An experimental program was initiated to investigate the seismic performance of built-up laced steel brace members. Quasi-static testing of twelve typical steel built-up laced member （BLM） specimens was conducted. T...An experimental program was initiated to investigate the seismic performance of built-up laced steel brace members. Quasi-static testing of twelve typical steel built-up laced member （BLM） specimens was conducted. These were designed to span a range of parameters typically encountered for such members based on findings from a survey of commonly used shapes and details that have been historically used. The specimens were subdivided into groups of three different cross-sectional shapes, namely built-up I-shape section, and built-up box shapes buckling about the x or the y axis. Within each group, global and local buckling slenderness ratios had either kl/r values of 60 or 120, and b/t ratios of 8 or 16. The specific inelastic cyclic behavior germane to each specimen, and general observations on overall member hysteretic behavior as a function of the considered parameters, are reported. A companion paper （Lee and Bruneau 2008） investigates this observed response against predictions from analytical models, and behavior in the perspective of system performance.展开更多
A quadratic bilevel programming problem is transformed into a single level complementarity slackness problem by applying Karush-Kuhn-Tucker（KKT） conditions.To cope with the complementarity constraints,a binary encod...A quadratic bilevel programming problem is transformed into a single level complementarity slackness problem by applying Karush-Kuhn-Tucker（KKT） conditions.To cope with the complementarity constraints,a binary encoding scheme is adopted for KKT multipliers,and then the complementarity slackness problem is simplified to successive quadratic programming problems,which can be solved by many algorithms available.Based on 0-1 binary encoding,an orthogonal genetic algorithm,in which the orthogonal experimental design with both two-level orthogonal array and factor analysis is used as crossover operator,is proposed.Numerical experiments on 10 benchmark examples show that the orthogonal genetic algorithm can find global optimal solutions of quadratic bilevel programming problems with high accuracy in a small number of iterations.展开更多
[目的]针对《生物统计与试验设计》课程中数据处理复杂、学生参与度低等问题,开发一款轻量化教学工具,探索数字化教学改革的有效路径。[方法]基于Uniapp跨平台框架,结合豆包人工智能辅助开发技术,构建集成生物统计计算、试验设计模拟及...[目的]针对《生物统计与试验设计》课程中数据处理复杂、学生参与度低等问题,开发一款轻量化教学工具,探索数字化教学改革的有效路径。[方法]基于Uniapp跨平台框架,结合豆包人工智能辅助开发技术,构建集成生物统计计算、试验设计模拟及案例实操功能的微信小程序,在实验班(医动2211,n=23)与对照班(医动2212,n=26)开展对比教学实验,评估小程序的应用效果。[结果]教学实践数据显示:实验组学生完成数据处理任务的平均耗时较对照组缩短43.75%(45 min vs.80 min),课堂主动提问频次提升149%(2.64次/课vs.1.06次/课),理论知识考核成绩提高21.4%(85分vs.70分),实践操作成绩提升33.3%(40分vs.30分),差异均具有统计学意义(P<0.05);问卷调查表明,实验组学生课堂参与积极性达70%,显著高于对照组的35%。[结论]基于Uniapp和豆包AI的轻量化开发的微信小程序,显著提升了学生的理论理解深度与实践能力,为职业院校专业课程的数字化转型提供了可复制的解决方案。未来可进一步优化小程序功能,深化工具与教学场景的融合。展开更多
Experimental allergic encephalomyelitis is a mouse model of human multiple sclerosis with similar pathology and pathogenesis. Thl cells play an important role in the pathogenesis of experimental allergic encephalomyel...Experimental allergic encephalomyelitis is a mouse model of human multiple sclerosis with similar pathology and pathogenesis. Thl cells play an important role in the pathogenesis of experimental allergic encephalomyelitis. This study determined the potential effect of programmed cell death 1 ligand 1 in the pathogenesis of experimental allergic encephalomyelitis induced by injecting myelin oligodendrocyte glycoprotein, complete Freund＇s adjuvant and Bordetella pertussis toxin into C57BL/6J mice. Experimental allergic encephalomyelitis mice developed disease and showed in- flammatory changes in the central nervous system by hematoxylin-eosin staining of spinal cord pathological sections, demyelination by Luxol fast-blue staining and clinical manifestations. The expression of programmed cell death 1 ligand 1 in mice was detected by immunohistochemistry, flow cytometry and western blot anatysis. The expression of programmed cell death 1 ligand 1 in the spinal cord and splenocytes of mice was significantly increased compared with normal mice. Our findings suggest the involvement of programmed cell death 1 ligand 1 in the pathogenesis of ex- perimental allergic encephalomyelitis and suggest this should be studied in multiple sclerosis.展开更多
基金Federal Highway Administration Under Grant No. DTFH61-98-C-00094
文摘An experimental program was initiated to investigate the seismic performance of built-up laced steel brace members. Quasi-static testing of twelve typical steel built-up laced member （BLM） specimens was conducted. These were designed to span a range of parameters typically encountered for such members based on findings from a survey of commonly used shapes and details that have been historically used. The specimens were subdivided into groups of three different cross-sectional shapes, namely built-up I-shape section, and built-up box shapes buckling about the x or the y axis. Within each group, global and local buckling slenderness ratios had either kl/r values of 60 or 120, and b/t ratios of 8 or 16. The specific inelastic cyclic behavior germane to each specimen, and general observations on overall member hysteretic behavior as a function of the considered parameters, are reported. A companion paper （Lee and Bruneau 2008） investigates this observed response against predictions from analytical models, and behavior in the perspective of system performance.
基金supported by the National Natural Science Foundation of China (60873099)
文摘A quadratic bilevel programming problem is transformed into a single level complementarity slackness problem by applying Karush-Kuhn-Tucker（KKT） conditions.To cope with the complementarity constraints,a binary encoding scheme is adopted for KKT multipliers,and then the complementarity slackness problem is simplified to successive quadratic programming problems,which can be solved by many algorithms available.Based on 0-1 binary encoding,an orthogonal genetic algorithm,in which the orthogonal experimental design with both two-level orthogonal array and factor analysis is used as crossover operator,is proposed.Numerical experiments on 10 benchmark examples show that the orthogonal genetic algorithm can find global optimal solutions of quadratic bilevel programming problems with high accuracy in a small number of iterations.
文摘[目的]针对《生物统计与试验设计》课程中数据处理复杂、学生参与度低等问题,开发一款轻量化教学工具,探索数字化教学改革的有效路径。[方法]基于Uniapp跨平台框架,结合豆包人工智能辅助开发技术,构建集成生物统计计算、试验设计模拟及案例实操功能的微信小程序,在实验班(医动2211,n=23)与对照班(医动2212,n=26)开展对比教学实验,评估小程序的应用效果。[结果]教学实践数据显示:实验组学生完成数据处理任务的平均耗时较对照组缩短43.75%(45 min vs.80 min),课堂主动提问频次提升149%(2.64次/课vs.1.06次/课),理论知识考核成绩提高21.4%(85分vs.70分),实践操作成绩提升33.3%(40分vs.30分),差异均具有统计学意义(P<0.05);问卷调查表明,实验组学生课堂参与积极性达70%,显著高于对照组的35%。[结论]基于Uniapp和豆包AI的轻量化开发的微信小程序,显著提升了学生的理论理解深度与实践能力,为职业院校专业课程的数字化转型提供了可复制的解决方案。未来可进一步优化小程序功能,深化工具与教学场景的融合。
基金financially sponsored by the Natural Science Foundation of Jiangsu Province in China,(General Program),No.BK2011267
文摘Experimental allergic encephalomyelitis is a mouse model of human multiple sclerosis with similar pathology and pathogenesis. Thl cells play an important role in the pathogenesis of experimental allergic encephalomyelitis. This study determined the potential effect of programmed cell death 1 ligand 1 in the pathogenesis of experimental allergic encephalomyelitis induced by injecting myelin oligodendrocyte glycoprotein, complete Freund＇s adjuvant and Bordetella pertussis toxin into C57BL/6J mice. Experimental allergic encephalomyelitis mice developed disease and showed in- flammatory changes in the central nervous system by hematoxylin-eosin staining of spinal cord pathological sections, demyelination by Luxol fast-blue staining and clinical manifestations. The expression of programmed cell death 1 ligand 1 in mice was detected by immunohistochemistry, flow cytometry and western blot anatysis. The expression of programmed cell death 1 ligand 1 in the spinal cord and splenocytes of mice was significantly increased compared with normal mice. Our findings suggest the involvement of programmed cell death 1 ligand 1 in the pathogenesis of ex- perimental allergic encephalomyelitis and suggest this should be studied in multiple sclerosis.
