In this study,novel micro and nanoparticle complexes of Ag(Ⅰ),Ni(Ⅱ),and Pd(Ⅱ)ion with new asymmetrical Schiff base triazole ligand(4-(((3-mercapto-5-(naphthalen-1-ylmethyl)-4H-1,2,4-triazol-4-yl)imino)methyl)phenol...In this study,novel micro and nanoparticle complexes of Ag(Ⅰ),Ni(Ⅱ),and Pd(Ⅱ)ion with new asymmetrical Schiff base triazole ligand(4-(((3-mercapto-5-(naphthalen-1-ylmethyl)-4H-1,2,4-triazol-4-yl)imino)methyl)phenol)were prepared.The Schiff base micro complexes were identified using Fourier-transform infrared spectroscopy(FTIR),Ultraviolet-visible spectroscopy(UV-Vis),flame atomic absorption,elemental analysis C.H.N.S,conductivity measurements and magnetic susceptibility.New nanoparticles Schiff base triazole ligand(4-(((3-mercapto-5-(naphthalen-1-ylmethyl)-4H-1,2,4-triazol-4-yl)imino)methyl)phenol)ligand and Ag(Ⅰ),Ni(Ⅱ)and Pd(Ⅱ)complexes were synthesized as a novel compounds by using sonication method,and were fully characterized by using FTIR,atomic force microscopy(AFM),scanning electron microscope(SEM),and X-ray powder diffraction(XRD).The antioxidant activity of tested compounds was tested using DPPH assay.The effect of synthetic novel compounds on cancer cell line MCF-7 proliferation was measured by MTT assay.The ability of synthetic novel compounds in induction of apotosis was achieved using acridine orange/ethidium bromide(AO/EB)stains.We found that the synthetic novel compounds had the potential to inhibit growth of cancer cell at low concentrations.The effect of synthetic compounds on cell growth and proliferation of MCF-7 cells was associated with cell cycle arrest,and increased apoptosis.Our results showed that the synthetic novel compounds inhibited cancer cell line proliferation with a mechanism of action similar to that of other tubulin inhibitors.In conclusion,the results of this study indicate that synthetic novel compounds represent a new chemo type with a novel mechanisms of action and that it has the potential to be developed for tumor therapy.展开更多
文摘In this study,novel micro and nanoparticle complexes of Ag(Ⅰ),Ni(Ⅱ),and Pd(Ⅱ)ion with new asymmetrical Schiff base triazole ligand(4-(((3-mercapto-5-(naphthalen-1-ylmethyl)-4H-1,2,4-triazol-4-yl)imino)methyl)phenol)were prepared.The Schiff base micro complexes were identified using Fourier-transform infrared spectroscopy(FTIR),Ultraviolet-visible spectroscopy(UV-Vis),flame atomic absorption,elemental analysis C.H.N.S,conductivity measurements and magnetic susceptibility.New nanoparticles Schiff base triazole ligand(4-(((3-mercapto-5-(naphthalen-1-ylmethyl)-4H-1,2,4-triazol-4-yl)imino)methyl)phenol)ligand and Ag(Ⅰ),Ni(Ⅱ)and Pd(Ⅱ)complexes were synthesized as a novel compounds by using sonication method,and were fully characterized by using FTIR,atomic force microscopy(AFM),scanning electron microscope(SEM),and X-ray powder diffraction(XRD).The antioxidant activity of tested compounds was tested using DPPH assay.The effect of synthetic novel compounds on cancer cell line MCF-7 proliferation was measured by MTT assay.The ability of synthetic novel compounds in induction of apotosis was achieved using acridine orange/ethidium bromide(AO/EB)stains.We found that the synthetic novel compounds had the potential to inhibit growth of cancer cell at low concentrations.The effect of synthetic compounds on cell growth and proliferation of MCF-7 cells was associated with cell cycle arrest,and increased apoptosis.Our results showed that the synthetic novel compounds inhibited cancer cell line proliferation with a mechanism of action similar to that of other tubulin inhibitors.In conclusion,the results of this study indicate that synthetic novel compounds represent a new chemo type with a novel mechanisms of action and that it has the potential to be developed for tumor therapy.
