Serious desertification caused by human activity and climate change,in addition to water loss and soil erosion related to arsenic sandstone in the Mu Us Sandy Land,lead to severe scarcity of soil and water resources,w...Serious desertification caused by human activity and climate change,in addition to water loss and soil erosion related to arsenic sandstone in the Mu Us Sandy Land,lead to severe scarcity of soil and water resources,which causes worse local agricultural conditions accordingly.Many physical properties of arsenic sandstone is complementary with that of sand,arsenic sandstone is therefore supposed to be blended to enhance water productivity and arability of sandy land.Container experiments are carried out to study the enhancement of water holding capacity of the mixture,the blending ratio of arsenic sandstone and sand,and the proper size of the arsenic sandstone particles,respectively.The results of the experiments show that particle size of 4 cm with a ratio of 1∶2 between arsenic sandstone and sand are the proper parameters on blending.Both water content and fertility increase after blending.Water use efficiency in the mixture is 2.7 times higher than that in sand by the water release curves from experiments.Therefore,a new sand control and development model,including arsenic sandstone blending with sand,efficient water irrigation management and reasonable farming system,is put forward to control and develop sandy land so that water-saving agriculture could be developed.Demonstration of potato planting about 153.1 ha in area in the Mu Us Sandy Land in China indicates that water consumption is 3018 m3/ha in the whole growth period.It means that about 61%of irrigation water can be saved compared with water use in coarse sand without treatment.Recycle economic mode and positive feedback of sand resource-crop planting-soil resource are constructed,which changes sand into arable soil and make it possible to develop water-saving agriculture on it.The proposed model will be helpful for soil-water resources utilization and management in the Mu Us Sandy Land.展开更多
How osteoblast cells are induced is a central question for understanding skeletal formation. Abnormal osteoblast differentiation leads to a broad range of devastating craniofacial diseases. Here we have investigated i...How osteoblast cells are induced is a central question for understanding skeletal formation. Abnormal osteoblast differentiation leads to a broad range of devastating craniofacial diseases. Here we have investigated intramembranous ossification during cranial bone development in mouse models of skeletal genetic diseases that exhibit craniofacial bone defects. The GNAS gene encodes Gαs that transduces GPCR signaling. GNAS activation or loss-of-function mutations in humans cause fibrous dysplasia(FD) or progressive osseous heteroplasia(POH) that shows craniofacial hyperostosis or craniosynostosis, respectively. We find here that, while Hh ligand-dependent Hh signaling is essential for endochondral ossification, it is dispensable for intramembranous ossification, where Gαsregulates Hh signaling in a ligand-independent manner. We further show that Gαscontrols intramembranous ossification by regulating both Hh and Wnt/β-catenin signaling. In addition, Gαsactivation in the developing cranial bone leads to reduced ossification but increased cartilage presence due to reduced cartilage dissolution, not cell fate switch. Small molecule inhibitors of Hh and Wnt signaling can effectively ameliorate cranial bone phenotypes in mice caused by loss or gain of Gnas function mutations, respectively. Our work shows that studies of genetic diseases provide invaluable insights in both pathological bone defects and normal bone development, understanding both leads to better diagnosis and therapeutic treatment of bone diseases.展开更多
This paper will discuss the computerised developm en t control and approval system being developed for the Planning and Development C ontrol Department, City Hall of Kuala Lumpur, with stress on the GIS architectur e ...This paper will discuss the computerised developm en t control and approval system being developed for the Planning and Development C ontrol Department, City Hall of Kuala Lumpur, with stress on the GIS architectur e developed within the system. The prospects and challenges towards implementati on of the system are also discussed.展开更多
Dear Editor,In this letter,several novel controllability results for a class of linear switched and impulsive systems are established.Different from the developed controllability conditions in most existing literature...Dear Editor,In this letter,several novel controllability results for a class of linear switched and impulsive systems are established.Different from the developed controllability conditions in most existing literature,the important role of switched and impulsive time sequence is considered.Applying the relevant geometric theory of matrix,a necessary and sufficient criterion for the controllability is firstly developed to judge when the controllability of such systems is affected by switched and impulsive time sequence.Furthermore,we further obtain a sufficient controllability condition that can be used to verify the controllability of such systems regardless of the switched and impulsive time sequence.Finally,a numerical example is given to verify the obtained theoretical results.展开更多
基金Under the auspices of National Natural Science Foundation of China(No.51079120)Education Department Research Program of Shaanxi Province(No.12JK0481)Water Conservancy Science and Technology Plan of Shaanxi Province(No.2012-07)
文摘Serious desertification caused by human activity and climate change,in addition to water loss and soil erosion related to arsenic sandstone in the Mu Us Sandy Land,lead to severe scarcity of soil and water resources,which causes worse local agricultural conditions accordingly.Many physical properties of arsenic sandstone is complementary with that of sand,arsenic sandstone is therefore supposed to be blended to enhance water productivity and arability of sandy land.Container experiments are carried out to study the enhancement of water holding capacity of the mixture,the blending ratio of arsenic sandstone and sand,and the proper size of the arsenic sandstone particles,respectively.The results of the experiments show that particle size of 4 cm with a ratio of 1∶2 between arsenic sandstone and sand are the proper parameters on blending.Both water content and fertility increase after blending.Water use efficiency in the mixture is 2.7 times higher than that in sand by the water release curves from experiments.Therefore,a new sand control and development model,including arsenic sandstone blending with sand,efficient water irrigation management and reasonable farming system,is put forward to control and develop sandy land so that water-saving agriculture could be developed.Demonstration of potato planting about 153.1 ha in area in the Mu Us Sandy Land in China indicates that water consumption is 3018 m3/ha in the whole growth period.It means that about 61%of irrigation water can be saved compared with water use in coarse sand without treatment.Recycle economic mode and positive feedback of sand resource-crop planting-soil resource are constructed,which changes sand into arable soil and make it possible to develop water-saving agriculture on it.The proposed model will be helpful for soil-water resources utilization and management in the Mu Us Sandy Land.
基金supported by the NIH grants R01DE025866 from NIDCRR01AR070877 from NIAMSsupported by the 111 Project, MOE (B14038), China
文摘How osteoblast cells are induced is a central question for understanding skeletal formation. Abnormal osteoblast differentiation leads to a broad range of devastating craniofacial diseases. Here we have investigated intramembranous ossification during cranial bone development in mouse models of skeletal genetic diseases that exhibit craniofacial bone defects. The GNAS gene encodes Gαs that transduces GPCR signaling. GNAS activation or loss-of-function mutations in humans cause fibrous dysplasia(FD) or progressive osseous heteroplasia(POH) that shows craniofacial hyperostosis or craniosynostosis, respectively. We find here that, while Hh ligand-dependent Hh signaling is essential for endochondral ossification, it is dispensable for intramembranous ossification, where Gαsregulates Hh signaling in a ligand-independent manner. We further show that Gαscontrols intramembranous ossification by regulating both Hh and Wnt/β-catenin signaling. In addition, Gαsactivation in the developing cranial bone leads to reduced ossification but increased cartilage presence due to reduced cartilage dissolution, not cell fate switch. Small molecule inhibitors of Hh and Wnt signaling can effectively ameliorate cranial bone phenotypes in mice caused by loss or gain of Gnas function mutations, respectively. Our work shows that studies of genetic diseases provide invaluable insights in both pathological bone defects and normal bone development, understanding both leads to better diagnosis and therapeutic treatment of bone diseases.
文摘This paper will discuss the computerised developm en t control and approval system being developed for the Planning and Development C ontrol Department, City Hall of Kuala Lumpur, with stress on the GIS architectur e developed within the system. The prospects and challenges towards implementati on of the system are also discussed.
基金supported in part by the National Natural Science Foundation of China(62322311,62303162,62233007,62203157)the Technology Development Program of Henan Province(242102211052).
文摘Dear Editor,In this letter,several novel controllability results for a class of linear switched and impulsive systems are established.Different from the developed controllability conditions in most existing literature,the important role of switched and impulsive time sequence is considered.Applying the relevant geometric theory of matrix,a necessary and sufficient criterion for the controllability is firstly developed to judge when the controllability of such systems is affected by switched and impulsive time sequence.Furthermore,we further obtain a sufficient controllability condition that can be used to verify the controllability of such systems regardless of the switched and impulsive time sequence.Finally,a numerical example is given to verify the obtained theoretical results.
