Due to the limited transmission resources for data relay in the tracking and data relay satellite system （TDRSS）, there are many job requirements in busy days which will be discarded in the conventional job scheduli...Due to the limited transmission resources for data relay in the tracking and data relay satellite system （TDRSS）, there are many job requirements in busy days which will be discarded in the conventional job scheduling model. Therefore, the improvement of scheduling efficiency in the TDRSS can not only help to increase the resource utilities, but also to reduce the scheduling failure ratio. A model of nonhomogeneous parallel machines scheduling problems with time window （NPM-TW） is firstly built up for the TDRSS, considering the distinct features of the variable preparation time and the nonhomogeneous transmission rates for different types of antennas on each tracking and data relay satellite （TDRS）. Then, an adaptive subsequence adjustment （ASA） framework with evolutionary asymmetric path-relinking （EvAPR） is proposed to solve this problem, in which an asymmetric progressive crossover operation is involved to overcome the local optima by the conventional job inserting methods. The numerical results show that, compared with the classical greedy randomized adaptive search procedure （GRASP） algorithm, the scheduling failure ratio of jobs can be reduced over 11% on average by the proposed ASA with EvAPR.展开更多
In this paper, with the aid of large deviation formulas established in strong topology of functional space generated by HSlder norm, we discuss the functional sample path properties of subsequence＇s C-R increments fo...In this paper, with the aid of large deviation formulas established in strong topology of functional space generated by HSlder norm, we discuss the functional sample path properties of subsequence＇s C-R increments for a Wiener process in HSlder norm. The obtained results, generalize the corresponding results of Chen and the classic Strassen＇s law of iterated logarithm for a Wiener process.展开更多
The recent advancements in sensor technology have made it possible to collect enormous amounts of data in real time.How to find out unusual pattern from time series data plays a very important role in data mining.In t...The recent advancements in sensor technology have made it possible to collect enormous amounts of data in real time.How to find out unusual pattern from time series data plays a very important role in data mining.In this paper,we focus on the abnormal subsequence detection.The original definition of discord subsequences is defective for some kind of time series,in this paper we give a more robust definition which is based on the k nearest neighbors.We also donate a novel method for time series representation,it has better performance than traditional methods(like PAA/SAX)to represent the characteristic of some special time series.To speed up the process of abnormal subsequence detection,we used the clustering method to optimize the outer loop ordering and early abandon subsequence which is impossible to be abnormal.The experiment results validate that the algorithm is correct and has a high efficiency.展开更多
Let X1,X2,…,Xn,…be a sequence of i.i.d.random variables uniformly distributed on[0;1],and denote by Ln the length of the longest increasing subsequences of X1,X2,…,Xn.Consider the poissonized version Hn based on Ha...Let X1,X2,…,Xn,…be a sequence of i.i.d.random variables uniformly distributed on[0;1],and denote by Ln the length of the longest increasing subsequences of X1,X2,…,Xn.Consider the poissonized version Hn based on Hammersley’s representation in the 2-dimensional space.A law of the iterated logarithm for Hn is established using the well-known subsequence method and Borel-Cantelli lemma.The key technical ingredients in the argument include superadditivity,increment independence and precise tail estimates for the Hn’s.The work was motivated by recent works due to Ledoux(J.Theoret.Probab.31,(2018)).It remains open to establish an analog for the Ln itself.展开更多
Let G be a finite abelian group and S be a sequence with elements of G.We say that S is a regular sequence over G if|SH|≤|H|-1 holds for every proper subgroup H of G,where SH denotes the subsequence of S consisting o...Let G be a finite abelian group and S be a sequence with elements of G.We say that S is a regular sequence over G if|SH|≤|H|-1 holds for every proper subgroup H of G,where SH denotes the subsequence of S consisting of all terms of S contained in H.We say that S is a zero-sum free sequence over G if 0■Σ(S),where Σ(S)■G denotes the set of group elements which can be expressed as a sum of a nonempty subsequence of S.In this paper,we study the inverse problems associated with Σ(S)when S is a regular sequence or a zero-sum free sequence over G=Cp■Cp,where p is a prime.展开更多
Parkinson's disease(PD) has a complex and multifactorial pathophysiology. Various studies, conducted both in pre-clinical models and PD patients, have reported a link between the disruption of calcium(Ca^(2+)) hom...Parkinson's disease(PD) has a complex and multifactorial pathophysiology. Various studies, conducted both in pre-clinical models and PD patients, have reported a link between the disruption of calcium(Ca^(2+)) homeostasis and the subsequent development of PD. Ca^(2+) regulation is crucial for neuronal survival, differentiation,exocytosis at synapses,gene transcription,and proliferation.展开更多
Background This study investigated the potential impacts of increasing linoleic andα-linolenic acid intake during lactation and wean-to-breeding on subsequent reproduction of sows.A total of 309 sows(PIC Camborough L...Background This study investigated the potential impacts of increasing linoleic andα-linolenic acid intake during lactation and wean-to-breeding on subsequent reproduction of sows.A total of 309 sows(PIC Camborough L42)were balanced by parity(140 and 169 sows representing parity 1 to 2[P1-2]and 3 to 9[P3+],respectively)and assigned within parity to a 2×2 factorial arrangement.Factors included essential fatty acid(EFA)supplementation(control diets containing 1.2%linoleic and 0.15%α-linolenic acid or diets with 3.0%linoleic and 0.38%α-linolenic acid)and supplementation period(lactation or wean-to-breeding).Tallow(low EFA diets)or soybean oil(high EFA diets)were included at 4%in sorghum-soybean meal-wheat middlings-based diets to attain targeted EFA levels.Results High levels of EFA fed during lactation had no effect on feed intake or litter performance,but increased subsequent farrowing rate(P=0.027;82.1%vs.70.4%),tended to reduce the proportion of sows removed(P=0.070;12.4%vs.20.8%),decreased the number of total pigs born in the following litter(P=0.072;15.3 vs.16.2),and increased total pigs born alive per 100 sows weaned(P=0.062;1,122 vs.974),regardless of sow parity.Young sows(P1-2)consuming the high EFA diet during lactation displayed a shorter wean-to-estrus interval(P=0.035;4.2 vs.4.6),but P3+sows were unaffected.Increasing EFA intake for P3+sows,but not P1-2 sows,resulted in more sows bred by d 5(P=0.028;91.1%vs.81.7%)and more mummies in the subsequent litter(P=0.040;0.32 vs.0.16).Feeding increased EFA to P1-2 sows during the wean-to-breeding period decreased subsequent farrowing rate(P=0.042;72.0%vs.87.7%),and increased removal rate(P=0.003;28.8%vs.9.4%).Total pigs born alive per 100 sows weaned was reduced(P=0.007)in P1-2 sows when supplemented with EFA during wean-breeding(939 vs.1,149)but was not impacted in P3+sows(1,131 vs.982).Conclusions Supplemental EFA in lactation diets benefited subsequent reproduction of sows,regardless of parity.Increasing dietary levels of EFA during the wean-to-breeding period to younger sows negatively impacted subsequent reproduction.展开更多
The automotive industry increasingly relies on numerical simulations to predict the geometry and forming processes of complex curved parts.Accurate yield stress functions that cover a wide range of stress states,such ...The automotive industry increasingly relies on numerical simulations to predict the geometry and forming processes of complex curved parts.Accurate yield stress functions that cover a wide range of stress states,such as uniaxial tension,equi-biaxial tension,near-plane strain tension,and simple shear,are essential for implementing virtual manufacturing technologies.In this work,a new additive-coupled analytical yield stress function,CPN2025,is proposed to accurately describe plastic anisotropy under various loading conditions.CPN2025 integrates the Poly4 anisotropic yield criterion with the Hosford isotropic yield criterion under a non-associated flow rule.A non-fixed-exponent calibration strategy is introduced,overcoming the limitations of existing yield criteria that typically offer curvature adjustment with only positive or negative correlations.CPN2025 is compared with other non-associated yield functions,including SY2009,CQN2017,and NAFR-Poly4,to evaluate its performance in predicting the plastic anisotropy of DP490,QP1180,AA5754-O,and AA6016-T4.Results show that,while meeting convexity requirements,the additive-coupled approach not only provides greater flexibility than the multiplicative-coupled but also simplifies the acquisition of partial derivative information.CPN2025 delivers the highest accuracy in characterizing anisotropic yield behavior,particularly for near-plane strain tension and simple shear loadings.Additionally,incorporating more uniaxial tensile yield stress-calibrated material parameters significantly improves the prediction capacity of in-plane anisotropic behavior.The use of anisotropic hardening concepts enhances the model's capability to capture the subsequent yield behavior across the entire plastic strain range.展开更多
BACKGROUND The combination of anti-epidermal growth factor receptor(EGFR)therapy and chemotherapy is currently a preferred first-line treatment for patients with unre-sectable,RAS and BRAF wild-type,left-sided metasta...BACKGROUND The combination of anti-epidermal growth factor receptor(EGFR)therapy and chemotherapy is currently a preferred first-line treatment for patients with unre-sectable,RAS and BRAF wild-type,left-sided metastatic colorectal cancer(mCRC).Several studies have also demonstrated the benefit of anti-EGFR therapy in sub-sequent line settings for this patient population.However,direct evidence com-paring the effectiveness of frontline vs subsequent anti-EGFR therapy remains limited,leaving a crucial gap in guiding optimal treatment strategies.AIM To compare overall survival(OS)between frontline and subsequent anti-EGFR treatment in patients with unresectable,RAS and BRAF wild-type,left-sided mCRC.METHODS We retrospectively reviewed the medical records of mCRC patients treated at The King Chulalongkorn Memorial Hospital and Songklanagarind Hospital,Thailand,between January 2013 and April 2023.Patients were classified into two groups based on the sequence of their anti-EGFR treatment.The primary endpoint was OS.RESULTS Among 222 patients with a median follow-up of 29 months,no significant difference in OS was observed between the frontline and subsequent-line groups(HR 1.03,95%CI:0.73-1.46,P=0.878).The median OS was 35.53 months(95%CI:26.59-44.47)for the frontline group and 31.60 months(95%CI:27.83-35.37)for the subsequent-line group.In the subsequent-line group,71 patients(32.4%)who ultimately never received anti-EGFR therapy had a significantly worse median OS of 19.70 months(95%CI:12.87-26.53).CONCLUSION Frontline and subsequent-line anti-EGFR treatments provide comparable OS in unresectable,RAS/BRAF wild-type,left-sided mCRC patients,but early exposure is vital for those unlikely to receive subsequent therapy.展开更多
A fundamental problem in sequence stratigraphy is whether the sequences are global in extent and whether the sea level changes are eustatic in nature. Study on the Upper Devonian and Lower Carboniferous depositional s...A fundamental problem in sequence stratigraphy is whether the sequences are global in extent and whether the sea level changes are eustatic in nature. Study on the Upper Devonian and Lower Carboniferous depositional sequences in different facies belts on the southern margin of the Upper Yangtze platform shows that different orders of sequences possess distinctive distribution and correlation in space, although the sea level changes in various orders of sequences may be primarily global in nature. The present paper regards the distribution in space, especially in different facies belts, as a criterion for defining and recognizing the various orders of sequences. The orthosequence (third order sequence) is probably global in nature, which may be discerned in various depositional facies belts on the continental margin and can be correlated over long distances, sometimes maybe worldwide. Commonly, correlation of the subsequences (fourth order sequences with time interval of 0.5 Ma to 1.5 Ma) is difficult in different facies belts, although some of them are probably also worldwide in distribution. A subsequence should be distinguishable and correlatable within at least one facies belt. The higher order sequences, including parasequences (fifth order sequences) and microsequences (sixth order sequences), are regional or local in distribution. They may have reflected the longer and shorter Milankovitch cycles respectively. Orthosequences and subsequences are usually recognizable in different facies belts, while parasequences and microsequences may be distinguished only in shallow marine deposits, but not in slope and basin facies deposits.展开更多
This paper introduces a novel transform method to produce the newly generated programs through code transform model called the second generation of Generative Pre-trained Transformer(GPT-2)reasonably,improving the pro...This paper introduces a novel transform method to produce the newly generated programs through code transform model called the second generation of Generative Pre-trained Transformer(GPT-2)reasonably,improving the program execution performance significantly.Besides,a theoretical estimation in statistics has given the minimum number of generated programs as required,which guarantees to find the best one within them.The proposed approach can help the voice assistant machine resolve the problem of inefficient execution of application code.In addition to GPT-2,this study develops the variational Simhash algorithm to check the code similarity between sample program and newly generated program,and conceives the piecewise longest common subsequence algorithm to examine the execution’s conformity from the two programs mentioned above.The code similarity check deducts the redundant generated programs,and the output conformity check finds the best-performing generative program.In addition to texts,the proposed approach can also prove the other media,including images,sounds,and movies.As a result,the newly generated program outperforms the sample program significantly because the number of code lines reduces 27.21%,and the program execution time shortens 24.62%.展开更多
A study was made on temporal sequence of the earthquake swarm with M6. 7 which took place in Batang County, Sichuan Province, from April to Sept., 1989. Temporal sequence of the swarm was characterized by obvious sect...A study was made on temporal sequence of the earthquake swarm with M6. 7 which took place in Batang County, Sichuan Province, from April to Sept., 1989. Temporal sequence of the swarm was characterized by obvious sectional release process, in dex rise of creeping curve, certain order behavior among the peak values in the early sequence, transient tranquility before strong aftershocks and abnormal high values in sequential entropy. Subsequence of the swarm were represented by the forms of isolation pattern and mainshock-aftershock pattern,changed from the former pattern to the latter and characterized by fast-slow-fast attenuating pattern. According to time fractional dimension calculation results of the swarm sequence and the subsequences, it was discovered that non-scaling regions existed in the complicated temporal sequence structure, the span of non-scaling region of capacity dimension Do was different from that of the information dimension D1 of the same sequence, and the self-organizational features of the same sequence were different when various magnitude threshold values were selected for calculating. From the stochastic non-uniform spread of swarming high fractures in the seismic regions, it was primarily explained that the exponential attenuation of time sequence variation was likely to occur.Meanwhile, the level structures of various order sequences of the strong seismic swarm and the order problems were discussed.展开更多
The scheduling efficiency of the tracking and data relay satellite system（TDRSS）is strictly limited by the scheduling degrees of freedom（DoF）,including time DoF defined by jobs＇ flexible time windows and spatial ...The scheduling efficiency of the tracking and data relay satellite system（TDRSS）is strictly limited by the scheduling degrees of freedom（DoF）,including time DoF defined by jobs＇ flexible time windows and spatial DoF brought by multiple servable tracking and data relay satellites（TDRSs）.In this paper,ageneralized multiple time windows（GMTW）model is proposed to fully exploit the time and spatial DoF.Then,the improvements of service capability and job-completion probability based on the GMTW are theoretically proved.Further,an asymmetric path-relinking（APR）based heuristic job scheduling framework is presented to maximize the usage of DoF provided by the GMTW.Simulation results show that by using our proposal 11%improvement of average jobcompletion probability can be obtained.Meanwhile,the computing time of the time-to-target can be shorten to 1/9 of the GRASP.展开更多
The existing multi-source contour matching studies have focused on the matching methods with consideration of topological relations and similarity measurement based on spatial Euclidean distance,while it is lack of ta...The existing multi-source contour matching studies have focused on the matching methods with consideration of topological relations and similarity measurement based on spatial Euclidean distance,while it is lack of taking the contour geometric features into account,which may lead to mismatching in map boundaries and areas with intensive contours or extreme terrain changes.In light of this,it is put forward that a matching strategy from coarse to precious based on the contour geometric features.The proposed matching strategy can be described as follows.Firstly,the point sequence is converted to feature sequence according to a feature descriptive function based on curvature and angle of normal vector.Then the level of similarity among multi-source contours is calculated by using the longest common subsequence solution.Accordingly,the identical contours could be matched based on the above calculated results.In the experiment for the proposed method,the reliability and efficiency of the matching method are verified using simulative datasets and real datasets respectively.It has been proved that the proposed contour matching strategy has a high matching precision and good applicability.展开更多
Our previous work has introduced the newly generated program using the code transformation model GPT-2,verifying the generated programming codes through simhash(SH)and longest common subsequence(LCS)algo-rithms.Howeve...Our previous work has introduced the newly generated program using the code transformation model GPT-2,verifying the generated programming codes through simhash(SH)and longest common subsequence(LCS)algo-rithms.However,the entire code transformation process has encountered a time-consuming problem.Therefore,the objective of this study is to speed up the code transformation process signicantly.This paper has proposed deep learning approaches for modifying SH using a variational simhash(VSH)algorithm and replacing LCS with a piecewise longest common subsequence(PLCS)algorithm to faster the verication process in the test phase.Besides the code transformation model GPT-2,this study has also introduced MicrosoMASS and Facebook BART for a comparative analysis of their performance.Meanwhile,the explainable AI technique using local interpretable model-agnostic explanations(LIME)can also interpret the decision-making ofAImodels.The experimental results show that VSH can reduce the number of qualied programs by 22.11%,and PLCS can reduce the execution time of selected pocket programs by 32.39%.As a result,the proposed approaches can signicantly speed up the entire code transformation process by 1.38 times on average compared with our previous work.展开更多
This paper investigates a procedure developed and reports on experiments performed to studying the utility of applying a combined structural property of a text’s sentences and term expansion using WordNet [1] and a l...This paper investigates a procedure developed and reports on experiments performed to studying the utility of applying a combined structural property of a text’s sentences and term expansion using WordNet [1] and a local thesaurus [2] in the selection of the most appropriate extractive text summarization for a particular document. Sentences were tagged and normalized then subjected to the Longest Common Subsequence (LCS) algorithm [3] [4] for the selection of the most similar subset of sentences. Calculated similarity was based on LCS of pairs of sentences that make up the document. A normalized score was calculated and used to rank sentences. A selected top subset of the most similar sentences was then tokenized to produce a set of important keywords or terms. The produced terms were further expanded into two subsets using 1) WorldNet;and 2) a local electronic dictionary/thesaurus. The three sets obtained (the original and the expanded two) were then re-cycled to further refine and expand the list of selected sentences from the original document. The process was repeated a number of times in order to find the best representative set of sentences. A final set of the top (best) sentences was selected as candidate sentences for summarization. In order to verify the utility of the procedure, a number of experiments were conducted using an email corpus. The results were compared to those produced by human annotators as well as to results produced using some basic sentences similarity calculation method. Produced results were very encouraging and compared well to those of human annotators and Jacquard sentences similarity.展开更多
An integration processing system of three-dimensional laser scanning information visualization in goaf was developed. It is provided with multiple functions, such as laser scanning information management for goaf, clo...An integration processing system of three-dimensional laser scanning information visualization in goaf was developed. It is provided with multiple functions, such as laser scanning information management for goaf, cloud data de-noising optimization, construction, display and operation of three-dimensional model, model editing, profile generation, calculation of goaf volume and roof area, Boolean calculation among models and interaction with the third party soft ware. Concerning this system with a concise interface, plentiful data input/output interfaces, it is featured with high integration, simple and convenient operations of applications. According to practice, in addition to being well-adapted, this system is favorably reliable and stable.展开更多
AIM:To compare the outcomes of concomitant cholangiocarcinoma(C-CCA)and subsequent cholangiocar-cinoma(S-CCA)associated with hepatolithiasis. METHODS:From December 1987 to December 2007, 276 patients underwent hepatic...AIM:To compare the outcomes of concomitant cholangiocarcinoma(C-CCA)and subsequent cholangiocar-cinoma(S-CCA)associated with hepatolithiasis. METHODS:From December 1987 to December 2007, 276 patients underwent hepatic resection for hepa-tolithiasis in Changhua Christian Hospital.Sixty-five patients were excluded due to incomplete medical records and the remaining 211 patients constituted our study population base.Ten patients were diag-nosed with C-CCA based on the preoperative biopsy or postoperative pathology.During the follow-up period, 12 patients developed S-CCA.The diagnosis of S-CCA was made by image-guided biopsy or by pathology if surgical intervention was carried out.Patient charts were reviewed to collect clinical information.Parameters such as CCA incidence,interval from operation to CCA diagnosis,interval from CCA diagnosis to disease-related death,follow-up time,and mortality rate were calculated for both the C-CCA and S-CCA groups.The outcomes of the C-CCA and S-CCA groups were math-ematically compared and analysed. RESULTS:Our study demonstrates the clinical implications and the survival outcomes of C-CCA and S-CCA. Among the patients with unilateral hepatolithiasis,the incidence rates of C-CCA and S-CCA were fairly similar (4.8%vs 4.5%,respectively,P=0.906).However,for the patients with bilateral hepatolithiasis,the incidence rate of S-CCA(12.2%)was higher than that of C-CCA (4.7%),although the sample size was limited and the difference between two groups was not statistically sig-nificant(P=0.211).The average follow-up time was 56 mo for the C-CCA group and 71 mo for the S-CCA group.Regard to the average time intervals from operation to CCA diagnosis,S-CCA was diagnosed after 67 mo from the initial hepatectomy.The average time intervals from the diagnoses of CCA to disease-related death was 41 mo for the C-CCA group and 4 mo for the S-CCA group,this difference approached statistical sig-nificance(P=0.075).Regarding the rates of overall and disease-related mortality,the C-CCA group had signifi-cantly lower overall mortality(70%vs 100%,P=0.041) and disease-related mortality(60%vs 100%,P=0.015) than the S-CCA group.For the survival outcomes of two groups,the Kaplan-Meier curves corresponding to each group also demonstrated better survival outcomes for the C-CCA group(log rank P=0.005).In the C-CCA group,three patients were still alive at the time of data analysis,all of them had free surgical margins and did not have pathologically proven lymph node metastasis at the time of the initial hepatectomy.In the S-CCA group,only one patient had chance to undergo a second hepatectomy,and all 12 S-CCA patients had died at the time of data analysis. CONCLUSION:C-CCA has better outcomes than S-CCA.The first hepatectomy is crucial because most patients with recurrent CCA or S-CCA are not eligible for repeated surgical intervention.展开更多
The genus Brassica belongs to the plant family Brassicaceae,which includes many important crop species that are used as oilseed,condiments,or vegetables throughout the world.Brassica plants comprise many diverse speci...The genus Brassica belongs to the plant family Brassicaceae,which includes many important crop species that are used as oilseed,condiments,or vegetables throughout the world.Brassica plants comprise many diverse species,and each species contains rich morphotypes showing extreme traits.Brassica species experienced an extra whole genome triplication(WGT)event compared with the model plant Arabidopsis thaliana.Whole genome sequencing of the Brassica species Brassica rapa,Brassica oleracea and others demonstrated that WGT plays an important role in the speciation and morphotype diversification of Brassica plants.Comparative genomic analysis based on the genome sequences of B.rapa and A.thaliana clearly identified the WGT event and further demonstrated that the translocated Proto-Calepine Karyotype(tPCK,n57)was the diploid ancestor of the three subgenomes in B.rapa.Following WGT,subsequent extensive genome fractionation,block reshuffling and chromosome reduction accompanied by paleocentromere descent from the three tPCK subgenomes during the rediploidization process produced stable diploid species.Genomic rearrangement of the diploid species and their hybridization then contributed to Brassica speciation.The subgenome dominance effect and biased gene retention,such as the over-retention of auxin-related genes after WGT,promoted functional gene evolution and thus propelled the expansion of rich morphotypes in the Brassica species.In conclusion,the WGT event initiated subsequent genomic and gene-level evolution,which further drove Brassica speciation and created rich morphotypes in each species.展开更多
基金supported by the National Natural Science Foundation of China(6113200291338101+3 种基金91338108)the National S&T Major Project(2011ZX03004-001-01)the Research Fund of Tsinghua University(2011Z05117)the Co-innovation Laboratory of Aerospace Broadband Network Technology
文摘Due to the limited transmission resources for data relay in the tracking and data relay satellite system （TDRSS）, there are many job requirements in busy days which will be discarded in the conventional job scheduling model. Therefore, the improvement of scheduling efficiency in the TDRSS can not only help to increase the resource utilities, but also to reduce the scheduling failure ratio. A model of nonhomogeneous parallel machines scheduling problems with time window （NPM-TW） is firstly built up for the TDRSS, considering the distinct features of the variable preparation time and the nonhomogeneous transmission rates for different types of antennas on each tracking and data relay satellite （TDRS）. Then, an adaptive subsequence adjustment （ASA） framework with evolutionary asymmetric path-relinking （EvAPR） is proposed to solve this problem, in which an asymmetric progressive crossover operation is involved to overcome the local optima by the conventional job inserting methods. The numerical results show that, compared with the classical greedy randomized adaptive search procedure （GRASP） algorithm, the scheduling failure ratio of jobs can be reduced over 11% on average by the proposed ASA with EvAPR.
基金Supported by the Natural Science Foundation of Hubei Province of China(2011CDB229)
文摘In this paper, with the aid of large deviation formulas established in strong topology of functional space generated by HSlder norm, we discuss the functional sample path properties of subsequence＇s C-R increments for a Wiener process in HSlder norm. The obtained results, generalize the corresponding results of Chen and the classic Strassen＇s law of iterated logarithm for a Wiener process.
文摘The recent advancements in sensor technology have made it possible to collect enormous amounts of data in real time.How to find out unusual pattern from time series data plays a very important role in data mining.In this paper,we focus on the abnormal subsequence detection.The original definition of discord subsequences is defective for some kind of time series,in this paper we give a more robust definition which is based on the k nearest neighbors.We also donate a novel method for time series representation,it has better performance than traditional methods(like PAA/SAX)to represent the characteristic of some special time series.To speed up the process of abnormal subsequence detection,we used the clustering method to optimize the outer loop ordering and early abandon subsequence which is impossible to be abnormal.The experiment results validate that the algorithm is correct and has a high efficiency.
基金supported by the National Natural Science Foundation of China(Nos.11871425,11731012)the Fundamental Research Funds for Central Universities.
文摘Let X1,X2,…,Xn,…be a sequence of i.i.d.random variables uniformly distributed on[0;1],and denote by Ln the length of the longest increasing subsequences of X1,X2,…,Xn.Consider the poissonized version Hn based on Hammersley’s representation in the 2-dimensional space.A law of the iterated logarithm for Hn is established using the well-known subsequence method and Borel-Cantelli lemma.The key technical ingredients in the argument include superadditivity,increment independence and precise tail estimates for the Hn’s.The work was motivated by recent works due to Ledoux(J.Theoret.Probab.31,(2018)).It remains open to establish an analog for the Ln itself.
基金supported in part by the Fundamental Research Funds for the Central Universities(No.3122019152)the National Natural Science Foundation of China(Grant Nos.11701256,11871258)+2 种基金the Youth Backbone Teacher Foundation of Henan's University(No.2019GGJS196)the China Scholarship Council(Grant No.201908410132)was also supported in part by a Discovery Grant from the Natural Sciences and Engineering Research Council of Canada(Grant No.RGPIN 2017-03903).
文摘Let G be a finite abelian group and S be a sequence with elements of G.We say that S is a regular sequence over G if|SH|≤|H|-1 holds for every proper subgroup H of G,where SH denotes the subsequence of S consisting of all terms of S contained in H.We say that S is a zero-sum free sequence over G if 0■Σ(S),where Σ(S)■G denotes the set of group elements which can be expressed as a sum of a nonempty subsequence of S.In this paper,we study the inverse problems associated with Σ(S)when S is a regular sequence or a zero-sum free sequence over G=Cp■Cp,where p is a prime.
文摘Parkinson's disease(PD) has a complex and multifactorial pathophysiology. Various studies, conducted both in pre-clinical models and PD patients, have reported a link between the disruption of calcium(Ca^(2+)) homeostasis and the subsequent development of PD. Ca^(2+) regulation is crucial for neuronal survival, differentiation,exocytosis at synapses,gene transcription,and proliferation.
文摘Background This study investigated the potential impacts of increasing linoleic andα-linolenic acid intake during lactation and wean-to-breeding on subsequent reproduction of sows.A total of 309 sows(PIC Camborough L42)were balanced by parity(140 and 169 sows representing parity 1 to 2[P1-2]and 3 to 9[P3+],respectively)and assigned within parity to a 2×2 factorial arrangement.Factors included essential fatty acid(EFA)supplementation(control diets containing 1.2%linoleic and 0.15%α-linolenic acid or diets with 3.0%linoleic and 0.38%α-linolenic acid)and supplementation period(lactation or wean-to-breeding).Tallow(low EFA diets)or soybean oil(high EFA diets)were included at 4%in sorghum-soybean meal-wheat middlings-based diets to attain targeted EFA levels.Results High levels of EFA fed during lactation had no effect on feed intake or litter performance,but increased subsequent farrowing rate(P=0.027;82.1%vs.70.4%),tended to reduce the proportion of sows removed(P=0.070;12.4%vs.20.8%),decreased the number of total pigs born in the following litter(P=0.072;15.3 vs.16.2),and increased total pigs born alive per 100 sows weaned(P=0.062;1,122 vs.974),regardless of sow parity.Young sows(P1-2)consuming the high EFA diet during lactation displayed a shorter wean-to-estrus interval(P=0.035;4.2 vs.4.6),but P3+sows were unaffected.Increasing EFA intake for P3+sows,but not P1-2 sows,resulted in more sows bred by d 5(P=0.028;91.1%vs.81.7%)and more mummies in the subsequent litter(P=0.040;0.32 vs.0.16).Feeding increased EFA to P1-2 sows during the wean-to-breeding period decreased subsequent farrowing rate(P=0.042;72.0%vs.87.7%),and increased removal rate(P=0.003;28.8%vs.9.4%).Total pigs born alive per 100 sows weaned was reduced(P=0.007)in P1-2 sows when supplemented with EFA during wean-breeding(939 vs.1,149)but was not impacted in P3+sows(1,131 vs.982).Conclusions Supplemental EFA in lactation diets benefited subsequent reproduction of sows,regardless of parity.Increasing dietary levels of EFA during the wean-to-breeding period to younger sows negatively impacted subsequent reproduction.
基金financial support from the National Natural Science Foundation of China(Grant Nos.52305396,52371116,and 52375310)support of the research fellowship from the Alexander von Humboldt Foundation.
文摘The automotive industry increasingly relies on numerical simulations to predict the geometry and forming processes of complex curved parts.Accurate yield stress functions that cover a wide range of stress states,such as uniaxial tension,equi-biaxial tension,near-plane strain tension,and simple shear,are essential for implementing virtual manufacturing technologies.In this work,a new additive-coupled analytical yield stress function,CPN2025,is proposed to accurately describe plastic anisotropy under various loading conditions.CPN2025 integrates the Poly4 anisotropic yield criterion with the Hosford isotropic yield criterion under a non-associated flow rule.A non-fixed-exponent calibration strategy is introduced,overcoming the limitations of existing yield criteria that typically offer curvature adjustment with only positive or negative correlations.CPN2025 is compared with other non-associated yield functions,including SY2009,CQN2017,and NAFR-Poly4,to evaluate its performance in predicting the plastic anisotropy of DP490,QP1180,AA5754-O,and AA6016-T4.Results show that,while meeting convexity requirements,the additive-coupled approach not only provides greater flexibility than the multiplicative-coupled but also simplifies the acquisition of partial derivative information.CPN2025 delivers the highest accuracy in characterizing anisotropic yield behavior,particularly for near-plane strain tension and simple shear loadings.Additionally,incorporating more uniaxial tensile yield stress-calibrated material parameters significantly improves the prediction capacity of in-plane anisotropic behavior.The use of anisotropic hardening concepts enhances the model's capability to capture the subsequent yield behavior across the entire plastic strain range.
文摘BACKGROUND The combination of anti-epidermal growth factor receptor(EGFR)therapy and chemotherapy is currently a preferred first-line treatment for patients with unre-sectable,RAS and BRAF wild-type,left-sided metastatic colorectal cancer(mCRC).Several studies have also demonstrated the benefit of anti-EGFR therapy in sub-sequent line settings for this patient population.However,direct evidence com-paring the effectiveness of frontline vs subsequent anti-EGFR therapy remains limited,leaving a crucial gap in guiding optimal treatment strategies.AIM To compare overall survival(OS)between frontline and subsequent anti-EGFR treatment in patients with unresectable,RAS and BRAF wild-type,left-sided mCRC.METHODS We retrospectively reviewed the medical records of mCRC patients treated at The King Chulalongkorn Memorial Hospital and Songklanagarind Hospital,Thailand,between January 2013 and April 2023.Patients were classified into two groups based on the sequence of their anti-EGFR treatment.The primary endpoint was OS.RESULTS Among 222 patients with a median follow-up of 29 months,no significant difference in OS was observed between the frontline and subsequent-line groups(HR 1.03,95%CI:0.73-1.46,P=0.878).The median OS was 35.53 months(95%CI:26.59-44.47)for the frontline group and 31.60 months(95%CI:27.83-35.37)for the subsequent-line group.In the subsequent-line group,71 patients(32.4%)who ultimately never received anti-EGFR therapy had a significantly worse median OS of 19.70 months(95%CI:12.87-26.53).CONCLUSION Frontline and subsequent-line anti-EGFR treatments provide comparable OS in unresectable,RAS/BRAF wild-type,left-sided mCRC patients,but early exposure is vital for those unlikely to receive subsequent therapy.
文摘A fundamental problem in sequence stratigraphy is whether the sequences are global in extent and whether the sea level changes are eustatic in nature. Study on the Upper Devonian and Lower Carboniferous depositional sequences in different facies belts on the southern margin of the Upper Yangtze platform shows that different orders of sequences possess distinctive distribution and correlation in space, although the sea level changes in various orders of sequences may be primarily global in nature. The present paper regards the distribution in space, especially in different facies belts, as a criterion for defining and recognizing the various orders of sequences. The orthosequence (third order sequence) is probably global in nature, which may be discerned in various depositional facies belts on the continental margin and can be correlated over long distances, sometimes maybe worldwide. Commonly, correlation of the subsequences (fourth order sequences with time interval of 0.5 Ma to 1.5 Ma) is difficult in different facies belts, although some of them are probably also worldwide in distribution. A subsequence should be distinguishable and correlatable within at least one facies belt. The higher order sequences, including parasequences (fifth order sequences) and microsequences (sixth order sequences), are regional or local in distribution. They may have reflected the longer and shorter Milankovitch cycles respectively. Orthosequences and subsequences are usually recognizable in different facies belts, while parasequences and microsequences may be distinguished only in shallow marine deposits, but not in slope and basin facies deposits.
基金This work is fully supported by the Ministry of Science and Technology,Taiwan,Republic of China,under Grant Nos.MOST 110-2622-E-390-001 and MOST 109-2622-E-390-002-CC3.
文摘This paper introduces a novel transform method to produce the newly generated programs through code transform model called the second generation of Generative Pre-trained Transformer(GPT-2)reasonably,improving the program execution performance significantly.Besides,a theoretical estimation in statistics has given the minimum number of generated programs as required,which guarantees to find the best one within them.The proposed approach can help the voice assistant machine resolve the problem of inefficient execution of application code.In addition to GPT-2,this study develops the variational Simhash algorithm to check the code similarity between sample program and newly generated program,and conceives the piecewise longest common subsequence algorithm to examine the execution’s conformity from the two programs mentioned above.The code similarity check deducts the redundant generated programs,and the output conformity check finds the best-performing generative program.In addition to texts,the proposed approach can also prove the other media,including images,sounds,and movies.As a result,the newly generated program outperforms the sample program significantly because the number of code lines reduces 27.21%,and the program execution time shortens 24.62%.
文摘A study was made on temporal sequence of the earthquake swarm with M6. 7 which took place in Batang County, Sichuan Province, from April to Sept., 1989. Temporal sequence of the swarm was characterized by obvious sectional release process, in dex rise of creeping curve, certain order behavior among the peak values in the early sequence, transient tranquility before strong aftershocks and abnormal high values in sequential entropy. Subsequence of the swarm were represented by the forms of isolation pattern and mainshock-aftershock pattern,changed from the former pattern to the latter and characterized by fast-slow-fast attenuating pattern. According to time fractional dimension calculation results of the swarm sequence and the subsequences, it was discovered that non-scaling regions existed in the complicated temporal sequence structure, the span of non-scaling region of capacity dimension Do was different from that of the information dimension D1 of the same sequence, and the self-organizational features of the same sequence were different when various magnitude threshold values were selected for calculating. From the stochastic non-uniform spread of swarming high fractures in the seismic regions, it was primarily explained that the exponential attenuation of time sequence variation was likely to occur.Meanwhile, the level structures of various order sequences of the strong seismic swarm and the order problems were discussed.
基金Supported by the National Natural Science Foundation of China(91338101,91338108,61132002,6132106)Research Fund of Tsinghua University(2011Z05117)Co-innovation Laboratory of Aerospace Broadband Network Technology
文摘The scheduling efficiency of the tracking and data relay satellite system（TDRSS）is strictly limited by the scheduling degrees of freedom（DoF）,including time DoF defined by jobs＇ flexible time windows and spatial DoF brought by multiple servable tracking and data relay satellites（TDRSs）.In this paper,ageneralized multiple time windows（GMTW）model is proposed to fully exploit the time and spatial DoF.Then,the improvements of service capability and job-completion probability based on the GMTW are theoretically proved.Further,an asymmetric path-relinking（APR）based heuristic job scheduling framework is presented to maximize the usage of DoF provided by the GMTW.Simulation results show that by using our proposal 11%improvement of average jobcompletion probability can be obtained.Meanwhile,the computing time of the time-to-target can be shorten to 1/9 of the GRASP.
基金National Science Foundation of China(Nos.41801388,41901397)。
文摘The existing multi-source contour matching studies have focused on the matching methods with consideration of topological relations and similarity measurement based on spatial Euclidean distance,while it is lack of taking the contour geometric features into account,which may lead to mismatching in map boundaries and areas with intensive contours or extreme terrain changes.In light of this,it is put forward that a matching strategy from coarse to precious based on the contour geometric features.The proposed matching strategy can be described as follows.Firstly,the point sequence is converted to feature sequence according to a feature descriptive function based on curvature and angle of normal vector.Then the level of similarity among multi-source contours is calculated by using the longest common subsequence solution.Accordingly,the identical contours could be matched based on the above calculated results.In the experiment for the proposed method,the reliability and efficiency of the matching method are verified using simulative datasets and real datasets respectively.It has been proved that the proposed contour matching strategy has a high matching precision and good applicability.
基金supported by the Ministry of Science and Technology,Taiwan,under Grant Nos.MOST 111-2221-E-390-012 and MOST 111-2622-E-390-001.
文摘Our previous work has introduced the newly generated program using the code transformation model GPT-2,verifying the generated programming codes through simhash(SH)and longest common subsequence(LCS)algo-rithms.However,the entire code transformation process has encountered a time-consuming problem.Therefore,the objective of this study is to speed up the code transformation process signicantly.This paper has proposed deep learning approaches for modifying SH using a variational simhash(VSH)algorithm and replacing LCS with a piecewise longest common subsequence(PLCS)algorithm to faster the verication process in the test phase.Besides the code transformation model GPT-2,this study has also introduced MicrosoMASS and Facebook BART for a comparative analysis of their performance.Meanwhile,the explainable AI technique using local interpretable model-agnostic explanations(LIME)can also interpret the decision-making ofAImodels.The experimental results show that VSH can reduce the number of qualied programs by 22.11%,and PLCS can reduce the execution time of selected pocket programs by 32.39%.As a result,the proposed approaches can signicantly speed up the entire code transformation process by 1.38 times on average compared with our previous work.
文摘This paper investigates a procedure developed and reports on experiments performed to studying the utility of applying a combined structural property of a text’s sentences and term expansion using WordNet [1] and a local thesaurus [2] in the selection of the most appropriate extractive text summarization for a particular document. Sentences were tagged and normalized then subjected to the Longest Common Subsequence (LCS) algorithm [3] [4] for the selection of the most similar subset of sentences. Calculated similarity was based on LCS of pairs of sentences that make up the document. A normalized score was calculated and used to rank sentences. A selected top subset of the most similar sentences was then tokenized to produce a set of important keywords or terms. The produced terms were further expanded into two subsets using 1) WorldNet;and 2) a local electronic dictionary/thesaurus. The three sets obtained (the original and the expanded two) were then re-cycled to further refine and expand the list of selected sentences from the original document. The process was repeated a number of times in order to find the best representative set of sentences. A final set of the top (best) sentences was selected as candidate sentences for summarization. In order to verify the utility of the procedure, a number of experiments were conducted using an email corpus. The results were compared to those produced by human annotators as well as to results produced using some basic sentences similarity calculation method. Produced results were very encouraging and compared well to those of human annotators and Jacquard sentences similarity.
基金Project(51274250)supported by the National Natural Science Foundation of ChinaProject(2012BAK09B02-05)supported by the National Key Technology R&D Program during the 12th Five-year Plan of China
文摘An integration processing system of three-dimensional laser scanning information visualization in goaf was developed. It is provided with multiple functions, such as laser scanning information management for goaf, cloud data de-noising optimization, construction, display and operation of three-dimensional model, model editing, profile generation, calculation of goaf volume and roof area, Boolean calculation among models and interaction with the third party soft ware. Concerning this system with a concise interface, plentiful data input/output interfaces, it is featured with high integration, simple and convenient operations of applications. According to practice, in addition to being well-adapted, this system is favorably reliable and stable.
文摘AIM:To compare the outcomes of concomitant cholangiocarcinoma(C-CCA)and subsequent cholangiocar-cinoma(S-CCA)associated with hepatolithiasis. METHODS:From December 1987 to December 2007, 276 patients underwent hepatic resection for hepa-tolithiasis in Changhua Christian Hospital.Sixty-five patients were excluded due to incomplete medical records and the remaining 211 patients constituted our study population base.Ten patients were diag-nosed with C-CCA based on the preoperative biopsy or postoperative pathology.During the follow-up period, 12 patients developed S-CCA.The diagnosis of S-CCA was made by image-guided biopsy or by pathology if surgical intervention was carried out.Patient charts were reviewed to collect clinical information.Parameters such as CCA incidence,interval from operation to CCA diagnosis,interval from CCA diagnosis to disease-related death,follow-up time,and mortality rate were calculated for both the C-CCA and S-CCA groups.The outcomes of the C-CCA and S-CCA groups were math-ematically compared and analysed. RESULTS:Our study demonstrates the clinical implications and the survival outcomes of C-CCA and S-CCA. Among the patients with unilateral hepatolithiasis,the incidence rates of C-CCA and S-CCA were fairly similar (4.8%vs 4.5%,respectively,P=0.906).However,for the patients with bilateral hepatolithiasis,the incidence rate of S-CCA(12.2%)was higher than that of C-CCA (4.7%),although the sample size was limited and the difference between two groups was not statistically sig-nificant(P=0.211).The average follow-up time was 56 mo for the C-CCA group and 71 mo for the S-CCA group.Regard to the average time intervals from operation to CCA diagnosis,S-CCA was diagnosed after 67 mo from the initial hepatectomy.The average time intervals from the diagnoses of CCA to disease-related death was 41 mo for the C-CCA group and 4 mo for the S-CCA group,this difference approached statistical sig-nificance(P=0.075).Regarding the rates of overall and disease-related mortality,the C-CCA group had signifi-cantly lower overall mortality(70%vs 100%,P=0.041) and disease-related mortality(60%vs 100%,P=0.015) than the S-CCA group.For the survival outcomes of two groups,the Kaplan-Meier curves corresponding to each group also demonstrated better survival outcomes for the C-CCA group(log rank P=0.005).In the C-CCA group,three patients were still alive at the time of data analysis,all of them had free surgical margins and did not have pathologically proven lymph node metastasis at the time of the initial hepatectomy.In the S-CCA group,only one patient had chance to undergo a second hepatectomy,and all 12 S-CCA patients had died at the time of data analysis. CONCLUSION:C-CCA has better outcomes than S-CCA.The first hepatectomy is crucial because most patients with recurrent CCA or S-CCA are not eligible for repeated surgical intervention.
基金This work was funded by the 973 program(2012CB113900 and 2013CB127000)the 863 program(2012AA100101)and a National Natural Science Foundation of China NSFC grant(31301771)Research was conducted at the Key Laboratory of Biology and Genetic Improvement of Horticultural Crops,Ministry of Agriculture,P.R.China,and the Sino-Dutch Joint Lab of Horticultural Genomics Technology.
文摘The genus Brassica belongs to the plant family Brassicaceae,which includes many important crop species that are used as oilseed,condiments,or vegetables throughout the world.Brassica plants comprise many diverse species,and each species contains rich morphotypes showing extreme traits.Brassica species experienced an extra whole genome triplication(WGT)event compared with the model plant Arabidopsis thaliana.Whole genome sequencing of the Brassica species Brassica rapa,Brassica oleracea and others demonstrated that WGT plays an important role in the speciation and morphotype diversification of Brassica plants.Comparative genomic analysis based on the genome sequences of B.rapa and A.thaliana clearly identified the WGT event and further demonstrated that the translocated Proto-Calepine Karyotype(tPCK,n57)was the diploid ancestor of the three subgenomes in B.rapa.Following WGT,subsequent extensive genome fractionation,block reshuffling and chromosome reduction accompanied by paleocentromere descent from the three tPCK subgenomes during the rediploidization process produced stable diploid species.Genomic rearrangement of the diploid species and their hybridization then contributed to Brassica speciation.The subgenome dominance effect and biased gene retention,such as the over-retention of auxin-related genes after WGT,promoted functional gene evolution and thus propelled the expansion of rich morphotypes in the Brassica species.In conclusion,the WGT event initiated subsequent genomic and gene-level evolution,which further drove Brassica speciation and created rich morphotypes in each species.
