In this work,the effect of dioctadecyl dimethyl ammonium chloride（DDAC,a kind of alkyl ammonium salt） on polar β phase content and the diameter of electrospun PVDF nanofibers was investigated for the first time.Our...In this work,the effect of dioctadecyl dimethyl ammonium chloride（DDAC,a kind of alkyl ammonium salt） on polar β phase content and the diameter of electrospun PVDF nanofibers was investigated for the first time.Our experimental results show that the diameter of the electrospun PVDF nanofiber could be largely reduced and the content of polar β phase also become dominant immediately by just adding a little amount of DDAC.When the mass fraction of DDAC reached 4%,the content of polar β phase increased by about 39.1% compared with PVDF nanofibers without DDAC.Besides,the crystallinity of PVDF nanofibers also increased with the addition of DDAC.Based on the results,the possible mechanism of cooperative effect between electrospinning and DDAC on fiber diameter and formation of β phase in PVDF was discussed.展开更多
阿尔茨海默病(Alzheimer’s Disease,AD)是一种慢性神经系统退行性疾病,其准确分类有助于实现AD的早期诊断,从而及时采取针对性的治疗和干预措施.本文提出了一种最近邻域聚合图神经网络(Graph neural network with nearest Neighborhood...阿尔茨海默病(Alzheimer’s Disease,AD)是一种慢性神经系统退行性疾病,其准确分类有助于实现AD的早期诊断,从而及时采取针对性的治疗和干预措施.本文提出了一种最近邻域聚合图神经网络(Graph neural network with nearest Neighborhood AgGrEgation,GraphNAGE)的AD分类新方法.首先进行图数据建模,将AD数据样本表示为图数据.采用基于互信息(Mutual Information,MI)的特征选择方法,从样本的114维大脑皮层与皮层下感兴趣区域(Cerebral Cortex and Subcortical Regions Of Interest,CCS-ROI)的体积特征中选取重要性高的体积特征,并将其用于节点建模.提出基于相似性度量的关系建模方法,利用重要性高的体积特征、遗传基因、人口统计信息和认知评分对样本之间的关系进行建模.进而构建GraphNAGE,针对每个节点,基于与该节点相关的边的权重进行最近邻域采样,然后使用均值聚合方法对采样得到的邻居节点和中心节点的数据进行聚合,最后通过一个全连接层和一个Softmax层实现AD分类.在TADPOLE(The Alzheimer’s Disease Prediction Of Longitudinal Evolution)数据集上进行实验,结果表明:本文提出的AD分类方法的准确率(ACCuracy,ACC)为98.20%,F_(1)分数为97.34%,曲线下面积(Area Under Curve,AUC)为97.80%.实验结果表明:本文提出的AD分类方法充分利用了AD数据样本之间的相关性,其性能优于传统的基于机器学习、深度学习和图神经网络(Graph Neural Network,GNN)的AD分类方法.展开更多
基金financially supported by the National Natural Science Foundation of China(Nos.51421061 and 51210005)
文摘In this work,the effect of dioctadecyl dimethyl ammonium chloride（DDAC,a kind of alkyl ammonium salt） on polar β phase content and the diameter of electrospun PVDF nanofibers was investigated for the first time.Our experimental results show that the diameter of the electrospun PVDF nanofiber could be largely reduced and the content of polar β phase also become dominant immediately by just adding a little amount of DDAC.When the mass fraction of DDAC reached 4%,the content of polar β phase increased by about 39.1% compared with PVDF nanofibers without DDAC.Besides,the crystallinity of PVDF nanofibers also increased with the addition of DDAC.Based on the results,the possible mechanism of cooperative effect between electrospinning and DDAC on fiber diameter and formation of β phase in PVDF was discussed.
文摘阿尔茨海默病(Alzheimer’s Disease,AD)是一种慢性神经系统退行性疾病,其准确分类有助于实现AD的早期诊断,从而及时采取针对性的治疗和干预措施.本文提出了一种最近邻域聚合图神经网络(Graph neural network with nearest Neighborhood AgGrEgation,GraphNAGE)的AD分类新方法.首先进行图数据建模,将AD数据样本表示为图数据.采用基于互信息(Mutual Information,MI)的特征选择方法,从样本的114维大脑皮层与皮层下感兴趣区域(Cerebral Cortex and Subcortical Regions Of Interest,CCS-ROI)的体积特征中选取重要性高的体积特征,并将其用于节点建模.提出基于相似性度量的关系建模方法,利用重要性高的体积特征、遗传基因、人口统计信息和认知评分对样本之间的关系进行建模.进而构建GraphNAGE,针对每个节点,基于与该节点相关的边的权重进行最近邻域采样,然后使用均值聚合方法对采样得到的邻居节点和中心节点的数据进行聚合,最后通过一个全连接层和一个Softmax层实现AD分类.在TADPOLE(The Alzheimer’s Disease Prediction Of Longitudinal Evolution)数据集上进行实验,结果表明:本文提出的AD分类方法的准确率(ACCuracy,ACC)为98.20%,F_(1)分数为97.34%,曲线下面积(Area Under Curve,AUC)为97.80%.实验结果表明:本文提出的AD分类方法充分利用了AD数据样本之间的相关性,其性能优于传统的基于机器学习、深度学习和图神经网络(Graph Neural Network,GNN)的AD分类方法.
