Müllerian adenosarcomas are rare mixed tumors with low malignant potential, and occur mainly in the uterus. Primary adenosarcomas arising in vaginal endometriosis are even more rarely reported. We report a very r...Müllerian adenosarcomas are rare mixed tumors with low malignant potential, and occur mainly in the uterus. Primary adenosarcomas arising in vaginal endometriosis are even more rarely reported. We report a very rare case with Müllerian adenosarcoma arising from vaginal endometriosis. A 43-year-old nulliparous woman has a history of endometriosis. Due to two parallel fistulas in cervix, severe endometriosis and adenosarcoma, she has undergone radical and multiple surgeries. After the surgery, persistent vaginal vault masses were noticed, and eight resections of the polyps at vaginal stump were performed. For the first six resections, all the pathological examinations showed endometriosis. And the last two resections demonstrated vaginal adenosarcoma. Transition between Müllerian adenosarcoma and endometriosis was gradual. Finally, adenosarcoma associated with endometriosis was diagnosed from recurrent vaginal masses. To our knowledge, this report is the sixth case that primary adenosarcomas arising in vaginal endometriosis. But chemo-therapy and radiation therapy were not taken and the patient remained in a good condition throughout the 9-year follow-up period. In addition, we present a review of the literature. The diagnosis and treatment of the tumor are also discussed.展开更多
Cervical adenosarcoma was an extremely rare kind of Mullerian mixed tumor,and there was no optimal method of treatment.The aim of this article was to approach the better treatment method for this kind of disease.In th...Cervical adenosarcoma was an extremely rare kind of Mullerian mixed tumor,and there was no optimal method of treatment.The aim of this article was to approach the better treatment method for this kind of disease.In this paper,the vaginal touch,the MRI image,and biopsy were used for diagnosis.And a conservative surgery was performed,followed by 4 cycles of VAC（VCR＋KSM＋CTX） chemotherapy.No evidence of recurrence was seen during follow-up till now.The conservative surgery and VAC chemotherapy in this patient was effective.展开更多
Uterine mullerian adenosareoma is a very rate tumor clinically. Shi et al 1 has reported 9 uterine adenosarcomas among 116 uterine sarcomas during 11 years in West China Second Hospital.It consists of benign or atypic...Uterine mullerian adenosareoma is a very rate tumor clinically. Shi et al 1 has reported 9 uterine adenosarcomas among 116 uterine sarcomas during 11 years in West China Second Hospital.It consists of benign or atypical neoplastic glands within a sarcomatous stroma and represents only 8% of uterine sarcomas.展开更多
目的 探讨子宫苗勒管腺肉瘤伴肉瘤过度生长（Müllerian adenosarcoma of the uterus with sarcomatous overgrowth，MASO）的临床病理特征、生物学行为及预后。方法 对3例MASO采用光镜、免疫组化染色观察，并复习相关文献。结果 3...目的 探讨子宫苗勒管腺肉瘤伴肉瘤过度生长（Müllerian adenosarcoma of the uterus with sarcomatous overgrowth，MASO）的临床病理特征、生物学行为及预后。方法 对3例MASO采用光镜、免疫组化染色观察，并复习相关文献。结果 3例患者分别表现为不规则阴道出血、绝经后阴道出血及子宫增大。大体上，宫腔内见息肉状肿物，直径2～13cm，2例浸润浅肌层，1例浸润深肌层达浆膜。组织学上，3例MASO均见典型腺肉瘤结构，即由良性腺体和低度恶性肉瘤样成分混合而成，其中纯粹肉瘤成分比例均超过25％，并且肉瘤级别比相邻的腺肉瘤高；例2含有异源成分。3例肉瘤成分均显示vimentin阳性，而EMA、CD10、desmin、SMA、S-100蛋白等均阴性。3例均行全子宫＋双侧附件切除术，1例进行了盆腔淋巴结清扫。2例术后分别随访3年及5年均无瘤生存，1例术后1个月死亡。结论 MASO是一种少见的Müllerian混合上皮和间质肿瘤，具有独特的临床病理形态特征；与经典的子宫Müllerian腺肉瘤相比，它更具有侵袭性，预后差。展开更多
文摘Müllerian adenosarcomas are rare mixed tumors with low malignant potential, and occur mainly in the uterus. Primary adenosarcomas arising in vaginal endometriosis are even more rarely reported. We report a very rare case with Müllerian adenosarcoma arising from vaginal endometriosis. A 43-year-old nulliparous woman has a history of endometriosis. Due to two parallel fistulas in cervix, severe endometriosis and adenosarcoma, she has undergone radical and multiple surgeries. After the surgery, persistent vaginal vault masses were noticed, and eight resections of the polyps at vaginal stump were performed. For the first six resections, all the pathological examinations showed endometriosis. And the last two resections demonstrated vaginal adenosarcoma. Transition between Müllerian adenosarcoma and endometriosis was gradual. Finally, adenosarcoma associated with endometriosis was diagnosed from recurrent vaginal masses. To our knowledge, this report is the sixth case that primary adenosarcomas arising in vaginal endometriosis. But chemo-therapy and radiation therapy were not taken and the patient remained in a good condition throughout the 9-year follow-up period. In addition, we present a review of the literature. The diagnosis and treatment of the tumor are also discussed.
文摘Cervical adenosarcoma was an extremely rare kind of Mullerian mixed tumor,and there was no optimal method of treatment.The aim of this article was to approach the better treatment method for this kind of disease.In this paper,the vaginal touch,the MRI image,and biopsy were used for diagnosis.And a conservative surgery was performed,followed by 4 cycles of VAC（VCR＋KSM＋CTX） chemotherapy.No evidence of recurrence was seen during follow-up till now.The conservative surgery and VAC chemotherapy in this patient was effective.
文摘Uterine mullerian adenosareoma is a very rate tumor clinically. Shi et al 1 has reported 9 uterine adenosarcomas among 116 uterine sarcomas during 11 years in West China Second Hospital.It consists of benign or atypical neoplastic glands within a sarcomatous stroma and represents only 8% of uterine sarcomas.
文摘目的 探讨子宫苗勒管腺肉瘤伴肉瘤过度生长（Müllerian adenosarcoma of the uterus with sarcomatous overgrowth，MASO）的临床病理特征、生物学行为及预后。方法 对3例MASO采用光镜、免疫组化染色观察，并复习相关文献。结果 3例患者分别表现为不规则阴道出血、绝经后阴道出血及子宫增大。大体上，宫腔内见息肉状肿物，直径2～13cm，2例浸润浅肌层，1例浸润深肌层达浆膜。组织学上，3例MASO均见典型腺肉瘤结构，即由良性腺体和低度恶性肉瘤样成分混合而成，其中纯粹肉瘤成分比例均超过25％，并且肉瘤级别比相邻的腺肉瘤高；例2含有异源成分。3例肉瘤成分均显示vimentin阳性，而EMA、CD10、desmin、SMA、S-100蛋白等均阴性。3例均行全子宫＋双侧附件切除术，1例进行了盆腔淋巴结清扫。2例术后分别随访3年及5年均无瘤生存，1例术后1个月死亡。结论 MASO是一种少见的Müllerian混合上皮和间质肿瘤，具有独特的临床病理形态特征；与经典的子宫Müllerian腺肉瘤相比，它更具有侵袭性，预后差。
