Invasive as well as non-invasive neurotechnologies conceptualized to interface the central and peripheral nervous system have been probed for the past decades,which refer to electroencephalography,electrocorticography...Invasive as well as non-invasive neurotechnologies conceptualized to interface the central and peripheral nervous system have been probed for the past decades,which refer to electroencephalography,electrocorticography and microelectrode arrays.The challenges of these mentioned approaches are characterized by the bandwidth of the spatiotemporal resolution,which in turn is essential for large-area neuron recordings(Abiri et al.,2019).展开更多
In recent years,with the continuous advancement of technolo-gies such as artificial intelligence,neurobiology,and sensors,braincomputer interface(Bcl)technology has embraced opportunitiesfor rapid development The"...In recent years,with the continuous advancement of technolo-gies such as artificial intelligence,neurobiology,and sensors,braincomputer interface(Bcl)technology has embraced opportunitiesfor rapid development The"Guidelines for the Establishment ofNeurological Medical Service Price ltems(Trial)"recently issued bythe National Healthcare Security Administration specifically sets upseparate prospective items for new BCl technologies,which will un-doubtedly strongly facilitate the clinical application of BCl technologyas soon as possible,benefiting a broad range of patients.展开更多
Brain-computer interfaces rely on electrodes to record neural activity,but most existing electrodes remain fixed once implanted,limiting their sampling range and often triggering immune responses that degrade signal q...Brain-computer interfaces rely on electrodes to record neural activity,but most existing electrodes remain fixed once implanted,limiting their sampling range and often triggering immune responses that degrade signal quality over time.As reported in a Nature paper(doi:10.1038/s41586-025-09344-w)on September 17,researchers from the Shenzhen Institutes of Advanced Technology(SIAT),Chinese Academy of Sciences,and Donghua University have now developed NeuroWorm-a soft,movable fiber electrode that can navigate through tissues while continuously recording high-quality signals.展开更多
When neurons fire,blood vessels nearby respond by expanding to deliver more oxygen and nutrients-a process called neurovascular coupling.This dynamic interaction is not only essential for normal brain function,but als...When neurons fire,blood vessels nearby respond by expanding to deliver more oxygen and nutrients-a process called neurovascular coupling.This dynamic interaction is not only essential for normal brain function,but also critical for robotic limbs or computer cursors:It allows for the development of a non-invasive brain-computer interfaces to control such external devices.However,existing imaging technologies cannot simultaneously capture both neural activity and blood vessel changes across the whole cortex with sufficient speed and resolution.展开更多
On March 13,China's National Medical Products Administration(NMPA)sent shock waves across the international medical technology sector by granting the world's first approval for an invasive,commercial-use brain...On March 13,China's National Medical Products Administration(NMPA)sent shock waves across the international medical technology sector by granting the world's first approval for an invasive,commercial-use brain-computer interface(BCI)system.Developed by Neuracle Medical Technology(Shanghai)Co.Ltd.,the system restores hand movement for people with severe paralysis.The approval marks the beginning of a new era in which BCI technologies,long confined to laboratories and science fiction,break through into clinical medicine and begin treating medical issues at scale.展开更多
Brain-computer interfaces(BCIs)have the potential to restore communication for people who have lost the ability to speak owing to a neurological disease or injury.BCIs have been used to translate the neural correlates...Brain-computer interfaces(BCIs)have the potential to restore communication for people who have lost the ability to speak owing to a neurological disease or injury.BCIs have been used to translate the neural correlates of attempted speech into text1-3.However,text communication fails to capture the nuances of human speech,such as prosody and immediately hearing one's own voice.展开更多
Brain-computer interfaces(BCIs)have become a hotspot in the field of neuroscience,and have been presented frequently in various media over the past few years.In general,BCIs are considered a revolutionary technology f...Brain-computer interfaces(BCIs)have become a hotspot in the field of neuroscience,and have been presented frequently in various media over the past few years.In general,BCIs are considered a revolutionary technology for building an alternative and direct link between the brain and external devices.1 In recent years,BCIs have been rapidly developed and widely applied in clinical practice for the prevention,diagnosis,treatment,rehabilitation,and functional assistance of neurological disorders.Notably,they have demonstrated promising clinical efficacy for the rehabilitation of severe neurological disorders such as stroke,spinal cord injury,and amyotrophic lateral sclerosis.2e4 As a result,BCIs remain a prominent investigational focus,attracting increasing numbers of researchers and groups in the field.However,certain misunderstandings about BCIs remain,at least in part because different media often confuse the concept of BCIs,5 which has caused confusion among readers of this journal who are engaged in basic research and the clinical applications of neurorestoration.展开更多
Neuropsychiatric disorders continue to be a significant global health challenge,with current pharmacological and behavioral interventions o ften yielding suboptimal results due to interindividual variability and limit...Neuropsychiatric disorders continue to be a significant global health challenge,with current pharmacological and behavioral interventions o ften yielding suboptimal results due to interindividual variability and limited long-term efficacy.In recent years,peripheral nerve stimulation(PNS)has emerged as a promising neuromodulation technique for these difficult-to-treat conditions.Accumulating clinical evidence,including randomized trials,demonstrates the efficacy of PNS approaches-such as transcutaneous auricular vagus nerve stimulation(taVNS)for depression[1],and trigeminal nerve stimulation(TNS)for attention deficit hyperactivity disorder(ADHD)[2]-with broader applications continuing to be explored[3-6](Fig.1).展开更多
Non-invasive brain–computer interfaces(NI-BCIs)have garnered significant attention due to their safety and wide range of applications.However,developing non-invasive electroencephalogram(EEG)electrodes that are highl...Non-invasive brain–computer interfaces(NI-BCIs)have garnered significant attention due to their safety and wide range of applications.However,developing non-invasive electroencephalogram(EEG)electrodes that are highly sensitive,comfortable to wear,and reusable has been challenging due to the limitations of conventional electrodes.Here,we introduce a simple method for fabricating semi-dry hydrogel EEG electrodes with antibacterial properties,enabling long-term,repeatable acquisition of EEG.By utilizing N-acryloyl glycinamide and hydroxypropyltrimethyl ammonium chloride chitosan,we have prepared electrodes that not only possess good mechanical properties(compression modulus 65 kPa)and anti-fatigue properties but also exhibit superior antibacterial properties.These electrodes effectively inhibit the growth of both Gram-negative(E.coli)and Gram-positive(S.epidermidis)bacteria.Furthermore,the hydrogel maintains stable water retention properties,resulting in an average contact impedance of<400Ωmeasured over 12 h,and an ionic conductivity of 0.39 mS cm^(−1).Cytotoxicity and skin irritation tests have confirmed the high biocompatibility of the hydrogel electrodes.In an N170 event-related potential(ERP)test on human volunteers,we successfully captured the expected ERP signal waveform and a high signal-to-noise ratio(20.02 dB),comparable to that of conventional wet electrodes.Moreover,contact impedance on the scalps remained below 100 kΩfor 12 h,while wet electrodes became unable to detect signals after 7–8 h due to dehydration.In summary,our hydrogel electrodes are capable of detecting ERPs over extended periods in an easy-to-use manner with antibacterial properties.This reduces the risk of bacterial infection associated with prolonged reuse and expands the potential of NI-BCIs in daily life.展开更多
文摘Invasive as well as non-invasive neurotechnologies conceptualized to interface the central and peripheral nervous system have been probed for the past decades,which refer to electroencephalography,electrocorticography and microelectrode arrays.The challenges of these mentioned approaches are characterized by the bandwidth of the spatiotemporal resolution,which in turn is essential for large-area neuron recordings(Abiri et al.,2019).
文摘In recent years,with the continuous advancement of technolo-gies such as artificial intelligence,neurobiology,and sensors,braincomputer interface(Bcl)technology has embraced opportunitiesfor rapid development The"Guidelines for the Establishment ofNeurological Medical Service Price ltems(Trial)"recently issued bythe National Healthcare Security Administration specifically sets upseparate prospective items for new BCl technologies,which will un-doubtedly strongly facilitate the clinical application of BCl technologyas soon as possible,benefiting a broad range of patients.
文摘Brain-computer interfaces rely on electrodes to record neural activity,but most existing electrodes remain fixed once implanted,limiting their sampling range and often triggering immune responses that degrade signal quality over time.As reported in a Nature paper(doi:10.1038/s41586-025-09344-w)on September 17,researchers from the Shenzhen Institutes of Advanced Technology(SIAT),Chinese Academy of Sciences,and Donghua University have now developed NeuroWorm-a soft,movable fiber electrode that can navigate through tissues while continuously recording high-quality signals.
文摘When neurons fire,blood vessels nearby respond by expanding to deliver more oxygen and nutrients-a process called neurovascular coupling.This dynamic interaction is not only essential for normal brain function,but also critical for robotic limbs or computer cursors:It allows for the development of a non-invasive brain-computer interfaces to control such external devices.However,existing imaging technologies cannot simultaneously capture both neural activity and blood vessel changes across the whole cortex with sufficient speed and resolution.
文摘On March 13,China's National Medical Products Administration(NMPA)sent shock waves across the international medical technology sector by granting the world's first approval for an invasive,commercial-use brain-computer interface(BCI)system.Developed by Neuracle Medical Technology(Shanghai)Co.Ltd.,the system restores hand movement for people with severe paralysis.The approval marks the beginning of a new era in which BCI technologies,long confined to laboratories and science fiction,break through into clinical medicine and begin treating medical issues at scale.
文摘Brain-computer interfaces(BCIs)have the potential to restore communication for people who have lost the ability to speak owing to a neurological disease or injury.BCIs have been used to translate the neural correlates of attempted speech into text1-3.However,text communication fails to capture the nuances of human speech,such as prosody and immediately hearing one's own voice.
文摘Brain-computer interfaces(BCIs)have become a hotspot in the field of neuroscience,and have been presented frequently in various media over the past few years.In general,BCIs are considered a revolutionary technology for building an alternative and direct link between the brain and external devices.1 In recent years,BCIs have been rapidly developed and widely applied in clinical practice for the prevention,diagnosis,treatment,rehabilitation,and functional assistance of neurological disorders.Notably,they have demonstrated promising clinical efficacy for the rehabilitation of severe neurological disorders such as stroke,spinal cord injury,and amyotrophic lateral sclerosis.2e4 As a result,BCIs remain a prominent investigational focus,attracting increasing numbers of researchers and groups in the field.However,certain misunderstandings about BCIs remain,at least in part because different media often confuse the concept of BCIs,5 which has caused confusion among readers of this journal who are engaged in basic research and the clinical applications of neurorestoration.
基金supported by the National Key Research and Development Program of China(2023YFC2506800)the National Programs for Brain Science and Brain-like Intelligence Technology of China(STI2030-Major Projects,2021ZD0200800)+1 种基金the National Natural Science Foundation of China(82201644 and 82471505)supported by the German Research Foundation(DFG KR 4555/10-1)。
文摘Neuropsychiatric disorders continue to be a significant global health challenge,with current pharmacological and behavioral interventions o ften yielding suboptimal results due to interindividual variability and limited long-term efficacy.In recent years,peripheral nerve stimulation(PNS)has emerged as a promising neuromodulation technique for these difficult-to-treat conditions.Accumulating clinical evidence,including randomized trials,demonstrates the efficacy of PNS approaches-such as transcutaneous auricular vagus nerve stimulation(taVNS)for depression[1],and trigeminal nerve stimulation(TNS)for attention deficit hyperactivity disorder(ADHD)[2]-with broader applications continuing to be explored[3-6](Fig.1).
基金supported by the Ministry of Science and Technology of China(STI 2030—Major Projects 10700,No.2022 ZD0210700).
文摘Non-invasive brain–computer interfaces(NI-BCIs)have garnered significant attention due to their safety and wide range of applications.However,developing non-invasive electroencephalogram(EEG)electrodes that are highly sensitive,comfortable to wear,and reusable has been challenging due to the limitations of conventional electrodes.Here,we introduce a simple method for fabricating semi-dry hydrogel EEG electrodes with antibacterial properties,enabling long-term,repeatable acquisition of EEG.By utilizing N-acryloyl glycinamide and hydroxypropyltrimethyl ammonium chloride chitosan,we have prepared electrodes that not only possess good mechanical properties(compression modulus 65 kPa)and anti-fatigue properties but also exhibit superior antibacterial properties.These electrodes effectively inhibit the growth of both Gram-negative(E.coli)and Gram-positive(S.epidermidis)bacteria.Furthermore,the hydrogel maintains stable water retention properties,resulting in an average contact impedance of<400Ωmeasured over 12 h,and an ionic conductivity of 0.39 mS cm^(−1).Cytotoxicity and skin irritation tests have confirmed the high biocompatibility of the hydrogel electrodes.In an N170 event-related potential(ERP)test on human volunteers,we successfully captured the expected ERP signal waveform and a high signal-to-noise ratio(20.02 dB),comparable to that of conventional wet electrodes.Moreover,contact impedance on the scalps remained below 100 kΩfor 12 h,while wet electrodes became unable to detect signals after 7–8 h due to dehydration.In summary,our hydrogel electrodes are capable of detecting ERPs over extended periods in an easy-to-use manner with antibacterial properties.This reduces the risk of bacterial infection associated with prolonged reuse and expands the potential of NI-BCIs in daily life.
