摘要
In this study,novel micro and nanoparticle complexes of Ag(Ⅰ),Ni(Ⅱ),and Pd(Ⅱ)ion with new asymmetrical Schiff base triazole ligand(4-(((3-mercapto-5-(naphthalen-1-ylmethyl)-4H-1,2,4-triazol-4-yl)imino)methyl)phenol)were prepared.The Schiff base micro complexes were identified using Fourier-transform infrared spectroscopy(FTIR),Ultraviolet-visible spectroscopy(UV-Vis),flame atomic absorption,elemental analysis C.H.N.S,conductivity measurements and magnetic susceptibility.New nanoparticles Schiff base triazole ligand(4-(((3-mercapto-5-(naphthalen-1-ylmethyl)-4H-1,2,4-triazol-4-yl)imino)methyl)phenol)ligand and Ag(Ⅰ),Ni(Ⅱ)and Pd(Ⅱ)complexes were synthesized as a novel compounds by using sonication method,and were fully characterized by using FTIR,atomic force microscopy(AFM),scanning electron microscope(SEM),and X-ray powder diffraction(XRD).The antioxidant activity of tested compounds was tested using DPPH assay.The effect of synthetic novel compounds on cancer cell line MCF-7 proliferation was measured by MTT assay.The ability of synthetic novel compounds in induction of apotosis was achieved using acridine orange/ethidium bromide(AO/EB)stains.We found that the synthetic novel compounds had the potential to inhibit growth of cancer cell at low concentrations.The effect of synthetic compounds on cell growth and proliferation of MCF-7 cells was associated with cell cycle arrest,and increased apoptosis.Our results showed that the synthetic novel compounds inhibited cancer cell line proliferation with a mechanism of action similar to that of other tubulin inhibitors.In conclusion,the results of this study indicate that synthetic novel compounds represent a new chemo type with a novel mechanisms of action and that it has the potential to be developed for tumor therapy.
