Objective: To explore the effect of Health Action Process Approach (HAPA) theory in patients with type D personality psoriasis. Methods: A total of 66 patients with type D personality psoriasis admitted to the dermato...Objective: To explore the effect of Health Action Process Approach (HAPA) theory in patients with type D personality psoriasis. Methods: A total of 66 patients with type D personality psoriasis admitted to the dermatology department of a top-three hospital in Jingzhou City from November 2022 to July 2023 were selected and divided into control group and test group with 33 cases in each group by random number table method. The control group received routine health education, and the experimental group received health education based on the HAPA theory. Chronic disease self-efficacy scale, hospital anxiety and depression scale and skin disease quality of life scale were used to evaluate the effect of intervention. Results: After 3 months of intervention, the scores of self-efficacy in experimental group were higher than those in control group (P P Conclusion: Health education based on the theory of HAPA can enhance the self-efficacy of patients with type D personality psoriasis, relieve negative emotions and improve their quality of life.展开更多
In this paper we present two new families of 2-(v,k,λ)designs with a flag-transitive and point-primitive automorphism group of product action type.More sur-prisingly,one of them is still a family of 2-(v,k,λ)designs...In this paper we present two new families of 2-(v,k,λ)designs with a flag-transitive and point-primitive automorphism group of product action type.More sur-prisingly,one of them is still a family of 2-(v,k,λ)designs with a fag-transitive and point-imprimitive automorphism group.展开更多
Insulin resistance(IR)is a significant feature and one of the basic links in the pathogenesis of type 2 diabetes mellitus(T2DM).Chinese material medica(CMM)has promoted the development of traditional Chinese medicine ...Insulin resistance(IR)is a significant feature and one of the basic links in the pathogenesis of type 2 diabetes mellitus(T2DM).Chinese material medica(CMM)has promoted the development of traditional Chinese medicine due to its definite clinical efficacy in the treatment of IR and T2DM.However,owing to the fact that the mechanism of CMM is characterized by“multiple components and multiple targets”,which has not been effectively interpreted,result in the scientificity of clinical efficacy with CMM is controversial.Therefore,this article summarized the mechanisms of CMM and its main active components in improving IR and preventing and treating T2DM,whose aim is to provide valuable reference for the research mechanism on the treatment of IR and T2DM.展开更多
Based on Hall et al. electrotopological state indices（EK） of atom types, two quantitative structure-activity relationship（QSAR） models were developed to estimate and predict the action strength（W） of D（OM）（di...Based on Hall et al. electrotopological state indices（EK） of atom types, two quantitative structure-activity relationship（QSAR） models were developed to estimate and predict the action strength（W） of D（OM）（dimethoxy-methyl-amphetamine） for 18 phenyl-isopropyl-amine dopes（PPAD） through linear method（multiple linear regression, MLR） and non-linear method（Back propagation artificial neural network, BP-ANN）. On the basis of EK, the optimal three-parameter（E14, E9, E7） QSAR model of W for 18 PPAD was constructed. The traditional correlation coefficient（R^2） and cross-validation correlation coefficient（Rcv^2） are 0.878 and 0.815, respectively. The result demonstrates that the model is highly reliable（from the point of view of statistics） and has good predictive ability by using R^2, Rcv^2, VIF, FIT, AIC and F tests. Form the three parameters of the model, it is known that the dominant influence factors of inhibited activity are the molecular structure fragments： =CH–（secondary carbon）, =C〈（tertiary carbon atom） in aromatic ring and –O–（phenol ether bond）. The results showed that the structure parameters E14, E9 and E7 have good rationality and efficiency for the W of phenyl-isopropyl-amine dope（PPAD） analogues. A BP-ANN with 3-3-1 architecture was generated by using three electrotopological state index descriptors（E14, E9, E7） appearing in the MLR model, the above descriptors were inputs and its output was action strength（W）. The nonlinear BP-ANN model has better predictive ability compared to the linear MLR model with R^2 and Rcv^2 of leave-one-out（LOO） to be 0.995 and 0.994, respectively. The regression method gave support to the neural network with physical explanation, which offers a more accurate model for QSAR. Those models can be used in the rational design of higher stimulating extent PPAD, which provide meaningful reference information to improve the detection methods of PPAD.展开更多
目的:基于健康行动过程取向(health action process approach,HAPA)模型探究2型糖尿病患者膳食模式和血糖控制的影响因素。方法:选取山东省东营市东城医院下属的11个社区卫生中心内的2型糖尿病患者作为研究对象,通过静脉抽血检测患者的...目的:基于健康行动过程取向(health action process approach,HAPA)模型探究2型糖尿病患者膳食模式和血糖控制的影响因素。方法:选取山东省东营市东城医院下属的11个社区卫生中心内的2型糖尿病患者作为研究对象,通过静脉抽血检测患者的糖化血红蛋白(glycosylated hemoglobin,HbA1c)水平,采用一般资料调查表、膳食频率调查问卷、2型糖尿病自我管理量表、HAPA量表收集信息。通过因子分析将患者的膳食模式划分为不同类型,通过结构方程模型分析HAPA模型各维度对于患者膳食模式和血糖控制的影响。结果:共纳入819例2型糖尿病患者,总体HbA1c水平为7.1%±1.1%。研究对象的总体饮食管理得分为5.0(1.0,7.0),具体日常饮食被划分为中低血糖生成指数(glycemic index,GI)膳食模式、肉类膳食模式、水果膳食模式、高GI/淀粉类膳食模式、蛋奶类膳食模式。结构方程模型结果显示,积极结果预期(β=0.417,P<0.001)、消极结果预期(β=-0.239,P<0.001)和感知风险严重性(β=0.075,P=0.036)影响饮食管理行为意向;饮食管理行为意向影响行动计划(β=0.531,P<0.001)和应对计划(β=0.228,P<0.001);行动计划影响总体饮食管理行为(β=0.183,P<0.001);总体饮食管理行为影响中低GI膳食模式(β=0.133,P<0.001)、水果膳食模式(β=-0.103,P=0.003)、高GI/淀粉类膳食模式(β=-0.110,P=0.002)和蛋奶类膳食模式(β=0.076,P=0.031);中低GI膳食模式(β=-0.086,P=0.013)、肉类膳食模式(β=0.084,P=0.015)影响HbA1c水平。此外,行动自我效能可以影响行为意向(β=0.384,P<0.001)、行动计划(β=0.122,P=0.006)和应对计划(β=0.146,P=0.001)。维持自我效能可以影响行动计划(β=0.170,P<0.001)、应对计划(β=0.408,P<0.001)和总体饮食管理行为(β=0.265,P<0.001)。结论:纳入的2型糖尿病患者的膳食模式存在差异,且每周饮食管理的水平欠佳,HAPA模型对于2型糖尿病患者的膳食模式和血糖控制水平具有较好的解释作用,因此,今后可基于HAPA模型制定针对性的饮食干预,提高患者的总体饮食管理水平,促进患者养成低GI的健康膳食模式,从而改善血糖水平,提高生活质量。展开更多
文摘Objective: To explore the effect of Health Action Process Approach (HAPA) theory in patients with type D personality psoriasis. Methods: A total of 66 patients with type D personality psoriasis admitted to the dermatology department of a top-three hospital in Jingzhou City from November 2022 to July 2023 were selected and divided into control group and test group with 33 cases in each group by random number table method. The control group received routine health education, and the experimental group received health education based on the HAPA theory. Chronic disease self-efficacy scale, hospital anxiety and depression scale and skin disease quality of life scale were used to evaluate the effect of intervention. Results: After 3 months of intervention, the scores of self-efficacy in experimental group were higher than those in control group (P P Conclusion: Health education based on the theory of HAPA can enhance the self-efficacy of patients with type D personality psoriasis, relieve negative emotions and improve their quality of life.
基金Zhilin Zhang was supported by the National Natural Science Foundation of China(12001204)Shenglin Zhou was supported by the National Natural Science Foundation of China(12271173).
文摘In this paper we present two new families of 2-(v,k,λ)designs with a flag-transitive and point-primitive automorphism group of product action type.More sur-prisingly,one of them is still a family of 2-(v,k,λ)designs with a fag-transitive and point-imprimitive automorphism group.
文摘Insulin resistance(IR)is a significant feature and one of the basic links in the pathogenesis of type 2 diabetes mellitus(T2DM).Chinese material medica(CMM)has promoted the development of traditional Chinese medicine due to its definite clinical efficacy in the treatment of IR and T2DM.However,owing to the fact that the mechanism of CMM is characterized by“multiple components and multiple targets”,which has not been effectively interpreted,result in the scientificity of clinical efficacy with CMM is controversial.Therefore,this article summarized the mechanisms of CMM and its main active components in improving IR and preventing and treating T2DM,whose aim is to provide valuable reference for the research mechanism on the treatment of IR and T2DM.
基金supported by the National Natural Science Foundation of China(21075138)special fund of State Key Laboratory of Structural Chemistry(20160003)
文摘Based on Hall et al. electrotopological state indices（EK） of atom types, two quantitative structure-activity relationship（QSAR） models were developed to estimate and predict the action strength（W） of D（OM）（dimethoxy-methyl-amphetamine） for 18 phenyl-isopropyl-amine dopes（PPAD） through linear method（multiple linear regression, MLR） and non-linear method（Back propagation artificial neural network, BP-ANN）. On the basis of EK, the optimal three-parameter（E14, E9, E7） QSAR model of W for 18 PPAD was constructed. The traditional correlation coefficient（R^2） and cross-validation correlation coefficient（Rcv^2） are 0.878 and 0.815, respectively. The result demonstrates that the model is highly reliable（from the point of view of statistics） and has good predictive ability by using R^2, Rcv^2, VIF, FIT, AIC and F tests. Form the three parameters of the model, it is known that the dominant influence factors of inhibited activity are the molecular structure fragments： =CH–（secondary carbon）, =C〈（tertiary carbon atom） in aromatic ring and –O–（phenol ether bond）. The results showed that the structure parameters E14, E9 and E7 have good rationality and efficiency for the W of phenyl-isopropyl-amine dope（PPAD） analogues. A BP-ANN with 3-3-1 architecture was generated by using three electrotopological state index descriptors（E14, E9, E7） appearing in the MLR model, the above descriptors were inputs and its output was action strength（W）. The nonlinear BP-ANN model has better predictive ability compared to the linear MLR model with R^2 and Rcv^2 of leave-one-out（LOO） to be 0.995 and 0.994, respectively. The regression method gave support to the neural network with physical explanation, which offers a more accurate model for QSAR. Those models can be used in the rational design of higher stimulating extent PPAD, which provide meaningful reference information to improve the detection methods of PPAD.
