A switch from avian-typeα-2,3 to human-typeα-2,6 receptors is an essential element for the initiation of a pandemic from an avian influenza virus.Some H9N2 viruses exhibit a preference for binding to human-typeα-2,...A switch from avian-typeα-2,3 to human-typeα-2,6 receptors is an essential element for the initiation of a pandemic from an avian influenza virus.Some H9N2 viruses exhibit a preference for binding to human-typeα-2,6 receptors.This identifies their potential threat to public health.However,our understanding of the molecular basis for the switch of receptor preference is still limited.In this study,we employed the random forest algorithm to identify the potentially key amino acid sites within hemagglutinin(HA),which are associated with the receptor binding ability of H9N2 avian influenza virus(AIV).Subsequently,these sites were further verified by receptor binding assays.A total of 12 substitutions in the HA protein(N158D,N158S,A160 N,A160D,A160T,T163I,T163V,V190T,V190A,D193 N,D193G,and N231D)were predicted to prefer binding toα-2,6 receptors.Except for the V190T substitution,the other substitutions were demonstrated to display an affinity for preferential binding toα-2,6 receptors by receptor binding assays.Especially,the A160T substitution caused a significant upregulation of immune-response genes and an increased mortality rate in mice.Our findings provide novel insights into understanding the genetic basis of receptor preference of the H9N2 AIV.展开更多
Soil erosion from water has become a relevant issue at global level.In Guinea in particular,erosion has worrying effects,due to natural conditions and human impact,especially in the Nzérékore city in forest ...Soil erosion from water has become a relevant issue at global level.In Guinea in particular,erosion has worrying effects,due to natural conditions and human impact,especially in the Nzérékore city in forest region.This paper proposed a soil erosion modeling by rainfall effect in the prefecture of N'Zérékoré.To achieve this objective,monthly and annual rainfall data for the N'Zérékorécity were collected at the meteorological station over the period from 1980 to 2024.The analysis of rainfall aggressiveness was possible using the Fournier index.For data processing,we used Microsoft Excel,Python and the ARIMA(AutoRegressive Integrated Moving Average)model for soil aggressiveness predicted by rainfall.It was found that,from 2000 to 2009,erosion was higher compared to other periods with a rate of 60%,or 6 years of high rainfall aggression.From the periods 1990 to 1999 and 2010 to 2019,the lowest rainfall aggressiveness was recorded,with 60%or 6 years of low erosivity.However,from period 1980 to 1989 the highest rate(70%)of very high rainfall erosivity was recorded.The results show three levels of rainfall aggressiveness on an annual scale:a very high level of erosivity with a rate of 22.2%or 10 years,followed by a high level of 35.6%or 16 years of strong erosion.The moderate erosivity level corresponds to 42.2%or 19 years.The model predicts a stability of the erosivity index around 77.14 over the period 2025-2034.During the forty(45)years the rainfall erosivity index was very unstable characterized by strong erosion,however it would be stable in the next ten(10)years.展开更多
This research investigates the comparative efficacy of generating zero divisor graphs (ZDGs) of the ring of integers ℤ<sub>n</sub> modulo n using MAPLE algorithm. Zero divisor graphs, pivotal in the study ...This research investigates the comparative efficacy of generating zero divisor graphs (ZDGs) of the ring of integers ℤ<sub>n</sub> modulo n using MAPLE algorithm. Zero divisor graphs, pivotal in the study of ring theory, depict relationships between elements of a ring that multiply to zero. The paper explores the development and implementation of algorithms in MAPLE for constructing these ZDGs. The comparative study aims to discern the strengths, limitations, and computational efficiency of different MAPLE algorithms for creating zero divisor graphs offering insights for mathematicians, researchers, and computational enthusiasts involved in ring theory and mathematical computations.展开更多
The linear consecutive-k-out-of-n:failure(good)(Lin/Con/k/n:F(G))system consists of n interchangeable components that have different reliabilities.These components are arranged in a line path and different component a...The linear consecutive-k-out-of-n:failure(good)(Lin/Con/k/n:F(G))system consists of n interchangeable components that have different reliabilities.These components are arranged in a line path and different component assignments change the system reliability.The optimization of Lin/Con/k/n:F(G)system is to find an optimal component assignment to maximize the system reliability.As the number of components increases,the computation time for this problem increases considerably.In this paper,we propose a Birnbaum importance-based ant colony optimization(BIACO)algorithm to obtain quasi optimal assignments for such problems.We compare its performance using the Birnbaum importance based two-stage approach(BITA)and Birnbaum importancebased genetic local search(BIGLS)algorithm from previous researches.The experimental results show that the BIACO algorithm has a good performance in the optimization of Lin/Con/k/n:F(G)system.展开更多
椭圆曲线公钥密码是公钥密码体制的主流方向之一.由于密钥短、计算速度快,该体制在智能卡和手机存储卡等受限的环境中得到了广泛的应用.椭圆曲线密码体系中最耗时的运算是标量乘.标量乘需要安全、有效、快速的实现算法.Montgomery算法...椭圆曲线公钥密码是公钥密码体制的主流方向之一.由于密钥短、计算速度快,该体制在智能卡和手机存储卡等受限的环境中得到了广泛的应用.椭圆曲线密码体系中最耗时的运算是标量乘.标量乘需要安全、有效、快速的实现算法.Montgomery算法是计算椭圆曲线标量乘的算法之一,它能够有效地抵抗简单能量分析.在Montgomery算法结构的基础上,文中首次利用统一Z坐标技巧和循环中间阶段不计算Y坐标的技巧,改进了有限域GF(3~m)上椭圆曲线的点加和倍点公式,构造了抵抗简单能量攻击的co-Z Montgomery算法.设I,M,C分别表示有限域上的求逆、乘法、立方.当域上的平方和乘法使用相同的算法时,理论分析表明每轮循环中,co-Z Montgomery算法比仿射Montgomery算法快I+C-5 M,比射影Montgomery算法快C+2 M,比使用"Selected Areas in Cryptography"2012上快速点加、倍点公式的Montgomery算法快2C+M.在文章"特征3有限域上椭圆曲线的Montgomery算法"的模拟实验环境下,结果表明该算法比上述算法分别快26.3%、19.0%、20.6%;Sage云平台的实验结果表明该算法比上述算法分别快24.1%、20.1%、23.1%.展开更多
基金supported by the National Natural Science Foundation of China(32273037 and 32102636)the Guangdong Major Project of Basic and Applied Basic Research(2020B0301030007)+4 种基金Laboratory of Lingnan Modern Agriculture Project(NT2021007)the Guangdong Science and Technology Innovation Leading Talent Program(2019TX05N098)the 111 Center(D20008)the double first-class discipline promotion project(2023B10564003)the Department of Education of Guangdong Province(2019KZDXM004 and 2019KCXTD001).
文摘A switch from avian-typeα-2,3 to human-typeα-2,6 receptors is an essential element for the initiation of a pandemic from an avian influenza virus.Some H9N2 viruses exhibit a preference for binding to human-typeα-2,6 receptors.This identifies their potential threat to public health.However,our understanding of the molecular basis for the switch of receptor preference is still limited.In this study,we employed the random forest algorithm to identify the potentially key amino acid sites within hemagglutinin(HA),which are associated with the receptor binding ability of H9N2 avian influenza virus(AIV).Subsequently,these sites were further verified by receptor binding assays.A total of 12 substitutions in the HA protein(N158D,N158S,A160 N,A160D,A160T,T163I,T163V,V190T,V190A,D193 N,D193G,and N231D)were predicted to prefer binding toα-2,6 receptors.Except for the V190T substitution,the other substitutions were demonstrated to display an affinity for preferential binding toα-2,6 receptors by receptor binding assays.Especially,the A160T substitution caused a significant upregulation of immune-response genes and an increased mortality rate in mice.Our findings provide novel insights into understanding the genetic basis of receptor preference of the H9N2 AIV.
文摘Soil erosion from water has become a relevant issue at global level.In Guinea in particular,erosion has worrying effects,due to natural conditions and human impact,especially in the Nzérékore city in forest region.This paper proposed a soil erosion modeling by rainfall effect in the prefecture of N'Zérékoré.To achieve this objective,monthly and annual rainfall data for the N'Zérékorécity were collected at the meteorological station over the period from 1980 to 2024.The analysis of rainfall aggressiveness was possible using the Fournier index.For data processing,we used Microsoft Excel,Python and the ARIMA(AutoRegressive Integrated Moving Average)model for soil aggressiveness predicted by rainfall.It was found that,from 2000 to 2009,erosion was higher compared to other periods with a rate of 60%,or 6 years of high rainfall aggression.From the periods 1990 to 1999 and 2010 to 2019,the lowest rainfall aggressiveness was recorded,with 60%or 6 years of low erosivity.However,from period 1980 to 1989 the highest rate(70%)of very high rainfall erosivity was recorded.The results show three levels of rainfall aggressiveness on an annual scale:a very high level of erosivity with a rate of 22.2%or 10 years,followed by a high level of 35.6%or 16 years of strong erosion.The moderate erosivity level corresponds to 42.2%or 19 years.The model predicts a stability of the erosivity index around 77.14 over the period 2025-2034.During the forty(45)years the rainfall erosivity index was very unstable characterized by strong erosion,however it would be stable in the next ten(10)years.
文摘This research investigates the comparative efficacy of generating zero divisor graphs (ZDGs) of the ring of integers ℤ<sub>n</sub> modulo n using MAPLE algorithm. Zero divisor graphs, pivotal in the study of ring theory, depict relationships between elements of a ring that multiply to zero. The paper explores the development and implementation of algorithms in MAPLE for constructing these ZDGs. The comparative study aims to discern the strengths, limitations, and computational efficiency of different MAPLE algorithms for creating zero divisor graphs offering insights for mathematicians, researchers, and computational enthusiasts involved in ring theory and mathematical computations.
基金the National Natural Science Foundation of China(Nos.71871181 and 71471147)the Overseas Expertise Introduction Project for Discipline Innovation(No.B13044)the Top International University Visiting Program for Outstanding Young Scholars of Northwestern Polytechnical University(No.201806295008)。
文摘The linear consecutive-k-out-of-n:failure(good)(Lin/Con/k/n:F(G))system consists of n interchangeable components that have different reliabilities.These components are arranged in a line path and different component assignments change the system reliability.The optimization of Lin/Con/k/n:F(G)system is to find an optimal component assignment to maximize the system reliability.As the number of components increases,the computation time for this problem increases considerably.In this paper,we propose a Birnbaum importance-based ant colony optimization(BIACO)algorithm to obtain quasi optimal assignments for such problems.We compare its performance using the Birnbaum importance based two-stage approach(BITA)and Birnbaum importancebased genetic local search(BIGLS)algorithm from previous researches.The experimental results show that the BIACO algorithm has a good performance in the optimization of Lin/Con/k/n:F(G)system.
基金supported by the National Natural Science Foundation of China(51602297)Fundamental Research Funds for the Central Universities(201612007)+1 种基金Postdoctoral Innovation Program of Shandong Province(201603043)the Major Research Project of Shandong Province(2016ZDJS11A04)
文摘椭圆曲线公钥密码是公钥密码体制的主流方向之一.由于密钥短、计算速度快,该体制在智能卡和手机存储卡等受限的环境中得到了广泛的应用.椭圆曲线密码体系中最耗时的运算是标量乘.标量乘需要安全、有效、快速的实现算法.Montgomery算法是计算椭圆曲线标量乘的算法之一,它能够有效地抵抗简单能量分析.在Montgomery算法结构的基础上,文中首次利用统一Z坐标技巧和循环中间阶段不计算Y坐标的技巧,改进了有限域GF(3~m)上椭圆曲线的点加和倍点公式,构造了抵抗简单能量攻击的co-Z Montgomery算法.设I,M,C分别表示有限域上的求逆、乘法、立方.当域上的平方和乘法使用相同的算法时,理论分析表明每轮循环中,co-Z Montgomery算法比仿射Montgomery算法快I+C-5 M,比射影Montgomery算法快C+2 M,比使用"Selected Areas in Cryptography"2012上快速点加、倍点公式的Montgomery算法快2C+M.在文章"特征3有限域上椭圆曲线的Montgomery算法"的模拟实验环境下,结果表明该算法比上述算法分别快26.3%、19.0%、20.6%;Sage云平台的实验结果表明该算法比上述算法分别快24.1%、20.1%、23.1%.
