbMAPKK9,IbWRKY61,IbWRKY75,IbSWEET10,IbBBX24 and IbPIF4 were activated in Xiangshu75-55 during the same period.This study provides spatiotemporal cytological and molecular insights into Fob pathogenicity and host resistance,offering a foundation for early disease detection and improved Fusarium wilt management in sweet potato.展开更多
This paper proposes a lightweight traffic sign detection system based on you only look once(YOLO).Firstly,the classification to fusion(C2f)structure is integrated into the backbone network,employing deformable convolu...This paper proposes a lightweight traffic sign detection system based on you only look once(YOLO).Firstly,the classification to fusion(C2f)structure is integrated into the backbone network,employing deformable convolution and bi-directional feature pyramid network(BiFPN)_Concat to improve the adaptability of the network.Secondly,the simple attention module(SimAm)is embedded to prioritize key features and reduce the complexity of the model after the C2f layer at the end of the backbone network.Next,the focal efficient intersection over union(EloU)is introduced to adjust the weights of challenging samples.Finally,we accomplish the design and deployment for the mobile app.The results demonstrate improvements,with the F1 score of 0.8987,mean average precision(mAP)@0.5 of 98.8%,mAP@0.5:0.95 of 75.6%,and the detection speed of 50 frames per second(FPS).展开更多
Wheat powdery mildew caused by Blumeria graminis f.sp.tritici(Bgt)is an important disease worldwide.Detection of latent infection of leaves by the pathogen in late autumn is valuable for estimating the inoculum potent...Wheat powdery mildew caused by Blumeria graminis f.sp.tritici(Bgt)is an important disease worldwide.Detection of latent infection of leaves by the pathogen in late autumn is valuable for estimating the inoculum potential to assess disease risks in the spring.We developed a new tool for rapid detection and quantification of latent infection of seedlings by the pathogen.The method was based on recombinase polymerase amplification(RPA)coupled with an end-point detection via lateral flow device(LFD).The limit of detection is 100 agμL^(-1)of Bgt DNA,without noticeable interference from either other common wheat pathogens or wheat material(Triticum aestivum).It was evaluated on wheat seedlings for this accuracy and sensitivity in detecting latent infection of Bgt.We further extended this RPALFD assay to estimate the level of latent infection by Bgt based on imaging analysis.There was a strong correlation between the image-based and real-time PCR assay estimates of Bgt DNA.The present results suggested that this new tool can provide rapid and accurate quantification of Bgt in latently infected leaves and can be further development as an on-site monitoring tool.展开更多
Fibre and fabric production technologies-especially in the area of com-posite reinforcements-have played an as-yet largely unheralded role in thedevelopment of the UKs Formula One industry,but the British Textile Mach...Fibre and fabric production technologies-especially in the area of com-posite reinforcements-have played an as-yet largely unheralded role in thedevelopment of the UKs Formula One industry,but the British Textile MachineryAssociation(BTMA)aims to change that.展开更多
We study age-structured branching models with reproduction law depending on the remaining lifetime of the parent. The lifespan of an individual is determined at its birth and its remaining lifetime decreases at the un...We study age-structured branching models with reproduction law depending on the remaining lifetime of the parent. The lifespan of an individual is determined at its birth and its remaining lifetime decreases at the unit speed. The models, without or with immigration, are constructed as measure-valued processes by pathwise unique solutions of stochastic equations driven by time-space Poisson random measures. In the subcritical branching case, we give a sufficient condition for the ergodicity of the process with immigration. Two large number laws and a central limit theorem of the occupation times are proved.展开更多
In this study,supported Pd catalysts were prepared and used as heterogeneous catalysts for the activation of peroxymonosulfate(PMS)which successfully degrade bisphenol F(BPF).Among the supported catalysts(i.e.,Pd/SiO_...In this study,supported Pd catalysts were prepared and used as heterogeneous catalysts for the activation of peroxymonosulfate(PMS)which successfully degrade bisphenol F(BPF).Among the supported catalysts(i.e.,Pd/SiO_(2),Pd/CeO_(2),Pd/TiO_(2)and Pd/Al2O3),Pd/TiO_(2)exhibited the highest catalytic activity due to the high isoelectric point and high Pd0 content.Pd/TiO_(2)prepared by the deposition method leads to high Pd dispersion,which are the key factors for efficient BPF degradation.The influencing factors were investigated during the reaction process and two possible degradation pathways were proposed.Density functional theory(DFT)calculations demonstrate that stronger BPF adsorption and BPF degradation with lower reaction barrier occurs on smaller Pd particles.The catalytic activities are strongly dependent on the structural features of the catalysts.Both experiments and theoretical calculations prove that the reaction is actuated by electron transfer rather than radicals.展开更多
OBJECTIVE:To explore the therapeutic mechanisms of Xiaoyin Anshen Yin( 消银安神饮, XYAS) in treating psoriasis associated with sleep focusing on melatonin and the regulation of the nuclear factor kappa-B(NF-κB) pathw...OBJECTIVE:To explore the therapeutic mechanisms of Xiaoyin Anshen Yin( 消银安神饮, XYAS) in treating psoriasis associated with sleep focusing on melatonin and the regulation of the nuclear factor kappa-B(NF-κB) pathway. METHODS:Forty Sprague-Dawley rats were randomly divided into four groups, and administered distilled water, XYAS and its two different disassembly prescriptions by gavage respectively. Four types of drug-containing serums corresponding to the four groups were then prepared. Tumor necrosis factor(TNF)-α stimulated Ha Ca T was used to establish a psoriasis cell model, and the serums and the retinoid related orphan receptor alpha(RORα) inverse agonist were used respectively to intervene in the model. Enzyme-linked immunosorbent assay was used to detect the levels of interleukin(IL)-6 and melatonin in each group;flow cytometry was used to detect the levels of reactive oxygen species(ROS), mitochondrial membrane potential, and apoptosis;Western blot was used to evaluate the levels of superoxide dismutase 2(SOD2), cytochrome-c(Cyt-c), inhibitor of kappa-B alpha(IκBα), p65 and phosphorylated p65. RESULTS:XYAS and its disassembly prescriptions inhibited the secretion of inflammatory factors such as IL-6, reduced the ROS content and Cyt-c expression, increased the mitochondrial membrane potential and SOD2 content, promoted the apoptosis in Ha Ca T cells and inhibited the activation of the NF-κB pathway. XYAS was also found increase the melatonin content. The above effects are beneficial in the treatment of psoriasis combined with sleep disorders. Meanwhile, XYAS no longer had a significant ameliorative effect after applying the RORα inverse agonist, suggesting that the therapeutic effect of XYAS is related to RORα. CONCLUSIONS:The results of this study confirm that XYAS can be utilized for the treatment of psoriasis combined with sleep disorders via inhibiting the NF-κB pathway, anti-inflammatory, antioxidant and proapoptotic, which is in part related to the regulatory role of melatonin and its receptor RORα.展开更多
Rotor-to-rotor interaction among neighboring rotors of a multirotor has great significance for aerodynamically efficient multirotor design. Current research is conducted to analyze aerodynamic performance of different...Rotor-to-rotor interaction among neighboring rotors of a multirotor has great significance for aerodynamically efficient multirotor design. Current research is conducted to analyze aerodynamic performance of different octocopter configurations amid hover and forward flight. Conventional and coaxial configurations are studied and a hybrid configuration is also proposed to rectify the disadvantages associated with the earlier two. Comparison is carried out for the aforementioned configurations along with comparison of coaxial and hybrid octocopters with bigger diameter rotors in the same confined space for high thrust requirement missions. Vertical spacing of coaxial configuration is also studied. Virtual Blade Method (VBM) is considered herein due to its great computational efficiency. The results show that there are 11.89% and 14.22% loss in thrust for coaxial octocopter compared to conventional and hybrid configurations with normal size rotors and 15.61% loss compared to hybrid configuration with bigger rotors in hover, whereas coaxial square configuration performs the worst in forward flight with a lift loss of 9.1%, 14.77% and 18.8% compared to coaxial diamond, conventional and hybrid configurations with normal size rotors and 9.96% and 17.82% loss compared to coaxial diamond and hybrid configurations with bigger rotors. Combined FM shows that hybrid configuration outperforms other octocopter configurations in overall aerodynamic performance.展开更多
Organofluorines play a crucial role in medicine,agrochemicals,and materials science.Adding fluorine to molecules creates structures with specific beneficial properties or tunes properties through interactions with the...Organofluorines play a crucial role in medicine,agrochemicals,and materials science.Adding fluorine to molecules creates structures with specific beneficial properties or tunes properties through interactions with their environment.Many popular pharmaceuticals and agrochemicals contain fluorine because it enhances hydrogen bonding at protein’s active sites.展开更多
The Hyperspectral Infrared Atmospheric Sounder-II(HIRAS-II)onboard China’s FungYun(FY)-3F meteorological satellite was launched in August 2023.This study presents the first attempt to retrieve the global carbon monox...The Hyperspectral Infrared Atmospheric Sounder-II(HIRAS-II)onboard China’s FungYun(FY)-3F meteorological satellite was launched in August 2023.This study presents the first attempt to retrieve the global carbon monoxide(CO)column from HIRAS-II/FY-3F spectra based on a newly established full-physics algorithm.The CO global columns derived from the HIRAS-II/FY-3F satellite are compared to measurements from the Infrared Atmospheric Sounding Interferometer(IASI)onboard Europe’s MetopB satellite,as both satellites have the same spectral range with a similar overpass time.The correlation coefficient between the IASI/Metop-B and HIRAS-II/FY-3F CO retrievals is about 0.8.The HIRAS-II/FY-3F satellite can capture well the regions with high CO values,e.g.,Africa,North America,and East Asia.The relative difference in the CO global column between HIRAS-II and IASI is 1.2±13.7(1)%,which is within their combined retrieval uncertainty.The CO plumes from the fire emissions in North America between 18 and 23 July 2024 were observed by the HIRAS-II/FY-3F satellite and consistent with the CAMS(Copernicus Atmosphere Monitoring Service)model simulations.Our results show that the HIRAS-II/FY-3F spectra are of good enough quality to provide quantitative observations of global CO column remote sensing observations.展开更多
基金supported by the National Natural Science Foundation of China(62272078)Chongqing Natural Science Foundation(CSTB2023NSCQ-LZX0069)the Science and Technology Research Program of Chongqing Municipal Education Commission(KJQN202300210)
文摘Dear Editor,This letter presents a novel latent factorization model for high dimensional and incomplete (HDI) tensor, namely the neural Tucker factorization (Neu Tuc F), which is a generic neural network-based latent-factorization-of-tensors model under the Tucker decomposition framework.
基金supported by the National Natural Science Foundation of China(Grant No.12274117)the Natural Science Foundation of Henan(Grant No.242300421214)+4 种基金the Program for Innovative Research Team(in Science and Technology)in the University of Henan Province(Grant No.24IRTSTHN025)the Open Fund of Guangdong Provincial Key Laboratory of Nanophotonic Manipulation(No.202502)Guangdong S&T Program(No.2023B1212010008)the High-Performance Computing Center of Henan Normal Universitysupported by the U.S.DOE,Office of Science(Grant No.DE-FG02-05ER46237)。
文摘Altermagnetism,a recently identified class of collinear magnetism,combines key features of antiferromagnets and ferromagnets.Despite having zero net magnetization,altermagnetic materials exhibit anomalous transport effects,including the anomalous Hall,Nernst,and thermal Hall effects,as well as magneto-optical Kerr and Faraday effects.These phenomena,previously thought unique to ferromagnets,are dictated by symmetry,as confirmed by density functional theory(DFT)calculations.However,an effective model-based approach to verify these symmetry constraints remains unavailable.In this Letter,we construct a k·ρ model for d-wave altermagnets CuX_(2)(X=F,Cl)using spin space group representations and apply it to calculate the anomalous Hall effect.The symmetry-imposed transport properties predicted by the model are in agreement with the DFT results,providing a foundation for further investigation into symmetry-restricted transport phenomena in altermagnetic materials.
文摘Microfinance institutions in Kenya play a unique role in promoting financial inclusion,loans,and savings provision,especially to low-income individuals and small-scale entrepreneurs.However,despite their benefits,most of their products and programs in Machakos County have been reducing due to re-payment challenges,threatening their financial ability to extend further credit.This could be attributed to ineffective credit scoring models which are not able to establish the nuanced non-linear repayment behavior and patterns of the loan applicants.The research objective was to enhance credit risk scoring for microfinance institutions in Machakos County using supervised machine learning algorithms.The study adopted a mixed research design under supervised machine learning approach.It randomly sampled 6771 loan application ac-count records and repayment history.Rstudio and Python programming lan-guages were deployed for data pre-processing and analysis.Logistic regression algorithm,XG Boosting and the random forest ensemble method were used.Metric evaluations used included the performance accuracy,Area under the Curve and F1-Score.Based on the study findings:XG Boosting was the best performer with 83.3%accuracy and 0.202 Brier score.Development of legal framework to govern ethical and open use of machine learning assessment was recommended.A similar research but using different machine learning al-gorithms,locations,and institutions,to ascertain the validity,reliability and the generalizability of the study findings was recommended for further re-search.
基金supported by the following grants,Earmarked fund for CARS-10-Sweet potato,High-quality development of agriculture“5511”collaborative innovation project(XTCXGC2021005)Natural Science Foundation of Fujian province(2021J01495)+1 种基金Basic Scientific Research Special Project for Fujian Provincial Public Research Institutes(2021R1031008)Science and Technology Innovation Team of Fujian Academy of Agricultural Sciences(CXTD2021012-1).
文摘Vascular wilt caused by Fusarium oxysporum f.sp.batatas(Fob)is a devastating disease threatening global sweet potato production.To elucidate Fob’s pathogenicitymechanisms and informeffective control strategies,we generated a green fluorescent protein(GFP)-tagged Fob strain to track infection dynamics in sweet potato susceptible cultivar Xinzhonghua and resistant cultivar Xiangshu75-55,respectively.Through cytological observation,we found in the susceptible Xinzhonghua,Fob predominantly colonized stem villi,injured root growth points,and directly invaded vascular bundles through stemwounds.Spore germination peaked at 2-3 h post-inoculation(hpi),followed by cyclical mycelial expansion and sporulation within vascular tissues with sustaining infection.In contrast,the resistant Xiangshu75-55 exhibited strong suppression of Fob:spores rarely germinated in vascular bundles or on trichomes by 3 hpi,and mature hyphae were absent in stems at 24 hpi.Quantitative reverse transcription PCR(qRT-PCR)confirmed significantly higher Fob biomass in Xinzhonghua than in Xiangshu75-55 by 16 hpi.Additionally,transcriptional profiling revealed distinct pathogen-host interactions during the compatible and incompatible reactions.In Xinzhonghua,Fob virulence genes FobPGX1,FobICL1,FobCTF2,FobFUB5 and FobFUB6 were upregulated within 16 hpi.Conversely,host defense genes IbMAPKK9,IbWRKY61,IbWRKY75,IbSWEET10,IbBBX24 and IbPIF4 were activated in Xiangshu75-55 during the same period.This study provides spatiotemporal cytological and molecular insights into Fob pathogenicity and host resistance,offering a foundation for early disease detection and improved Fusarium wilt management in sweet potato.
基金supported by the Shanxi Agricultural University Science and Technology Innovation Enhancement Project。
文摘This paper proposes a lightweight traffic sign detection system based on you only look once(YOLO).Firstly,the classification to fusion(C2f)structure is integrated into the backbone network,employing deformable convolution and bi-directional feature pyramid network(BiFPN)_Concat to improve the adaptability of the network.Secondly,the simple attention module(SimAm)is embedded to prioritize key features and reduce the complexity of the model after the C2f layer at the end of the backbone network.Next,the focal efficient intersection over union(EloU)is introduced to adjust the weights of challenging samples.Finally,we accomplish the design and deployment for the mobile app.The results demonstrate improvements,with the F1 score of 0.8987,mean average precision(mAP)@0.5 of 98.8%,mAP@0.5:0.95 of 75.6%,and the detection speed of 50 frames per second(FPS).
基金supported by the funding from the National Natural Science Foundation of China(32072359)。
文摘Wheat powdery mildew caused by Blumeria graminis f.sp.tritici(Bgt)is an important disease worldwide.Detection of latent infection of leaves by the pathogen in late autumn is valuable for estimating the inoculum potential to assess disease risks in the spring.We developed a new tool for rapid detection and quantification of latent infection of seedlings by the pathogen.The method was based on recombinase polymerase amplification(RPA)coupled with an end-point detection via lateral flow device(LFD).The limit of detection is 100 agμL^(-1)of Bgt DNA,without noticeable interference from either other common wheat pathogens or wheat material(Triticum aestivum).It was evaluated on wheat seedlings for this accuracy and sensitivity in detecting latent infection of Bgt.We further extended this RPALFD assay to estimate the level of latent infection by Bgt based on imaging analysis.There was a strong correlation between the image-based and real-time PCR assay estimates of Bgt DNA.The present results suggested that this new tool can provide rapid and accurate quantification of Bgt in latently infected leaves and can be further development as an on-site monitoring tool.
文摘Fibre and fabric production technologies-especially in the area of com-posite reinforcements-have played an as-yet largely unheralded role in thedevelopment of the UKs Formula One industry,but the British Textile MachineryAssociation(BTMA)aims to change that.
基金supported by the National Key R&D Program of China(2020YFA0712901).
文摘We study age-structured branching models with reproduction law depending on the remaining lifetime of the parent. The lifespan of an individual is determined at its birth and its remaining lifetime decreases at the unit speed. The models, without or with immigration, are constructed as measure-valued processes by pathwise unique solutions of stochastic equations driven by time-space Poisson random measures. In the subcritical branching case, we give a sufficient condition for the ergodicity of the process with immigration. Two large number laws and a central limit theorem of the occupation times are proved.
基金supported by the National Natural Science Foundation of China(NSFC)(No.21978137).
文摘In this study,supported Pd catalysts were prepared and used as heterogeneous catalysts for the activation of peroxymonosulfate(PMS)which successfully degrade bisphenol F(BPF).Among the supported catalysts(i.e.,Pd/SiO_(2),Pd/CeO_(2),Pd/TiO_(2)and Pd/Al2O3),Pd/TiO_(2)exhibited the highest catalytic activity due to the high isoelectric point and high Pd0 content.Pd/TiO_(2)prepared by the deposition method leads to high Pd dispersion,which are the key factors for efficient BPF degradation.The influencing factors were investigated during the reaction process and two possible degradation pathways were proposed.Density functional theory(DFT)calculations demonstrate that stronger BPF adsorption and BPF degradation with lower reaction barrier occurs on smaller Pd particles.The catalytic activities are strongly dependent on the structural features of the catalysts.Both experiments and theoretical calculations prove that the reaction is actuated by electron transfer rather than radicals.
基金National Natural Science Foundation of China:Study on the Mechanism of Cooling Blood and Tranquilizing Mind in the Treatment of Psoriasis with Sleep Disorder based on the Regulation of Oxidative Stress by Melatonin (No. 82074436)。
文摘OBJECTIVE:To explore the therapeutic mechanisms of Xiaoyin Anshen Yin( 消银安神饮, XYAS) in treating psoriasis associated with sleep focusing on melatonin and the regulation of the nuclear factor kappa-B(NF-κB) pathway. METHODS:Forty Sprague-Dawley rats were randomly divided into four groups, and administered distilled water, XYAS and its two different disassembly prescriptions by gavage respectively. Four types of drug-containing serums corresponding to the four groups were then prepared. Tumor necrosis factor(TNF)-α stimulated Ha Ca T was used to establish a psoriasis cell model, and the serums and the retinoid related orphan receptor alpha(RORα) inverse agonist were used respectively to intervene in the model. Enzyme-linked immunosorbent assay was used to detect the levels of interleukin(IL)-6 and melatonin in each group;flow cytometry was used to detect the levels of reactive oxygen species(ROS), mitochondrial membrane potential, and apoptosis;Western blot was used to evaluate the levels of superoxide dismutase 2(SOD2), cytochrome-c(Cyt-c), inhibitor of kappa-B alpha(IκBα), p65 and phosphorylated p65. RESULTS:XYAS and its disassembly prescriptions inhibited the secretion of inflammatory factors such as IL-6, reduced the ROS content and Cyt-c expression, increased the mitochondrial membrane potential and SOD2 content, promoted the apoptosis in Ha Ca T cells and inhibited the activation of the NF-κB pathway. XYAS was also found increase the melatonin content. The above effects are beneficial in the treatment of psoriasis combined with sleep disorders. Meanwhile, XYAS no longer had a significant ameliorative effect after applying the RORα inverse agonist, suggesting that the therapeutic effect of XYAS is related to RORα. CONCLUSIONS:The results of this study confirm that XYAS can be utilized for the treatment of psoriasis combined with sleep disorders via inhibiting the NF-κB pathway, anti-inflammatory, antioxidant and proapoptotic, which is in part related to the regulatory role of melatonin and its receptor RORα.
基金supported by the National Natural Science Foundation of China(No.11972190).
文摘Rotor-to-rotor interaction among neighboring rotors of a multirotor has great significance for aerodynamically efficient multirotor design. Current research is conducted to analyze aerodynamic performance of different octocopter configurations amid hover and forward flight. Conventional and coaxial configurations are studied and a hybrid configuration is also proposed to rectify the disadvantages associated with the earlier two. Comparison is carried out for the aforementioned configurations along with comparison of coaxial and hybrid octocopters with bigger diameter rotors in the same confined space for high thrust requirement missions. Vertical spacing of coaxial configuration is also studied. Virtual Blade Method (VBM) is considered herein due to its great computational efficiency. The results show that there are 11.89% and 14.22% loss in thrust for coaxial octocopter compared to conventional and hybrid configurations with normal size rotors and 15.61% loss compared to hybrid configuration with bigger rotors in hover, whereas coaxial square configuration performs the worst in forward flight with a lift loss of 9.1%, 14.77% and 18.8% compared to coaxial diamond, conventional and hybrid configurations with normal size rotors and 9.96% and 17.82% loss compared to coaxial diamond and hybrid configurations with bigger rotors. Combined FM shows that hybrid configuration outperforms other octocopter configurations in overall aerodynamic performance.
文摘Organofluorines play a crucial role in medicine,agrochemicals,and materials science.Adding fluorine to molecules creates structures with specific beneficial properties or tunes properties through interactions with their environment.Many popular pharmaceuticals and agrochemicals contain fluorine because it enhances hydrogen bonding at protein’s active sites.
基金supported by the FengYun Application Pioneering Project (Grant No. FY-APP-2022.0502)the National Natural Science Foundation of China (42205140)the State Key Laboratory of Atmospheric Environment end Extreme Meteorology (Grant No. 2024QN04)
文摘The Hyperspectral Infrared Atmospheric Sounder-II(HIRAS-II)onboard China’s FungYun(FY)-3F meteorological satellite was launched in August 2023.This study presents the first attempt to retrieve the global carbon monoxide(CO)column from HIRAS-II/FY-3F spectra based on a newly established full-physics algorithm.The CO global columns derived from the HIRAS-II/FY-3F satellite are compared to measurements from the Infrared Atmospheric Sounding Interferometer(IASI)onboard Europe’s MetopB satellite,as both satellites have the same spectral range with a similar overpass time.The correlation coefficient between the IASI/Metop-B and HIRAS-II/FY-3F CO retrievals is about 0.8.The HIRAS-II/FY-3F satellite can capture well the regions with high CO values,e.g.,Africa,North America,and East Asia.The relative difference in the CO global column between HIRAS-II and IASI is 1.2±13.7(1)%,which is within their combined retrieval uncertainty.The CO plumes from the fire emissions in North America between 18 and 23 July 2024 were observed by the HIRAS-II/FY-3F satellite and consistent with the CAMS(Copernicus Atmosphere Monitoring Service)model simulations.Our results show that the HIRAS-II/FY-3F spectra are of good enough quality to provide quantitative observations of global CO column remote sensing observations.
