We prepared a novel pitch-based activated carbon microsphere（ACM）and studied its in vitro adsorption characteristics for biological molecules.The original spherical asphalt particles were prepared through bitumen em...We prepared a novel pitch-based activated carbon microsphere（ACM）and studied its in vitro adsorption characteristics for biological molecules.The original spherical asphalt particles were prepared through bitumen emulsification.After oxidation and burning,ACMs with a range of parameters were prepared.In vitro adsorption experiments of ACMs for biological molecules were carried out.The prepared ACMs possessed a BET specific surface of 1566 m^2/g with a voidage of 0.653 cm^3/g and a volume of micropores of 0.478 cm^3/g.They showed high adsorption for glucose and creatintine.Compared with the medically used carbon powder,the prepared ACMs exhibited significantly lower adsorption for digestion enzymes.In conclusion,the prepared ACMs,as an oral adsorbent candidate,possessed higher BET specific surface area and larger volume of micropores;they also exhibited favorable selective adsorption features for biological molecules.展开更多
In this work, the existence of interaction between metal in metallo enzyme and small biological molecules such as amino acid in aqueous solution is confirmed for the first time by the experimental data of ESR, NMR,UV-...In this work, the existence of interaction between metal in metallo enzyme and small biological molecules such as amino acid in aqueous solution is confirmed for the first time by the experimental data of ESR, NMR,UV-VIS and enzyme activity. This kind of interaction can affect the enzyme catalytic activity.展开更多
The cornea is a transparent tissue that serves as the main refractive element of the eye ball.Limbal epithelial stem cells(LESCs),residing in the basal epithelial layer of the Palisades of Vogt located in the corneal ...The cornea is a transparent tissue that serves as the main refractive element of the eye ball.Limbal epithelial stem cells(LESCs),residing in the basal epithelial layer of the Palisades of Vogt located in the corneal limbus between cornea and scleral,are believed to be crucial for the continuous turnover of the corneal epithelium.The proliferation,migration,and differentiation of the LESCs are modulated by unique physical and chemical futures contained within the microenvironment known as the limbal niche.This niche,composed of nerve terminals,cells,extracellular matrix,vasculature,and signaling molecules,is the home for processes such as proliferation,migration and differentiation.Corneal nerve terminals possess special anatomical structures in the limbal region and basal epithelial cells,and they demonstrate pivotal biological effects in the regulation of the LESC function and corneal epithelium homeostasis.Biological molecules such as neuropeptides,neurotransmitters,and neurotrophic factors play a crucial role in modulating the LESCs phenotype responsible for corneal epithelium homeostasis.This paper will review recent studies on how these nerve derived molecules function in this process and provide clear orientations for future research.展开更多
We present a brief review about recent results regarding carbon nanotube （CNT）-based chemical and biomolecular sensors. For the fabrication of CNT-based sensors, devices containing CNT channels between two metal ele...We present a brief review about recent results regarding carbon nanotube （CNT）-based chemical and biomolecular sensors. For the fabrication of CNT-based sensors, devices containing CNT channels between two metal electrodes are first fabricated usually via chemical vapor deposition （CVD） process or ＂surface programmed assembly＂ method. Then, the CNT surfaces are often functionalized to enhance the selectivity of the sensors. Using this process, highly-sensitive CNT-based sensors can be fabricated for the selective detection of various chemical and biological molecules such as hydrogen, ammonia, carbon monoxide, chlorine gas, DNA, glucose, alcohol, and proteins.展开更多
The title compound, 5-methoxy-butyrolacto[3,4-b]-1-N-cyclohexylaziridine 1, has been synthesized via tandem Micheal addition and intramolecular nucleophilic substitution reactions of 5-methoxy-3-bromo-2（5H）-furanone...The title compound, 5-methoxy-butyrolacto[3,4-b]-1-N-cyclohexylaziridine 1, has been synthesized via tandem Micheal addition and intramolecular nucleophilic substitution reactions of 5-methoxy-3-bromo-2（5H）-furanones 4 with primary amines 5, and structurally determined by single-crystal X-ray diffraction. Crystal data： C11H17NO3, Mr = 211.26, monoclinic system, space group P21/c, a = 17.800（3）, b = 5.3864（10）, c = 12.2571（10）A°, β = 90.449（3）°, V = 1175.1（3） A°^3, Z= 4, De= 1.194 g/cm^3, λ（MoKα） = 0.071073 nm, μ = 0.087 mm^-1 and F（000） = 456. The structure was refined to R = 0.0505 and wR = 0.1208 for 2579 observed reflections （I 〉 2σ（I））. The crystallographic results of molecule 1 show that the functionalized aziridine ring is fused with a lactone ring to form the component with [3.1.0] bicyclic skeleton.展开更多
The title compound, 2（S）,3（R）-dihydroxymethyl-N-cyclohexylaziridine 1, has been synthesized via tandem Micheal addition and internal nucleophilic substitution reactions of 5-methoxy-3-bromo-2（5H）-furanones 2 wit...The title compound, 2（S）,3（R）-dihydroxymethyl-N-cyclohexylaziridine 1, has been synthesized via tandem Micheal addition and internal nucleophilic substitution reactions of 5-methoxy-3-bromo-2（5H）-furanones 2 with cyclohexylamine 3 and subsequent reduction of intermediate 5. Its crystal structure was determined by single-crystal X-ray diffraction. Crystal data：C10H19NO2, Mr = 185.26, monoclinic system, space group P21/n, a = 8.0620（16）, b = 7.2013（14）, c= 18.555（4） A°, β= 102.30（3）°, V= 1052.5（4）A°^3, Z= 4, De= 1.169 g/cm^3, λ（MoKα） = 0.071073 nm,μ = 0.080 mm^- 1 and F（000） = 408. The structure was refined to R = 0.0439 and wR = 0.1178 for 1839 observed reflections （I 〉 2σ（I））. The crystallographic structure of 1 shows that the functionalized aziridine ring links two hyroxymethyl groups.展开更多
Chiral butyrolacto[3,4-b]-2(S)-6(R)-1-N-akylaziridines 7 were synthesized in enantiopure form utilizing racemic 5-methoxy-3-bromo-2(5H)-furanone (5) and available amines (6) as key precursors. After highly effective r...Chiral butyrolacto[3,4-b]-2(S)-6(R)-1-N-akylaziridines 7 were synthesized in enantiopure form utilizing racemic 5-methoxy-3-bromo-2(5H)-furanone (5) and available amines (6) as key precursors. After highly effective reduction of 7, the functionalized 2(S),3(R)-dihyroxymethyl-N-alkylaziridines (8) were obtained in good yields with ≥98% ee. This is a simple and pratical method for the preparation of enantiopure aziridines which are important interme-diates in the synthesis of biologic active molecules.展开更多
Due to the coronavirus disease 2019(COVID‐19)pandemic,the development of antiviral drugs has attracted increasing attention.Clinical antiviral drugs show weak solubility,low bioavailability,adverse side effects,or on...Due to the coronavirus disease 2019(COVID‐19)pandemic,the development of antiviral drugs has attracted increasing attention.Clinical antiviral drugs show weak solubility,low bioavailability,adverse side effects,or only limited targets.With the advancement of nanotechnology and material science,biosafety nanomaterials have been constructed for drug delivery systems of antiviral disease therapy,such as liposomes,polymers,gold nanoparticles,and graphene.These nanodrug systems can either deliver synthesized antiviral drugs siRNA/miRNA and small molecular compounds,deliver bioactive large molecular drug proteins and mRNA,or show antiviral activity by themselves.Nanodelivery systems could effectively enhance the efficiency of antiviral drugs by increasing drug loading and host cell uptake with a small size and high specific surface area.This review focused on the biosafety nanomaterials used for antiviral therapy and discussed the options for the design of antiviral drugs in the future.展开更多
文摘We prepared a novel pitch-based activated carbon microsphere（ACM）and studied its in vitro adsorption characteristics for biological molecules.The original spherical asphalt particles were prepared through bitumen emulsification.After oxidation and burning,ACMs with a range of parameters were prepared.In vitro adsorption experiments of ACMs for biological molecules were carried out.The prepared ACMs possessed a BET specific surface of 1566 m^2/g with a voidage of 0.653 cm^3/g and a volume of micropores of 0.478 cm^3/g.They showed high adsorption for glucose and creatintine.Compared with the medically used carbon powder,the prepared ACMs exhibited significantly lower adsorption for digestion enzymes.In conclusion,the prepared ACMs,as an oral adsorbent candidate,possessed higher BET specific surface area and larger volume of micropores;they also exhibited favorable selective adsorption features for biological molecules.
文摘In this work, the existence of interaction between metal in metallo enzyme and small biological molecules such as amino acid in aqueous solution is confirmed for the first time by the experimental data of ESR, NMR,UV-VIS and enzyme activity. This kind of interaction can affect the enzyme catalytic activity.
文摘The cornea is a transparent tissue that serves as the main refractive element of the eye ball.Limbal epithelial stem cells(LESCs),residing in the basal epithelial layer of the Palisades of Vogt located in the corneal limbus between cornea and scleral,are believed to be crucial for the continuous turnover of the corneal epithelium.The proliferation,migration,and differentiation of the LESCs are modulated by unique physical and chemical futures contained within the microenvironment known as the limbal niche.This niche,composed of nerve terminals,cells,extracellular matrix,vasculature,and signaling molecules,is the home for processes such as proliferation,migration and differentiation.Corneal nerve terminals possess special anatomical structures in the limbal region and basal epithelial cells,and they demonstrate pivotal biological effects in the regulation of the LESC function and corneal epithelium homeostasis.Biological molecules such as neuropeptides,neurotransmitters,and neurotrophic factors play a crucial role in modulating the LESCs phenotype responsible for corneal epithelium homeostasis.This paper will review recent studies on how these nerve derived molecules function in this process and provide clear orientations for future research.
基金the Seoul R&BD program.the financial support from Nano/Bio Science & Technology Program of MOST(2006-0955).
文摘We present a brief review about recent results regarding carbon nanotube （CNT）-based chemical and biomolecular sensors. For the fabrication of CNT-based sensors, devices containing CNT channels between two metal electrodes are first fabricated usually via chemical vapor deposition （CVD） process or ＂surface programmed assembly＂ method. Then, the CNT surfaces are often functionalized to enhance the selectivity of the sensors. Using this process, highly-sensitive CNT-based sensors can be fabricated for the selective detection of various chemical and biological molecules such as hydrogen, ammonia, carbon monoxide, chlorine gas, DNA, glucose, alcohol, and proteins.
基金Supported by the National Natural Science Foundation of China (No. 29672004)
文摘The title compound, 5-methoxy-butyrolacto[3,4-b]-1-N-cyclohexylaziridine 1, has been synthesized via tandem Micheal addition and intramolecular nucleophilic substitution reactions of 5-methoxy-3-bromo-2（5H）-furanones 4 with primary amines 5, and structurally determined by single-crystal X-ray diffraction. Crystal data： C11H17NO3, Mr = 211.26, monoclinic system, space group P21/c, a = 17.800（3）, b = 5.3864（10）, c = 12.2571（10）A°, β = 90.449（3）°, V = 1175.1（3） A°^3, Z= 4, De= 1.194 g/cm^3, λ（MoKα） = 0.071073 nm, μ = 0.087 mm^-1 and F（000） = 456. The structure was refined to R = 0.0505 and wR = 0.1208 for 2579 observed reflections （I 〉 2σ（I））. The crystallographic results of molecule 1 show that the functionalized aziridine ring is fused with a lactone ring to form the component with [3.1.0] bicyclic skeleton.
基金Supported by the National Natural Science Foundation of China (No. 29672004)
文摘The title compound, 2（S）,3（R）-dihydroxymethyl-N-cyclohexylaziridine 1, has been synthesized via tandem Micheal addition and internal nucleophilic substitution reactions of 5-methoxy-3-bromo-2（5H）-furanones 2 with cyclohexylamine 3 and subsequent reduction of intermediate 5. Its crystal structure was determined by single-crystal X-ray diffraction. Crystal data：C10H19NO2, Mr = 185.26, monoclinic system, space group P21/n, a = 8.0620（16）, b = 7.2013（14）, c= 18.555（4） A°, β= 102.30（3）°, V= 1052.5（4）A°^3, Z= 4, De= 1.169 g/cm^3, λ（MoKα） = 0.071073 nm,μ = 0.080 mm^- 1 and F（000） = 408. The structure was refined to R = 0.0439 and wR = 0.1178 for 1839 observed reflections （I 〉 2σ（I））. The crystallographic structure of 1 shows that the functionalized aziridine ring links two hyroxymethyl groups.
基金by the National Natural Science Foundation of China (No. 29672004).
文摘Chiral butyrolacto[3,4-b]-2(S)-6(R)-1-N-akylaziridines 7 were synthesized in enantiopure form utilizing racemic 5-methoxy-3-bromo-2(5H)-furanone (5) and available amines (6) as key precursors. After highly effective reduction of 7, the functionalized 2(S),3(R)-dihyroxymethyl-N-alkylaziridines (8) were obtained in good yields with ≥98% ee. This is a simple and pratical method for the preparation of enantiopure aziridines which are important interme-diates in the synthesis of biologic active molecules.
基金supported by the National Key Research&Development Program of China(No.2021YFA1201000)the Government Guided Local Science and Technology Development Fund Projects of Hebei Province(No.216Z2403G)+2 种基金Natural Science Foundation of Hebei Province(No.B2019201449,H2019201466)the Priority Strategy Project of the Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education(ts2020003)the Hebei Province“Three Three Three Talents Program”(A202003001).
文摘Due to the coronavirus disease 2019(COVID‐19)pandemic,the development of antiviral drugs has attracted increasing attention.Clinical antiviral drugs show weak solubility,low bioavailability,adverse side effects,or only limited targets.With the advancement of nanotechnology and material science,biosafety nanomaterials have been constructed for drug delivery systems of antiviral disease therapy,such as liposomes,polymers,gold nanoparticles,and graphene.These nanodrug systems can either deliver synthesized antiviral drugs siRNA/miRNA and small molecular compounds,deliver bioactive large molecular drug proteins and mRNA,or show antiviral activity by themselves.Nanodelivery systems could effectively enhance the efficiency of antiviral drugs by increasing drug loading and host cell uptake with a small size and high specific surface area.This review focused on the biosafety nanomaterials used for antiviral therapy and discussed the options for the design of antiviral drugs in the future.
