Neural organoids and confocal microscopy have the potential to play an important role in microconnectome research to understand neural patterns.We present PLayer,a plug-and-play embedded neural system,which demonstrat...Neural organoids and confocal microscopy have the potential to play an important role in microconnectome research to understand neural patterns.We present PLayer,a plug-and-play embedded neural system,which demonstrates the utilization of sparse confocal microscopy layers to interpolate continuous axial resolution.With an embedded system focused on neural network pruning,image scaling,and post-processing,PLayer achieves high-performance metrics with an average structural similarity index of 0.9217 and a peak signal-to-noise ratio of 27.75 dB,all within 20 s.This represents a significant time saving of 85.71%with simplified image processing.By harnessing statistical map estimation in interpolation and incorporating the Vision Transformer–based Restorer,PLayer ensures 2D layer consistency while mitigating heavy computational dependence.As such,PLayer can reconstruct 3D neural organoid confocal data continuously under limited computational power for the wide acceptance of fundamental connectomics and pattern-related research with embedded devices.展开更多
A new technique for designing a varactor-tunable frequency selective surface （FSS） with an embedded bias network is proposed and experimentally verified. The proposed FSS is based on a square-ring slot FSS. The freq...A new technique for designing a varactor-tunable frequency selective surface （FSS） with an embedded bias network is proposed and experimentally verified. The proposed FSS is based on a square-ring slot FSS. The frequency tuning is achieved by inserting varactor diodes between the square mesh and each unattached square patch. The square mesh is divided into two parts for biasing the varactor diodes. Full-wave numerical simulations show that a wide tuning range can be achieved by changing the capacitances of these loaded varactors. Two homo-type samples using fixed lumped capacitors are fabricated and measured using a standard waveguide measurement setup. Excellent agreement between the measured and simulated results is demonstrated.展开更多
Software security analysts typically only have access to the executable program and cannot directly access the source code of the program.This poses significant challenges to security analysis.While it is crucial to i...Software security analysts typically only have access to the executable program and cannot directly access the source code of the program.This poses significant challenges to security analysis.While it is crucial to identify vulnerabilities in such non-source code programs,there exists a limited set of generalized tools due to the low versatility of current vulnerability mining methods.However,these tools suffer from some shortcomings.In terms of targeted fuzzing,the path searching for target points is not streamlined enough,and the completely random testing leads to an excessively large search space.Additionally,when it comes to code similarity analysis,there are issues with incomplete code feature extraction,which may result in information loss.In this paper,we propose a cross-platform and cross-architecture approach to exploit vulnerabilities using neural network obfuscation techniques.By leveraging the Angr framework,a deobfuscation technique is introduced,along with the adoption of a VEX-IR-based intermediate language conversion method.This combination allows for the unified handling of binary programs across various architectures,compilers,and compilation options.Subsequently,binary programs are processed to extract multi-level spatial features using a combination of a skip-gram model with self-attention mechanism and a bidirectional Long Short-Term Memory(LSTM)network.Finally,the graph embedding network is utilized to evaluate the similarity of program functionalities.Based on these similarity scores,a target function is determined,and symbolic execution is applied to solve the target function.The solved content serves as the initial seed for targeted fuzzing.The binary program is processed by using the de-obfuscation technique and intermediate language transformation method,and then the similarity of program functions is evaluated by using a graph embedding network,and symbolic execution is performed based on these similarity scores.This approach facilitates cross-architecture analysis of executable programs without their source codes and concurrently reduces the risk of symbolic execution path explosion.展开更多
Objective:To elucidate the biological basis of the heart qi deficiency(HQD)pattern,an in-depth understanding of which is essential for improving clinical herbal therapy.Methods: We predicted and characterized HQD patt...Objective:To elucidate the biological basis of the heart qi deficiency(HQD)pattern,an in-depth understanding of which is essential for improving clinical herbal therapy.Methods: We predicted and characterized HQD pattern genes using the new strategy,TCM-HIN2Vec,which involves heterogeneous network embedding and transcriptomic experiments.First,a heterogeneous network of traditional Chinese medicine(TCM)patterns was constructed using public databases.Next,we predicted HQD pattern genes using a heterogeneous network-embedding algorithm.We then analyzed the functional characteristics of HQD pattern genes using gene enrichment analysis and examined gene expression levels using RNA-seq.Finally,we identified TCM herbs that demonstrated enriched interactions with HQD pattern genes via herbal enrichment analysis.Results: Our TCM-HIN2Vec strategy revealed that candidate genes associated with HQD pattern were significantly enriched in energy metabolism,signal transduction pathways,and immune processes.Moreover,we found that these candidate genes were significantly differentially expressed in the transcriptional profile of mice model with heart failure with a qi deficiency pattern.Furthermore,herbal enrichment analysis identified TCM herbs that demonstrated enriched interactions with the top 10 candidate genes and could potentially serve as drug candidates for treating HQD.Conclusion: Our results suggested that TCM-HIN2Vec is capable of not only accurately identifying HQD pattern genes,but also deciphering the basis of HQD pattern.Furthermore our finding indicated that TCM-HIN2Vec may be further expanded to develop other patterns,leading to a new approach aimed at elucidating general TCM patterns and developing precision medicine.展开更多
Network embedding(NE)tries to learn the potential properties of complex networks represented in a low-dimensional feature space.However,the existing deep learningbased NE methods are time-consuming as they need to tra...Network embedding(NE)tries to learn the potential properties of complex networks represented in a low-dimensional feature space.However,the existing deep learningbased NE methods are time-consuming as they need to train a dense architecture for deep neural networks with extensive unknown weight parameters.A sparse deep autoencoder(called SPDNE)for dynamic NE is proposed,aiming to learn the network structures while preserving the node evolution with a low computational complexity.SPDNE tries to use an optimal sparse architecture to replace the fully connected architecture in the deep autoencoder while maintaining the performance of these models in the dynamic NE.Then,an adaptive simulated algorithm to find the optimal sparse architecture for the deep autoencoder is proposed.The performance of SPDNE over three dynamical NE models(i.e.sparse architecture-based deep autoencoder method,DynGEM,and ElvDNE)is evaluated on three well-known benchmark networks and five real-world networks.The experimental results demonstrate that SPDNE can reduce about 70%of weight parameters of the architecture for the deep autoencoder during the training process while preserving the performance of these dynamical NE models.The results also show that SPDNE achieves the highest accuracy on 72 out of 96 edge prediction and network reconstruction tasks compared with the state-of-the-art dynamical NE algorithms.展开更多
基金supported by the National Key R&D Program of China(Grant No.2021YFA1001000)the National Natural Science Foundation of China(Grant Nos.82111530212,U23A20282,and 61971255)+2 种基金the Natural Science Founda-tion of Guangdong Province(Grant No.2021B1515020092)the Shenzhen Bay Laboratory Fund(Grant No.SZBL2020090501014)the Shenzhen Science,Technology and Innovation Commission(Grant Nos.KJZD20231023094659002,JCYJ20220530142809022,and WDZC20220811170401001).
文摘Neural organoids and confocal microscopy have the potential to play an important role in microconnectome research to understand neural patterns.We present PLayer,a plug-and-play embedded neural system,which demonstrates the utilization of sparse confocal microscopy layers to interpolate continuous axial resolution.With an embedded system focused on neural network pruning,image scaling,and post-processing,PLayer achieves high-performance metrics with an average structural similarity index of 0.9217 and a peak signal-to-noise ratio of 27.75 dB,all within 20 s.This represents a significant time saving of 85.71%with simplified image processing.By harnessing statistical map estimation in interpolation and incorporating the Vision Transformer–based Restorer,PLayer ensures 2D layer consistency while mitigating heavy computational dependence.As such,PLayer can reconstruct 3D neural organoid confocal data continuously under limited computational power for the wide acceptance of fundamental connectomics and pattern-related research with embedded devices.
基金supported by the National Natural Science Foundation of China (Grant Nos. 60901029, 61172148, and 60925005)the Natural Science Foundation of Shaanxi Province, China (Grant No. 2011JQ8040)
文摘A new technique for designing a varactor-tunable frequency selective surface （FSS） with an embedded bias network is proposed and experimentally verified. The proposed FSS is based on a square-ring slot FSS. The frequency tuning is achieved by inserting varactor diodes between the square mesh and each unattached square patch. The square mesh is divided into two parts for biasing the varactor diodes. Full-wave numerical simulations show that a wide tuning range can be achieved by changing the capacitances of these loaded varactors. Two homo-type samples using fixed lumped capacitors are fabricated and measured using a standard waveguide measurement setup. Excellent agreement between the measured and simulated results is demonstrated.
文摘Software security analysts typically only have access to the executable program and cannot directly access the source code of the program.This poses significant challenges to security analysis.While it is crucial to identify vulnerabilities in such non-source code programs,there exists a limited set of generalized tools due to the low versatility of current vulnerability mining methods.However,these tools suffer from some shortcomings.In terms of targeted fuzzing,the path searching for target points is not streamlined enough,and the completely random testing leads to an excessively large search space.Additionally,when it comes to code similarity analysis,there are issues with incomplete code feature extraction,which may result in information loss.In this paper,we propose a cross-platform and cross-architecture approach to exploit vulnerabilities using neural network obfuscation techniques.By leveraging the Angr framework,a deobfuscation technique is introduced,along with the adoption of a VEX-IR-based intermediate language conversion method.This combination allows for the unified handling of binary programs across various architectures,compilers,and compilation options.Subsequently,binary programs are processed to extract multi-level spatial features using a combination of a skip-gram model with self-attention mechanism and a bidirectional Long Short-Term Memory(LSTM)network.Finally,the graph embedding network is utilized to evaluate the similarity of program functionalities.Based on these similarity scores,a target function is determined,and symbolic execution is applied to solve the target function.The solved content serves as the initial seed for targeted fuzzing.The binary program is processed by using the de-obfuscation technique and intermediate language transformation method,and then the similarity of program functions is evaluated by using a graph embedding network,and symbolic execution is performed based on these similarity scores.This approach facilitates cross-architecture analysis of executable programs without their source codes and concurrently reduces the risk of symbolic execution path explosion.
基金supported by the National Natural Science Foundation of China(32088101)National key Research and Development Program of China(2017YFC1700105,2021YFA1301603).
文摘Objective:To elucidate the biological basis of the heart qi deficiency(HQD)pattern,an in-depth understanding of which is essential for improving clinical herbal therapy.Methods: We predicted and characterized HQD pattern genes using the new strategy,TCM-HIN2Vec,which involves heterogeneous network embedding and transcriptomic experiments.First,a heterogeneous network of traditional Chinese medicine(TCM)patterns was constructed using public databases.Next,we predicted HQD pattern genes using a heterogeneous network-embedding algorithm.We then analyzed the functional characteristics of HQD pattern genes using gene enrichment analysis and examined gene expression levels using RNA-seq.Finally,we identified TCM herbs that demonstrated enriched interactions with HQD pattern genes via herbal enrichment analysis.Results: Our TCM-HIN2Vec strategy revealed that candidate genes associated with HQD pattern were significantly enriched in energy metabolism,signal transduction pathways,and immune processes.Moreover,we found that these candidate genes were significantly differentially expressed in the transcriptional profile of mice model with heart failure with a qi deficiency pattern.Furthermore,herbal enrichment analysis identified TCM herbs that demonstrated enriched interactions with the top 10 candidate genes and could potentially serve as drug candidates for treating HQD.Conclusion: Our results suggested that TCM-HIN2Vec is capable of not only accurately identifying HQD pattern genes,but also deciphering the basis of HQD pattern.Furthermore our finding indicated that TCM-HIN2Vec may be further expanded to develop other patterns,leading to a new approach aimed at elucidating general TCM patterns and developing precision medicine.
基金National Natural Science Foundation of China,Grant/Award Numbers:62173236,61876110,61806130,61976142,82304204.
文摘Network embedding(NE)tries to learn the potential properties of complex networks represented in a low-dimensional feature space.However,the existing deep learningbased NE methods are time-consuming as they need to train a dense architecture for deep neural networks with extensive unknown weight parameters.A sparse deep autoencoder(called SPDNE)for dynamic NE is proposed,aiming to learn the network structures while preserving the node evolution with a low computational complexity.SPDNE tries to use an optimal sparse architecture to replace the fully connected architecture in the deep autoencoder while maintaining the performance of these models in the dynamic NE.Then,an adaptive simulated algorithm to find the optimal sparse architecture for the deep autoencoder is proposed.The performance of SPDNE over three dynamical NE models(i.e.sparse architecture-based deep autoencoder method,DynGEM,and ElvDNE)is evaluated on three well-known benchmark networks and five real-world networks.The experimental results demonstrate that SPDNE can reduce about 70%of weight parameters of the architecture for the deep autoencoder during the training process while preserving the performance of these dynamical NE models.The results also show that SPDNE achieves the highest accuracy on 72 out of 96 edge prediction and network reconstruction tasks compared with the state-of-the-art dynamical NE algorithms.
