The essence of prose lies in expressing meaning and feeling of the prose, describing things and reasoning in real,plain and direct way, which is referred as its natural character. What the prose requires is to strive ...The essence of prose lies in expressing meaning and feeling of the prose, describing things and reasoning in real,plain and direct way, which is referred as its natural character. What the prose requires is to strive to make equivalence in the meaning, forms, taste, style and other aspects with the original text. What the prose express is not only the thematic meaning but also the stylistic meaning, in other words, the meaning that was contained in the content and forms. Hilaire Belloc, a famous prolific writer and historian, have formulated the six principles in translation of prose, in which he believes that the essence of translating is the resurrection of an alien thing in a native body.展开更多
The objective of the present work was to obtain pure ovine reproducers.Starting 2010 work began with the sheep herd of the Faculty of Veterinary Medicine and Animal Science of the Universidad Autónoma de Guerrero...The objective of the present work was to obtain pure ovine reproducers.Starting 2010 work began with the sheep herd of the Faculty of Veterinary Medicine and Animal Science of the Universidad Autónoma de Guerrero,located in the municipality of Pungarabato,Guerrero State,México.The faculty is 250 meters above sea level.The climate of the region is warm subhumid,with average temperature between 24 and 30°C,but in the heat season maximum temperatures up to 46°down in the shade.The rainfall regimen is 800-1,200 mm of rainfall per year.The production of sheep in Mexico is characterized mainly by creole animals and crosses are made with pure breeds imported from several European countries and USA.Therefore,there is a need to form local breeds adapted to the climatic conditions and production systems of Mexico.The sheep herd initially had 100 animal of hair,with 70 sheep with their lambs and a reproducer.These animals had phenotype Pelibuey,Black Belly,Doper and Katahdin.As of May 2010,consanguineous crosses were established.During this period the parameters were registered:date and type of birth,weight and sex of the newborn.Data on BW(Birth Weight)of males and females were analyzed by ANOVA(Analysis of Variance)and multiple comparison test was used for the comparison of means(Duncan,1955),with a significance level of P<0.05.The first reproducer was brown tobacco and had antlers,and the females had different phenotypes.Up to the present time,there are twenty studs with their respective descendants,and year 2019 the herd has 100 animals light brown and tobacco with their lambs(30),and a reproducer.The sheep are of medium size with 45 and 60 kg of average weight in females and male,respectively.Out of a total of 326 females and 335 males born,with an average weight of 2.62 kg at birth and a proliferative index of 1.41,20 MEVEZUG males were selected to be used as reproducers in 20 herds distributed in different sheep production units of the state of Guerrero.From the crosses of these breeders to the females of these herds,F1 animals(MEVEZUG×Criollo)are obtained.The sheep of different color to light brown or tobacco are discarded for the supply;the males are fed for the fodder in native meadows with irrigation with 95.17±19.45 g of daily gain of weight.In 2016,the trademark MEVEZUG was registered.It is concluded that to date the color of the breed has been fixed in females and males,which is light brown and tobacco brown,the registered productive indexes are acceptable and work will be continued to improve size and productive indexes,through selection of the best sheep.展开更多
The solution processibility of perovskites provides a costeffective and high-throughput route for fabricating state-of-the-art solar cells.However,the fast kinetics of precursor-to-perovskite transformation is suscept...The solution processibility of perovskites provides a costeffective and high-throughput route for fabricating state-of-the-art solar cells.However,the fast kinetics of precursor-to-perovskite transformation is susceptible to processing conditions,resulting in an uncontrollable variance in device performance.Here,we demonstrate a supramolecule confined approach to reproducibly fabricate perovskite films with an ultrasmooth,electronically homogeneous surface.The assembly of a calixarene capping layer on precursor surface can induce host-vip interactions with solvent molecules to tailor the desolvation kinetics,and initiate the perovskite crystallization from the sharp molecule-precursor interface.These combined effects significantly reduced the spatial variance and extended the processing window of perovskite films.As a result,the standard efficiency deviations of device-to-device and batch-to-batch devices were reduced from 0.64-0.26%to 0.67-0.23%,respectively.In addition,the perovskite films with ultrasmooth top surfaces exhibited photoluminescence quantum yield>10%and surface recombination velocities<100 cm s^(-1)for both interfaces that yielded p-i-n structured solar cells with power conversion efficiency over 25%.展开更多
The aim of the present paper is to study 2-complex symmetric bounded weighted composition operators on the Fock space of C^(N) with the conjugations J and J_(t,A,b) defined by ■ respectively,where k(z_(1),...,z_N)=(...The aim of the present paper is to study 2-complex symmetric bounded weighted composition operators on the Fock space of C^(N) with the conjugations J and J_(t,A,b) defined by ■ respectively,where k(z_(1),...,z_N)=(■,...,■),t∈C,b∈C^(N) and A is a linear operator on C^(N).An example of 2-complex symmetric bounded weighted composition operator with the conjugation J_(t,A,b) is given.展开更多
Reproducibility is a key aspect of the scientific method as it provides evidence for research claims. It is essential to promote openness, accessibility, and collaboration within the scientific community. This article...Reproducibility is a key aspect of the scientific method as it provides evidence for research claims. It is essential to promote openness, accessibility, and collaboration within the scientific community. This article aims to provide an introduction to best practices in reproducibility that are relevant to the transportation research community, to discuss issues and barriers to reproducibility, and to describe methods for addressing these issues. This article starts by discussing openness and transparency, then discusses several key best practices for reproducibility in transportation engineering, highlighting common methods and techniques, as well as the associated benefits. The paper concludes with a discussion of the key barriers to implementing reproducibility practices in transportation research and potential solutions. The barriers include existing culture and attitudes, data sensitivity, insufficient methodological detail, lack of code sharing, limited validation, additional time and research burden, and skill and knowledge gaps. Discussing each of these items provides an opportunity for the transportation research community to evolve to become one that embraces the openness and transparency of reproducibility.展开更多
Nuclear magnetic resonance(NMR)spectroscopy is an excellent tool for simultaneous identification and quantification of metabolites(metabolomics).NMR quantification of human lipoprotein subfractions and their component...Nuclear magnetic resonance(NMR)spectroscopy is an excellent tool for simultaneous identification and quantification of metabolites(metabolomics).NMR quantification of human lipoprotein subfractions and their components has proven to be a powerful approach to reveal pathophysiological insights in numerous diseases[1,2].This method has now been standardized with excellent inter-laboratory reproducibility within 10 days for simultaneous quantification of 105 lipoprotein components and 24 low-molecular weight(LMW)metabolites[3];close clustering was also shown for 12 quality-control(QC)samples measured in 3 months although without statistical details[2].However,these reports[[1],[2],[3]]did not cover many vital parameters for lipoprotein components(e.g.,cholesterol-esters and total-lipids),fatty acids,and N-acetyl-glycoproteins(NAGs).展开更多
We present and explore a new shock-capturing particle hydrodynamics approach.Our starting point is a commonly used discretization of smoothed particle hydrodynamics.We enhance this discretization with Roe’s approx-im...We present and explore a new shock-capturing particle hydrodynamics approach.Our starting point is a commonly used discretization of smoothed particle hydrodynamics.We enhance this discretization with Roe’s approx-imate Riemann solver,we identify its dissipative terms,and in these terms,we use slope-limited linear reconstruction.All gradients needed for our method are calculated with linearly reproducing kernels that are constructed to enforce the two lowest-order consistency relations.We scrutinize our reproducing kernel implementation carefully on a“glass-like”particle distribution,and we find that constant and linear functions are recovered to machine precision.We probe our method in a series of challenging 3D benchmark problems ranging from shocks over instabilities to Schulz-Rinne-type vorticity-creating shocks.All of our simulations show excellent agreement with analytic/reference solutions.展开更多
Signatures of superconductivity near 80 K have recently been discovered in single crystals of La_(3)Ni_(2)O_(7)under pressure,which makes it a new candidate for high-temperature superconductors dominated by 3d transit...Signatures of superconductivity near 80 K have recently been discovered in single crystals of La_(3)Ni_(2)O_(7)under pressure,which makes it a new candidate for high-temperature superconductors dominated by 3d transition elements,following the cuprate and iron-pnictide superconductors.However,there are several critical questions that have been perplexing the scientificommunity:(1)What factors contribute to the inconsistent reproducibility of the experimental results?(2)What is the fundamental nature of pressure-induced superconductivity:bulk or nonbulk(filamentary-like)(3)Where is the superconducting phase located within the sample if it is filamentary-like(4)Is the oxygen content important for the development and stabilization of superconductivity?In this study,we employ comprehensive high-pressure techniques to address these questions.Through our modulated ac susceptibility measurements,we are the firs to fin that the superconductivity in this nickelate is filamentary-like Our scanning transmission electron microscopy investigations suggest that the filamentary-lik superconductivity most likely emerges at the interface between La_(3)Ni_(2)O_(7)and La_(4)Ni_(3)O_(10)phases.By tuning the oxygen content of polycrystalline La_(3)Ni_(2)O_(7),we also fin that it plays vital role in the development and stabilization of superconductivity in this material.The upper and lower bounds on the oxygen content are 7.35 and 6.89,respectively.Our results provide not only new insights into the puzzling issues regarding this material,but also significan information that will enable a better understanding of its superconductivity.展开更多
BACKGROUND Syngeneic orthotopic tumor models offer an optimal functional tumor–immune interface for hepatocellular carcinoma research.Yet,unpredictable growth kinetics and spontaneous regression pose major obstacles....BACKGROUND Syngeneic orthotopic tumor models offer an optimal functional tumor–immune interface for hepatocellular carcinoma research.Yet,unpredictable growth kinetics and spontaneous regression pose major obstacles.Efficient induction protocols and continuous monitoring are therefore essential.Routine exploratory surgeries are ethically untenable,making non-invasive imaging modalities attractive alternatives.High-resolution magnetic resonance imaging and microcomputed tomography deliver detailed insights but incur substantial equipment costs,radiation risks,time demands,and require specialized expertise—challenges that limit their routine use.In contrast,ultrasound(US)imaging emerges as a cost-effective,radiation-free,and rapid approach,facilitating practical and ethical longitudinal assessment of tumor progression in preclinical studies.AIM To optimize the orthotopic hepatocellular carcinoma model and evaluate the potential of US imaging for accurate and cost-effective tumor monitoring.METHODS Hepatocellular carcinoma was induced in 28 Sprague Dawley rats by implanting 5×10^(6) N1S1 cells into the left lateral hepatic lobe.Tumor progression was monitored weekly via US.Upon reaching 100-150 mm^(3),an experimental group(n=14)received Sorafenib(40 mg/kg)orally on alternate days for 28 days;efficacy was compared to untreated controls.US accuracy was validated against micro-computed tomography,gross caliper measurements and histopathological analysis.Reliability and operator proficiency in US assessment were also evaluated.RESULTS US images procured 7-day post-surgery revealed a well-defined hypoechoic nodule at the left liver lobe tip,confirming successful tumor induction(mean volume 130±39 mm^(3)).Only three animals exhibited spontaneous regression by week 2,underscoring the model’s stability.Sorafenib treatment elicited a marked tumor reduction(678±103 mm^(3))vs untreated control(6005±1760 mm^(3)).US assessment demonstrated robust intra and interobserver reproducibility with high sensitivity and specificity for tumor detection.Moreover,US derived volumes correlated strongly with gross caliper measurements,histopathological analysis,and microcomputed tomography imaging,validating its reliability as a non-invasive monitoring tool in preclinical hepatocellular carcinoma studies.CONCLUSION The results demonstrate that US imaging is a reliable,cost-effective,and animal sparing approach with an easy tomaster protocol,enabling monitoring of tumor progression and therapeutic response in orthotopic liver tumor models.展开更多
The relationship among Mercer kernel, reproducing kernel and positive definite kernel in support vector machine （SVM） is proved and their roles in SVM are discussed. The quadratic form of the kernel matrix is used t...The relationship among Mercer kernel, reproducing kernel and positive definite kernel in support vector machine （SVM） is proved and their roles in SVM are discussed. The quadratic form of the kernel matrix is used to confirm the positive definiteness and their construction. Based on the Bochner theorem, some translation invariant kernels are checked in their Fourier domain. Some rotation invariant radial kernels are inspected according to the Schoenberg theorem. Finally, the construction of discrete scaling and wavelet kernels, the kernel selection and the kernel parameter learning are discussed.展开更多
(an original scientific journal published monthly in English in two volumes,twelve issues per year.Published since 1982)Published monthly in hard copy by Chinese Physical Society and online by IOP Publishing.Temple Ci...(an original scientific journal published monthly in English in two volumes,twelve issues per year.Published since 1982)Published monthly in hard copy by Chinese Physical Society and online by IOP Publishing.Temple Circus.Temple Way.Bristol BS1 6HG.UK.International Institutional subscription information:2014 volume For international subscription information for 2014 please contact the Journals Subscription Fulfilment Department on cust.servSiop.org展开更多
A collision model, an automobile model and a multi-rigid-body model in PC-crash are analyzed. By simulating a side collision accident between a car and an electric bicycle (EB), a method that reproduces the car-electr...A collision model, an automobile model and a multi-rigid-body model in PC-crash are analyzed. By simulating a side collision accident between a car and an electric bicycle (EB), a method that reproduces the car-electric bicycle side collision accident based on PC-crash is presented according to some important information such as the final position, the contacting location between the cyclist and the car. A result is obtained by comparing with the reproduced result, the deformation of accident vehicle and the surveillance video. The rollover direction and fells-over sliding direction after the collision and the contacting location and wrap motion of cyclist and electric bicycle are fitting in with the real situation better compared with the reconstruction result in PC-crash. Then the responsive-surface method and MONTEKARLO method are used in MATLAB to analyze the uncertainty of the vehicle speed in reproduced scene results. And the range of values of the pre-collision speed is obtained which makes the reproduced result more objective and convincible that could provide the basis of the accident assessment.展开更多
Dear Editor,Transposable phages,which are reproduced by transposition(Harshey,2012;Taylor,1963),have been widely applied in the field of biotechnology to manipulate operon/gene fusions,in vivo cloning,randomion mutage...Dear Editor,Transposable phages,which are reproduced by transposition(Harshey,2012;Taylor,1963),have been widely applied in the field of biotechnology to manipulate operon/gene fusions,in vivo cloning,randomion mutagenesis,and integration of DNA into bacterial genomes(Abalakina et al.,2008;Akhverdyan et al.,2011).One of the best-studied transposable phages is展开更多
Firstly,the relationship between the accuracy of low altitude aerial photogrammetry and the field angle of camera is made by a quantitative analysis from the theory.The conclusion that the low altitude photogrammetry ...Firstly,the relationship between the accuracy of low altitude aerial photogrammetry and the field angle of camera is made by a quantitative analysis from the theory.The conclusion that the low altitude photogrammetry should use wide-angle camera as much as possible is done.Then,the limitation of the single lens camera to expand field angle and the combined wide-angle camera existing on the market not suitable for light load of low altitude UAV(Unmanned Aerial Vehicle)due to excessive weight are pointed out.The characteristics of combined wide-angle low altitude light camera with self-calibration and self-stabilization developed by the author are described,especially the principle of self-calibration for the combination of static error and dynamic error.Based on the practice of large scale mapping,a technical procedure in aerial photography by taking with wide-angle camera and large overlap simultaneously for improving the accuracy of low altitude photogrammetry is proposed.The typical engineering produced data is used to verity the above theoretical analysis.A technical route for increasing accuracy of low altitude photogrammetry with combined wide-angle camera is expounded.展开更多
To examine the circulation in shallow water with tidal flat, a finite element model for the numerical solution of the shallow water equations was developed by means of standard Galerkin's method. The domain comput...To examine the circulation in shallow water with tidal flat, a finite element model for the numerical solution of the shallow water equations was developed by means of standard Galerkin's method. The domain computed was covered with triangular finite elements, and water elevation and velocity were approximated by linear interpolation functions, and the lumped coefficients were used to substitute for solving the high order algebraic equation system. The time-dependent land-water boundary changes are treated mathematically by interrelating the location of the land-water boundary with the instantaneous tidal level. The implicit scheme was adopted for the terms of the bottom friction and the Coriolis effect in the motion equation so that the numerical stability of the model has been improved.The model was applied to the tidal current on shoaling water with large tidal flat off Pikou, and a comparison between observed and calculated values showed good agreement, the flow pattern being reproduced. The result shows that the model is able to be widely applied to predicting the circulation in shoaling waters.展开更多
During the past ten years. our molecular studies haddemonstrated that myelodysplasia of MDS bone marrowwas associated with the rearrangement/amplification ofc-erbB and deletion/ inactivation of c-erbA and identifiedth...During the past ten years. our molecular studies haddemonstrated that myelodysplasia of MDS bone marrowwas associated with the rearrangement/amplification ofc-erbB and deletion/ inactivation of c-erbA and identifiedthe sites of the rearrangement by v-erbB PCR genediagnosis of MDS and confirmed their etiogenicsignificance by the follow-up of MDS cases. These resultsprovided 2 target sequences of c-erbB.The展开更多
An experimental model using laboratory animals wasdeveloped in order to reproduce cultural and socialconditions of some human populations.BALB/c mice ofboth sexes were employed.After weaning,animals werefed with two d...An experimental model using laboratory animals wasdeveloped in order to reproduce cultural and socialconditions of some human populations.BALB/c mice ofboth sexes were employed.After weaning,animals werefed with two diets,one containing 25% protein(S25)展开更多
Geneod hpers snuttehfor pnwcahon sM山 b new pncahons.nor rtlollcatlon In CoMrence prnceetunp danatract,smp,orMer山brevated,prmnaly form d matend sh not Preclude Pncanon In this Joumd when nobce ofsuchpor or concllrren...Geneod hpers snuttehfor pnwcahon sM山 b new pncahons.nor rtlollcatlon In CoMrence prnceetunp danatract,smp,orMer山brevated,prmnaly form d matend sh not Preclude Pncanon In this Joumd when nobce ofsuchpor or concllrrent p山icahon given at the same ime of eMl’llsalonaed maten.which M not ben publishd in En-gah,。11 alBo e c。iders4.hPe。sdouM cover set。n皿c and teeMed。ubfocts,andthey may。展开更多
文摘The essence of prose lies in expressing meaning and feeling of the prose, describing things and reasoning in real,plain and direct way, which is referred as its natural character. What the prose requires is to strive to make equivalence in the meaning, forms, taste, style and other aspects with the original text. What the prose express is not only the thematic meaning but also the stylistic meaning, in other words, the meaning that was contained in the content and forms. Hilaire Belloc, a famous prolific writer and historian, have formulated the six principles in translation of prose, in which he believes that the essence of translating is the resurrection of an alien thing in a native body.
文摘The objective of the present work was to obtain pure ovine reproducers.Starting 2010 work began with the sheep herd of the Faculty of Veterinary Medicine and Animal Science of the Universidad Autónoma de Guerrero,located in the municipality of Pungarabato,Guerrero State,México.The faculty is 250 meters above sea level.The climate of the region is warm subhumid,with average temperature between 24 and 30°C,but in the heat season maximum temperatures up to 46°down in the shade.The rainfall regimen is 800-1,200 mm of rainfall per year.The production of sheep in Mexico is characterized mainly by creole animals and crosses are made with pure breeds imported from several European countries and USA.Therefore,there is a need to form local breeds adapted to the climatic conditions and production systems of Mexico.The sheep herd initially had 100 animal of hair,with 70 sheep with their lambs and a reproducer.These animals had phenotype Pelibuey,Black Belly,Doper and Katahdin.As of May 2010,consanguineous crosses were established.During this period the parameters were registered:date and type of birth,weight and sex of the newborn.Data on BW(Birth Weight)of males and females were analyzed by ANOVA(Analysis of Variance)and multiple comparison test was used for the comparison of means(Duncan,1955),with a significance level of P<0.05.The first reproducer was brown tobacco and had antlers,and the females had different phenotypes.Up to the present time,there are twenty studs with their respective descendants,and year 2019 the herd has 100 animals light brown and tobacco with their lambs(30),and a reproducer.The sheep are of medium size with 45 and 60 kg of average weight in females and male,respectively.Out of a total of 326 females and 335 males born,with an average weight of 2.62 kg at birth and a proliferative index of 1.41,20 MEVEZUG males were selected to be used as reproducers in 20 herds distributed in different sheep production units of the state of Guerrero.From the crosses of these breeders to the females of these herds,F1 animals(MEVEZUG×Criollo)are obtained.The sheep of different color to light brown or tobacco are discarded for the supply;the males are fed for the fodder in native meadows with irrigation with 95.17±19.45 g of daily gain of weight.In 2016,the trademark MEVEZUG was registered.It is concluded that to date the color of the breed has been fixed in females and males,which is light brown and tobacco brown,the registered productive indexes are acceptable and work will be continued to improve size and productive indexes,through selection of the best sheep.
基金financially supported by the National Natural Science Foundation of China(22379044,22472053)the Science and Technology Commission of Shanghai Municipality(23520710700)+6 种基金the Key Program of the National Natural Science Foundation of China(22239001)the Shanghai Pilot Program for Basic Research(22TQ1400100-5)the ShanghaiMunicipal Natural Science Foundation(25ZR1401081)the Fundamental Research Funds for the Central Universities(JKD01251505,JKVD1251041)the Postdoctoral Fellowship Program of CPSF(GZC20250071)the Shanghai Engineering Research Center of Hierarchical Nanomaterials(18DZ2252400)the Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism(Shanghai Municipal Education Commission)。
文摘The solution processibility of perovskites provides a costeffective and high-throughput route for fabricating state-of-the-art solar cells.However,the fast kinetics of precursor-to-perovskite transformation is susceptible to processing conditions,resulting in an uncontrollable variance in device performance.Here,we demonstrate a supramolecule confined approach to reproducibly fabricate perovskite films with an ultrasmooth,electronically homogeneous surface.The assembly of a calixarene capping layer on precursor surface can induce host-vip interactions with solvent molecules to tailor the desolvation kinetics,and initiate the perovskite crystallization from the sharp molecule-precursor interface.These combined effects significantly reduced the spatial variance and extended the processing window of perovskite films.As a result,the standard efficiency deviations of device-to-device and batch-to-batch devices were reduced from 0.64-0.26%to 0.67-0.23%,respectively.In addition,the perovskite films with ultrasmooth top surfaces exhibited photoluminescence quantum yield>10%and surface recombination velocities<100 cm s^(-1)for both interfaces that yielded p-i-n structured solar cells with power conversion efficiency over 25%.
基金Supported by Sichuan Science and Technology Program (No.2022ZYD0010)。
文摘The aim of the present paper is to study 2-complex symmetric bounded weighted composition operators on the Fock space of C^(N) with the conjugations J and J_(t,A,b) defined by ■ respectively,where k(z_(1),...,z_N)=(■,...,■),t∈C,b∈C^(N) and A is a linear operator on C^(N).An example of 2-complex symmetric bounded weighted composition operator with the conjugation J_(t,A,b) is given.
文摘Reproducibility is a key aspect of the scientific method as it provides evidence for research claims. It is essential to promote openness, accessibility, and collaboration within the scientific community. This article aims to provide an introduction to best practices in reproducibility that are relevant to the transportation research community, to discuss issues and barriers to reproducibility, and to describe methods for addressing these issues. This article starts by discussing openness and transparency, then discusses several key best practices for reproducibility in transportation engineering, highlighting common methods and techniques, as well as the associated benefits. The paper concludes with a discussion of the key barriers to implementing reproducibility practices in transportation research and potential solutions. The barriers include existing culture and attitudes, data sensitivity, insufficient methodological detail, lack of code sharing, limited validation, additional time and research burden, and skill and knowledge gaps. Discussing each of these items provides an opportunity for the transportation research community to evolve to become one that embraces the openness and transparency of reproducibility.
基金financial supports from the National Key R&D Program of China(Grant Nos.:2022YFC3400700 and 2022YFA0806400)the Shanghai Municipal Science and Technology Major Project,China(Grant No.:2017SHZDZX01)the National Natural Science Foundation of China(Grant No.:31821002).
文摘Nuclear magnetic resonance(NMR)spectroscopy is an excellent tool for simultaneous identification and quantification of metabolites(metabolomics).NMR quantification of human lipoprotein subfractions and their components has proven to be a powerful approach to reveal pathophysiological insights in numerous diseases[1,2].This method has now been standardized with excellent inter-laboratory reproducibility within 10 days for simultaneous quantification of 105 lipoprotein components and 24 low-molecular weight(LMW)metabolites[3];close clustering was also shown for 12 quality-control(QC)samples measured in 3 months although without statistical details[2].However,these reports[[1],[2],[3]]did not cover many vital parameters for lipoprotein components(e.g.,cholesterol-esters and total-lipids),fatty acids,and N-acetyl-glycoproteins(NAGs).
基金supported by the Swedish Research Council(VR)under grant number 2020-05044by the research environment grant"Gravitational Radiation and Electromagnetic Astrophysical Transients"(GREAT)funded by the Swedish Research Council(VR)under Dnr 2016-06012+2 种基金by the Knut and Alice Wallenberg Foundation under grant Dnr.KAW 2019.0112by the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)under Germany's Excellence Strategy-EXC 2121"Quantum Universe"-390833306by the European Research Council(ERC)Advanced Grant INSPIRATION under the European Union's Horizon 2020 Research and Innovation Programme(Grant agreement No.101053985).
文摘We present and explore a new shock-capturing particle hydrodynamics approach.Our starting point is a commonly used discretization of smoothed particle hydrodynamics.We enhance this discretization with Roe’s approx-imate Riemann solver,we identify its dissipative terms,and in these terms,we use slope-limited linear reconstruction.All gradients needed for our method are calculated with linearly reproducing kernels that are constructed to enforce the two lowest-order consistency relations.We scrutinize our reproducing kernel implementation carefully on a“glass-like”particle distribution,and we find that constant and linear functions are recovered to machine precision.We probe our method in a series of challenging 3D benchmark problems ranging from shocks over instabilities to Schulz-Rinne-type vorticity-creating shocks.All of our simulations show excellent agreement with analytic/reference solutions.
基金supported by the National Key Research and Development Program of China(Grant Nos.2022YFA1403900 and 2021YFA1401800)the NSF of China(Grant Nos.U2032214,12122414,12104487,and 12004419)+2 种基金the Strategic Priority Research Program(B)of the Chinese Academy of Sciences(Grant No.XDB25000000)support from the Youth Innovation Promotion Association of the CAS(2019008)supported by the Synergetic Extreme Condition User Facility(SECUF)。
文摘Signatures of superconductivity near 80 K have recently been discovered in single crystals of La_(3)Ni_(2)O_(7)under pressure,which makes it a new candidate for high-temperature superconductors dominated by 3d transition elements,following the cuprate and iron-pnictide superconductors.However,there are several critical questions that have been perplexing the scientificommunity:(1)What factors contribute to the inconsistent reproducibility of the experimental results?(2)What is the fundamental nature of pressure-induced superconductivity:bulk or nonbulk(filamentary-like)(3)Where is the superconducting phase located within the sample if it is filamentary-like(4)Is the oxygen content important for the development and stabilization of superconductivity?In this study,we employ comprehensive high-pressure techniques to address these questions.Through our modulated ac susceptibility measurements,we are the firs to fin that the superconductivity in this nickelate is filamentary-like Our scanning transmission electron microscopy investigations suggest that the filamentary-lik superconductivity most likely emerges at the interface between La_(3)Ni_(2)O_(7)and La_(4)Ni_(3)O_(10)phases.By tuning the oxygen content of polycrystalline La_(3)Ni_(2)O_(7),we also fin that it plays vital role in the development and stabilization of superconductivity in this material.The upper and lower bounds on the oxygen content are 7.35 and 6.89,respectively.Our results provide not only new insights into the puzzling issues regarding this material,but also significan information that will enable a better understanding of its superconductivity.
基金Supported by Amrita Vishwa Vidyapeetham Seed Grant,No.K-PHAR-24-722DST INSPIRE Fellowship,No.IF190226.
文摘BACKGROUND Syngeneic orthotopic tumor models offer an optimal functional tumor–immune interface for hepatocellular carcinoma research.Yet,unpredictable growth kinetics and spontaneous regression pose major obstacles.Efficient induction protocols and continuous monitoring are therefore essential.Routine exploratory surgeries are ethically untenable,making non-invasive imaging modalities attractive alternatives.High-resolution magnetic resonance imaging and microcomputed tomography deliver detailed insights but incur substantial equipment costs,radiation risks,time demands,and require specialized expertise—challenges that limit their routine use.In contrast,ultrasound(US)imaging emerges as a cost-effective,radiation-free,and rapid approach,facilitating practical and ethical longitudinal assessment of tumor progression in preclinical studies.AIM To optimize the orthotopic hepatocellular carcinoma model and evaluate the potential of US imaging for accurate and cost-effective tumor monitoring.METHODS Hepatocellular carcinoma was induced in 28 Sprague Dawley rats by implanting 5×10^(6) N1S1 cells into the left lateral hepatic lobe.Tumor progression was monitored weekly via US.Upon reaching 100-150 mm^(3),an experimental group(n=14)received Sorafenib(40 mg/kg)orally on alternate days for 28 days;efficacy was compared to untreated controls.US accuracy was validated against micro-computed tomography,gross caliper measurements and histopathological analysis.Reliability and operator proficiency in US assessment were also evaluated.RESULTS US images procured 7-day post-surgery revealed a well-defined hypoechoic nodule at the left liver lobe tip,confirming successful tumor induction(mean volume 130±39 mm^(3)).Only three animals exhibited spontaneous regression by week 2,underscoring the model’s stability.Sorafenib treatment elicited a marked tumor reduction(678±103 mm^(3))vs untreated control(6005±1760 mm^(3)).US assessment demonstrated robust intra and interobserver reproducibility with high sensitivity and specificity for tumor detection.Moreover,US derived volumes correlated strongly with gross caliper measurements,histopathological analysis,and microcomputed tomography imaging,validating its reliability as a non-invasive monitoring tool in preclinical hepatocellular carcinoma studies.CONCLUSION The results demonstrate that US imaging is a reliable,cost-effective,and animal sparing approach with an easy tomaster protocol,enabling monitoring of tumor progression and therapeutic response in orthotopic liver tumor models.
基金Supported by the National Natural Science Foundation of China(60473035)~~
文摘The relationship among Mercer kernel, reproducing kernel and positive definite kernel in support vector machine （SVM） is proved and their roles in SVM are discussed. The quadratic form of the kernel matrix is used to confirm the positive definiteness and their construction. Based on the Bochner theorem, some translation invariant kernels are checked in their Fourier domain. Some rotation invariant radial kernels are inspected according to the Schoenberg theorem. Finally, the construction of discrete scaling and wavelet kernels, the kernel selection and the kernel parameter learning are discussed.
文摘(an original scientific journal published monthly in English in two volumes,twelve issues per year.Published since 1982)Published monthly in hard copy by Chinese Physical Society and online by IOP Publishing.Temple Circus.Temple Way.Bristol BS1 6HG.UK.International Institutional subscription information:2014 volume For international subscription information for 2014 please contact the Journals Subscription Fulfilment Department on cust.servSiop.org
文摘A collision model, an automobile model and a multi-rigid-body model in PC-crash are analyzed. By simulating a side collision accident between a car and an electric bicycle (EB), a method that reproduces the car-electric bicycle side collision accident based on PC-crash is presented according to some important information such as the final position, the contacting location between the cyclist and the car. A result is obtained by comparing with the reproduced result, the deformation of accident vehicle and the surveillance video. The rollover direction and fells-over sliding direction after the collision and the contacting location and wrap motion of cyclist and electric bicycle are fitting in with the real situation better compared with the reconstruction result in PC-crash. Then the responsive-surface method and MONTEKARLO method are used in MATLAB to analyze the uncertainty of the vehicle speed in reproduced scene results. And the range of values of the pre-collision speed is obtained which makes the reproduced result more objective and convincible that could provide the basis of the accident assessment.
基金supported by the National Basic Research Program(973 Program)of China(2014CB745100)the National Key Technologies R&D Program of China(2012AA022101)
文摘Dear Editor,Transposable phages,which are reproduced by transposition(Harshey,2012;Taylor,1963),have been widely applied in the field of biotechnology to manipulate operon/gene fusions,in vivo cloning,randomion mutagenesis,and integration of DNA into bacterial genomes(Abalakina et al.,2008;Akhverdyan et al.,2011).One of the best-studied transposable phages is
文摘Firstly,the relationship between the accuracy of low altitude aerial photogrammetry and the field angle of camera is made by a quantitative analysis from the theory.The conclusion that the low altitude photogrammetry should use wide-angle camera as much as possible is done.Then,the limitation of the single lens camera to expand field angle and the combined wide-angle camera existing on the market not suitable for light load of low altitude UAV(Unmanned Aerial Vehicle)due to excessive weight are pointed out.The characteristics of combined wide-angle low altitude light camera with self-calibration and self-stabilization developed by the author are described,especially the principle of self-calibration for the combination of static error and dynamic error.Based on the practice of large scale mapping,a technical procedure in aerial photography by taking with wide-angle camera and large overlap simultaneously for improving the accuracy of low altitude photogrammetry is proposed.The typical engineering produced data is used to verity the above theoretical analysis.A technical route for increasing accuracy of low altitude photogrammetry with combined wide-angle camera is expounded.
文摘To examine the circulation in shallow water with tidal flat, a finite element model for the numerical solution of the shallow water equations was developed by means of standard Galerkin's method. The domain computed was covered with triangular finite elements, and water elevation and velocity were approximated by linear interpolation functions, and the lumped coefficients were used to substitute for solving the high order algebraic equation system. The time-dependent land-water boundary changes are treated mathematically by interrelating the location of the land-water boundary with the instantaneous tidal level. The implicit scheme was adopted for the terms of the bottom friction and the Coriolis effect in the motion equation so that the numerical stability of the model has been improved.The model was applied to the tidal current on shoaling water with large tidal flat off Pikou, and a comparison between observed and calculated values showed good agreement, the flow pattern being reproduced. The result shows that the model is able to be widely applied to predicting the circulation in shoaling waters.
文摘During the past ten years. our molecular studies haddemonstrated that myelodysplasia of MDS bone marrowwas associated with the rearrangement/amplification ofc-erbB and deletion/ inactivation of c-erbA and identifiedthe sites of the rearrangement by v-erbB PCR genediagnosis of MDS and confirmed their etiogenicsignificance by the follow-up of MDS cases. These resultsprovided 2 target sequences of c-erbB.The
文摘An experimental model using laboratory animals wasdeveloped in order to reproduce cultural and socialconditions of some human populations.BALB/c mice ofboth sexes were employed.After weaning,animals werefed with two diets,one containing 25% protein(S25)
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